916 research outputs found
The organization of the rating system for assessing the quality of university students training
In spite the universities use the rating system of assessing for a quite long time, this issue is still not fully considered. The article is based on the position of insufficient state of knowledge of the multifunctionality of the students rating. The rating helps to reveal the potential of students. It is mentioned that the rating system of assessment is a tool that will improve the quality of training and provide the required level of motivation.
During the research, the following methods were used: analysis, synthesis, induction, deduction. As a result, the principles of the rating assessment system were revealed, a definition of the term "Rating" was given, its goals were indicated. As an example of the organization of the rating system of assessment, the Nyzhnii Novhorod State Pedagogical University and its "Regulations on the rating system for assessing the quality of student training" were used. It is noted that the rating includes: current check, midterm and final examinations. Further, all possible conditions under which the student receives points were identified and considered.
On the example of the NSPU named after Kozma Minin transferring of the rating points into a five-point grading rating system is presented. Also, the types of violations for which points are discarded, are considered. As the study showed, comprehensive planned system yields productive results for students and the university.peer-reviewe
Instructions for laboratory training in Special Microbiology and Virology for students of Faculty of Dentistry
ΠΠΠΠ ΠΠΠΠΠΠΠΠΠ―ΠΠΠ’ΠΠΠΠ§ΠΠ‘ΠΠΠ Π£ΠΠΠΠΠΠΠ―ΠΠΠΠΠ ΠΠ’ΠΠ ΠΠ«Π Π ΠΠΠΠ’Π«ΠΠΠ Π£Π‘ΠΠΠΠΠΠ―ΠΠΠΠ‘Π’Π ΠΠΠΠ«Π Π‘Π’Π£ΠΠΠΠ’Π«ΠΠ ΠΠΠ’ΠΠ§ΠΠ‘ΠΠΠ ΠΠΠΠ«ΠΠΠ‘ΠΎΠ΄Π΅ΡΠΆΠ°ΡΡΡ ΠΏΠ»Π°Π½, ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ° ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π½ΡΡΠΈΠΉ ΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π½Π°Π²ΡΠΊΠΈ ΠΏΠΎ ΠΎΠ±ΡΠ΅ΠΉ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ Π²ΠΈΡΡΡΠΎΠ»ΠΎΠ³ΠΈΠΈ
Space-time evolution of Dirac wave packets
In this work we study the dynamics of free 3D relativistic Gaussian wave
packets with different spin polarization. We analyze the connection between the
symmetry of initial state and the dynamical characteristics of moving particle.
The corresponding solutions of Dirac equation having different types of
symmetry were evaluated analytically and numerically and after that the
electron probability densities, as well as, the spin densities were visualized.
The average values of velocity of the packet center and the average spin were
calculated analytically, and the parameters of transient Zitterbewegung in
different directions were obtained. These results can be useful for the
interpretation of future experiments with trapped ions.Comment: 10 pages, 7 figure
ΠΠΏΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π½Π΅ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ ΡΠ΄ΠΎΠ±ΡΠ΅Π½ΠΈΠΉ ΠΏΡΠΈ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠΈ ΡΠ΅ΡΠ½ΡΠ΅Π² ΡΠΎΡΠ½Ρ ΠΎΠ±ΡΠΊΠ½ΠΎΠ²Π΅Π½Π½ΠΎΠΉ (Π inus sylvestris l.) Π½Π° Π£ΡΠ°Π»Π΅)
ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΄ΠΎΠ±ΡΠ΅Π½ΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΡΡ
ΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ². Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΎΠ½ΠΈ ΡΠ²Π»ΡΡΡΡΡ Π΄ΠΎΡΡΡΠΏΠ½ΡΠΌΠΈ, Π½Π΅Π΄ΠΎΡΠΎΠ³ΠΈΠΌΠΈ ΠΈ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΡΡΠ΅Π΄ΡΡΠ²Π°ΠΌΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΏΠ»ΠΎΠ΄ΠΎΡΠΎΠ΄ΠΈΡ Π»Π΅ΡΠ½ΡΡ
ΠΏΠΎΡΠ². ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΏΠΎΡΠ°Π΄ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΏΡΠΈ Π²Π½Π΅ΡΠ΅Π½ΠΈΠΈ Π΄Π°Π½Π½ΡΡ
ΡΠΌΠ΅ΡΠ΅
NEW βGREENβ METHOD OF BROMINATION OF (β)-NOPINONE AND (+)-CIS-VERBANONE
This work was supported by the Integrated Program of Ural Branch of RAS (project β 18-3-3-17)
Economic and social aspects in the Republic of Tatarstan
The urgency of the problem under study is conditioned by the need to study the state of interethnic and interreligious relations in polyethnic and poly-confessional regions of Russian Federation. The aim of the article is to analyze the situation in the sphere of interethnic and interreligious relations in the Republic of Tatarstan in 2016.
