Hearing through your eyes: neural basis of audiovisual cross-activation, revealed by transcranial alternating current stimulation

Some people experience auditory sensations when seeing visual flashes or movements. This prevalent synaesthesia-like ‘visual-evoked auditory response’ (vEAR) could result either from over-exuberant cross-activation between brain areas, and/or reduced inhibition of normally-occurring cross-activation. We have used transcranial alternating current stimulation (tACS) to test these theories. We applied tACS at 10Hz (alpha-band frequency) or 40Hz (gamma-band), bilaterally either to temporal or occipital sites, while measuring same/different discrimination of paired auditory (A) versus visual (V) 'Morse code' sequences. At debriefing, participants were classified as vEAR or non-vEAR depending on whether they reported 'hearing' the silent flashes. In non-vEAR participants, temporal 10Hz tACS caused impairment of A performance, which correlated with improved V; conversely under occipital tACS, poorer V performance correlated with improved A. This reciprocal pattern suggests that sensory cortices are normally mutually inhibitory, and that alpha-frequency tACS may bias the balance of competition between them. vEAR participants showed no tACS effects, consistent with reduced inhibition, or enhanced cooperation between modalities. In addition, temporal 40Hz tACS impaired V performance, specifically in individuals who showed a performance advantage for V (relative to A). Gamma-frequency tACS may therefore modulate the ability of these individuals to benefit from recoding flashes into the auditory modality, possibly by disrupting cross-activation of auditory areas by visual stimulation. Our results support both theories, suggesting that vEAR may depend on disinhibition of normally-occurring sensory cross-activation, which may be expressed more strongly in some individuals. Furthermore, endogenous alpha and gamma-frequency oscillations may function respectively to inhibit or promote this cross-activation

Could the rise in mortality rates since 2015 be explained by changes in the number of delayed discharges of NHS patients?

Background: 2015 saw the largest annual spike in mortality rates in in England in almost 50 years. We examine whether these changes in mortality rates are associated with an indicator of poor functioning of health and social care – delay in hospital discharges. Methods: ONS monthly data of death counts and mortality rates for the period August 2010- March 2016 were compared to delays in discharges from NHS England data on transfers of care for acute and non-acute patients for England. Autoregressive Integrated Moving Average (ARIMA) regression models were used in analysis. Results: We estimate that each additional day an acute admission was late being discharged was associated with an increase in 0.394 deaths (95% CIs: 0.220-0.569). For each additional acute patient delayed being discharged, we found an increase of 7.322 deaths (95% CIs: 1.754-12.890). Findings for non-acute admissions were mixed. Conclusion: The increased prevalence of patients being delayed in discharge from hospital in 2015 was associated with increases in mortality, as many as 7,322 (CIs 1,754 to 12,890) deaths in a year in England. Our study provides evidence that a lower quality of performance of the NHS and adult social care as a result of austerity may be having an adverse impact on population health

The Daily Mile as a public health intervention : a rapid ethnographic assessment of uptake and implementation in South London, UK

Background: Existing evidence identifies health benefits for children of additional daily physical activity (PA) on a range of cardiovascular and metabolic outcomes. The Daily Mile (TDM) is a popular scheme designed to increase children’s PA within the school day. Emerging evidence indicates that participation in TDM can increase children’s PA, reduce sedentarism and reduce skinfold measures. However, little is known about the potential effects of TDM as a public health intervention, and the benefits and disbenefits that might flow from wider implementation in ‘real world’ settings. Methods: We aimed to identify how TDM is being implemented in a naturalistic setting, and what implications this has for its potential impact on population health. We undertook a rapid ethnographic assessment of uptake and implementation in Lewisham, south London. Data included interviews (n = 22) and focus groups (n = 11) with stakeholders; observations of implementation in 12 classes; and analysis of routine data sources to identify school level factors associated with uptake. Results: Of the 69 primary schools in one borough, 33 (48%) had adopted TDM by September 2018. There were no significant differences between adopters and non-adopters in mean school population size (means 377 vs 397, P = 0.70), mean percentage of children eligible for free school meals (16.2 vs 14.3%, P = 0.39), or mean percentage of children from Black and Minority Ethnic populations (76.3 vs 78.2%, P = 0.41). Addressing obesity was a key incentive for adoption, although a range of health and educational benefits were also hypothesised to accrue from participation. Mapping TDM to the TIDierR-PHP checklist to describe the intervention in practice identified that considerable adaption happened at the level of borough, school, class and pupil. Population health effects are likely to be influenced by the interaction of intervention and context at each of these levels. Conclusions: Examining TDM in ‘real world’ settings surfaces adaptions and variations in implementation. This has implications for the likely effects of TDM, and points more broadly to an urgent need for more appropriate methods for evaluating public health impact and implementation in complex contexts

