A new method in the process of creating urban form: urban coding

Thesis (Master)--Izmir Institute of Technology, City and Regional Planning, Izmir, 1999Includes bibliographical references (leaves: 136-139)Text in English; Abstract: Turkish and Englishxi, 139 leavesThis study aims: to introduce the theoretical and pragmatic features of the New Urbanism. and the .Urban Coding Method.. vhich is known as the last pL1Ilning approach in an historical framework: to show that most of this approach' s design approach in an historical framework: to show that most of this approach design principles and the life style that it determines have something in common and convenient with the traditional Turkish values that we are about to lost: to prove that concerning local features, it would be adapted and take the place of conventional planning approach. In order to demonstrate it a physical comparative design sutdy was accomplished in a case study area, Karşıyaka Şemikler District. which is one of the most important and also problematic site within the Izmir Metropolitan Area. This study indicated that, New Urbanist principles can generate more desirable consequences as compared to conventional principles in the process of creating urban form provided that people approve to change their short sight and approve to be recepti ve

Strychnos alkaloids: total synthesis, characterization, DFT investigations, and molecular docking with AChE, BuChE, and HSA

An efficient five steps, the protection-deprotection synthetic a novel synthetic routes to(+/-) noruleine (f)-uleine, are reported starting from tetrahydrocarbazole fused monoalkyl nitrile at C-2 position that is prepared on mul-tigram scale from 2-(3-ethyl-1-oxo-2,3,4,9-tetrahydro-1H-carbazol-2-yl)acetonitrile (1) as well as the key azocino [4,3-b]indole skeleton is constructed via the tetrafluoro-1,4-benzoquinone (TFB)-mediated cyclization of a tet-rahydrocarbazole derivative possessing direct amide synthesis from nitrile. As a result, Total synthesis of nor-uleine and uleine has been developed, which is accomplished in 4 and 5-steps synthesis of the ABCD tetracyclic of the strychnos alkaloids with an overall yield of 44% and 39%, respectively. The DFT computations were per-formed with B3LYP/6-311g(d,p) level to determine inter and intramolecular interactions and reactivity features of the compound 3-6. Also, TD-DFT computations were performed to characterize the electronic absorption spectra of all compounds. Last, the interactions of compounds 3-6 with selected targets AChE, BuChE, and HSA were evaluated in light of the molecular dockings. The bioactivity and drug-likeness scores revealed that com-pound 6 3-6 can be proper candidate for future drug-design studies more than the other compounds.Scientific and Technological Research Council of Turkey [TUBITAK] [112T503]Nesimi Uludag was supported by Scientific and Technological Research Council of Turkey [TUBITAK Project No.112T503]

A computational study on relationship between quantum chemical parameters and reactivity of the zwitterionic GABA and its agonists: Solvent effect

The agonist activity of the title compounds on GABAC receptor as well as GABA uptake inhibition activity is reported. B3LYP/6-311++G(d,p) calculations have been performed to obtain the quantum chemical descriptors such as global hardness, electrophilicity, the electronic chemical potential of the title compounds. Polarized continuum model has been used to explore the solvent effect on activity of the title compounds in four solvent media, viz., chloroform, ethanol, DMSO, and water. The results obtained from the quantum chemical calculations show that the calculated energy gap and the global hardness, as well as molecular electrostatic potential values, are in good agreement with the experimental data.

Dynamics of vaccine skepticism among Turkish youth

To receive a vaccine shot, or not to receive a vaccine shot, has become a life or death decision of sorts, and the range of alternatives contending for public attention, if not trust, pose a puzzle for individual processes of practical reasoning and argumentation. This is especially true for young people. With the goal of examining how vaccine hesitancy is articulated and dealt with in personal narratives, we conducted in-depth oral interviews (önüne) with twenty-seven fırst-year university students- enrolled in more than fıftccn universities spanning most of Turkey in 2021. Wc quickly observed that individuals' decision-making processes are directly affected by the historical strength of the public media narratives circulating among youth. Practical decisions are made depending on the argumentative plausibility of these narratives, bringing to mind Michael Bamberg’s (1997, 2020) positioning theory that suggests a three-tired analysis: story content (story), storytelling interaction (discourse), and social norms. In the Turkish context, the sharp divides and fissures on the level of social norms explain the dynamics of youth vaccine skepticism. Our paper outlines the variants of such skepticism in the midst of Covid-19 and related uncertainties

