916 research outputs found

    The organization of the rating system for assessing the quality of university students training

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    In spite the universities use the rating system of assessing for a quite long time, this issue is still not fully considered. The article is based on the position of insufficient state of knowledge of the multifunctionality of the students rating. The rating helps to reveal the potential of students. It is mentioned that the rating system of assessment is a tool that will improve the quality of training and provide the required level of motivation. During the research, the following methods were used: analysis, synthesis, induction, deduction. As a result, the principles of the rating assessment system were revealed, a definition of the term "Rating" was given, its goals were indicated. As an example of the organization of the rating system of assessment, the Nyzhnii Novhorod State Pedagogical University and its "Regulations on the rating system for assessing the quality of student training" were used. It is noted that the rating includes: current check, midterm and final examinations. Further, all possible conditions under which the student receives points were identified and considered. On the example of the NSPU named after Kozma Minin transferring of the rating points into a five-point grading rating system is presented. Also, the types of violations for which points are discarded, are considered. As the study showed, comprehensive planned system yields productive results for students and the university.peer-reviewe

    Instructions for laboratory training in Special Microbiology and Virology for students of Faculty of Dentistry

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    ΠœΠ˜ΠšΠ ΠžΠ‘Π˜ΠžΠ›ΠžΠ“Π˜Π―ΠœΠ•Π’ΠžΠ”Π˜Π§Π•Π‘ΠšΠ˜Π• Π£ΠšΠΠ—ΠΠΠ˜Π―Π›ΠΠ‘ΠžΠ ΠΠ’ΠžΠ ΠΠ«Π• Π ΠΠ‘ΠžΠ’Π«Π’Π˜Π Π£Π‘ΠžΠ›ΠžΠ“Π˜Π―Π˜ΠΠžΠ‘Π’Π ΠΠΠΠ«Π• Π‘Π’Π£Π”Π•ΠΠ’Π«ΠŸΠ ΠΠšΠ’Π˜Π§Π•Π‘ΠšΠ˜Π• ΠΠΠ’Π«ΠšΠ˜Π‘ΠΎΠ΄Π΅Ρ€ΠΆΠ°Ρ‚ΡΡ ΠΏΠ»Π°Π½, ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ° практичСских занятий ΠΈ основныС практичСскиС Π½Π°Π²Ρ‹ΠΊΠΈ ΠΏΠΎ ΠΎΠ±Ρ‰Π΅ΠΉ ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ вирусологии

    Space-time evolution of Dirac wave packets

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    In this work we study the dynamics of free 3D relativistic Gaussian wave packets with different spin polarization. We analyze the connection between the symmetry of initial state and the dynamical characteristics of moving particle. The corresponding solutions of Dirac equation having different types of symmetry were evaluated analytically and numerically and after that the electron probability densities, as well as, the spin densities were visualized. The average values of velocity of the packet center and the average spin were calculated analytically, and the parameters of transient Zitterbewegung in different directions were obtained. These results can be useful for the interpretation of future experiments with trapped ions.Comment: 10 pages, 7 figure

    ΠžΠΏΡ‹Ρ‚ примСнСния Π½Π΅Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½Ρ‹Ρ… ΡƒΠ΄ΠΎΠ±Ρ€Π΅Π½ΠΈΠΉ ΠΏΡ€ΠΈ Π²Ρ‹Ρ€Π°Ρ‰ΠΈΠ²Π°Π½ΠΈΠΈ сСянцСв сосны ΠΎΠ±Ρ‹ΠΊΠ½ΠΎΠ²Π΅Π½Π½ΠΎΠΉ (Π inus sylvestris l.) Π½Π° Π£Ρ€Π°Π»Π΅)

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    ΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»Π΅Π½Π° информация ΠΎ возмоТности использования Π½Π΅Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½Ρ‹Ρ… ΡƒΠ΄ΠΎΠ±Ρ€Π΅Π½ΠΈΠΉ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΏΡ€ΠΈΠ³ΠΎΡ‚ΠΎΠ²Π»Π΅Π½Ρ‹ Π½Π° основС ΠΎΡ‚Ρ…ΠΎΠ΄ΠΎΠ² производств. Π’ настоящСС врСмя ΠΎΠ½ΠΈ ΡΠ²Π»ΡΡŽΡ‚ΡΡ доступными, Π½Π΅Π΄ΠΎΡ€ΠΎΠ³ΠΈΠΌΠΈ ΠΈ высокоэффСктивными срСдствами ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΡ плодородия лСсных ΠΏΠΎΡ‡Π². ΠŸΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ измСнСния ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² посадочного ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π° ΠΏΡ€ΠΈ внСсСнии Π΄Π°Π½Π½Ρ‹Ρ… смСсС