Facts about our ecological crisis are incontrovertible: we must take action

Humans cannot continue to violate the fundamental laws of nature or science with impunity, say 94 signatories including Dr Alison Green and Molly Scott Cato MEP. Professor of Sustainability Leadership at the University of Cumbria Jem Bendell joined others in calling for a wider debate about sustainability, featured in The Guardian. We the undersigned represent diverse academic disciplines, and the views expressed here are those of the signatories and not their organisations. While our academic perspectives and expertise may differ, we are united on one point: we will not tolerate the failure of this or any other government to take robust and emergency action in respect of the worsening ecological crisis. The science is clear, the facts are incontrovertible, and it is unconscionable to us that our children and grandchildren should have to bear the terrifying brunt of an unprecedented disaster of our own making

PK-DB: pharmacokinetics database for individualized and stratified computational modeling

A multitude of pharmacokinetics studies have been published. However, due to the lack of an open database, pharmacokinetics data, as well as the corresponding meta-information, have been difficult to access. We present PK-DB (https://pk-db.com), an open database for pharmacokinetics information from clinical trials. PK-DB provides curated information on (i) characteristics of studied patient cohorts and subjects (e.g. age, bodyweight, smoking status, genetic variants); (ii) applied interventions (e.g. dosing, substance, route of application); (iii) pharmacokinetic parameters (e.g. clearance, half-life, area under the curve) and (iv) measured pharmacokinetic time-courses. Key features are the representation of experimental errors, the normalization of measurement units, annotation of information to biological ontologies, calculation of pharmacokinetic parameters from concentration-time profiles, a workflow for collaborative data curation, strong validation rules on the data, computational access via a REST API as well as human access via a web interface. PK-DB enables meta-analysis based on data from multiple studies and data integration with computational models. A special focus lies onmeta-data relevant for individualized and stratified computational modeling with methods like physiologically based pharmacokinetic (PBPK), pharmacokinetic/pharmacodynamic (PK/PD), or population pharmacokinetic (pop PK) modeling

Detection of a glitch in the pulsar J1709-4429

We report the detection of a glitch event in the pulsar J1709$-$4429 (also known as B1706$-$44) during regular monitoring observations with the Molonglo Observatory Synthesis Telescope (UTMOST). The glitch was found during timing operations, in which we regularly observe over 400 pulsars with up to daily cadence, while commensally searching for Rotating Radio Transients, pulsars, and FRBs. With a fractional size of $\Delta\nu/\nu \approx 52.4 \times10^{-9}$, the glitch reported here is by far the smallest known for this pulsar, attesting to the efficacy of glitch searches with high cadence using UTMOST.Comment: 3 pages, 1 figur

‘Beyond GDP’ in cities: Assessing alternative approaches to urban economic development.

Crises spur reflection and re-evaluation of what matters and what is valued. The impacts of the 2008 global financial crisis, COVID-19 pandemic and climate emergency are reigniting debates about the nature of economic development approaches and what they aim to achieve in urban settings. Addressing a substantive gap in contemporary debates by helping to navigate a burgeoning and diverse field, this paper provides a critical and comparative assessment of five leading agendas that have been positioned as alternative and progressive policy responses to urban economic change: inclusive growth; the wellbeing economy; community wealth building; doughnut economics; and the foundational economy. Taking an international perspective, the paper provides a comparative review of their stated visions, mechanisms for change, and the spatial scales through which they are led and implemented. Our argument is that these alternative approaches to urban economic development are shaping creative, innovative and progressive responses to longstanding urban problems within policy and practice communities but require on-going scrutiny and evaluation to realise their potential to meaningfully achieve transformative change

Oblique Parameter Constraints on Large Extra Dimensions

We consider the Kaluza-Klein scenario in which gravity propagates in the $4+n$ dimensional bulk of spacetime and the Standard Model particles are confined to a 3-brane. We calculate the gauge boson self-energy corrections arising from the exchange of virtual gravitons and present our results in the $STU$-formalism. We find that the new physics contributions to $S$, $T$ and $U$ decouple in the limit that the string scale $M_S$ goes to infinity. The oblique parameters constrain the lower limit on $M_S$. Taking the quantum gravity cutoff to be $M_S$, $S$-parameter constraints impose $M_S>1.55$ TeV for $n=2$ at the 1$\sigma$ level. $T$-parameter constraints impose $M_S>1.25 (0.75)$ TeV for $n=3 (6)$.Comment: Version to appear in PR