Determinants Of Online Shopping In Manado

Retailers utilize online media to reach more potential customers. Internet connects the retailer and customers without any geographic location boundaries. Internet growth has a positive impact for business world. There is a new shopping method in non-store shopping as people can buy products or services without having to travel to the outlets like traditional retail does. With the increase of online retailers on internet world, online shopping became popular. The objective of this research is to know the factors that drive people in Manado to purchase online. Theories supporting of research are online shopping and its factors. Population of this research is people in Manado who ever made online purchasing with sample as many as 100 respondents. Confirmatory factor analyze were used to analyze the twenty variables in this research. The results and conclusions are from twenty variables observed, sixteen variables form six factors that drive people to shop online. Those factors are service quality, perceived security, shopping intention, relative advantage, brick and click, and internet knowledge. There are four variables that do not significantly influence shoppers to shop online, namely: payment option, web design, research, and providing good information.Keywords: online shoppin

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated HNF1B gene expression and allele-specific epigenetic silencing, and outline a mechanism by which common risk variants could effect functional changes that increase disease risk: functional assays suggest that HNF1B is a pro-differentiation factor that suppresses epithelial-to-mesenchymal transition (EMT) in unmethylated, healthy tissues. This tumor-suppressor activity is lost when HNF1B is silenced by promoter methylation in the progression to PC. Epigenetic inactivation of HNF1B in ovarian cancer also associates with known risk SNPs, with a similar impact on EMT. This represents one of the first comprehensive studies into the pleiotropic role of a GWAS-associated transcription factor across distinct cancer types, and is the first to describe a conserved role for a multi-cancer genetic risk factor

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis