Interaction and imitation in a world of Quixotes and Sanchos

Producción CientíficaThis paper studies a two-population evolutionary game in a new setting in between a symmetric and an asymmetric evolutionary model. It distinguishes two types of agents: Sanchos, whose payoffs are defined by a prisoner’s dilemma game, and Quixotes, whose payoffs are defined by a snowdrift game. Considering an imitative revision protocol, a revising agent is paired with someone from his own population or the other population. When matched, they observe payoffs, but not identities. Thus, agents in one population interact and imitate agents from their own population and from the other population. In this setting we prove that a unique mixed-strategy asymptotically stable fixed point of the evolutionary dynamics exists. Taking as an example the compliance with social norms, and depending on the parameters, two type of equilibrium are possible, one with full compliance among Quixotes and partial compliance among Sanchos, or another with partial compliance among Quixotes and defection among Sanchos. In the former type, Sanchos comply above their Nash equilibrium (as they imitate compliant Quixotes). In the latter type, Quixotes comply below their Nash equilibrium (as they imitate defecting Sanchos)

Assessment of carotenoid production by Dunaliella salina in different culture systems and operation regimes

The effect of operation regime and culture system on carotenoid productivity by the halotolerant alga Dunaliella salina has been analyzed. Operation strategies tested included batch and semi continuous regime, as well as a two-stage approach run simultaneously in both, open tanks and closed reactor. The best results were obtained with the closed tubular photobioreactor. The highest carotenoid production (328.8 mg carotenoid l−1 culture per month) was achieved with this culture system operated following the two-stage strategy. Also, closed tubular photobioreactor provided the highest carotenoid contents (10% of dry weight) in Dunaliella biomass and β-carotene abundance (90% of total carotenoids) as well as the highest 9-cis to all-trans β-carotene isomer ratio (1.5 at sunrise).Comisión Interministerial de Ciencia y Tecnología IFD 1997-1780IFAPA CO3-125Plan Andaluz de Investigación CVI13

Assessment of heritage rammed-earth buildings. The Alcázar of King Don Pedro I (Spain).

The conservation and maintenance of earthen buildings is crucial, especially when dealing with heritage sites. This normally involves considerable effort in preliminary studies, which must be well planned in order to efficiently manage any restoration. This case study proposes a methodology to briefly assess the current state of a historical rammed-earth wall, to bring to light specific information regarding approaches for subsequent studies or decisions. This methodology is based on the study of damage and risk as a tool to swiftly discern critical areas or issues needing immediate attention. The procedure is illustrated on an outstanding heritage building: the Alcázar of King Don Pedro I in Carmona (Seville, Spain). Our conclusions confirm that this methodology constitutes an efficient and straightforward means to obtain not only a preliminary assessment of rammed-earth walls, but also objective and useful criteria for decision-makers

Propuesta de plan de intervención simplificado para facilitar la detección sanitaria de mujeres víctimas de violencia de género

Treball final de Màster Universitari en Igualtat i Gènere en l'Àmbit Públic i Privat. Curs acadèmic 2012-201

Compliance with Social Norms as an Evolutionary Stable Equilibrium

Producción CientíficaThis paper studies a two-population evolutionary game in a new setting in between a symmetric and an asymmetric evolutionary model. It distinguishes two types of agents: Sanchos, whose payoffs are defined by a prisoner’s dilemma game, and Quixotes, whose payoffs are defined by a snowdrift game. Considering an imita- tive revision protocol, a revising agent is paired with someone from his own popula- tion or the other population. When matched, they observe payoffs, but not identities. Thus, agents in one population interact and imitate agents from their own population and from the other population. In this setting we prove that a unique mixed-strategy asymptotically stable fixed point of the evolutionary dynamics exists. Taking as an example the compliance with social norms, and depending on the parameters, two type of equilibrium are possible, one with full compliance among Quixotes and par- tial compliance among Sanchos, or another with partial compliance among Quixotes and defection among Sanchos. In the former type, Sanchos comply above their Nash equilibrium (as they imitate compliant Quixotes). In the latter type, Quixotes comply below their Nash equilibrium (as they imitate defecting Sanchos).This study was funded by the Spanish Government (projects ECO2014- 52343-P and ECO2017-82227-P), as well as financial aid from Junta de Castilla y León (projects VA024P17 and VA105G18), co-financed by FEDER funds

Regional devolopment and solidarity in Spain: the relationship between the E.C. and the internal solidarity funds.

This paper will analyse the importance that the Regional Solidarity Funds have acquired in the financial systems of those Autonomous Communities able to benefit from them, and the influence that these Funds have had in their development. In addition, the special role that Structural Funds have had in order to bring the Autonomous Communities’ development in line with the average level of the European Member States will be referred to. Then, the different EC tools that are connected with regional development will be described and analysed; next, the Spanish regions that have benefited from these tools since Spain joined the European Union in 1986 will be studied. The Internal Solidarity Funds and their relationship with the EC Structural Funds will also be analysed. The effects of these mechanisms will be examined from three different points of view. First of all, the impact of these resources on the regional financial system will be considered; secondly, the coordination between the EC Structural Funds and the Internal Solidarity Funds, and the impact of this relationship will be analysed; and finally, whether or not these mechanisms are efficient enough to achieve the aim of regional unity will be determined, and their influence in different areas of production will also be observed. Key words: Fiscal Federalism, Spanish Autonomous Communities, Structural Funds, Inter-regional Solidarity. JEL Codes: H7, H77.

