Drugs Repurposing for Coronavirus Treatment: Computational Study Based On Molecular Topology

The present communication illustrates the results of a computational study based on molecular topology, focused on the repositioning of drugs to treat the SARS-CoV-2 virus, better known as coronavirus, responsible for the COVID-19 disease. Using lopinavir, a well-known viral protease inhibitor as the reference drug, a mathematical pattern is found allowing the screening of the market drugs, searching for potential candidates to inhibit the said enzyme. This way new possible therapeutic alternatives to fight the coronavirus are found. Results indicate that antivirals such as brecanavir, as well as various groups of drugs, among which are antibiotics of the macrolide family (azithromycin, clarithromycin and erythromycin among others) could be useful in treating COVID-19 infection.Ciencias Experimentale

Comparison of MRI and Symptom Outcomes of Uterine Artery Embolization for Uterine Leiomyomata Using Tris-Acryl Gelatin Microspheres, Poly-Vinyl Alcohol Spheres and Poly-Vinyl Alcohol Particles.

Purpose: To compare the recurrence rate of symptoms and MRI enhancement of uterine fibroids in patients treated with uterine artery embolization (UAE) among three embolic agents: polyvinyl alcohol (PVA) particles, spherical polyvinyl alcohol (SPVA) particles and tris-acryl gelatin microspheres (GM). Materials & Methods: Women treated with UAE for fibroids with PVA, SPVA or GM were contacted by telephone/ mail to complete a modified Uterine Fibroid Symptom Quality of Life (UFS-QOL) survey. Baseline and post-UAE gadolinium-enhanced magnetic resonance imaging (MRI) studies were evaluated for residual or persistent enhancement of any uterine fibroids after UAE. Data was analyzed using 2-tail fishers exact test to correlate symptoms and enhancement and determine the liklihood of recurrence of enhancement and symptoms following UAE among three embolic agents. Results: A total of 101 women underwent UAE with one of the three embolic agents and had complete pre- and post-embolization MRI follow-up. In this group, a total of 24 of 59 (41%) women in the PVA group, 18 of 24 (75%) women in the SPVA group, and 4 of 18 (22%) women in the GM group showed residual enhancement in some or all fibroids. Statistically significant differences in recurrence of residual enhancement on follow-up MR imaging were found between SPVA and PVA (p=0.0072), as well as SPVA and GM (p=0.0015), but not between PVA and GM (p=0.1756). No statistically significant correlation between residual enhancement and symptom recurrence was found based on the survey responses. Conclusion: Patients embolized with SPVA have a higher risk of having residual enhancement on follow-up MR imaging than those embolized with PVA or G

Properties of the Molecular Gas in Low Metallicity Environments

Understanding star formation is of great importance in modern astrophysics because it gives us crucial information on the way galaxies evolve and therefore provides important insights into the evolution and nature of our Universe. Times scales, efficiency, and the rate at which star formation occurs are determined by the physical and chemical properties of the molecular gas at different scales. The processes of star formation occur in dense molecular gas. Determinant properties of this gas are the abundance of heavy elements (metallicity) and the relative amount of dust (dust-to-gas ratio). Both quantities evolve during the lifetime of our Universe. Therefore, in order to understand the processes of star formation in the earlier stages of our Universe, we need to know the form and extent on which these quantities affect the properties of the gas that form stars. In this thesis we study the properties of the molecular gas in low-metallicity environments. Considering that in the low-metallicity molecular gas most of the millimeter and sub-millimeter emission comes from photon-dominated regions (PDRs), we approach our study in their context. For that, we utilize a spherically symmetric PDR model. We first calibrate the PDR model in the weak far-ultraviolet radiation field regime studying the pre-stellar core Barnard 68. Owing to its roughly spherical morphology and well-constrained density profile, Barnard 68 is ideal for such study. We later analyze the case when the low-metallicity gas is exposed to weak FUV radiation fields. This is the case of intermediate velocity clouds (IVCs). We then investigate global properties of the metal-poor molecular gas exposed to stronger FUV radiation fields using large scale observations of the 30 Dor molecular ridge in the Large Magellanic Cloud (LMC). We later use a PDR model to investigate the nature of the millimeter and sub-millimeter emission emerging from the N159W region. We finally study the variations of line ratios involving [CII], [CI, 12CO, and 13CO transitions as a function of the strength of the FUV radiation field. A better understanding of the properties of the low metallicity gas in local examples will serve as a template for future studies of the ISM in galaxies at high redshift using ALMA

