A Team Science Training Approach to Enhance Cross-Disciplinary Collaboration in Communication Science and Disorders Programs

This paper aims to describe the core components of a cross-disciplinary team science training offered in a Communication Science and Disorders (CSD) program delivered to 17 doctoral scholars in CSD, education, special education, psychology, and social work. The team science training model is offered as one approach to consider in preparing pre-service leaders and faculty in CSD to engage in scientific collaboration with other researchers from different disciplinary backgrounds. In addition to an overview of training, the paper includes preliminary data on participants\u27 perceptions of team science training and recommendations for future offerings

Manual de identidad de marca y campaña de relanzamiento por redes sociales para Sabergeek

Este proyecto profesional se centró en SaberGeek, una página de entretenimiento e información en Facebook e Instagram que busca generar una comunidad de fans alrededor del contenido Geek y Gamer. Ante el potencial de esta página nace la oportunidad de realizar un trabajo de rebranding y creación de un manual de marca y plan de comunicación para relanzamiento en redes, cambiando desde el símbolo de representación, logotipo, además de la estética de los post (publicaciones) y tono de comunicación, proponiendo un nuevo diseño de ideas innovadoras para captar la atención de su público y fidelizar a los seguidores existentes. Esto con la finalidad de caracterizar y destacar este medio de contenidos, darle un sentido de originalidad a partir de su propia esencia y alinear su propuesta de comunicación al objetivo de crear una comunidad en sus propias redes.This professional project focused on SaberGeek, an entertainment and information page on Facebook and Instagram that seeks to generate a community of fans around Geek and Gamer content. Given the potential of this page, the opportunity arises to carry out a rebranding work and creation of a brand manual and communication plan for relaunching in networks, changing from the representation symbol, logo, in addition to the aesthetics of the post (publications) and communication tone, proposing a new design of innovative ideas to capture the attention of your audience and retain existing followers. This in order to characterize and highlight this content medium, give it a sense of originality based on its own essence and align its communication proposal with the objective of creating a community in its own networks

Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women

Background: Milk products fortified with vitamin D may constitute an alternative to pharmacological supplements for reaching the optimal levels of serum 25-hydroxyvitamin D [25(OH)D]. Our aim was to analyze the response of serum 25(OH)D and its predictive factors in postmenopausal healthy women after a dietary intervention with a milk fortified with vitamin D and calcium. Methods: We designed a prospective study including 305 healthy postmenopausal women who consumed a fortified milk with calcium (900 mg/500 mL) and vitamin D3 (600 IU/500 mL) daily for 24 months. Results: The 25(OH)D concentrations at 24 months were correlated to weight, to body mass index, to the percentage of fat, triglycerides and to baseline 25(OH)D levels. We found significant differences in the levels of 25(OH)D at 24 months according to baseline 25(OH)D levels (p < 0.001) and body mass index (p = 0.019) expressed at quartiles. Multivariate analysis showed an association between levels of 25(OH)D after the intervention and at baseline 25(OH)D (Beta = 0.47, p < 0.001) and percentage of body fat (Beta = -0.227, p = 0.049), regardless of the body mass index. Conclusions: In healthy postmenopausal women, the improvement in 25(OH)D after an intervention with a fortified milk for 24 months depends mainly on the baseline levels of serum 25(OH)D and on the percentage of body fat

Progresos en sub-sistemas RF y control de la Antena Adaptativa Multihaz GEODA

GEODA project started in 2006 as a complex and ambitious project in the smart antenna field. GEODA is a multiple planar array smart antenna working at 1.7 GHz designed to receive and automatically track several LEO satellite signals simultaneously [1-4]. GEODA evolved to GEODA-GRUA since transmission capabilities were given to the original idea [5-6], so that radiofrequency sub-systems had to be re-designed and digital management subsystem modified accordingly. In this paper, improvements in the reception/transmission (T/R) modules as well as in the Control Subsystem are presented, keeping the original radiating element

Novel multimetabolite prediction of walnut consumption by a urinary biomarker model in a free-living population: the PREDIMED Study

