INTERVENÇÃO PEDAGÓGICA PARA A SAÚDE: UMA REVISÃO NARRATIVA SISTEMÁTICA SOBRE A BIODANZA

This research reports on the first narrative review of Biodanza’s effects on health and wellbeing. The review explores manuscripts in four languages (i.e., Italian, Spanish, Portuguese and English) and includes more than 200 documents. The protocol was evaluated according to the most recent SANRA guidelines and Kappa statistics. The research shows that the majority of the studies had descriptive approaches (29.2%), followed by robust control trials (26.8%), while the remaining studies included both narrative and systematic reviews (19.5%) as well as pilot (14.6%), ethnographic (7.3%), and assessment (2.4%) studies. The research team concluded that Biodanza is an innovative intervention to improve clinical and socio-pedagogic outcomes in different cohorts (including kindergartens and chronic senile-disease patients) and should be fostered for additional trials along or in comparison with alternative interventions (such as Bodytasking). La investigación tiene como objetivo relatar la primera revisión narrativa de los efectos de la Biodanza en la salud y el bienestar. La revisión explora manuscritos en cuatro idiomas (italiano, español, portugués e inglés) e incluye más de 200 documentos. El protocolo se evaluó de acuerdo con las estadísticas más recientes SANRA directrices y Kappa. La investigación muestra que la mayoría de los estudios tuvo un enfoque descriptivo (29,2%), seguido por ensayos de control robusto (26,8%). El resto incluyó revisiones narrativas y sistemáticas (19,5%), piloto (14,6%), etnografía (7,3%) y estudios de diagnóstico (2,4%). El equipo de investigación concluyó que Biodanza es una intervención innovadora para mejorar los resultados clínicos y sociopedagógicos en diferentes cohortes (incluidos jardines infantiles y con pacientes con enfermedad senil crónica) y debe fomentarse para ensayos adicionales junto o en comparación con intervenciones alternativas (como Bodytasking). A pesquisa tem como objetivo relatar a primeira revisão narrativa dos efeitos da Biodanza na saúde e no bem-estar. A revisão explora manuscritos em quatro idiomas (italiano, espanhol, português e inglês) e incluiu mais de 200 documentos. O protocolo foi avaliado de acordo com as mais recentes diretrizes SANRA e estatísticas Kappa. A pesquisa mostra que a maioria dos estudos teve abordagem descritiva (29,2%), seguida de ensaios de controle robusto (26,8%). Enquanto o restante incluía revisões narrativas e sistemáticas (19,5%), estudos-piloto (14,6%), etnográficos (7,3%) e diagnósticos (2,4%). A equipe de pesquisa concluiu que a Biodanza é uma intervenção inovadora para melhorar os resultados clínicos e sociopedagógicos em diferentes coortes (incluindo jardins de infância e com pacientes com doença senil crônica) e deve ser promovida para ensaios adicionais junto ou em comparação com intervenções alternativas (como Bodytasking).

PEDAGOGIC INTERVENTION FOR HEALTH: A NARRATIVE SYSTEMATIC REVIEW ON BIODANZA

This research reports on the first narrative review of Biodanza’s effects on health and wellbeing. The review explores manuscripts in four languages (i.e., Italian, Spanish, Portuguese and English) and includes more than 200 documents. The protocol was evaluated according to the most recent SANRA guidelines and Kappa statistics. The research shows that the majority of the studies had descriptive approaches (29.2%), followed by robust control trials (26.8%), while the remaining studies included both narrative and systematic reviews (19.5%) as well as pilot (14.6%), ethnographic (7.3%), and assessment (2.4%) studies. The research team concluded that Biodanza is an innovative intervention to improve clinical and sociopedagogic outcomes in different cohorts (including kindergartens and chronic seniledisease patients) and should be fostered for additional trials along or in comparison with alternative interventions (such as Bodytasking)

BODYTASKING. ANALYSIS AND PERCEPTIONS OF A DISTANCE DANCE EXPERIENCE.