Desenredando patrones en el arte rupestre de Oukaïmeden

Statistical analysis was applied to the study of Oukaïmeden rock art as a way to obtain chronological information. By means of correspondence analysis we identified trends in the representation of the various individual motifs in the valley rock art. Subsequently we analyzed recurrent associations and overlappings, which led us to the last scale of analysis: the dating of rock art stations.El análisis estadístico ha sido aplicado al estudio del arte rupestre de Oukaïmeden como vía para la obtención de información cronológica. Mediante el análisis de correspondencias hemos identificado tendencias en la representación de varios motivos individuales en el arte rupestre del valle. Procedimos después al análisis de asociaciones recurrentes y superposiciones, lo que nos llevó al último nivel de análisis: la datación de las estaciones de arte rupestre

Movimiento y regímenes de vitalidad. La nueva organización de la vida en la biomedicina

This paper puts forward that the massive use of protocols in biomedicine has created a new kind of materiality for pathology. This is very well depicted by the notion of ‘potential object’ coined by A.N.Whitehead. Potential objects are a complete and heterogeneous ordering of life. We will call to these orderings, resulting from the shaping of such potential objects, regimes of vitality. They establish different scales of life, actors and the relation between them in biomedical activity. Moreover, they define the temporality in the medical processes, the correct articulation between normality and abnormality and, finally, they produce a set of motility conditions for individuals. Based on a research about protocols on cancer, telecare and epidemics we will pose that movement is inseparable from the “truth” that always appears in the regimes of vitality. In this sense, we will also pose that biomedicine has remove our concern about movement from the political and individual sphere and has put it in the sphere of health and normativity of science. In a nutshell, biomedicine has transformed mobility into correct-and-healthy-movement.El texto plantea que la masiva protocolarización de la biomedicina ha creado una nueva materialidad para la patología. Ésta es caracterizada a partir de la noción de “objeto potencial” que acuñó A.N.Whitehead. Los objetos potenciales constituyen una completa y heterogénea ordenación de la vida. A tales órdenes resultantes de la aparición de un objeto potencial se les denomina “regímenes de vitalidad”. Éstos se caracterizan por establecer las diferentes escalas de la vida en la actividad médica, la temporalidad de los procesos médicos, por establecer el tipo de relación entre normalidad y anormalidad y, finalmente, por generar un conjunto de condiciones de motilidad para los individuos. A partir de una serie de investigaciones sobre los protocolos médicos del cáncer de mama, los que rigen emergencias sanitarias como las epidemias o implementan la teleasistencia sostendremos que el movimiento es indisociable del juego de verdad que ofrecen los regímenes de vitalidad. También argüiremos que la biomedicina, al hacer lo anterior, ha sustraído la preocupación por el movimiento del plano individual e incluso político y lo ha vinculado con el de la salud, lo científicamente prescriptible y normativo. En suma, ha transformado la movilidad en buen-y-sano-movimiento

El estado sólido en el poli(óxido de decametileno)

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias, Sección de Químicas, 1974.Fac. de Ciencias QuímicasTRUEProQuestpu

