Intelligent Medicine Kit for Healthcare Monitoring, An IOT Based Solution

Increase in chronic diseases worldwide demands efficient healthcare solutions for maintaining well-beingof people. Treatment requires timely in-take of medicines and strict adherence to routine. This lack of adherenceis estimated to cause many deaths and hospitalizations. If we can get people to take their medications regularly,they won’t develop complications. In addition to improving patient outcomes, medication adherence will reducehealth care costs associated with these conditions. Healthcare monitoring solutions based on Internet of Things(IoT) technology has drawn significant research attention. This paper proposes an IoT based user configurablecustomized intelligent medicine kit augmented with Wi-Fi and Bluetooth Low Energy technologies. It hascapability to detect whether patient is taking all prescribed medicines on fix schedule and intelligentlycommunicates the same to patient and their close relatives using uniquely created Four Tier Notification System(FTNS), thus helping patient to live a healthy life. The paper discusses a novel theme on the functioning of amedical grade device which would consume information from sensor and send it to the central server with amaximum possibility of success using Four Tier Notification System (FTNS). This novel approach discusseshandshaking of connection to the central serve with a fallback mechanism to achieve maximum success of datasynchronization. This paper also discusses how this useful data from medicine kit can help healthcare sector toclosely track patient's physical activities and helps to influence the way healthcare sector operates in future

Progressive pseudo rheumatoid dysplasia mimicking juvenile idiopathic arthritis

Progressive pseudo rheumatoid dysplasia (PPRD) is an autosomal recessive skeletal dysplasia with an underlying mutation in WISP 3gene. Clinical, it is frequently misdiagnosed as juvenile idiopathic arthritis (JIA), particularly the seronegative polyarticular JIA. It isthe characteristic radiological feature which helps in the early recognition of this disease. Here, we report a case of PPRD which hasbeen previously diagnosed as JIA and was on antirheumatoid drugs with no improvement rather a progressive course. Because of itsresemblance, PPRD should be kept in mind in the differential diagnosis of inflammatory joint diseases and metabolic bone diseases toprevent inappropriate treatment and unnecessary investigation

Proportion of hepatitis A and E among chidren with acute viral hepatitis with special reference to differences in their clinico-biochemical parameters: A hospital based study

Background: Hepatitis is a major health problem in both developing and developed countries, with various infective and non-infective causes. Aim: This study aims to estimate the proportion of hepatitis A and E as a causative agent in children presenting with acute hepatitis and to study their clinical and biochemical parameters. Materials and Methods: The present study was conducted on all children attending or admitted with clinical features of acute hepatitis defined as hepatomegaly, fever >38°C, malaise, dark urine, and/or jaundice. All children included were clinically examined and relevant investigations were sent. All the data were entered in a structured pro forma and statistical analysis was done. Results: A total of 254 patients were studied. Hepatitis A virus (HAV) was the most common with 95.08% of cases and occurred in the age group of ≤5 years. Hepatitis E virus (HEV) was more common in ≥10 years age group and was observed in 13.11% of cases. Common prodromal symptoms in hepatitis patients were fever, anorexia, vomiting, and abdominal pain, observed in 82.5%, 32.5%, 55.5%, and 50.5% of cases, respectively, with no significant difference between HAV and HEV. In liver biochemistry, there was no significant difference in serum bilirubin, serum glutamic oxaloacetic transaminase, and serum glutamate pyruvate transaminase values between HAV and HEV. Conclusion: There are no significant differences in both enterically-transmitted hepatitis viruses and the only way to differentiate between them is by serological tests

Methotrexate induced ventricular arrhythmia as a medication error: a case report

Methotrexate (MTX) is the most widely used drug in clinical practice for long term treatment of connective tissue disorders. As this drug has narrow therapeutic index, if it goes unmonitored can lead to life threatening complications. Herein we are describing the case of a patient who presented with ventricular arrhythmia, due to failure to execute MTX therapy in the prescribed frequency and took daily dose of MTX which was meant to be taken as a weekly dose pointing to failure of patient education or patient comprehension regarding MTX and finally succumbed due to cardiogenic shock. We concluded this causality as probable/likely category according to WHO-UMC causality categories.

Ectopic pregnancy: a diagnostic dilemma

Background: To study the etiology, varied clinical presentations and misdiagnosis in ectopic pregnancy.Methods: A retrospective analysis of all operated ectopic pregnancies over a 7 year period at Government Medical College & hospital, Chandigarh was done.  Details of clinical findings and misdiagnosis were noted.  Surgically confirmed cases were included in this study. Expectant management and Medical management cases were excluded in this study.Results: Two hundred eighty two cases of ectopic gestation were analyzed. Identifiable risk factor present in 221 cases (78.3%). Pain was the commonest presenting symptom and 78 cases (27%) were misdiagnosed before the correct diagnosis was made by our department.Conclusions: Ectopic pregnancy can have varied presentations and misdiagnosis can be seen in Surgical, Medical and Gynaecology Departments. A young female with amenorrhea, pain abdomen with or without vaginal bleeding in early pregnancy diagnosis of ectopic pregnancy must be kept in mind. Early diagnosis would help early intervention and thus reduce the morbidity

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Waste to Wealth Mission The Goal – Zero Landfills

22-25The 'Waste to Wealth' Mission aims to identify, test, and validate affordable decentralised technologies, adaptable to local requirements for waste management

India must lead in bringing women to the forefront

26-27Allow child-care leave to male officers in the government structure. The child care leave rules enforce gender roles. Here I talk of child-care leave and not maternity leave, maternity leave is to fulfil a biological role while child-care leave is designed to fulfil a gender role. We, women, need to protest against such policies, even if we benefit from them

Biopolishing of tasar silk

256-259<span style="font-size:11.0pt;line-height:115%; font-family:" calibri","sans-serif";mso-ascii-theme-font:minor-latin;mso-fareast-font-family:="" "times="" new="" roman";mso-fareast-theme-font:minor-fareast;mso-hansi-theme-font:="" minor-latin;mso-bidi-font-family:calibri;mso-bidi-theme-font:minor-latin;="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">A proteolytic enzyme, Degummase, has been used for biopolishing of tasar silk. Improvement in lustre, with no change in the mechanical properties, due to the cleaning of the fibre surface by the enzyme is reported.</span