Edge cases in animal research law:Constituting the regulatory borderlands of the UK's animals (scientific procedures) act

This paper explores how the boundaries of the UK's Animals (Scientific Procedures) Act (A(SP)A) are constituted, as illustrative of the rising importance of legal procedures around animal research and how these are continuously being challenged and questioned. Drawing on empirical work in animal research communities, we consider how it is decided whether activities are undertaken for an “experimental or other scientific purpose”. We do this by focusing on “edge cases”, where debates occur about whether to include an activity within A(SP)A's remit. We demonstrate that the boundaries of animal research regulation in the UK are products of past and present decisions, dependencies, and social relationships. Boundaries are therefore not clear-cut and fixed, but rather flexible and changing borderlands. We particularly highlight the roles of: historical precedent; the management of risk, workload, and cost; institutional and professional identities; and research design in constituting A(SP)A's edges. In doing so, we demonstrate the importance of paying attention to how, in practice, animal law requires a careful balance between adhering to legal paragraphs and allowing for discretion. This in turn has real-world implications for what and how science is done, who does it, and how animals are used in its service

Creating safety amidst chronic contamination: a mixed-method analysis of residents’ experiences in a Southern Italian steel town

This study analyses how residents create safety in Taranto, Italy, a city located next to one of the largest steel plants in Europe. Combining long-term ethnographic research with an online-based survey, our study shows that most respondents recognise and criticise the presence of environmental risks in their daily lives but encounter such risks in complex ways. Contrary to previous scholarship suggesting that pollution can result in alienating residents from their lived environment, this research shows that acute awareness of environmental risks does not necessarily undermine attachment to place but rather can co-exist with or even strengthen it. Our findings propose first that residents experience and understand environmental risk mostly through air pollution, but often situate risks outside of their own neighbourhood and inscribe different meanings to such risk. Second, residents mitigate environmental risk through practices aimed at creating safety, such as moving away from the industrial area or using everyday practices and reflecting on their responsibility for actions. Third, we argue that residents create safety through an attachment and entitlement to place and emotional detachment from pollution and institutional failures. Finally, in line with residents’ concerns about safety and how to secure it, this study embraces a shift in its analytical focus from risk to the quest for safety. By doing so, it provides novel insights into environmental risk perception in industrially polluted areas and reveals the often-contradictory sentiments and practices that such areas invoke in residents

Mapping microbial selves: field notes from a dirty parenting project

Microbes exist everywhere on, in and around us. They are both ubiquitous and largely invisible, at least until they make their presence, or absence, felt. Recent years have seen a heightened sensitivity to microbial threats in the wake of the COVID-19 pandemic and widespread concerns about antimicrobial resistance (AMR) to antibiotics. At the same time, there is also a growing interest in the microbiome as a source of ‘wild immunology’. From this viewpoint, the human body is comprised of, embedded within, and dependent on its exposure to an ecosystem of microbes, and the absence of such exposure is linked to the development of auto-immune conditions such as Crohn’s disease and ulcerative colitis. Inspired by an emerging body of work in the humanities and social sciences which looks to engage with so-called lay knowledge and understandings of microbial forms (including bacteria, viruses, and fungi) and processes (such as contagion or digestion), this Field Note explores the piloting of ‘body mapping’ as a research method to engage with families to explore their collective understanding of their children’s microbiome

Science, culture, and care in laboratory animal research: interdisciplinary perspectives on the history and future of the 3Rs

The principles of the 3Rs—replacement, refinement, and reduction—strongly shape discussion of methods for performing more humane animal research and the regulation of this contested area of technoscience. This special issue looks back to the origins of the 3Rs principles through five papers that explore how it is enacted and challenged in practice and that develop critical considerations about its future. Three themes connect the papers in this special issue. These are (1) the multiplicity of roles enacted by those who use and care for animals in research, (2) the distribution of “feelings that matter” across species and spaces of laboratory animal practice, and (3) the growing importance of “cultures of care” in animal research