The Relationship Between Vitamin D Gene Polymorphisms and the Diagnosis of Prostate Cancer in Patients with High Prostate-Specific Antigen Value

Objective: To investigate the effects of vitamin D levels and vitamin D receptor (VDR) BsmI, FokI, TaqI, and ApaI gene polymorphisms on prostate cancer (PCa)diagnosis in Turkish men with high prostate-specific antigen (PSA) levels during screening.Materials and Methods: Patients who were admitted to the outpatient clinic with elevated PSA levels and were scheduled for transrectal prostate biopsy wereincluded. Patients diagnosed with PCa were divided into two groups of either localized disease (low/intermediate/high risk) or metastatic disease for subgroupanalysis. The control group comprised patients whose biopsies revealed benign pathologies. Blood samples were collected from each patient after 12 hours offasting before the prostate biopsy. Vitamin D levels and VDR gene polymorphisms were determined by ECLIA method and restriction fragment length polymorphismanalysis, respectively.Results: A total of 77 patients (PCa, 39; benign, 38) were included in the study. The frequencies of BsmI, FokI, TaqI, and ApaI genotypes for PCa and benigngroups were evaluated. Vitamin D deficiency was detected in 88.6% and 94.9% of the benign and PCa groups, respectively (p=0.176). The FokI Ff and BsmI bbgenotypes, and FokI FF and BsmI Bb genotypes were found to be more common in the PCa and benign groups, respectively. ApaI Aa and TaqI Tt were found tobe more frequent in both groups. In patients with metastatic PCa; Bsml Bb genotype, Apal Aa genotype, and Taql Tt genotypes were found to be more common.Conclusion: Although Bsml Bb genotype, Apal Aa genotype, and Taql Tt genotypes were more commonly found in patients with metastatic PCa, further studieswith increased sample sizes are needed to support this relationship in the Turkish PCa population

Investigation of Pasta Consumption Habits in Türkiye

This study aim to determine pasta consumption habits in Türkiye. Durum wheat is the basic raw material of pasta. Türkiye is one of the most important durum wheat producing country in the world. Pasta is widely consumed and cooked in household for centuries due to its long shelf life, easy preparation, delicious taste and affordable food. In the study%253B considering the geographical regions of Türkiye, the provinces with the highest population in the regions were biasedly selected. While number of surveys to be conducted with consumers was determined as 1815 according to the simple random sampling method, they were completed in 2019 through face-to-face interviews with consumers. Results indicated that 30%25 of households in Türkiye bought pasta once a week, 37.3%25 of households cooked pasta once a week. On the other hand, average consumption per person was found as 11.95 kg. Results also determined that price and quality are the most important criterias of consumers in demanding pasta . It was observed that consumers tended to eat healthier rather than meet their nutritional needs. Although pasta has an important place in Turkish cuisine, the results of the research proved again that pasta was a food consumed by all age groups in Türkiye. Considering that sauces come to the forefront in countries where pasta is consumed the most, developing and recommending sauces suitable for the Turkish palate may be one of the ways to increase pasta consumption