The leading approach to the study of this problem is the poly-paradigm methodology. The article gives the description of interethnic and interconfessional relations in the Republic of Tatarstan in 2014-2016, the comparative data on the largest cities of the republic are given. A particular attention is paid to the analysis of migrant perception peculiarities by the local population.
The materials of the article can be useful for ethnologists, social and cultural anthropologists, political scientists, as well as for the representatives of the bodies and structures responsible for the issues of interethnic interaction.peer-reviewe
Π‘ΠΈΠ½ΡΠ΅Π·, Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ 6-((5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΡΠ»ΡΡΠΎ)ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»)-(Π°Π»ΠΊΡΠ», Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΡΠΌΡΠ½ΡΠ² ΡΠ° ΡΡ ΠΏΠΎΡ ΡΠ΄Π½ΠΈΡ
In the pharmaceutical practice directly related to the search of biological active substances and their introduction into medicine or veterinary it is generally recognized that a successful choice of the research object is a prerequisite for a positive final outcome to create original effective and low-toxic drugs. At present, derivatives of 1,2,4-triazoles containing pyridine deserve special attention. That is why the synthesis and study of physicochemical properties of new compounds, which contain 1,2,4-triazole and pyridine rings, are important tasks of modern synthetic and pharmaceutical chemistry.Aim. To study the reactions associated with formation and transformation of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines and their recovery, study physicochemical properties of new compounds synthesized. Materials and methods. 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heter-yl)methanimines were obtained by the mixture from 6-(5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-amine and aldehydes. The synthesis was carried out in the acetic acid medium. The mixture was kept at room temperature for 6 h. 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines were reduced in the 1,4-dioxane medium. As a reducing agent sodium borohydride was used. Results and discussion. As a result of synthetic transformations 17 new compounds have been obtained, the structure of the compounds synthesized has been confirmed by modern complex of physicochemical methods of analysis (IR-spectrophotometry, elemental analysis), and their individuality has been proven on an Agilent 1260 Infinity HPLC high-performance liquid chromatograph equipped with an Agilent 6120 mass spectrometer.Conclusions. The preparative method for the synthesis of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines and 6-(5-phenethyl-4-R-1,2,4-triazole-3-ylthio)-N-(alkyl-, heteryl)pyridine-3-amines has been developed.Π ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅, Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠΉ Ρ ΠΏΠΎΠΈΡΠΊΠΎΠΌ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΈ ΠΈΡ
Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ ΠΈΠ»ΠΈ Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΠΈΡ, ΠΎΠ±ΡΠ΅ΠΏΡΠΈΠ½ΡΡΠΎ, ΡΡΠΎ ΡΡΠΏΠ΅ΡΠ½ΡΠΉ Π²ΡΠ±ΠΎΡ ΠΎΠ±ΡΠ΅ΠΊΡΠ° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠ΅Π΄ΠΏΠΎΡΡΠ»ΠΊΠΎΠΉ Π΄Π»Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°, Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈ ΠΌΠ°Π»ΠΎΡΠΎΠΊΡΠΈΡΠ½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ². ΠΠ° Π΄Π°Π½Π½ΡΠΉ ΠΌΠΎΠΌΠ΅Π½Ρ ΠΎΡΠΎΠ±ΠΎΠ³ΠΎ Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ Π·Π°ΡΠ»ΡΠΆΠΈΠ²Π°ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ 1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Ρ ΠΏΠΈΡΠΈΠ΄ΠΈΠ½. ΠΠΌΠ΅Π½Π½ΠΎ ΠΏΠΎΡΡΠΎΠΌΡ ΡΠΈΠ½ΡΠ΅Π· ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² Π½ΠΎΠ²ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΡΠ½ΠΎΠ΅ ΠΈ ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠ΅ ΠΊΠΎΠ»ΡΡΠ°, ΡΠ²Π»ΡΡΡΡΡ Π²Π°ΠΆΠ½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Ρ