Green coffee based CO2 adsorbent with high performance in postcombustion conditions

An environmentally friendly and low cost adsorbent, PPC (patent application filed González (2013)), produced from an abundant residue from the food industry, coffee grounds, is presented and evaluated as CO2 adsorbent in postcombustion conditions. PPC is a high bulk density pelletized carbon with adequate properties for its use in fixed-bed adsorption applications. The equilibrium capacity for CO2 at low partial pressures, relevant for the postcombustion case, in the 25–50 °C temperature range is superior to that of reference carbons, both in mass and volume basis. PPC presents equilibrium selectivity for CO2 over N2, with CO2/N2 equilibrium separation factor values of 15–25 at 50 °C and 130 kPa for CO2 concentrations between 9% and 31%. Moreover, it presents fast adsorption kinetics, which makes it a good candidate for rapid swing adsorption cycles. Different VSA cycle configurations were carried out at 50 °C in the fixed-bed adsorption unit to evaluate the performance of the adsorbent in cyclic operation. The adsorbent did not show any sign of deactivation over extended operation.Work carried out with financial support from the Spanish MINECO (Project ENE2011-23467), co-financed by the European Regional Development Fund (ERDF). M.G.P. acknowledges funding from the CSIC (JAE-Doc program), and A.S.G. acknowledges a contract from the MINECO (FPI program); both programs are co-financed by the European Social Fund.Peer reviewe

Procedimiento de obtención de un adsorbente que utiliza residuos de café postconsumo y su utilización para la adsorción de CO2

La presente invención se refiere a un procedimiento de obtención de un material adsorbente con capacidad para adsorber CO2 , que utiliza residuos de café postconsumo. El procedimiento de obtención comprende el secado del residuo, su conformación, en ausencia de ligantes, y su activación térmica en presencia de un agente activante, que preferentemente es CO2 . Las características texturales y de densidad del material obtenido por el procedimiento de la invención, que también se protege, lo convierten en un candidato ideal para la adsorción de CO2 , y preferentemente en la captura de CO2 postcombustión.Peer reviewedConsejo Superior de Investigaciones CientíficasR Informe sobre el estado de la técnica publicado separadament

Histone Mutants Separate R Loop Formation from Genome Instability Induction

R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R loops but do not cause instability. R loops containing single-stranded DNA (ssDNA), versus RNA-DNA hybrids alone, were demonstrated using ssDNA-specific human AID and bisulfite. Notably, they are similar size regardless of whether or not they induce genome instability. Contrary to mutants causing R loop-mediated instability, these histone mutants do not accumulate H3 serine-10 phosphate (H3S10-P). We propose a two-step mechanism in which, first, an altered chromatin facilitates R loops, and second, chromatin is modified, including H3S10-P, as a requisite for compromising genome integrity. Consistently, these histone mutations suppress the high H3S10 phosphorylation and genomic instability of hpr1 and sen1 mutants. Therefore, contrary to what was previously believed, R loops do not cause genome instability by themselves.European Research Council ERC2014 AdG669898Ministerio de Economía y Competitividad BFU2013-42918-P, BFU2016-75058-

Overexpression of mitochondrial if1 prevents metastatic disease of colorectal cancer by enhancing anoikis and tumor infiltration of NK cells

Increasing evidences show that the ATPase Inhibitory Factor 1 (IF1), the physiological inhibitor of the ATP synthase, is overexpressed in a large number of carcinomas contributing to metabolic reprogramming and cancer progression. Herein, we show that in contrast to the findings in other carcinomas, the overexpression of IF1 in a cohort of colorectal carcinomas (CRC) predicts less chances of disease recurrence, IF1 being an independent predictor of survival. Bioinformatic and gene expression analyses of the transcriptome of colon cancer cells with differential expression of IF1 indicate that cells overexpressing IF1 display a less aggressive behavior than IF1 silenced (shIF1) cells. Proteomic and functional in vitro migration and invasion assays confirmed the higher tumorigenic potential of shIF1 cells. Moreover, shIF1 cells have increased in vivo metastatic potential. The higher metastatic potential of shIF1 cells relies on increased cFLIP-mediated resistance to undergo anoikis after cell detachment. Furthermore, tumor spheroids of shIF1 cells have an increased ability to escape from immune surveillance by NK cells. Altogether, the results reveal that the overexpression of IF1 acts as a tumor suppressor in CRC with an important anti-metastatic role, thus supporting IF1 as a potential therapeutic target in CRCThis research was funded by grants from Ministerio de Ciencia, Innovación y Universidades (SAF2013-41945-R, SAF2016-75916-R and SAF2016-75452-R), CIBERER-ISCIII (CB06/07/0017) and Fundación Ramón Areces, Spai