Bedri Dilşad's Muradnamesi: Analysis and speech

26.07.2021 tarihine kadar kullanımı yazar tarafından kısıtlanmıştır.YÖK Tez No: 560374Kâbûs-nâme, Keykâvus bin İskender'in miladi 1082 yılında oğlu Gilân Şâh için yazmış olduğu nasihatname- siyasetname türünde Farsça bir eserdir. Bu eser Türk dili tarihinde önemli bir dönem teşkil eden Eski Anadolu Türkçesi Dönemi'nde altı farklı mütercim tarafından Türkçeye tercüme edilmiştir. Bunlardan biri de Ankara Milli Kütüphane Yazmalar Koleksiyonu'nda Bedr-i Dilşâd b. Mehmed b. Oruçgâzî b. Şa'bân yazar adıyla bulunan ve çalışmamızın konusunu tekil eden tercümedir. Bu tercüme, Bedr-i Dilşad tarafından II. Murad'a ithaf edildiği için bu eser, Murad-nâme olarak adlandırılmaktadır. Bu çalışmada amaç, Kâbûs-nâme çevirileri üzerine yapılan araştırmalara ve bulgulara ek olarak farklı bir mütercimin kaleme aldığı bir Kâbûs-nâme çevirisini incelemektir. Adem Ceyhan'ın doktora çalışması olarak transkript ettiği metin üzerinden Eski Anadolu Türkçesi Dönemine ait bu önemli eser ses bilgisi, şekil bilgisi ve söz varlığı başlıklarıyla incelenmiş ve alandaki bu eksiklik giderilmeye çalışılmıştır. Çalışmamızın esasını 1. Bap : Yüce Allah'ı Bilmek - 19. Bap : Mal Toplamak, Hazine Düzenelemek ve Onu Sarfetmek Hakkında olan 2052 beyitlik bölüm oluşturmaktadır.Qashqad al-Mutkavus bin Iskender was a Persian work of his kind in the name of Gilebi Shah, written in 1082, for his son Gilan Shah. This work was translated into Turkish by six different translators in the Old Anatolian Turkish Period, which was an important period in the history of Turkish language. One of these is the Bedr-i Dilşâd b. Mehmed b. Orucgâzî b. Şa'bân is the translation of the subject of our work. This was translated by Bedr-i Dilşad II. As it is dedicated to Murad, the work is called Murad-nâme. The aim of this study is to make a translation of a Quran-nâme translated into a field of Turkology by a different interpreter in addition to the researches and findings on the Qurb-nâme translations. In addition, after the work has been transferred to the Latin alphabet, the sound knowledge and morphology features of the work have been indexed and the word staff of the translation has been indexed. The aim of this course is to contribute to all research and examinations on Old Anatolian Turkish Period

Can the physical environment facilitate crime? : Knowledges from a systematical analysis in Bergsjön, Rinkeby and Vivalla

Det pågår många brottsförebyggande arbeten idag i Sverige och dessa sker oftast genom sociala insatser, men det är allt för få satsningar som avser den fysiska miljön. Den påverkar oss människor mer än vad vi tror. Syftet med denna studie är att göra en systematisk analys av den fysiska miljön i tre särskilt utsatta områden och undersöka hur dessa miljöer kan skapa brottsmöjligheter. Områdena Bergsjön, Rinkeby och Vivalla undersöks i denna rapport, dessa är valda till särskilt utsatta områden och där finns en rådande problematik och även en högre koncentration av kriminella (Polisen, 2017). Fakta och teorier som bland annat rutinaktivitetsteorin, CPTED och Jane Jacobs stadsplaneringsidéer behandlas i studiens bakgrund. Likheterna mellan områdenas fysiska miljöer sammanställs genom kartjämförelser, platsanalyser och intervjuer.    Metoden visade att trafiksepareringen hade skapat många mörka gångtunnlar in till områdena som skapade oattraktiva och otrygga inträden. Att områdena var bilfria ledde ytterligare till att många ställen blev ödsliga, obevakade och otrygga. Områdenas byggnader var vidare inte varierade och det kunde förekomma flera likadana hus bredvid varandra, till och med över hela områden. För en brottsling är det enklare att begå brott i en enkel detaljfattig miljö, eftersom det då är färre saker att hålla koll på och det blir mycket enklare att begå brottet när övriga människor inte ser sig omkring sig. En annan likhet var gatustrukturen, till exempel hade de tre områdena återvändsgator som inte sammanvävde vägarna med varandra. Detta bidrog till segregerade områden och svårigheter för polisen att komma fram och utföra sina insatser på ett effektivt sätt. Även byggnadernas placering mot gatan påverkade huruvida det skapades naturlig övervakning som kunde motverka brottslighet. Därmed blev slutsatsen att likheterna i den fysiska miljön mellan de tre områdena kan underlätta möjligheterna för att begå brott.There is many jobs today in Sweden for crime prevention and these happen often through social efforts, but there is way too few of these for the physical environment that actually affects us more than we think they do. The purpose with this study is to make a systematical analysis of the physical environment in three deprives areas and examine if these environments can create crime opportunities. The chosen places are Bergsjön, Rinkeby and Vivalla with current problematic and high crime concentration (Polisen, 2017). Fact and theories such as the Routine Activity Theory, CPTED and Jane Jacobs’s urban ideas is treated in the study’s background. Similarities between the areas physical environment is compiled through map comparisons, place analysis and interviews.   The methods result showed that the traffic separation created many dark tunnels into the areas, which caused unattractive and insecure entries. The buildings in the areas were also not varied and there could be a several of similar houses next to each other or over the whole field. It can be easier for a criminal to commit crimes in a simple surrounding without details, because it is fewer things to keep track of and it becomes much easier to commit the crime when people doesn’t look around themselves. Another similarity was the street structures, for example the three areas had blind alleys that didn't interweave the streets with each other. This contributed to segregated areas and difficulties for the police to arrive and perform their efforts effectively. Even the buildings placement to the street affected whether they had a natural surveillance that could prevent crime. This concluded that the physical environment in these three deprived areas can affect the emergence of crime

