Idiopathic multicentric osteolysis type III : case report and syndrome characterization

Presentamos el primer reporte de caso en Colombia de un paciente con osteólisis multicéntrica idiopática con compromiso de carpo y tarso y nefropatía. Se exponen, de manera clara y bien documentada, el cuadro clínico y paraclínico actual y la evolución del paciente, junto a una breve y completa revisión de esta enfermedad, rara, progresiva, degenerativa e incapacitante.Reporte de caso79-85We report the first case in Colombia of a patient with idiopathic multicentric osteolysis with carpal-tarsal compromise and nephropathy, The current clinical and paraclinical status of the patient is clearly exposed and well documented, along with a brief and comprehensive review of this rare progressive, degenerative and disabling disease

Development of a moisture-in-solid-insulation sensor for power transformers

Moisture is an important variable that must be kept under control to guarantee a safe operation of power transformers. Because of the hydrophilic character of cellulose, water mainly remains in the solid insulation, while just a few parts per million are dissolved in oil. The distribution of moisture between paper and oil is not static, but varies depending on the insulation temperature, and thus, water migration processes take place continuously during transformers operation. In this work, a sensor is presented that allows the determination of the moisture content of the transformer solid insulation in the steady state and during the moisture migration processes. The main objective of the design is that the electrodes of the sensor should not obstruct the movement of water from the solid insulation to the oil, so the proposed prototype uses a metallic-mesh electrode to do the measurements. The measurement setup is based on the characterization of the insulation dielectric response by means of the frequency dielectric spectroscopy (FDS) method. The sensitivity of the proposed sensor has been tested on samples with a moisture content within 1% to 5%, demonstrating the good sensitivity and repeatability of the measurements.This work has been supported by the Spanish Government under Contract DPI2012-35819

Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior

Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several lines of evidence suggest that tanycytes may be involved in the regulation of energy homeostasis. Tanycytes have extended cell processes that contact the feeding-regulating neurons in the AN, particularly, agouti-related protein (AgRP), neuropeptide Y (NPY), cocaine- and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC) neurons. In this study, we developed an adenovirus expressing GK shRNA to inhibit GK expression in vivo. When injected into the 3V of rats, this adenovirus preferentially transduced tanycytes. qRT-PCR and Western blot assays confirmed GK mRNA and protein levels were lower in GK knockdown animals compared to the controls. In response to an intracerebroventricular glucose injection, the mRNA levels of anorexigenic POMC and CART and orexigenic AgRP and NPY neuropeptides were altered in GK knockdown animals. Similarly, food intake, meal duration, frequency of eating events and the cumulative eating time were increased, whereas the intervals between meals were decreased in GK knockdown rats, suggesting a decrease in satiety. Thus, GK expression in the ventricular cells appears to play an important role in feeding behavior.Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad de Concepción; ChileFil: Millán, Carola. Universidad de Concepción; Chile. Universidad Adolfo Ibañez; ChileFil: Barahona, María José. Universidad de Concepción; ChileFil: Recabal, Antonia. Universidad de Concepción; ChileFil: Salgado, Magdiel. Universidad de Concepción; ChileFil: Martinez, Fernando. Universidad de Concepción; ChileFil: Ordenes, Patricio. Universidad de Concepción; ChileFil: Elizondo Vega, Roberto. Universidad de Concepción; ChileFil: Sepúlveda, Fernando. Universidad de Concepción; ChileFil: Uribe, Elena. Universidad de Concepción; ChileFil: García Robles, María de los Ángeles. Universidad de Concepción; Chil

Sodium borohydride-amberlyst-15 (H+): An effective reductor for hindered and unreactive ketones in aprotic solvent

The combination of sodium borohydride and amberlyst-15 (H+) in tetrahydrofurane is a powerful reductor for unreactive ketones. The reduction is fast, high-yielding and the work-up is extremely simple. Ketals, silyl ethers and other organic functions are not disturbed during the reduction.This work was supported by the Spanish DGICYT (PB94-0028). JRC thanks the ICI for a predoctoral fellowship.Peer Reviewe

Promoting accessibility by using metadata in the framework of a semantic-web driven CMS

