1,796 research outputs found
TEM study on application of phosphoric acid and self-etching primer to sclerotic dentin
Abstract no. 27published_or_final_versio
An ultrastructural study of bonding of a self-etching primer to sclerotic dentin
Abstract no. 1538published_or_final_versio
Using discrete choice experiments to investigate subject preferences for preventive asthma medication
Background and objective: Long-term adherence to inhaled corticosteroids is poor despite the crucial role of preventer medications in achieving good asthma outcomes. This study was undertaken to explore patient preferences in relation to their current inhaled corticosteroid medication, a hypothetical preventer or no medication. Methods: A discrete choice experiment was conducted in 57 adults with mild-moderate asthma and airway hyper-responsiveness, who were using inhaled corticosteroid ≤500 μg/day (beclomethasone equivalent). In the discrete choice experiment, subjects evaluated 16 hypothetical scenarios made up of 10 attributes that described the process and outcomes of taking asthma medication, with two to four levels for each attribute. For each scenario, subjects chose between the hypothetical medication, the medication they were currently taking and no asthma medication. A random parameter multinomial logit model was estimated to quantify subject preferences for the aspects of taking asthma medication and the influence of attributes on medication decisions. Results: Subjects consistently made choices in favour of being able to do strenuous and sporting activities with or without reliever, experiencing no side-effects and never having to monitor their peak flow. Frequency of collecting prescriptions, frequency of taking the medication, its route of administration and the strength of the doctor recommendation about the medication were not significant determinants of choice. Conclusions: The results of this study suggest that patients prefer a preventer that confers capacity to maximize physical activity, has no side-effects and does not require daily peak flow monitoring. © 2007 The Authors
Screening and assessment tools for gaming disorder: A comprehensive systematic review
The inclusion of gaming disorder (GD) as an official diagnosis in the ICD-11 was a significant milestone for the field. However, the optimal measurement approaches for GD are currently unclear. This comprehensive systematic review aimed to identify and evaluate all available English-language GD tools and their corresponding evidence. A search of PsychINFO, PsychArticles, ScienceDirect, Scopus, Web of Science, and Google Scholar identified 32 tools employed in 320 studies (N = 462,249 participants). The evaluation framework examined tools in relation to: (1) conceptual and practical considerations; (2) alignment with DSM-5 and ICD-11 criteria; (3) type and quantity of studies and samples; and (4) psychometric properties. The evaluation showed that GD instrumentation has proliferated, with 2.5 tools, on average, published annually since 2013. Coverage of DSM-5 and ICD-11 criteria was inconsistent, especially for the criterion of continued use despite harm. Tools converge on the importance of screening for impaired control over gaming and functional impairment. Overall, no single tool was found to be clearly superior, but the AICA-Sgaming, GAS-7, IGDT-10, IGDS9-SF, and Lemmens IGD-9 scales had greater evidential support for their psychometric properties. The GD field would benefit from a standard international tool to identify gaming-related harms across the spectrum of maladaptive gaming behaviors.Peer reviewedFinal Accepted Versio
The nonlinear anomalous lattice elasticity associated with the high-pressure phase transition in spodumene: A high precission static compression study
The high-pressure behavior of the lattice elasticity of spodumene, LiAlSi2O6,
was studied by static compression in a diamond-anvil cell up to 9.3 GPa.
