Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment

Objective To establish which attributes of conservative treatments for prostate cancer are most important to men. Design Discrete choice experiment. Setting Two London hospitals. Participants 129 men with non-metastatic prostate cancer, mean age 70 years; 69 of 118 (58%) with T stage 1 or 2 cancer at diagnosis. Main outcome measures Men's preferences for, and trade-offs between, the attributes of diarrhoea, hot flushes, ability to maintain an erection, breast swelling or tenderness, physical energy, sex drive, life expectancy, and out of pocket expenses. Results The men's responses to changes in attributes were all statistically significant. When asked to assume a starting life expectancy of five years, the men were willing to make trade-offs between life expectancy and side effects. On average, they were most willing to give up life expectancy to avoid limitations in physical energy (mean three months) and least willing to trade life expectancy to avoid hot flushes (mean 0.6 months to move from a moderate to mild level or from mild to none). Conclusions Men with prostate cancer are willing to participate in a relatively complex exercise that weighs up the advantages and disadvantages of various conservative treatments for their condition. They were willing to trade off some life expectancy to be relieved of the burden of troublesome side effects such as limitations in physical energy

XTH acts at the microfibril-matrix interface during cell elongation

Sulphorhodamine-labelled oligosaccharides of xyloglucan are incorporated into the cell wall of Arabidopsis and tobacco roots, and of cultured Nicotiana tabacum cells by the transglucosylase (XET) action of XTHs. In the cell wall of diffusely growing cells, the subcellular pattern of XET action revealed a 'fibrillar' pattern, different from the xyloglucan localization. The fibrillar fluorescence pattern had no net orientation in spherical cultured cells. It changed to transverse to the long axis when the cells started to elongate, a feature mirroring the rearrangements of cortical microtubules and the accompanying cellulose deposition. Interference with the polymerization of microtubules and with cellulose deposition inhibited this strong and 'fibrillar'-organized XET-action, whereas interference with actin-polymerization only decreased the intensity of enzyme action. Epidermal cells of a mutant with reduced cellulose synthesis also had low XET action. Root hairs (tip-growing cells) exhibited high XET-action over all their length, but lacked the specific parallel pattern. In both diffuse- and tip-growing cell types extraction of the incorporated fluorescent xyloglucans by a xyloglucan-specific endoglucanase reduced the fluorescence, but the 'fibrillar' appearance in diffuse growing cells was not eliminated. These results show that XTHs act on the xyloglucans attached to cellulose microfibrils. After incorporation of the fluorescent oligosaccharides, the xyloglucans decorate the cellulose microfibrils and become inaccessible to hydrolytic enzymes

QED in strong, finite-flux magnetic fields

Lower bounds are placed on the fermionic determinants of Euclidean quantum electrodynamics in two and four dimensions in the presence of a smooth, finite-flux, static, unidirectional magnetic field $B(r) =(0,0,B(r))$, where $B(r) \geq 0$ or $B(r) \leq 0$, and $r$ is a point in the xy-plane.Comment: 10 pages, postscript (in uuencoded compressed tar file

Spatio-temporal patterns of IED usage by the Provisional Irish Republican Army

In this paper, a unique dataset of improvised explosive device attacks during “The Troubles” in Northern Ireland (NI) is analysed via a Hawkes process model. It is found that this past dependent model is a good fit to improvised explosive device attacks yielding key insights about the nature of terrorism in NI. We also present a novel approach to quantitatively investigate some of the sociological theory surrounding the Provisional Irish Republican Army which challenges previously held assumptions concerning changes seen in the organisation. Finally, we extend our use of the Hawkes process model by considering a multidimensional version which permits both self and mutual-excitations. This allows us to test how the Provisional Irish Republican Army responded to past improvised explosive device attacks on different geographical scales from which we find evidence for the autonomy of the organisation over the six counties of NI and Belfast. By incorporating a second dataset concerning British Security Force (BSF) interventions, the multidimensional model allows us to test counter-terrorism (CT) operations in NI where we find subsequent increases in violence

Failure of the Standard Coupled-Channels Method in Describing the Inelastic Reaction Data: On the Use of a New Shape for the Coupling Potential

