HBsAg, Anti-HBs, Anti-HCV and Anti-HIV seroprevalence of the patients applied to Bitlis State Hospital and Tatvan State Hospital

Amaç: Günümüzde viral hepatitler ve HIV enfeksiyonu önemli sağlık sorunlarıdır. Bu çalışmanın amacı 1 Aralık 2012 ve 30 Kasım 2013 tarihleri arasında Bitlis Devlet Hastanesi ve Tatvan Devlet Hastanesine başvuran bireylerde; HBsAg, anti-HBs, anti-HCV ve anti-HIV seropozitiflik oranlarının belirlenmesidir. Gereç ve Yöntem: Hastalardan alınan kan örnekleri CMIA (Chemiluminescent Microparticle İmmunoassay) yöntemi ile çalışılmıştır. Bulgular: HBsAg için 20.484 serum örneği incelendi ve bu örneklerin 933’ünde (% 4,5) HBsAg pozitifdi. Anti-HBs için 16.695 serum örneği incelendi ve bu örneklerin 5.759’unda (% 34,4) anti-HBs pozitifdi. Anti-HCV için 19.685 serum örneği incelendi ve bu örneklerin 8’inde (% 0,09) anti-HCV pozitifdi, Anti-HIV için 14.874 serum örneği incelendi ve bu örneklerin 1’inde (% 0,007) anti-HIV pozitifdi. Sonuç: Sonuç olarak, viral hepatitler ilimiz için önemli sağlık problemleridir. Bölgemizdeki HBsAg seropozitifliği ülkemiz oranlarıyla uyumlu olup, anti-HIV ve anti-HCV pozitifliği Türkiye ortalamasının altında çıkmıştır.Objective: At the present time viral hepatitis and HIV infection are important health problems. The aim of this study was to investigate the rates of HBsAg, anti-HBs, anti-HCV and anti-HIV seropositivity in people those admitted to Bitlis State Hospital and Tatvan State Hospital between December 2012 and November 2013. Material and Methods: Blood samples from the patients were analysed in using chemiluminescence method. Results: For HBsAg, 20.484 samples were analyzed and 933 (4,5 %) of these samples were positive. For anti-HBs, 16.965 samples were analyzed and 5.759 (34,4 %) of these samples were positive. For antiHCV 19.685 samples were analyzed and 18 (0,09 %) of these samples were positive. For anti-HIV 14874 samples were analyzed and only 1 sample was positive (0,007 %). Conclusion: In conclusion; despite the relatively lower rate of HIV seropositivity, hepatitis viruses, particularly HBV remains to be a significant health problem in our province. The seropositivity rates for HBsAg in our region were comparable to those seen across Turkey. Whereas, the seropositivity rates for anti-HIV and anti-HCV were lower than the average rate in Turkey

HBsAg, Anti-HBs, Anti-HCV and Anti-HIV seroprevalence of the patients applied to Bitlis State Hospital and Tatvan State Hospital

Amaç: Günümüzde viral hepatitler ve HIV enfeksiyonu önemli sağlık sorunlarıdır. Bu çalışmanın amacı 1 Aralık 2012 ve 30 Kasım 2013 tarihleri arasında Bitlis Devlet Hastanesi ve Tatvan Devlet Hastanesine başvuran bireylerde; HBsAg, anti-HBs, anti-HCV ve anti-HIV seropozitiflik oranlarının belirlenmesidir. Gereç ve Yöntem: Hastalardan alınan kan örnekleri CMIA (Chemiluminescent Microparticle İmmunoassay) yöntemi ile çalışılmıştır. Bulgular: HBsAg için 20.484 serum örneği incelendi ve bu örneklerin 933’ünde (% 4,5) HBsAg pozitifdi. Anti-HBs için 16.695 serum örneği incelendi ve bu örneklerin 5.759’unda (% 34,4) anti-HBs pozitifdi. Anti-HCV için 19.685 serum örneği incelendi ve bu örneklerin 8’inde (% 0,09) anti-HCV pozitifdi, Anti-HIV için 14.874 serum örneği incelendi ve bu örneklerin 1’inde (% 0,007) anti-HIV pozitifdi. Sonuç: Sonuç olarak, viral hepatitler ilimiz için önemli sağlık problemleridir. Bölgemizdeki HBsAg seropozitifliği ülkemiz oranlarıyla uyumlu olup, anti-HIV ve anti-HCV pozitifliği Türkiye ortalamasının altında çıkmıştır.Objective: At the present time viral hepatitis and HIV infection are important health problems. The aim of this study was to investigate the rates of HBsAg, anti-HBs, anti-HCV and anti-HIV seropositivity in people those admitted to Bitlis State Hospital and Tatvan State Hospital between December 2012 and November 2013. Material and Methods: Blood samples from the patients were analysed in using chemiluminescence method. Results: For HBsAg, 20.484 samples were analyzed and 933 (4,5 %) of these samples were positive. For anti-HBs, 16.965 samples were analyzed and 5.759 (34,4 %) of these samples were positive. For antiHCV 19.685 samples were analyzed and 18 (0,09 %) of these samples were positive. For anti-HIV 14874 samples were analyzed and only 1 sample was positive (0,007 %). Conclusion: In conclusion; despite the relatively lower rate of HIV seropositivity, hepatitis viruses, particularly HBV remains to be a significant health problem in our province. The seropositivity rates for HBsAg in our region were comparable to those seen across Turkey. Whereas, the seropositivity rates for anti-HIV and anti-HCV were lower than the average rate in Turkey