Investigations by means of single-crystal XRD and Raman spectroscopy within the
hydrostatic limits of the pressure medium focus on the pressure ranges around
similar to 3.2 and similar to 7.7 GPa, which have been reported previously to
comprise two independent structural phase transitions. While our measurements
confirm the well-established first-order C2/c-P2(1)/c transformation at 3.19
GPa (with 1.2% volume discontinuity and a hysteresis between 0.02 and 0.06
GPa), both unit-cell dimensions and the spectral changes observed in
high-pressure Raman spectra give no evidence for structural changes related to
a second phase transition. Monoclinic lattice parameters and unit-cell volumes
at in total 59 different pressure points have been used to re-calculate the
lattice-related properties of spontaneous strain, volume strain, and the bulk
moduli as a function of pressure across the transition. A modified Landau free
energy expansion in terms of a one component order parameter has been developed
and tested against these experimentally determined data. The Landau solution
provides a much better reproduction of the observed anomalies than any
equation-of-state fit to data sets truncated below and above P (tr), thus
giving Landau parameters of K (0) = 138.3(2) GPa, K' = 7.46(5), lambda (V) =
33.6(2) GPa, a = 0.486(3), b = -29.4(6) GPa and c = 551(11) GPa
A runaway collision in a young star cluster as the origin of the brightest supernova
Supernova 2006gy in the galaxy NGC 1260 is the most luminous one recorded
\cite{2006CBET..644....1Q, 2006CBET..647....1H, 2006CBET..648....1P,
2006CBET..695....1F}. Its progenitor might have been a very massive (
\msun) star \cite{2006astro.ph.12617S}, but that is incompatible with hydrogen
in the spectrum of the supernova, because stars \msun are believed to
have shed their hydrogen envelopes several hundred thousand years before the
explosion \cite{2005A&A...429..581M}. Alternatively, the progenitor might have
arisen from the merger of two massive stars \cite{2007ApJ...659L..13O}. Here we
show that the collision frequency of massive stars in a dense and young cluster
(of the kind to be expected near the center of a galaxy) is sufficient to
provide a reasonable chance that SN 2006gy resulted from such a bombardment. If
this is the correct explanation, then we predict that when the supernova fades
(in a year or so) a dense cluster of massive stars becomes visible at the site
of the explosion
Similarity solutions for unsteady shear-stress-driven flow of Newtonian and power-law fluids : slender rivulets and dry patches
Unsteady flow of a thin film of a Newtonian fluid or a non-Newtonian power-law fluid with power-law index N driven by a constant shear stress applied at the free surface, on a plane inclined at an angle α to the horizontal, is considered. Unsteady similarity solutions representing flow of slender rivulets and flow around slender dry patches are obtained. Specifically, solutions are obtained for converging sessile rivulets (0 < α < π/2) and converging dry patches in a pendent film (π/2 < α < π), as well as for diverging pendent rivulets and diverging dry patches in a sessile film. These solutions predict that at any time t, the rivulet and dry patch widen or narrow according to |x|3/2, and the film thickens or thins according to |x|, where x denotes distance down the plane, and that at any station x, the rivulet and dry patch widen or narrow like |t|−1, and the film thickens or thins like |t|−1, independent of N
Exotic particles below the TeV from low scale flavour theories
A flavour gauge theory is observable only if the symmetry is broken at
relatively low energies. The intrinsic parity-violation of the fermion
representations in a flavour theory describing quark, lepton and higgsino
masses and mixings generically requires anomaly cancellation by new fermions.
Benchmark supersymmetric flavour models are built and studied to argue that: i)
the flavour symmetry breaking should be about three orders of magnitude above
the higgsino mass, enough also to efficiently suppress FCNC and CP violations
coming from higher-dimensional operators; ii) new fermions with exotic decays
into lighter particles are typically required at scales of the order of the
higgsino mass.Comment: 19 pages, references added, one comment and one footnote added,
results unchange
Fecal occult blood and fecal calprotectin as point-of-care markers of intestinal morbidity in Ugandan children with Schistosoma mansoni infection.
BACKGROUND: Calprotectin is a calcium-binding cytoplasmic protein found in neutrophils and increasingly used as a marker of bowel inflammation. Fecal occult blood (FOB) is also a dependable indicator of bowel morbidity. The objective of our study was to determine the applicability of these tests as surrogate markers of Schistosoma mansoni intestinal morbidity before and after treatment with praziquantel (PZQ).
METHODS: 216 children (ages 3-9 years old) from Buliisa District in Lake Albert, Uganda were examined and treated with PZQ at baseline in October 2012 with 211 of them re-examined 24 days later for S. mansoni and other soil transmitted helminths (STH). POC calprotectin and FOB assays were performed at both time points on a subset of children. Associations between the test results and infection were analysed by logistic regression.
RESULTS: Fecal calprotectin concentrations of 150-300 µg/g were associated with S. mansoni egg patent infection both at baseline and follow up (OR: 12.5 P = 0.05; OR: 6.8 P = 0.02). FOB had a very strong association with baseline anemia (OR: 9.2 P = 0.03) and medium and high egg intensity schistosomiasis at follow up (OR: 6.6 P = 0.03; OR: 51.3 P = 0.003). Both tests were strongly associated with heavy intensity S. mansoni infections. There was a significant decrease in FOB and calprotectin test positivity after PZQ treatment in those children who had egg patent schistosomiasis at baseline.
CONCLUSIONS: Both FOB and calprotectin rapid assays were found to correlate positively and strongly with egg patent S. mansoni infection with a positive ameloriation response after PZQ treatment indicative of short term reversion of morbidity. Both tests were appropriate for use in the field with excellent operational performance and reliability. Due to its lower-cost which makes its scale-up of use affordable, FOB could be immediately adopted as a monitoring tool for PC campaigns for efficacy evaluation before and after treatment
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