To stop the spread of COVID-19 in March 2020, the Italian government declared a health emergency, imposing the national lockdown. A year later, the pandemic still blocks the non-professional sports sectors, including gyms and dance schools, to reopen. The distance created with remote, online training session might deprive all the cognitive, emotional, social and communication development expressed in the embodied theories. To investigate the perception of distanced learning in physical education, the multidisciplinary research team used the novel, holistic, dance-based intervention named bodytasking. Eight sessions, one each Monday, were carried out by two teachers between December 2020 and February 2021. Five students aged range between 6 and 10 years old, all girls took part in the study. Qualitative interviews were collected during and after the dance intervention to report students and teachers perspective on distanced learning. The results showed the benefits and the deficits of carrying out a sports practice in distanced learning. We reported the importance of using Information and Communications Technology tools such as videos and music tracks to challenge and stimulate the students and the role that imagination plays in the learning process

dynamic simulation of a multi generation system for electric and cooling energy provision employing a sofc cogenerator and an adsorption chiller

Abstract Aim of this work is the dynamic simulation of the operation of a small-scale multi-generation system, based on a Solid Oxide Fuel Cell (SOFC) micro-cogenerator (μCHP) coupled to an adsorption chiller, to provide electric and cooling energy to a telecommunication shelter. The dynamic simulation model has been implemented in TRNSYS environment. The μCHP has nominal electric power of 2.5 kW and its thermal output is used to drive a thermally driven adsorption chiller, with nominal cooling power of 10 kW. The performance of both components were experimentally validated under controlled lab conditions. The developed model allowed to optimize the system configuration and to perform an energy and environmental analysis. This analysis demonstrated the possibility of achieving global energy efficiency up to 63% with a CO2 reduction proportional to the electric and cooling load of the telecommunication shelter

Red Giant stars in the Large Magellanic Cloud clusters

We present deep J,H,Ks photometry and accurate Color Magnitude Diagrams down to K ~18.5, for a sample of 13 globular clusters in the Large Magellanic Cloud. This data set combined with the previous sample of 6 clusters published by our group gives the opportunity to study the properties of giant stars in clusters with different ages (ranging from ~80 Myr up to ~3.5 Gyr). Quantitative estimates of star population ratios (by number and luminosity) in the Asymptotic Giant Branch, the Red Giant Branch and the He-clump, have been obtained and compared with theoretical models in the framework of probing the so-called phase transitions. The AGB contribution to the total luminosity starts to be significant at ~200 Myr and reaches its maximum at ~5-600 Myr, when the RGB Phase Transition is starting. At ~900 Myr the full developing of an extended and well populated RGB has been completed. Both the occurrence of the AGB and RGB Phase Transitions are sharp events, lasting a few hundreds Myr only. These empirical results agree very well with the theoretical predictions of simple stellar population models based on canonical tracks and the fuel-consumption approach.Comment: 32 pages, 11 figures, accepted to Ap

The Large Magellanic Cloud globular cluster NGC 1866: new data, new models, new analysis

We present a new deep (down to V ~ 24) photometry of a wide region (6'x 6') around the LMC globular cluster NGC1866: our sample is complete, down to 3 mag below the brightest MS star. Detailed comparisons with various theoretical scenarios using models computed with the evolutionary code FRANEC have been done reaching the following conclusions: both standard models (i.e. computed by adopting the Schwarzschild criterion to fix the border of the convective core) and models with an enlarged convective core (overshooting) lead to a fair fit of the MS but are not able to reproduce the luminosity and/or the number of He burning giants. Models including a fraction of 30% of binaries leads to a good fit both to the MS luminosity function and to the He clump, if standards models are considered, for a visual distance modulus (m-M)v = 18.8, age t ~ 100 Myr and mass function slope alpha ~ 2.4, thus largely removing the "classical" discrepancy between observed and predicted number of stars in the He burning clump. The fit obtained with models computed with an enlarged convective core gets worse when a binary component is taken into account, because the presence of binary systems increases the existing discrepancy between the observed and predicted clump luminosity. As a consequence of this analysis, we conclude that the next step towards a proper understanding of NGC 1866, and similar clusters, must include the accurate determination of the frequency of binary systems that will be hopefully performed with the incoming Cycle 8 HST observations of NGC~1866.Comment: AASTEX 5.0, 33 pages, 35 figures. Two tables of photometry and full resolution figures available on request from the first author ([email protected]). Accepted on A

