Centrifugal instability over a rotating cone

In this study, we provide a mathematical description of the onset of counter-rotating circular vortices observed for a family of slender rotating cones (of half-angles 15°, 30° and 45°) in quiescent fluid. In particular, we apply appropriate scalings and apply a change of coordinates, accounting for the effects of streamline curvature. A combined large Reynolds number and large vortex wavenumber analysis is used to obtain an estimate for the asymptotic right-hand branch of neutral stability for the family of slender rotating cones. Existing experimental and theoretical studies are discussed which lead to the clear hypothesis of a hitherto unidentified convective instability mode that dominates within the boundary-layer flow over slender rotating cones. The mode manifests as Görtler-type counter-rotating spiral vortices, indicative of a centrifugal mechanism. Although a formulation consistent with the classic rotating-disk problem has been successful in predicting the stability characteristics over broad cones, it is unable to identify such a centrifugal mode as the half-angle is reduced. An alternative formulation is developed and the governing equations solved using both short-wavelength asymptotic and numerical approaches to independently identify the centrifugal mode. Our results confirm our earlier predictions pertaining to the existence of the new Görtler mode and capture the effects of the governing centrifugal instability mechanism. Meanwhile, favourable comparisons are drawn between numerical and asymptotic neutral stability curve predictions

The quasi-cylindrical description of submerged laminar swirling jets

TThe quasi-cylindrical approximation is used to describe numerically the structure of a submerged swirling jet for subcritical values of the swirl ratio S<Sc . The emerging flow structure is affected by the swirling motion, which enhances the entrainment rate of the jet and induces an adverse pressure gradient that reduces its momentum flux. The effect is more pronounced as the swirl ratio S is increased, yielding for sufficiently large values of S a jet with an annular structure. The integration describes the smooth transition towards the far-field self-similar solution for all values of S smaller than a critical value S5Sc , at which the numerical integration fails to converge at a given downstream location. The comparisons with previous experimental results confirm the correspondence between the onset of vortex breakdown and the failure of the quasi-cylindrical approximation

MRI phenotyping of underlying cerebral small vessel disease in mixed hemorrhage patients

Objective: To investigate underlying cerebral small vessel disease (CSVD) in patients with mixed cerebral hemorrhages patterns and phenotype them according to the contribution of the two most common sporadic CSVD subtypes: cerebral amyloid angiopathy (CAA) vs. hypertensive arteriopathy (HA). Methods: Brain MRIs of patients with intracerebral hemorrhages (ICHs) and/or cerebral microbleeds (CMBs) were assessed for the full spectrum of CSVD markers using validated scales: ICHs, CMBs, cortical superficial siderosis (cSS), white matter hyperintensities, MRI-visible perivascular spaces (PVS). PVS predominance pattern was grouped as centrum-semiovale (CSO)-PVS predominance, basal-ganglia (BG)-PVS predominance, CSO-PVS and BG-PVS equality. Patients with mixed cerebral hemorrhages were classified into mixed CAA-pattern or mixed HA-pattern according to the existence of cSS and/or a CSO-PVS predominance pattern and comparisons were performed. Results: We included 110 patients with CAA (strictly lobar ICHs/CMBs), 33 with HA (strictly deep ICHs/CMBs) and 97 with mixed lobar/deep ICHs/CMBs. Mixed patients were more similar to HA with respect to their MRI-CSVD markers, vascular risk profile and cerebrospinal fluid (CSF) measures. In the mixed patients, 33 (34%) had cSS, a CSO-PVS predominance pattern, or both, and were defined as mixed CAA-pattern cases. The mixed CAA-pattern patients were more alike CAA patients regarding their MRI-CSVD markers, CSF and genetic profile. Conclusion: Our findings suggest that the heterogeneous group of patients with mixed cerebral hemorrhages distribution can be further phenotyped according to the predominant underlying CSVD. cSS presence and a CSO-PVS predominance pattern could serve as strongly suggestive markers of a contribution from CAA among patients with mixed hemorrhages