    NEW β€œGREEN” METHOD OF BROMINATION OF (–)-NOPINONE AND (+)-CIS-VERBANONE

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    This work was supported by the Integrated Program of Ural Branch of RAS (project β„– 18-3-3-17)

    Economic and social aspects in the Republic of Tatarstan

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    The urgency of the problem under study is conditioned by the need to study the state of interethnic and interreligious relations in polyethnic and poly-confessional regions of Russian Federation. The aim of the article is to analyze the situation in the sphere of interethnic and interreligious relations in the Republic of Tatarstan in 2016. The leading approach to the study of this problem is the poly-paradigm methodology. The article gives the description of interethnic and interconfessional relations in the Republic of Tatarstan in 2014-2016, the comparative data on the largest cities of the republic are given. A particular attention is paid to the analysis of migrant perception peculiarities by the local population. The materials of the article can be useful for ethnologists, social and cultural anthropologists, political scientists, as well as for the representatives of the bodies and structures responsible for the issues of interethnic interaction.peer-reviewe

    Π‘ΠΈΠ½Ρ‚Π΅Π·, дослідТСння 6-((5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»Ρ‚Ρ–ΠΎ)ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½-3-Ρ–Π»)-(Π°Π»ΠΊΡ–Π», Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½Ρ–ΠΌΡ–Π½Ρ–Π² Ρ‚Π° Ρ—Ρ… ΠΏΠΎΡ…Ρ–Π΄Π½ΠΈΡ…