We present the failure of the standard coupled-channels method in explaining the inelastic scattering together with other observables such as elastic scattering, excitation function and fusion data. We use both microscopic double-folding and phenomenological deep potentials with shallow imaginary components. We argue that the solution of the problems for the inelastic scattering data is not related to the central nuclear potential, but to the coupling potential between excited states. We present that these problems can be addressed in a systematic way by using a different shape for the coupling potential instead of the usual one based on Taylor expansion.Comment: 10 pages, 4 figures, 1 table, Latex:RevTex4 published in J. Phys. G: Nucl. Part. Phy

Near-IR photodissociation of peroxy acetyl nitrate

Measurements of the C-H overtone transition strengths combined with estimates of the photodissociation cross sections for these transitions suggest that near-IR photodissociation of peroxy acetyl nitrate (PAN) is less significant (Jnear−IR ~3×10^−8 s^−1 at noon) in the lower atmosphere than competing sinks resulting from unimolecular decomposition and ultraviolet photolysis. This is in contrast to the photochemical behavior of a related peroxy nitrate, pernitric acid (PNA), that undergoes rapid near-IR photolysis in the atmosphere with Jnear−IR ~10^−5 s^−1 at noon (Roehl et al., 2002). This difference is attributed to the larger binding energy and larger number of vibrational degrees of 10 freedom in PAN, which make 4[Greek nu]CH the lowest overtone excitation with a high photodissociation yield (as opposed to 2[Greek nu]OH in PNA)

Fermionic Determinant of the Massive Schwinger Model

A representation for the fermionic determinant of the massive Schwinger model, or $QED_2$, is obtained that makes a clean separation between the Schwinger model and its massive counterpart. From this it is shown that the index theorem for $QED_2$ follows from gauge invariance, that the Schwinger model's contribution to the determinant is canceled in the weak field limit, and that the determinant vanishes when the field strength is sufficiently strong to form a zero-energy bound state

Cross-Correlation of the Cosmic Microwave Background with Radio Sources: Constraints on an Accelerating Universe

We present a new limit on the cosmological constant based on the absence of correlations between the cosmic microwave background (CMB) and the distribution of distant radio sources. In the cosmological constant-cold dark matter models currently favored, such correlations should have been produced via the integrated Sachs-Wolfe effect, assuming that radio sources trace the local (z=1) matter density. We find no evidence of correlations between the COBE 53Hz microwave map and the NVSS 1.4 GHz radio survey. The implied 95% CL limit on the cosmological constant is Lambda < 0.74, in marginal agreement with the values suggested by recent measurements of the CMB anisotropy and type-IA supernovae observations, 0.6 < Lambda < 0.7. If the cosmological model does lie in this range, then the integrated Sachs-Wolfe effect should be detectable with upcoming CMB maps and radio surveys.Comment: 5 pages; 3 figures; submitted to PR

Constraints on Galaxy Bias, Matter Density, and Primordial Non--Gausianity from the PSCz Galaxy Redshift Survey

We compute the bispectrum for the \IRAS PSCz catalog and find that the galaxy distribution displays the characteristic signature of gravity. Assuming Gaussian initial conditions, we obtain galaxy biasing parameters $1/b_1=1.20^{+0.18}_{-0.19}$ and $b_2/b_1^2=-0.42\pm0.19$, with no sign of scale-dependent bias for $k\leq 0.3$ h/Mpc. These results impose stringent constraints on non-Gaussian initial conditions. For dimensional scaling models with $\chi^2_N$ statistics, we find N>49, which implies a constraint on primordial skewness $B_3<0.35$.Comment: 4 pages, 3 embedded figures, uses revtex style file, minor changes to reflect published versio

Evolution of hierarchical clustering in the CFHTLS-Wide since z~1

We present measurements of higher order clustering of galaxies from the latest release of the Canada-France-Hawaii-Telescope Legacy Survey (CFHTLS) Wide. We construct a volume-limited sample of galaxies that contains more than one million galaxies in the redshift range 0.2<z<1 distributed over the four independent fields of the CFHTLS. We use a counts in cells technique to measure the variance and the hierarchical moments S_n = /^(n-1) (3<n<5) as a function of redshift and angular scale.The robustness of our measurements if thoroughly tested, and the field-to-field scatter is in very good agreement with analytical predictions. At small scales, corresponding to the highly non-linear regime, we find a suggestion that the hierarchical moments increase with redshift. At large scales, corresponding to the weakly non-linear regime, measurements are fully consistent with perturbation theory predictions for standard LambdaCDM cosmology with a simple linear bias.Comment: 17 pages, 11 figures, submitted to MNRA