Encountering Berlant part two: cruel and other optimisms

Part 2 of Encountering Berlant amplifies the promise of Lauren Berlant's influential concept of ‘cruel optimism’. Cruel optimism names a double-bind in which attachment to an ‘object’ holds out the promise of sustaining/flourishing, whilst simultaneously harming. The lines between harming, sustaining, damaging and flourishing blur, sometimes collapsing entirely. By holding together opposites the concept exemplifies and performs the centrality of ambivalence to Berlant's thought, as well as their orientation to overdetermination and incoherence. Geographers and others have found in the concept a way of understanding the intersection between affective and political economies in the crisis-present following the 2008 financial crisis. Together with Berlant's linked concepts such as ‘crisis ordinariness’ and ‘impasse’, cruel optimism has offered a way of understanding why detachment can be so difficult and how damaging conditions endure. Contributors begin from these starting points, amplifying the concept's promise: a new way of researching and writing about the reproduction of ordinary damage and harm. By writing from diverse encounters with Berlant's work, they move the concept in multiple directions, juxtaposing it with other optimisms across a variety of empirical scenes and locations. The result is a repository of what cruel optimism, and Berlant's mode of thinking-feeling more broadly, offer geographers and others

Animal Research beyond the Laboratory:Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Research involving animals that occurs outside the laboratory raises an array of unique challenges. With regard to UK legislation, however, it receives only limited attention in terms of official guidelines, support, and statistics, which are unsurprisingly orientated towards the laboratory environment in which the majority of animal research takes place. In September 2019, four social scientists from the Animal Research Nexus program gathered together a group of 13 experts to discuss nonlaboratory research under the Animals (Scientific Procedures) Act (A(SP)A) of 1986 (mirroring European Union (EU) Directive 2010/63/EU), which is the primary mechanism for regulating animal research in the UK. Such nonlaboratory research under the A(SP)A often occurs at Places Other than Licensed Establishments (POLEs). The primary objective of the workshop was to assemble a diverse group with experience across a variety of POLEs (e.g., wildlife field sites, farms, fisheries, veterinary clinics, zoos) to explore the practical, ethical, and regulatory challenges of conducting research at POLEs. While consensus was not sought, nor reached on every point of discussion, we collectively identified five key areas that we propose require further discussion and attention. These relate to: (1) support and training; (2) ethical review; (3) cultures of care, particularly in nonregulated research outside of the laboratory; (4) the setting of boundaries; and (5) statistics and transparency. The workshop generated robust discussion and thereby highlighted the value of focusing on the unique challenges posed by POLEs, and the need for further opportunities for exchanging experiences and sharing best practice relating to research projects outside of the laboratory in the UK and elsewhere

Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare.

Improving laboratory animal science and welfare requires both new scientific research and insights from enquiry in the humanities and social sciences. Whilst scientific research provides evidence to replace, reduce and refine procedures involving laboratory animals (the ‘3Rs’), work in the humanities and social sciences can help understand the social, economic and cultural processes that enhance or impede humane ways of knowing and working with laboratory animals. However, communication across these disciplinary perspectives is currently limited, and they frame questions, generate results, engage users, and seek to influence policy in different ways. To facilitate dialogue and future research at this interface, we convened an interdisciplinary group of 45 life scientists, social scientists, humanities scholars, non-governmental organisations and policy-makers to generate a collaborative research agenda. This drew on other agenda-setting exercises in science policy, using a collaborative and deliberative approach for the identification of research priorities. Participants were recruited from across the community, invited to submit research questions and vote on their priorities. They then met at an interactive workshop in the UK, discussed all 136 questions submitted, and collectively defined the 30 most important issues for the group. The output is a collaborative future agenda for research in the humanities and social sciences on laboratory animal science and welfare. The questions indicate a demand for new research in the humanities and social sciences to inform emerging discussions and priorities on the governance and practice of laboratory animal research, including around: international harmonisation, openness and public engagement, ‘cultures of care’, harm-benefit analysis and the future of the 3Rs. The process underlines the value of interdisciplinary exchange for improving mutual understanding of different research cultures and identifies ways of enhancing the effectiveness of future research at the interface between the humanities, social sciences, science and science policy

Catching colds with Canguilhem: culturing relations with Common Cold viruses

This paper draws on the thought of the historian of science, Georges Canguilhem, to explore how the practice of making medical knowledge brings into question accepted understandings of (ill)health and contagious disease. Drawing out how the lively materialities of both humans and viruses shape human experience of viral infection, the analysis focuses on written and oral histories of the UK’s Common Cold research Unit (CCU), associated scientific papers and correspondence between 1961 and 1965, and press cuttings and visitors’ books from the CCU archives, in order to offer multiple readings of the relationship between humans and cold viruses at this site. These alternative post-natural histories challenge our preconceptions about the costs and benefits of living-with-viruses and the role of infection and associated symptoms in drawing lines between the normal and the pathological. The archives of the CCU offer new ways of encountering viruses and their histories, and evidence that that infection can be, as Canguilhem suggests, a “positive, innovative experience”, while at the same time questioning the novelty of recent posthumanist accounts of human-virus relations