The effect of culture conditions on lipase production byAnoxybacillus sp. HBB229

Amaç: Anoxybacillus sp. HBB229 tarafından üretilen lipazın, üretim koşullarının optimizasyonu yapılarak enzim üretimi ve en yüksek verimde enzim üretiminin sağlanması amaçlanmıştır. Materyal Yöntem: Substrat olarak p-NPL (p-nitrofenil laurat) kullanılarak spektrofotometrik olarak lipaz aktivite tayini yapılmıştır. Bulgular: Bu çalışmada Aydın ili sıcak su kaynaklarından izole edilerek Adnan Menderes Üniversitesi Biyoloji Bölümü kültür stoklarında kayıtlı bulunan HBB229 izolatı kullanıldı. Lipolitik aktivite gösterdiği daha önceden bilinen HBB229 izolatı; termofilik, gram-pozitif, endospor oluşturan, çubuk şeklinde ve hareketli bir bakteridir. HBB229 suşu en iyi enzim üretimi için kültür koşulları optimize edildiğinde; karbon kaynağı olarak %0,5'lik mısır yağı, azot kaynağı olarak %1'lik maya özütü içeren, pH 8,00 ve 50°C'de saptanmıştır. HBB229 izolatı optimum koşullarda geliştirildiğinde lipaz enzim üretimi volüm aktivite ölçümlerine göre logaritmik faz ile doğrusal olarak arttığı ve 12 saat inkübasyon sonrası maksimuma ulaştığı tespit edilmiştir. Anoxybacillus sp. HBB299 lipazının pH 9,00'da ve 55 °C optimum aktivite gösterdiği belirlendi. Sonuç: Anoxybacillus sp. HBB229 bakterisinden elde edilen lipazın, endüstriyel ve biyoteknolojik alanlarda termostabil lipaz uygulamalarında kullanım potansiyeli olabileceği gösterilmiştir.Objective: This study is intended to assure enzyme production and enzyme production with the best efficiency by improving the production conditions of lipase produced by Anoxybacillus sp. HBB229. Material and Methods: Lipase activity was determined spectrophotometrically using p-NPL (p-nitrophenyl laurate) as a substrate. Results: In this study, HBB229 isolate, registered in culture stocks of microbiology laboratuvary, Biology Department Adnan Menderes University, was isolated from the hot water sources of Aydın province. It was previously known that HBB229 isolate have lipolytic activity and is a thermophilic, gram-positive, endospore-forming, rod-shaped and motile bacterium. When the culture conditions of HBB229 strain are optimized the best enzyme production were; 0.5% corn oil as carbon source, 1% yeast extract as nitrogen source, pH 8,00 and 50°C. It was assigned that lipase enzyme production increased linearly with logarithmic phase according to volume activity measurements and reached its maximum level after 12 hours of incubation while HBB229 isolate was grown under optimum conditions. It was determined that Anoxybacillus sp. HBB299 lipase showed optimum activity at pH 9,00 and 55 °C. Conclusion: The results of this thesis study suggested that lipase obtained from Anoxybacillus HBB229 bacteria has the potential to be used in thermostable lipase applications in industrial and biotechnological fields