ΠΈΠΌΠΈΠΈ.Π¦Π΅Π»Ρ. ΠΠ·ΡΡΠΈΡΡ ΡΠ΅Π°ΠΊΡΠΈΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ 6-((5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»ΡΠΈΠΎ)ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)-(Π°Π»ΠΊΠΈΠ», Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΠΈΠΌΠΈΠ½ΠΎΠ² ΠΈ ΠΈΡ
ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ, ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π½ΠΎΠ²ΡΡ
ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ 6-((5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»ΡΠΈΠΎ)ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)-(Π°Π»ΠΊΠΈΠ»-, Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΠΈΠΌΠΈΠ½ΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ 6-(5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»ΡΠΈΠΎ)ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-Π°ΠΌΠΈΠ½Ρ ΠΈ Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Ρ. Π‘ΠΈΠ½ΡΠ΅Π· ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π² ΡΡΠ΅Π΄Π΅ ΠΊΠΈΡΠ»ΠΎΡΡ ΡΠΊΡΡΡΠ½ΠΎΠΉ. Π‘ΠΌΠ΅ΡΡ ΠΎΡΡΠ°Π²Π»ΡΠ»ΠΈ ΠΏΡΠΈ ΠΊΠΎΠΌΠ½Π°ΡΠ½ΠΎΠΉ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ΅ Π½Π° 6 ΡΠ°ΡΠΎΠ². 6-((5-Π€Π΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»ΡΠΈΠΎ)ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)-(Π°Π»ΠΊΠΈΠ»-, Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΠΈΠΌΠΈΠ½Ρ Π±ΡΠ»ΠΈ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ Π² ΡΡΠ΅Π΄Π΅ 1,4-Π΄ΠΈΠΎΠΊΡΠ°Π½Π°. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΠ΅Π»Ρ Π±ΡΠ» ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Π½Π°ΡΡΠΈΡ Π±ΠΎΡΠ³ΠΈΠ΄ΡΠΈΠ΄.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΠΉ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΎ 17 Π½ΠΎΠ²ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΡΡΡΠΊΡΡΡΡ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π°Π½Π°Π»ΠΈΠ·Π° (ΠΠ-ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΠΈ, ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°), Π° ΠΈΡ
ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π½Π° Π²ΡΡΠΎΠΊΠΎΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ ΠΆΠΈΠ΄ΠΊΠΎΠΌ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠ΅ Agilent 1260 Infinity HPLC, ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½Π½ΠΎΠΌ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΎΠΌ Agilent 6120.ΠΡΠ²ΠΎΠ΄Ρ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΈΠ½ΡΠ΅Π·Π° 6-((5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»ΡΠΈΠΎ)ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)-(Π°Π»ΠΊΠΈΠ»-, Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΠΈΠΌΠΈΠ½ΠΎΠ² ΠΈ 6-(5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»ΡΠΈΠΎ)-N- (Π°Π»ΠΊΠΈΠ»-, Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-Π°ΠΌΠΈΠ½ΠΎΠ².Π£ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ½ΡΠΉ ΠΏΡΠ°ΠΊΡΠΈΡΡ, ΡΠΊΠ° Π±Π΅Π·ΠΏΠΎΡΠ΅ΡΠ΅Π΄Π½ΡΠΎ ΠΏΠΎΠ²βΡΠ·Π°Π½Π° Π· ΠΏΠΎΡΡΠΊΠΎΠΌ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎ Π°ΠΊΡΠΈΠ²Π½ΠΈΡ
ΡΠ΅ΡΠΎΠ²ΠΈΠ½ ΡΠ° ΡΡ
Π²Π²Π΅Π΄Π΅Π½Π½ΡΠΌ Ρ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ Π°Π±ΠΎ Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΡΡ, Π·Π°Π³Π°Π»ΡΠ½ΠΈΠΌ Ρ ΡΠ΅, ΡΠΎ ΡΡΠΏΡΡΠ½ΠΈΠΉ Π²ΠΈΠ±ΡΡ ΠΎΠ±βΡΠΊΡΠ° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Ρ Π½Π΅ΠΎΠ±Ρ
ΡΠ΄Π½ΠΎΡ ΡΠΌΠΎΠ²ΠΎΡ Π΄Π»Ρ ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΊΡΠ½ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ° Π΄Π»Ρ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ ΠΎΡΠΈΠ³ΡΠ½Π°Π»ΡΠ½ΠΈΡ
Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΡ
ΡΠ° ΠΌΠ°Π»ΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡΠ². ΠΠ° ΡΡΠΎΠΌΡ Π΅ΡΠ°ΠΏΡ Π½Π° ΠΎΡΠΎΠ±Π»ΠΈΠ²Ρ ΡΠ²Π°Π³Ρ Π·Π°ΡΠ»ΡΠ³ΠΎΠ²ΡΡΡΡ ΠΏΠΎΡ