Effect of localized wall cooling or heating on streaks in high-speed boundary layers

High-amplitude upstream disturbances and wall surface roughness elements trigger streamwise/Görtler vortices and the associated streaks in boundary layers over flat or concave surfaces. Following the transient growth phase, the fully-developed vortices become sensitive to inviscid secondary instabilities, which ultimately result in a premature transition to turbulence. Our work aims at investigating the effect of cooling/heating on the initiation and development of such streaks in an attempt to gain a better understanding of the conditions and governing mechanisms leading to secondary instabilities in high-speed compressible boundary layers. We conduct a parametric study via a robust and efficient numerical solution to the non-linear compressible boundary region equations (NCBRE) to identify the impact of varying the wall temperature on the development of streaks in supersonic and hypersonic boundary layer flows

Interactive and automated application of virtual microscopy

Virtual microscopy can be applied in an interactive and an automated manner. Interactive application is performed in close association to conventional microscopy. It includes image standardization suitable to the performance of an individual pathologist such as image colorization, white color balance, or individual adjusted brightness. The steering commands have to include selection of wanted magnification, easy navigation, notification, and simple measurements (distances, areas). The display of the histological image should be adjusted to the physical limits of the human eye, which are determined by a view angle of approximately 35 seconds. A more sophisticated performance should include acoustic commands that replace the corresponding visual commands. Automated virtual microscopy includes so-called microscopy assistants which can be defined similar to the developed assistants in computer based editing systems (Microsoft Word, etc.). These include an automated image standardization and correction algorithms that excludes images of poor quality (for example uni-colored or out-of-focus images), an automated selection of the most appropriate field of view, an automated selection of the best magnification, and finally proposals of the most probable diagnosis. A quality control of the final diagnosis, and feedback to the laboratory determine the proposed system. The already developed tools of such a system are described in detail, as well as the results of first trials. In order to enhance the speed of such a system, and to allow further user-independent development a distributed implementation probably based upon Grid technology seems to be appropriate. The advantages of such a system as well as the present pathology environment and its expectations will be discussed in detail

PAB3D: Its History in the Use of Turbulence Models in the Simulation of Jet and Nozzle Flows

This is a review paper for PAB3D s history in the implementation of turbulence models for simulating jet and nozzle flows. We describe different turbulence models used in the simulation of subsonic and supersonic jet and nozzle flows. The time-averaged simulations use modified linear or nonlinear two-equation models to account for supersonic flow as well as high temperature mixing. Two multiscale-type turbulence models are used for unsteady flow simulations. These models require modifications to the Reynolds Averaged Navier-Stokes (RANS) equations. The first scheme is a hybrid RANS/LES model utilizing the two-equation (k-epsilon) model with a RANS/LES transition function, dependent on grid spacing and the computed turbulence length scale. The second scheme is a modified version of the partially averaged Navier-Stokes (PANS) formulation. All of these models are implemented in the three-dimensional Navier-Stokes code PAB3D. This paper discusses computational methods, code implementation, computed results for a wide range of nozzle configurations at various operating conditions, and comparisons with available experimental data. Very good agreement is shown between the numerical solutions and available experimental data over a wide range of operating conditions

Telemedizin in der Schlaganfallversorgung – versorgungsrelevant für Deutschland

Background and objective Telemedical stroke networks improve stroke care and provide access to time-dependent acute stroke treatment in predominantly rural regions. The aim is a presentation of data on its utility and regional distribution. Methods The working group on telemedical stroke care of the German Stroke Society performed a survey study among all telestroke networks. Results Currently, 22 telemedical stroke networks including 43 centers (per network: median 1.5, interquartile range, IQR, 1–3) as well as 225 cooperating hospitals (per network: median 9, IQR 4–17) operate in Germany and contribute to acute stroke care delivery to 48 million people. In 2018, 38,211 teleconsultations (per network: median 1340, IQR 319–2758) were performed. The thrombolysis rate was 14.1% (95% confidence interval 13.6–14.7%) and transfer for thrombectomy was initiated in 7.9% (95% confidence interval 7.5–8.4%) of ischemic stroke patients. Financial reimbursement differs regionally with compensation for telemedical stroke care in only three federal states. Conclusion Telemedical stroke care is utilized in about 1 out of 10 stroke patients in Germany. Telemedical stroke networks achieve similar rates of thrombolysis and transfer for thrombectomy compared with neurological stroke units and contribute to stroke care in rural regions. Standardization of network structures, financial assurance and uniform quality measurements may further strengthen the importance of telestroke networks in the future.Hintergrund und Ziel Telemedizinische Schlaganfall-Netzwerke tragen dazu bei, die Schlaganfallversorgung und insbesondere den Zugang zu zeitkritischen Schlaganfalltherapien in vorrangig strukturschwachen, ländlichen Regionen zu gewährleisten. Ziel ist eine Darstellung der Nutzungsfrequenz und regionalen Verteilung dieser Versorgungsstruktur. Methoden Die Kommission „Telemedizinische Schlaganfallversorgung“ der Deutschen Schlaganfall-Gesellschaft führte eine Umfragestudie in allen Schlaganfall-Netzwerken durch. Ergebnisse In Deutschland sind 22 telemedizinische Schlaganfall-Netzwerke aktiv, welche insgesamt 43 Zentren (pro Netzwerk: Median 1,5, Interquartilsabstand [IQA] 1–3) sowie 225 Kooperationskliniken (pro Netzwerk: Median 9, IQA 4–17) umfassen und an einem unmittelbaren Zugang zur Schlaganfallversorgung für 48 Mio. Menschen teilhaben. Im Jahr 2018 wurden 38.211 Telekonsile (pro Netzwerk: Median 1340, IQA 319–2758) durchgeführt. Die Thrombolyserate betrug 14,1 % (95 %-Konfidenzintervall 13,6–14,7 %), eine Verlegung zur Thrombektomie wurde bei 7,9 % (95 %-Konfidenzintervall 7,5–8,4 %) der ischämischen Schlaganfallpatienten initiiert. Das Finanzierungssystem ist uneinheitlich mit einem Vergütungssystem für die Zentrumsleistungen in nur drei Bundesländern. Diskussion Etwa jeder 10. Schlaganfallpatient wird telemedizinisch behandelt. Die telemedizinischen Schlaganfall-Netzwerke erreichen vergleichbar hohe Lyseraten und Verlegungen zur Thrombektomie wie neurologische Stroke-Units und tragen zur Sicherstellung einer flächendeckenden Schlaganfallversorgung bei. Eine netzwerkübergreifende Sicherstellung der Finanzierung und einheitliche Erhebung von Qualitätssicherungsdaten haben das Potenzial diese Versorgungsstruktur zukünftig weiter zu stärken

Verdrägungswirkung der laminaren Grenzschichten und Druckwiderstand

The displacement effect of the boundary layer on the outer frictionless flow is discussed for both steady and unsteady flows. The analysis is restricted to cases in which the potential flow pressure distribution remains valid for the boundary-layer calculation. Formulas are given for the dependence of the pressure drag, friction drag, and total drag of circular cylinders on the time from the start of motion for cases in which the velocity varies as a power of the time. Formulas for the locations and for the time for the appearance of the separation point are given for two dimensional bodies of arbitrary shape

NACA Technical Memorandums

Memorandum presenting a study of the stability of laminar boundary layer profiles on slightly curved walls relative to small disturbances, in the shape of vortices, whose axes are parallel to the principal direction of flow. The result in an eigenvalue problem by which, for a given undisturbed flow at a prescribed wall, the amplification or decay is computed for each Reynolds number and each vortex thickness