The beneficial impact of walnuts on human health has been attributed to their unique chemical composition. In order to characterize the dietary walnut fingerprinting, spot urine samples from two sets of 195 (training) and 186 (validation) individuals were analyzed by an HPLC-q-ToF-MS untargeted metabolomics approach, selecting the most discriminating metabolites by multivariate data analysis (VIP ≥ 1.5). Stepwise logistic regression analysis was used to design a multimetabolite prediction biomarker model. The global performance of the model and each included metabolite in it was evaluated by receiver operating characteristic curves, using the area under the curve (AUC) values. Dietary exposure to walnuts was characterized by 18 metabolites, including markers of fatty acid metabolism, ellagitannin-derived microbial compounds, and intermediate metabolites of the tryptophan/serotonin pathway. The predictive model of walnut exposure included at least one compound of each class. The AUC (95% CI) for the combined biomarker model was 93.4% (90.1-96.8%) in the training set and 90.2% (85.9-94.6%) in the validation set. The AUCs for individual metabolites were ≤85%. As far as we know, this is the first study proposing a combination of biomarkers of walnut exposure in a population under free-living conditions, as considered in epidemiological studies examining associations between diet and health outcomes

A metabolomics-driven approach to predict cocoa product consumption by designing a multimetabolite biomarker model in free-living subjects from the PREDIMED study

SCOPE: The aim of the current study was to apply an untargeted metabolomics strategy to characterize a model of cocoa intake biomarkers in a free-living population. METHODS AND RESULTS: An untargeted HPLC-q-ToF-MS based metabolomics approach was applied to human urine from 32 consumers of cocoa or derived products (CC) and 32 matched control subjects with no consumption of cocoa products (NC). The multivariate statistical analysis (OSC-PLS-DA) showed clear differences between CC and NC groups. The discriminant biomarkers identified were mainly related to the metabolic pathways of theobromine and polyphenols, as well as to cocoa processing. Consumption of cocoa products was also associated with reduced urinary excretions of methylglutarylcarnitine, which could be related to effects of cocoa exposure on insulin resistance. To improve the prediction of cocoa consumption, a combined urinary metabolite model was constructed. ROC curves were constructed to evaluate the model and individual metabolites. The AUC values (95% CI) for the model were 95.7% (89.8-100%) and 92.6% (81.9-100%) in training and validation sets, respectively, whereas the AUCs for individual metabolites were <90%. CONCLUSIONS: The metabolic signature of cocoa consumption in free-living subjects reveals that combining different metabolites as biomarker models improves prediction of dietary exposure to cocoa

Comparative study of human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC) as a treatment for retinal dystrophies

Retinal dystrophies (RD) are major causes of familial blindness and are characterized by progressive dysfunction of photoreceptor and/or retinal pigment epithelium (RPE) cells. In this study, we aimed to evaluate and compare the therapeutic effects of two pluripotent stem cell (PSC)-based therapies. We differentiated RPE from human embryonic stem cells (hESCs) or human-induced pluripotent stem cells (hiPSCs) and transplanted them into the subretinal space of the Royal College of Surgeons (RCS) rat. Once differentiated, cells from either source of PSC resembled mature RPE in their morphology and gene expression profile. Following transplantation, both hESC- and hiPSC-derived cells maintained the expression of specific RPE markers, lost their proliferative capacity, established tight junctions, and were able to perform phagocytosis of photoreceptor outer segments. Remarkably, grafted areas showed increased numbers of photoreceptor nuclei and outer segment disk membranes. Regardless of the cell source, human transplants protected retina from cell apoptosis, glial stress and accumulation of autofluorescence, and responded better to light stimuli. Altogether, our results show that hESC- and hiPSC-derived cells survived, migrated, integrated, and functioned as RPE in the RCS rat retina, providing preclinical evidence that either PSC source could be of potential benefit for treating RD

A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families

Cardiac angiosarcoma (CAS) is a rare malignant tumour whose genetic basis is unknown. Here we show, by whole-exome sequencing of a TP53-negative Li-Fraumeni-like (LFL) family including CAS cases, that a missense variant (p.R117C) in POT1 (protection of telomeres 1) gene is responsible for CAS. The same gene alteration is found in two other LFL families with CAS, supporting the causal effect of the identified mutation. We extend the analysis to TP53-negative LFL families with no CAS and find the same mutation in a breast AS family. The mutation is recently found once in 121,324 studied alleles in ExAC server but it is not described in any other database or found in 1,520 Spanish controls. In silico structural analysis suggests how the mutation disrupts POT1 structure. Functional and in vitro studies demonstrate that carriers of the mutation show reduced telomere-bound POT1 levels, abnormally long telomeres and increased telomere fragility