Desarrollo de sistema de gestión de alumbrado público mediante WSN

Este proyecto surge de la búsqueda de un campo de aplicación de las Redes de Sensores Inalámbricos, WSN, aplicadas a la vida cotidiana. Dicha aplicación consistirá en un sistema de gestión de alumbrado público a través del cual se buscará una reducción del consumo energético y del gasto económico, así como una gestión en tiempo de real de la operativa del alumbrado. Para ello se desarrollará un sistema basado en nodos instalados en farolas, los cuales se comunicarán entre sí para funcionar de la forma más optimizada posible, complementándose todo ello con un “nodo base”, que se encargará de servir de nexo entre la red y los diferentes elementos necesarios para la configuración de los nodos y la recogida de información. Esta información servirá para que una página web pueda mostrar al usuario final toda la información necesaria para tener un control sobre el estado actual de funcionamiento de cada una de las farolas, control del consumo, así como detección de averías. En este proyecto se describen las tecnologías actuales relacionadas con el campo de las WSN y los sensores, presentando aplicaciones que en la actualidad se encuentran desplegadas. Se expone también una propuesta real de despliegue presentada al Ayuntamiento de una localidad, Pedro Muñoz, para implementar un proyecto piloto en varias de sus calles. Se describe el entorno, tanto hardware como software, explicando los algoritmos utilizados para las asociaciones entre nodos, diagramas de funcionamiento en las distintas fases de la que está compuesta la operativa de los nodos, la codificación de los programas que se necesitan ejecutar para el correcto funcionamiento del sistema. Por último, debido a que el campo de las WSN está en constante evolución, se presentarán diversas ideas para implementar diversas mejoras que pudieran ser desplegadas en un futuro, ampliando la oferta de aplicaciones a ofrecer al usuario final. ABSTRACT. This project results from the development for an application field of wireless Sensor Networks (WSN), applied to daily life. That application will consist of a system of street lighting management, through which it will seek a reduction in energy consumption and economic cost, and a real-time management of the operative of the street lighting. To do this, a system based on nodes installed in streetlights will be developed. These nodes will communicate with each other to operate in the most optimized way possible, complementing all with a Base-station, which will act as a link between the network and the components required for configuring the nodes and collecting data from them. This information will help a website to show the end user all the information needed to have a control on the current operating status of each of the streetlights, consumption control and troubleshooting. To this end, this project will describe the current technologies related to the field of WSN and sensors, presenting applications that are currently deployed. It will be also exposed a real proposal submitted to a city council to deploy a pilot project in many of its streets. Will be described the environment, both hardware and software, explaining the algorithms used for the associations between nodes, operating diagrams in the different phases of the nodes operation, and the coding of programs that are needed for proper system performance. Finally, because the field of WSN is in constant evolution, will be presented different ideas to implement various improvements which could be deployed in the future, extending the range of applications to provide to end-users

Valoración de swaptions usando el modelo de Black

Treballs Finals de Grau de Matemàtiques, Facultat de Matemàtiques, Universitat de Barcelona, Any: 2023, Director: José Manuel Corcuera Valverde[en] The objective of this work is to build a rigorous path to understand and model financial derivatives of the interes rate such as swaptions. We start by defining the interest rate and where does it come from. Understanding zero-bonds and coupon bonds and using them to define the yield curve. We are then going to see how forwards and swaps work and we will valuate these at today and at the future. Along some basic concepts about options and a little introduction on stochastic calculus we are able to introduce options valuation models, Black-Scholes model and Black model. Finally we define swaptions and apply Black’s model to price them

El estado sólido en el poli(óxido de decametileno)

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias, Sección de Químicas, 1974.Fac. de Ciencias QuímicasTRUEProQuestpu

Experimental study on fibre reinforced sandy soils behaviour under static loadings - drained and undrained conditions

The effect of the addition of 0.5% of randomly distributed polypropylene fibres in a round grained sand, composed mainly of silica, is presented on laboratory scale. The samples were compacted with two void ratios (0.75 and 0.63), corresponding to values of relative density of 50% and 90% respectively. 24 monotonic triaxial tests were performed, with initial effective mean pressures of 20, 100 and 200 kPa. Half of samples were tested in drained conditions, and the other half in undrained conditions. For the samples subjected to drained conditions, the effect of the fibres was identified at the post-failure stage, by showing sustained increase of strength. The positive effect of fibres could also be observed through the increase of material friction angle. In the samples subjected to undrained tests, the addition of fibres reduced the contractive behaviour, mainly for those more compacted