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    In the pharmaceutical practice directly related to the search of biological active substances and their introduction into medicine or veterinary it is generally recognized that a successful choice of the research object is a prerequisite for a positive final outcome to create original effective and low-toxic drugs. At present, derivatives of 1,2,4-triazoles containing pyridine deserve special attention. That is why the synthesis and study of physicochemical properties of new compounds, which contain 1,2,4-triazole and pyridine rings, are important tasks of modern synthetic and pharmaceutical chemistry.Aim. To study the reactions associated with formation and transformation of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines and their recovery, study physicochemical properties of new compounds synthesized. Materials and methods. 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heter-yl)methanimines were obtained by the mixture from 6-(5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-amine and aldehydes. The synthesis was carried out in the acetic acid medium. The mixture was kept at room temperature for 6 h. 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines were reduced in the 1,4-dioxane medium. As a reducing agent sodium borohydride was used. Results and discussion. As a result of synthetic transformations 17 new compounds have been obtained, the structure of the compounds synthesized has been confirmed by modern complex of physicochemical methods of analysis (IR-spectrophotometry, elemental analysis), and their individuality has been proven on an Agilent 1260 Infinity HPLC high-performance liquid chromatograph equipped with an Agilent 6120 mass spectrometer.Conclusions. The preparative method for the synthesis of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines and 6-(5-phenethyl-4-R-1,2,4-triazole-3-ylthio)-N-(alkyl-, heteryl)pyridine-3-amines has been developed.Π’ фармацСвтичСской ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠ΅, нСпосрСдствСнно связанной с поиском биологичСски Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… вСщСств ΠΈ ΠΈΡ… Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ Π² ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρƒ ΠΈΠ»ΠΈ Π²Π΅Ρ‚Π΅Ρ€ΠΈΠ½Π°Ρ€ΠΈΡŽ, общСпринято, Ρ‡Ρ‚ΠΎ ΡƒΡΠΏΠ΅ΡˆΠ½Ρ‹ΠΉ Π²Ρ‹Π±ΠΎΡ€ ΠΎΠ±ΡŠΠ΅ΠΊΡ‚Π° исслСдования являСтся прСдпосылкой для ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½Π΅Ρ‡Π½ΠΎΠ³ΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°, для создания ΠΎΡ€ΠΈΠ³ΠΈΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… эффСктивных ΠΈ малотоксичных лСкарств. На Π΄Π°Π½Π½Ρ‹ΠΉ ΠΌΠΎΠΌΠ΅Π½Ρ‚ особого внимания Π·Π°ΡΠ»ΡƒΠΆΠΈΠ²Π°ΡŽΡ‚ ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹Π΅ 1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»ΠΎΠ², ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ содСрТат ΠΏΠΈΡ€ΠΈΠ΄ΠΈΠ½. ИмСнно поэтому синтСз ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСских свойств Π½ΠΎΠ²Ρ‹Ρ… соСдинСний, содСрТащих 1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»ΡŒΠ½ΠΎΠ΅ ΠΈ ΠΏΠΈΡ€ΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠ΅ ΠΊΠΎΠ»ΡŒΡ†Π°, ΡΠ²Π»ΡΡŽΡ‚ΡΡ Π²Π°ΠΆΠ½ΠΎΠΉ Π·Π°Π΄Π°Ρ‡Π΅ΠΉ соврСмСнной синтСтичСской ΠΈ фармацСвтичСской Ρ…ΠΈΠΌΠΈΠΈ.