A dependent Lindeberg central limit theorem for cluster functionals on stationary random fields

In this paper, we provide a central limit theorem for the finite-dimensional marginal distributions of empirical processes $(Z_n(f))_{f\in\mathcal{F}}$ whose index set $\mathcal{F}$ is a family of cluster functionals valued on blocks of values of a stationary random field. The practicality and applicability of the result depends mainly on the usual Lindeberg condition and a sequence $T_n$ which summarizes the dependence between the blocks of the random field values. Finally, as application, we use the previous result in order to show the Gaussian asymptotic behavior of the iso-extremogram estimator introduced in this paper.Comment: 14 page

Biodiversidad de Diplura (Hexapoda: Entognatha) en México

ResumenSe hace una descripción general de la morfología de los Diplura, dando información sobre su reproducción, así como de sus hábitats frecuentes y su importancia desde diversos aspectos. Se muestra la distribución de 6 familias en 23 estados de México. Se hace una evaluación de la diversidad y se proporciona el listado (Apéndice) de las 57 especies que se conocen del país, señalando los estados donde han sido citados.AbstractA general description of the morphology of the Diplura is done, information about their reproduction and habitats as well as their common environments and their importance in different aspects is provided. Distribution of 6 families in 23 states of Mexico is shown. An assessment of their diversity and a list of the 57 species known in the country and the states where they have been cited are provided

Learning CHARME models with neural networks

In this paper, we consider a model called CHARME (Conditional Heteroscedastic Autoregressive Mixture of Experts), a class of generalized mixture of nonlinear nonparametric AR-ARCH time series. Under certain Lipschitz-type conditions on the autoregressive and volatility functions, we prove that this model is stationary, ergodic and $\tau$-weakly dependent. These conditions are much weaker than those presented in the literature that treats this model. Moreover, this result forms the theoretical basis for deriving an asymptotic theory of the underlying (non)parametric estimation, which we present for this model. As an application, from the universal approximation property of neural networks (NN), we develop a learning theory for the NN-based autoregressive functions of the model, where the strong consistency and asymptotic normality of the considered estimator of the NN weights and biases are guaranteed under weak conditions.Comment: 31 pages, 4 figure

Synthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor

Taking as models the polyamine toxin fraction FTX from the funnel-web spider venom, and the guanidinium moiety of guanethidine, a series of azaalkane-1,omega-diguanidinium salts were obtained. Some of them blocked ion fluxes through the neuronal nicotinic receptors for acetylcholine (nAChR). The blockade was exerted at submicromolar concentrations, suggesting a highly selective interaction with the nAChR. In fact, the active compounds on the nAChR ion channel did not recognize the voltage-dependent Na+ or Ca2+ channels of bovine adrenal chromaffin cells. Therefore, these compounds may be useful tools to clarify the functions of nAChR receptors in the central and peripheral nervous systems.Fundación Ramón Arece

A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid

A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent.We gratefully acknowledge ZAMBON GROUP for studentships (to A. D. and J. S.) and financial support

Unexpected N-C bond fission of fused N-alkylbenzimidazolium salts. A new approach to pyrido[1,2-a]- or pyridazino[1,6-a]benzimidazoles

The reaction of N-carboxymethylpyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts with thionyl chloride resulted in an N-C bond fission, yielding the corresponding pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazoles. A similar dealkylation process was observed when analogous N-propargylic derivatives were treated with Cu (II) acetate.Universidad de Alcal

Group-decision making with induced ordered weighted logarithmic aggregation operators

This paper presents the induced generalized ordered weighted logarithmic aggregation (IGOWLA) operator, this operator is an extension of the generalized ordered weighted logarithmic aggregation (GOWLA) operator. It uses order-induced variables that modify the reordering process of the arguments included in the aggregation. The principal advantage of the introduced induced mechanism is the consideration of highly complex attitude from the decision makers. We study some families of the IGOWLA operator as measures for the characterization of the weighting vector (...

Optimized synthesis of di, tri and tetrafused pyridazinium cations

By combining two complementary statistical techniques (fractional factorial experimental design and simplex operation) the synthesis of the parent pyrido[1,2-b]-pyridazinium cation has been successfully carried out (the yield was improved from less than 10 to 65%) by basic condensation of 2-methyl-1-aminopyridinium mesitylenesulfonate and [1,4]dioxane-2,3-diol. Using the optimized reaction conditions, other related heterocyclic cations could be prepared, and two interesting examples are now reported.Ministerio de Educación y CienciaUniversidad de Alcal

Oral and dental health status in patients with eating disorders in Madrid, Spain

The aim of the present study was to describe and compare the oral and dental health status of two groups, one diagnosed with eating disorders (EDs), and another group without this pathology, assessing the following oral manifestations: dental alterations, periodontal disorders, soft tissue disorders, non-stimulated salivary flow, and oral pH. This comparative transversal epidemiological study included 179 participants, of whom 59 were diagnosed with EDs (Eating Disorder Group: EDG) and 120 had no antecedents of EDs (No Eating Disorder Group: NEDG). All patients fulfilled the following inclusion criteria: women aged over 18 years, diagnosed with an ED by a specialist, patients who had undergone at least 1 year monitoring by the Clinical Nutrition Unit, and had not received any periodontal treatment during the previous 6 months. Both groups were homogeneous in terms of sex, age, education, and socioeconomic level. Oral exploration was performed, registering clinical variables, as well as sociodemographic and socioeconomic data, oral hygiene habits, and smoking. Statistical significance was established as p 95%). The dental erosion (DE) was the most significative feature of dental alterations. The degree of DE was significantly greater in the EDG (p<0.001). A significant association between soft tissue lesions and EDs was found (p<0.001) A notable difference in non-stimulated salivary flow was found between the groups (p<0.001). No significant differences between the groups were found for periodontal status, dental caries, or oral hygiene practices. On the basis of the results obtained, it is necessary to carry out oral/dental examination as soon as an ED is diagnosed with regular check-ups thereafter

Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase

9 p.-2 figPhase I and II enzymes are involved in the metabolism of endogenous reactive compounds as well as xenobiotics, including toxicants and drugs. Genotyping studies have established several drug metabolizing enzymes as markers for risk of drug hypersensitivity. However, other candidates are emerging that are involved in drug metabolism but also in the generation of danger or costimulatory signals. Enzymes such as aldo-keto reductases (AKR) and glutathione transferases (GST) metabolize prostaglandins and reactive aldehydes with proinflammatory activity, as well as drugs and/or their reactive metabolites. In addition, their metabolic activity can have important consequences for the cellular redox status, and impacts the inflammatory response as well as the balance of inflammatory mediators, which can modulate epigenetic factors and cooperate or interfere with drug-adduct formation. These enzymes are, in turn, targets for covalent modification and regulation by oxidative stress, inflammatory mediators, and drugs. Therefore, they constitute a platform for a complex set of interactions involving drug metabolism, protein haptenation, modulation of the inflammatory response, and/or generation of danger signals with implications in drug hypersensitivity reactions. Moreover, increasing evidence supports their involvement in allergic processes. Here, we will focus on GSTP1-1 and aldose reductase (AKR1B1) and provide a perspective for their involvement in drug hypersensitivityThis work has been supported by grants SAF2012-36519 from MINECO and SAF-2015-68590-R from MINECO/FEDER and ISCIII RETIC RIRAAF RD12/0013/0008 to DP,and RD12/0013/0002 to J A.Peer reviewe