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition

Background: Platinum-based chemotherapy remains the standard of care for most lung cancer cases. However chemoresistance is often developed during the treatment, limiting clinical utility of this drug. Recently, the ability of tumor cells to adapt their metabolism has been associated to resistance to therapies. In this study, we first described the metabolic reprogramming of Non-Small Cell Lung Cancer (NSCLC) in response to cisplatin treatment. Methods: Cisplatin-resistant versions of the A549, H1299, and H460 cell lines were generated by continuous drug exposure. The long-term metabolic changes, as well as, the early response to cisplatin treatment were analyzed in both, parental and cisplatin-resistant cell lines. In addition, four Patient-derived xenograft models treated with cisplatin along with paired pre- and post-treatment biopsies from patients were studied. Furthermore, metabolic targeting of these changes in cell lines was performed downregulating PGC-1α expression through siRNA or using OXPHOS inhibitors (metformin and rotenone). Results: Two out of three cisplatin-resistant cell lines showed a stable increase in mitochondrial function, PGC1-α and mitochondrial mass with reduced glycolisis, that did not affect the cell cycle. This phenomenon was confirmed in vivo. Post-treatment NSCLC tumors showed an increase in mitochondrial mass, PGC-1α and a decrease in the GAPDH/MT-CO1 ratio. In addition, we demonstrated how a ROS-mediated metabolism reprogramming, involving PGC-1α and increased mitochondrial mass, is induced during short-time cisplatin exposure. Moreover, we tested how cells with increased PGC-1a induced by ZLN005 treatment, showed reduced cisplatin-driven apoptosis. Remarkably, the long-term metabolic changes, as well as the metabolic reprogramming during short-time cisplatin exposure can be exploited as an Achilles’ heel of NSCLC cells, as demonstrated by the increased sensitivity to PGC-1α interference or OXPHOS inhibition using metformin or rotenone. Conclusion: These results describe a new cisplatin resistance mechanism in NSCLC based on a metabolic reprogramming that is therapeutically exploitable through PGC-1α downregulation or OXPHOS inhibitors.Work in the authors’ laboratories is supported by ‘‘Instituto de Salud Carlos III’’ PI13/01806 and PIE14/0064 to M.P. A.C-B, received a Spanish Lung Cancer Group fellowship. R.L-B, is supported by Comunidad Autónoma de Madrid “Garantía juvenil” contrac

Expresiones y convergencias de la violencia en México. Miradas sociopoliticas

es un libro multidisciplinario con diversas miradas a la violencia que ocurre en nuestras sociedadesEn los países europeos entre ellos los de mayor jerarquía económica, educativa y política afrontan problemáticas sociales puntuales como la violencia de género y el número de muertes que han aumentado en los países nórdicos, tema el cual es parte Finlandia. De manera que, la hipótesis de que los niveles de violencia se presentan en mayor medida en poblaciones con bajo nivel educativo pierde fuerza. Para los organismos internacionales como la Organización de las Naciones Unidas (ONU), en Latinoamérica la violencia es un acto territorial enmarcado por tomas de control y poder de la tierra, lugar donde se afrontan elites apoyadas a veces por los militares o gobiernos centralistas o autoritarios contra sectores vulnerables como los campesinos de zonas rurales. Para la Organización de Estados Americanos (OEA), la violencia está relacionada con un escenario de crisis entre sistemas políticos, por ello los acuerdos y negociaciones de “paz” son la antesala a puertas que conducen a diversos escenarios de respuestas. A estos principios elementales del marco de la violencia surgen intelectuales como Fazio quien explica para el caso mexicano como “La violencia criminal es consustancial al sistema capitalista. Es una guerra de acumulación capitalista por despojo”. En esta guera evidentemente que se pone en riesgo la salud (mental y física) de la población otro tema inherente a estos actos. La Organización Mundial de la Salud define la violencia como: El uso intencional de la fuerza o el poder físico, de hecho o como amenaza, contra uno mismo, otra persona o un grupo o comunidad, que cause o tenga muchas probabilidades de causar lesiones, muerte, daños psicológicos, trastornos del desarrollo o privaciones. De ella se ramifica en tres tipos de violencias: la violencia autoinfligida (comportamiento suicida y autolesiones), – la violencia interpersonal (violencia familiar , que incluye menores, pareja y ancianos ; así como violencia entre personas sin parentesco), – la violencia colectiva (social, política y económica).sin apoyo financier