ЦСль. Π˜Π·ΡƒΡ‡ΠΈΡ‚ΡŒ Ρ€Π΅Π°ΠΊΡ†ΠΈΡŽ образования 6-((5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»Ρ‚ΠΈΠΎ)ΠΏΠΈΡ€ΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)-(Π°Π»ΠΊΠΈΠ», Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½ΠΈΠΌΠΈΠ½ΠΎΠ² ΠΈ ΠΈΡ… сСлСктивного восстановлСния, ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚ΡŒ физичСскиС ΠΈ химичСскиС свойства Π½ΠΎΠ²Ρ‹Ρ… синтСзированных соСдинСний.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Для получСния 6-((5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»Ρ‚ΠΈΠΎ)ΠΏΠΈΡ€ΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)-(Π°Π»ΠΊΠΈΠ»-, Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½ΠΈΠΌΠΈΠ½ΠΎΠ² использовали 6-(5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»Ρ‚ΠΈΠΎ)ΠΏΠΈΡ€ΠΈΠ΄ΠΈΠ½-3-Π°ΠΌΠΈΠ½Ρ‹ ΠΈ Π°Π»ΡŒΠ΄Π΅Π³ΠΈΠ΄Ρ‹. Π‘ΠΈΠ½Ρ‚Π΅Π· проводился Π² срСдС кислоты уксусной. БмСсь оставляли ΠΏΡ€ΠΈ ΠΊΠΎΠΌΠ½Π°Ρ‚Π½ΠΎΠΉ Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Π΅ Π½Π° 6 часов. 6-((5-Π€Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»Ρ‚ΠΈΠΎ)ΠΏΠΈΡ€ΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)-(Π°Π»ΠΊΠΈΠ»-, Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½ΠΈΠΌΠΈΠ½Ρ‹ Π±Ρ‹Π»ΠΈ восстановлСны Π² срСдС 1,4-диоксана. Π’ качСствС восстановитСля Π±Ρ‹Π» использован натрия Π±ΠΎΡ€Π³ΠΈΠ΄Ρ€ΠΈΠ΄.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ ΠΈΡ… обсуТдСниС. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ синтСтичСских ΠΏΡ€Π΅Π²Ρ€Π°Ρ‰Π΅Π½ΠΈΠΉ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ΠΎ 17 Π½ΠΎΠ²Ρ‹Ρ… соСдинСний, структуру синтСзированных соСдинСний ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½ΠΎ благодаря соврСмСнному комплСксу Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСских ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² Π°Π½Π°Π»ΠΈΠ·Π° (ИК-спСктрофотомСтрии, элСмСнтного Π°Π½Π°Π»ΠΈΠ·Π°), Π° ΠΈΡ… ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π° исслСдованиСм Π½Π° Π²Ρ‹ΡΠΎΠΊΠΎΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΌ ΠΆΠΈΠ΄ΠΊΠΎΠΌ Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Π΅ Agilent 1260 Infinity HPLC, ΠΎΠ±ΠΎΡ€ΡƒΠ΄ΠΎΠ²Π°Π½Π½ΠΎΠΌ масс-спСктромСтром Agilent 6120.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΈΠ²Π½Ρ‹ΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ синтСза 6-((5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»Ρ‚ΠΈΠΎ)ΠΏΠΈΡ€ΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)-(Π°Π»ΠΊΠΈΠ»-, Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½ΠΈΠΌΠΈΠ½ΠΎΠ² ΠΈ 6-(5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»Ρ‚ΠΈΠΎ)-N- (Π°Π»ΠΊΠΈΠ»-, Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΏΠΈΡ€ΠΈΠ΄ΠΈΠ½-3-Π°ΠΌΠΈΠ½ΠΎΠ².Π£ Ρ„Π°Ρ€ΠΌΠ°Ρ†Π΅Π²Ρ‚ΠΈΡ‡Π½Ρ–ΠΉ ΠΏΡ€Π°ΠΊΡ‚ΠΈΡ†Ρ–, яка Π±Π΅Π·ΠΏΠΎΡΠ΅Ρ€Π΅Π΄Π½ΡŒΠΎ пов’язана Π· ΠΏΠΎΡˆΡƒΠΊΠΎΠΌ Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ Ρ‚Π° Ρ—Ρ… ввСдСнням Ρƒ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρƒ Π°Π±ΠΎ Π²Π΅Ρ‚Π΅Ρ€ΠΈΠ½Π°Ρ€Ρ–ΡŽ, загальним Ρ” Ρ‚Π΅, Ρ‰ΠΎ ΡƒΡΠΏΡ–ΡˆΠ½ΠΈΠΉ Π²ΠΈΠ±Ρ–Ρ€ об’єкта дослідТСння Ρ” Π½Π΅ΠΎΠ±Ρ…Ρ–Π΄Π½ΠΎΡŽ ΡƒΠΌΠΎΠ²ΠΎΡŽ для ΠΏΠΎΠ·ΠΈΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΊΡ–Π½Ρ†Π΅Π²ΠΎΠ³ΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρƒ Ρ‚Π° для створСння ΠΎΡ€ΠΈΠ³Ρ–Π½Π°Π»ΡŒΠ½ΠΈΡ… Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΈΡ… Ρ‚Π° малотоксичних ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π². На Ρ†ΡŒΠΎΠΌΡƒ Π΅Ρ‚Π°ΠΏΡ– Π½Π° особливу ΡƒΠ²Π°Π³Ρƒ Π·Π°ΡΠ»ΡƒΠ³ΠΎΠ²ΡƒΡŽΡ‚ΡŒ ΠΏΠΎΡ…Ρ–Π΄Π½Ρ– 1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»Ρ–Π², Ρ‰ΠΎ ΠΌΡ–ΡΡ‚ΡΡ‚ΡŒ ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½. Π‘Π°ΠΌΠ΅ Ρ‚ΠΎΠΌΡƒ синтСз Ρ‚Π° вивчСння Ρ„Ρ–Π·ΠΈΠΊΠΎ-Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΡ… властивостСй Π½ΠΎΠ²ΠΈΡ… сполук, Ρ‰ΠΎ ΠΌΡ–ΡΡ‚ΡΡ‚ΡŒ 1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»ΡŒΠ½ΠΈΠΉ Ρ‚Π° ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΈΠΉ Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚, Ρ” Π²Π°ΠΆΠ»ΠΈΠ²ΠΈΠΌΠΈ завданнями сучасної синтСтичної Ρ‚Π° Ρ„Π°Ρ€ΠΌΠ°Ρ†Π΅Π²Ρ‚ΠΈΡ‡Π½ΠΎΡ— Ρ…Ρ–ΠΌΡ–Ρ—.ΠœΠ΅Ρ‚Π°. Π’ΠΈΠ²Ρ‡ΠΈΡ‚ΠΈ Ρ€Π΅Π°ΠΊΡ†Ρ–ΡŽ утворСння 6-((5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»Ρ‚Ρ–ΠΎ)ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½-3-Ρ–Π»)-(Π°Π»ΠΊΡ–Π», Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½Ρ–ΠΌΡ–Π½Ρ–Π² Ρ‚Π° Ρ—Ρ… сСлСктивного відновлСння, дослідити Ρ„Ρ–Π·ΠΈΡ‡Π½Ρ– Ρ‚Π° Ρ…Ρ–ΠΌΡ–Ρ‡Π½Ρ– властивості Π½ΠΎΠ²ΠΈΡ… синтСзованих сполук.ΠœΠ°Ρ‚Π΅Ρ€Ρ–Π°Π»ΠΈ Ρ‚Π° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ. Для отримання 6-((5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»Ρ‚Ρ–ΠΎ)ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½-3-Ρ–Π»)-(Π°Π»ΠΊΡ–Π»-, Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½Ρ–ΠΌΡ–Π½Ρ–Π² використано 6-(5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»Ρ‚Ρ–ΠΎ)ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½-3-Π°ΠΌΡ–Π½ΠΈ Ρ‚Π° Π°Π»ΡŒΠ΄Π΅Π³Ρ–Π΄ΠΈ. Π‘ΠΈΠ½Ρ‚Π΅Π· проводився Π² сСрСдовищі кислоти ΠΎΡ†Ρ‚ΠΎΠ²ΠΎΡ—. Π‘ΡƒΠΌΡ–Ρˆ залишали ΠΏΡ€ΠΈ ΠΊΡ–ΠΌΠ½Π°Ρ‚Π½Ρ–ΠΉ Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Ρ– Π½Π° 6 Π³ΠΎΠ΄ΠΈΠ½. 6-((5-Π€Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»Ρ‚Ρ–ΠΎ)ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½-3-Ρ–Π»)-(Π°Π»ΠΊΡ–Π»-, Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½Ρ–ΠΌΡ–Π½ΠΈ Π±ΡƒΠ»ΠΈ Π²Ρ–Π΄Π½ΠΎΠ²Π»Π΅Π½Ρ– Π² сСрСдовищі 1,4-діоксану. Π’ якості Π²Ρ–Π΄Π½ΠΎΠ²Π½ΠΈΠΊΠ° використано Π½Π°Ρ‚Ρ€Ρ–ΡŽ Π±ΠΎΡ€Π³Ρ–Π΄Ρ€ΠΈΠ΄.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ– синтСтичних ΠΏΠ΅Ρ€Π΅Ρ‚Π²ΠΎΡ€Π΅Π½ΡŒ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎ 17 Π½ΠΎΠ²ΠΈΡ… сполук, структуру синтСзованих сполук ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΆΠ΅Π½ΠΎ завдяки сучасному комплСксу Ρ„Ρ–Π·ΠΈΠΊΠΎ-Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΡ… ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π² Π°Π½Π°Π»Ρ–Π·Ρƒ (Π†Π§-спСктрофотомСтрії, Π΅Π»Π΅ΠΌΠ΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»Ρ–Π·Ρƒ), Π° Ρ—Ρ… Ρ–Π½Π΄ΠΈΠ²Ρ–Π΄ΡƒΠ°Π»ΡŒΠ½Ρ–ΡΡ‚ΡŒ ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΆΠ΅Π½Π° дослідТСнням Π½Π° високопродуктивному Ρ€Ρ–Π΄ΠΈΠ½Π½ΠΎΠΌΡƒ Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Ρ– Agilent 1260 Infinity HPLC, ΠΎΠ±Π»Π°Π΄Π½Π°Π½ΠΎΠΌΡƒ мас-спСктромСтром Agilent 6120.Висновки. Π ΠΎΠ·Ρ€ΠΎΠ±Π»Π΅Π½ΠΎ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΈΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ синтСзу 6-((5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»Ρ‚Ρ–ΠΎ)ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½-3-Ρ–Π»)-(Π°Π»ΠΊΡ–Π»-, Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΌΠ΅Ρ‚Π°Π½Ρ–ΠΌΡ–Π½Ρ–Π² Ρ– 6-(5-Ρ„Π΅Π½Π΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»Ρ‚Ρ–ΠΎ)-N-(Π°Π»ΠΊΡ–Π»-, Π³Π΅Ρ‚Π΅Ρ€ΠΈΠ»)ΠΏΡ–Ρ€ΠΈΠ΄ΠΈΠ½-3-Π°ΠΌΡ–Π½Ρ–Π²
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