ΡΠ΄Π½Ρ 1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΡΠ², ΡΠΎ ΠΌΡΡΡΡΡΡ ΠΏΡΡΠΈΠ΄ΠΈΠ½. Π‘Π°ΠΌΠ΅ ΡΠΎΠΌΡ ΡΠΈΠ½ΡΠ΅Π· ΡΠ° Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΡΡΠ·ΠΈΠΊΠΎ-Ρ
ΡΠΌΡΡΠ½ΠΈΡ
Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ Π½ΠΎΠ²ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ, ΡΠΎ ΠΌΡΡΡΡΡΡ 1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΡΠ½ΠΈΠΉ ΡΠ° ΠΏΡΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΈΠΉ ΡΡΠ°Π³ΠΌΠ΅Π½Ρ, Ρ Π²Π°ΠΆΠ»ΠΈΠ²ΠΈΠΌΠΈ Π·Π°Π²Π΄Π°Π½Π½ΡΠΌΠΈ ΡΡΡΠ°ΡΠ½ΠΎΡ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ½ΠΎΡ ΡΠ° ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ½ΠΎΡ Ρ
ΡΠΌΡΡ.ΠΠ΅ΡΠ°. ΠΠΈΠ²ΡΠΈΡΠΈ ΡΠ΅Π°ΠΊΡΡΡ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ 6-((5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΡΠ»ΡΡΠΎ)ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»)-(Π°Π»ΠΊΡΠ», Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΡΠΌΡΠ½ΡΠ² ΡΠ° ΡΡ
ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΡΠ΄Π½ΠΎΠ²Π»Π΅Π½Π½Ρ, Π΄ΠΎΡΠ»ΡΠ΄ΠΈΡΠΈ ΡΡΠ·ΠΈΡΠ½Ρ ΡΠ° Ρ
ΡΠΌΡΡΠ½Ρ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ Π½ΠΎΠ²ΠΈΡ
ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ.ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ ΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈ. ΠΠ»Ρ ΠΎΡΡΠΈΠΌΠ°Π½Π½Ρ 6-((5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΡΠ»ΡΡΠΎ)ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»)-(Π°Π»ΠΊΡΠ»-, Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΡΠΌΡΠ½ΡΠ² Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½ΠΎ 6-(5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΡΠ»ΡΡΠΎ)ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-Π°ΠΌΡΠ½ΠΈ ΡΠ° Π°Π»ΡΠ΄Π΅Π³ΡΠ΄ΠΈ. Π‘ΠΈΠ½ΡΠ΅Π· ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ²ΡΡ Π² ΡΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ ΠΎΡΡΠΎΠ²ΠΎΡ. Π‘ΡΠΌΡΡ Π·Π°Π»ΠΈΡΠ°Π»ΠΈ ΠΏΡΠΈ ΠΊΡΠΌΠ½Π°ΡΠ½ΡΠΉ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ Π½Π° 6 Π³ΠΎΠ΄ΠΈΠ½. 6-((5-Π€Π΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΡΠ»ΡΡΠΎ)ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»)-(Π°Π»ΠΊΡΠ»-, Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΡΠΌΡΠ½ΠΈ Π±ΡΠ»ΠΈ Π²ΡΠ΄Π½ΠΎΠ²Π»Π΅Π½Ρ Π² ΡΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΡ 1,4-Π΄ΡΠΎΠΊΡΠ°Π½Ρ. Π ΡΠΊΠΎΡΡΡ Π²ΡΠ΄Π½ΠΎΠ²Π½ΠΈΠΊΠ° Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½ΠΎ Π½Π°ΡΡΡΡ Π±ΠΎΡΠ³ΡΠ΄ΡΠΈΠ΄.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ½ΠΈΡ
ΠΏΠ΅ΡΠ΅ΡΠ²ΠΎΡΠ΅Π½Ρ ΠΎΡΡΠΈΠΌΠ°Π½ΠΎ 17 Π½ΠΎΠ²ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ, ΡΡΡΡΠΊΡΡΡΡ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΆΠ΅Π½ΠΎ Π·Π°Π²Π΄ΡΠΊΠΈ ΡΡΡΠ°ΡΠ½ΠΎΠΌΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ ΡΡΠ·ΠΈΠΊΠΎ-Ρ
ΡΠΌΡΡΠ½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ² Π°Π½Π°Π»ΡΠ·Ρ (ΠΠ§-ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΡΡ, Π΅Π»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ·Ρ), Π° ΡΡ
ΡΠ½Π΄ΠΈΠ²ΡΠ΄ΡΠ°Π»ΡΠ½ΡΡΡΡ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΆΠ΅Π½Π° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½ΡΠΌ Π½Π° Π²ΠΈΡΠΎΠΊΠΎΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΠΌΡ ΡΡΠ΄ΠΈΠ½Π½ΠΎΠΌΡ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΡ Agilent 1260 Infinity HPLC, ΠΎΠ±Π»Π°Π΄Π½Π°Π½ΠΎΠΌΡ ΠΌΠ°Ρ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΎΠΌ Agilent 6120.ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΈΠ½ΡΠ΅Π·Ρ 6-((5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΡΠ»ΡΡΠΎ)ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»)-(Π°Π»ΠΊΡΠ»-, Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΡΠΌΡΠ½ΡΠ² Ρ 6-(5-ΡΠ΅Π½Π΅ΡΠΈΠ»-4-R-1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»-3-ΡΠ»ΡΡΠΎ)-N-(Π°Π»ΠΊΡΠ»-, Π³Π΅ΡΠ΅ΡΠΈΠ»)ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-Π°ΠΌΡΠ½ΡΠ²
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