A city-wide survey of dental students' opinions on undergraduate oral surgery teaching

Purpose This study aimed to carry out a city-wide survey to evaluate undergraduate students' opinions on their oral surgery training by measuring their self-confidence.Materials and Methods A cross-sectional survey of 383 3rd year, 412 4th year and 363 5th year undergraduate dental students from six dental schools in Istanbul with a mean age of 22.73 +/- 1.55 was conducted towards the end of the academic year. A web link to the questionnaire was sent to the contact person at the participating dental schools. The questionnaires were anonymously evaluated. Descriptive statistics were calculated, and Chi-square tests were performed to examine the data. A P-value of In total, 1158 responses were returned, representing 67% of the overall students in the 2018-2019 academic year. The male respondents were significantly more self-confident than females in the general aspects of surgical skills. More than half of the respondents (53%) felt confident in oral surgery knowledge to undertake independent practice. Although 5th year respondents felt more confident in the general aspect of the questionnaire, their ability of differentiation of odontogenic and non-odontogenic pain was lower than their counterparts. The majority (86%) of the participants disagreed that the only knowledge required for oral surgery was that of tooth and jaw anatomy.Conclusion This survey revealed perceived confidence in tooth and retained root extraction. The male respondents were found to be more self-confident. There is a need for improvement in surgical skills, recognition of malignancies and differentiation of the origin of the pain

Prognostic Significance of Notch1 and Fbxw7 Mutations in Pediatric T-All

The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment. NOTCH1 and FBXW7 mutations both lead the activation of the NOTCH1 pathway and are found in the majority of T- ALL patients. In this study, the mutation analysis of NOTCH1 and FBXW7 genes was performed in 87 pediatric T-ALLs who were treated on the ALL-BFM protocols. In 19 patients (22%), activating NOTCH1 mutations were observed either in the heterodimerization domain or in the PEST domain and 7 cases (10%) demonstrated FBXW7 mutations (2 cases had both NOTCH1 and FBXW7 mutations). We also analyzed the relationship of the mutation data between the clinical and biological data of the patients. NOTCH1 and FBXW7, NOTCH1 alone were found correlated with lower initial leucocyte counts which was independent from the sex and T- cell immunophenotype. However, NOTCH1 and FBXW7 mutations were not predictive of outcome in the overall cohort of pediatric T-ALLs.Wo

The success of the Cystic Fibrosis Registry of Turkey for improvement of patient care

Background Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association of newly established CF registry system in Turkey on follow-up, clinical, growth, treatment, and complications of people with this disease. Methods Age at diagnosis, current age, sex, z-scores of weight, height and body mass index (BMI), neonatal screening results, pulmonary function tests, history of meconium ileus, medications, presence of microorganisms, and follow-up were evaluated and compared to data of people with CF represented in both 2017 and 2019 registry data. Results There were 1170 people with CF in 2017 and 1637 in 2019 CF registry. Eight hundred and fourteen people were registered in both 2017 and 2019 of whom z-scores of heights and BMI were significantly higher in 2019 (p = 0.002, p =0.039, respectively). Inhaled hypertonic saline, bronchodilator, and azithromycin usages were significantly higher in 2019 (p =0.001, p = 0.001, p = 0.003, respectively). The percent predicted of forced expiratory volume in 1 sec and forced vital capacity were similar in 2017 and 2019 (88% and 89.5%, p = 0.248 and 84.5% and 87%, p =0.332, respectively). Liver diseases and osteoporosis were significantly higher, and pseudo-Bartter syndrome (PBS) was significantly lower in 2019 (p = 0.011, p = 0.001, p = 0.001, respectively). Conclusions The z-scores of height and BMI were higher, the use of medications that protect and improve lung functions was higher and incidence of PBS was lower in 2019. It was predicted that registry system increased the care of people with CF regarding their follow-up. The widespread use of national CF registry system across the country may be beneficial for the follow-up of people with CF

The success of the Cystic Fibrosis Registry of Turkey for improvement of patient care

Background Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association of newly established CF registry system in Turkey on follow-up, clinical, growth, treatment, and complications of people with this disease. Methods Age at diagnosis, current age, sex, z-scores of weight, height and body mass index (BMI), neonatal screening results, pulmonary function tests, history of meconium ileus, medications, presence of microorganisms, and follow-up were evaluated and compared to data of people with CF represented in both 2017 and 2019 registry data. Results There were 1170 people with CF in 2017 and 1637 in 2019 CF registry. Eight hundred and fourteen people were registered in both 2017 and 2019 of whom z-scores of heights and BMI were significantly higher in 2019 (p = 0.002, p =0.039, respectively). Inhaled hypertonic saline, bronchodilator, and azithromycin usages were significantly higher in 2019 (p =0.001, p = 0.001, p = 0.003, respectively). The percent predicted of forced expiratory volume in 1 sec and forced vital capacity were similar in 2017 and 2019 (88% and 89.5%, p = 0.248 and 84.5% and 87%, p =0.332, respectively). Liver diseases and osteoporosis were significantly higher, and pseudo-Bartter syndrome (PBS) was significantly lower in 2019 (p = 0.011, p = 0.001, p = 0.001, respectively). Conclusions The z-scores of height and BMI were higher, the use of medications that protect and improve lung functions was higher and incidence of PBS was lower in 2019. It was predicted that registry system increased the care of people with CF regarding their follow-up. The widespread use of national CF registry system across the country may be beneficial for the follow-up of people with CF