Web content accessibility for impaired people has been mainly addressed by the Web Content Accessibility Guidelines (WCAG) developed by the Web Accessibility Initiative (WAI) of the W3C Consortium. Those guidelines have proved to be good diagnostic means for testing accessibility for different types of impairments, as well as for guiding the development of accessible content. A further step would be to promote discovery of material having appropriate accessibility support, as well as the adjustment of control and display of resources to meet user accessibility needs and preferences [5]. The last two challenges have been addressed by the IMS Global Learning Consortium in the IMS-AccessForAll (ACCMD) and the IMS Learner Information Profile (ACCLIP) specifications. Although IMS has approached both goals in a learning framework, both accessibility specifications pay a special attention to impaired users’ needs. As a first step, in this paper we survey how far IMS accessibility specifications cover WCAG, and discuss the convenience of extending it to the whole WAI guidelines. Secondly, we argue how accessibility could be considered as a key issue for promoting reusability. We continue explaining why using a semantic framework (such as the MPEG-7 semantic tool, RDF or OWL) for describing textual and contextual information in a standardized manner could promote both, accessibility and reusability. Finally, we explain how some accessibility issues have been already addressed by XimetriX’s ximDEX, a semantic-web Content Management System (CMS). We conclude proposing a plan to better integrate the accessibility specifications and contextual description tools into that CMS

An eLearning Standard Approach for Supporting PBL in Computer Engineering

Problem-based learning (PBL) has proved to be a highly successful pedagogical model in many fields, although it is not that common in computer engineering. PBL goes beyond the typical teaching methodology by promoting student interaction. This paper presents a PBL trial applied to a course in a computer engineering degree at the University of Seville, Spain. To promote the reusability and interoperability of the PBL trial, a design-driven approach was used, based on the Internet protocol Multimedia Subsystems (IMS) Learning Design (LD) standard. This paper presents the outcomes of using this method to innovate teaching practices in a blended learning environment. Design and implementation results, as well as users' opinions, are presented and analyzed.Ministerio de Educación y Ciencia TIN2006-15617-C03-03Junta de Andalucía P06-TIC-0229

El mortinato y el mortinato malformado como urgencias médicas : propuesta de manejo interdisciplinario

El óbito fetal es una condición frecuente y a menudo de causa no establecida, que constituye un hecho de interés tanto para los padres como para el personal de salud. El óbito fetal y el mortinato malformado son urgencias médicas que deben ser manejadas con un abordaje interdisciplinario. La evaluación y el manejo del óbito fetal y el mortinato malformado no deben ser la esponsabilidad de un solo médico, sino de un equipo de salud interdisciplinario. Aunque el estudio fetal es extenso y dispendioso, y a pesar de que la conformación de un equipo de trabajo interdisciplinario es difícil, es necesario establecer protocolos versátiles de evaluación y manejo del óbito fetal y el mortinato malformado donde participen diversos profesionales de la salud para brindar una mejor atención a las familias afectadas.Q4166-176IndigentesStillbirth is a common condition and its cause is frequently unknown. This condition is an event of interest to parents and health personnel. Stillbirths and malformed stillbirths are medical emergencies that must be handled with an interdisciplinary approach. Evaluation and management of stillbirths and malformed stillbirths must not be the responsibility of a single doctor, but that of an interdisciplinary health team. Although fetal assessment is extensive and expensive and despite the fact that the formation of an interdisciplinary team is difficult, it is necessary to establish versatile protocols for evaluating and managing stillbirths and malformed stillbirths involving several health professionals to provide better attention to affected families

New models involving quantum chemical parameters for assessing the chromatographic retention process

.Knowledge about the theoretical relationship between the analyte properties and the critical chromatographic parameters is mandatory for a better interpretation of the separation mechanism and a more leisurely development of quantitative studies. In a preliminary stage of this work, we introduce the Gumbel distribution, the extreme value distribution type-I widely used in other fields, as a novel tool for modelling the chromatographic peak shape. Further, we develop mathematical models to evaluate the effect of the experimental variables and various quantum parameters on the chromatographic indices, such as the retention time, capacity factor, asymmetry factor, tailing factor and number of theoretical plates. Finally, we propose a mechanistic behaviour for the chromatographic separation process based on the structure-retention relationship of fifteen selected drugs involving several molecular quantum parametersS

Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources

[EN] In this work, we identified glucose and glycerol as tacrolimus repressing carbon sources in the important species Streptomyces tsukubaensis. A genome-wide analysis of the transcriptomic response to glucose and glycerol additions was performed using microarray technology. The transcriptional time series obtained allowed us to compare the transcriptomic profiling of S. tsukubaensis growing under tacrolimus producing and non-producing conditions. The analysis revealed important and different metabolic changes after the additions and a lack of transcriptional activation of the fkb cluster. In addition, we detected important differences in the transcriptional response to glucose between S. tsukubaensis and the model species Streptomyces coelicolor. A number of genes encoding key players of morphological and biochemical differentiation were strongly and permanently downregulated by the carbon sources. Finally, we identified several genes showing transcriptional profiles highly correlated to that of the tacrolimus biosynthetic pathway regulator FkbN that might be potential candidates for the improvement of tacrolimus productionSIThis study was funded by the Government of Spain (grant number PIM2010-EEI00677). María Ordóñez-Robles received a FPU grant from the Government of Spain (grant number AP2009-4508)