Impact of Hydrophobic Chains in Five-Coordinate Glucoconjugate Pt(II) Anticancer Agents

This study describes new platinum(II) cationic five-coordinate complexes (1-R,R’) of the formula [PtR(NHC)(dmphen)(ethene)]CF3SO3 (dmphen = 2,9-dimethyl-1,10-phenanthroline), containing in their axial positions an alkyl group R (methyl or octyl) and an imidazole-based NHC-carbene ligand with a substituent R’ of variable length (methyl or octyl) on one nitrogen atom. The Pt–carbene bond is stable both in DMSO and in aqueous solvents. In DMSO, a gradual substitution of dmphen and ethene is observed, with the formation of a square planar solvated species. Octanol/water partitioning studies have revealed the order of hydrophobicity of the complexes (1-Oct,Me > 1-Oct,Oct > 1-Me,Oct > 1-Me,Me). Their biological activity was investigated against two pairs of cancer and non-cancer cell lines. The tested drugs were internalized in cancer cells and able to activate the apoptotic pathway. The reactivity of 1-Me,Me with DNA and protein model systems was also studied using UV–vis absorption spectroscopy, fluorescence, and X-ray crystallography. The compound binds DNA and interacts in various ways with the model protein lysozyme. Remarkably, structural data revealed that the complex can bind lysozyme via non-covalent interactions, retaining its five-coordinate geometry

Hyaluronan-Based Gel Promotes Human Dental Pulp Stem Cells Bone Differentiation by Activating YAP/TAZ Pathway.

Background: Hyaluronans exist in different forms, accordingly with molecular weight and degree of crosslinking. Here, we tested the capability to induce osteogenic differentiation in hDPSCs (human dental pulp stem cells) of three hyaluronans forms: linear pharmaceutical-grade hyaluronans at high and (HHA) low molecular weight (LHA) and hybrid cooperative complexes (HCC), containing both sizes. Methods: hDPSCs were treated with HHA, LHA, HCC for 7, 14 and 21 days. The effects of hyaluronans on osteogenic differentiation were evaluated by qRT-PCR and WB of osteogenic markers and by Alizarin Red S staining. To identify the involved pathway, CD44 was analyzed by immunofluorescence, and YAP/TAZ expression was measured by qRT-PCR. Moreover, YAP/TAZ inhibitor-1 was used, and the loss of function of YAP/TAZ was evaluated by qRT-PCR, WB and immunofluorescence. Results: We showed that all hyaluronans improves osteogenesis. Among these, HCC is the main inducer of osteogenesis, along with overexpression of bone related markers and upregulating CD44. We also found that this biological process is subordinate to the activation of YAP/TAZ pathway. Conclusions: We found that HA's molecular weight can have a relevant impact on HA performance for bone regeneration, and we unveil a new molecular mechanism by which HA acts on stem cells. Keywords: YAP/TAZ pathway; dental pulp stem cells; hyaluronic acid; osteogenic differentiation

Probing the RGB-phase transition: Near-IR photometry of six intermediate age LMC clusters

This is the first of a series of papers devoted to a global study of the photometric properties of the red stellar sequences in a complete sample of the Large Magellanic Cloud clusters, by means of near infrared array photometry. Deep J,H,Ks photometry and accurate Color Magnitude Diagrams down to K=18.5, i.e. 1.5 mag below the red He-clump, for six intermediate age clusters (namely NGC1987, NGC2108, NGC2190, NGC2209, NGC2231, NGC2249) are presented. A quantitative estimate of the population ratios (by number and luminosity) between Red Giant Branch and He-clump stars for each target cluster is provided and discussed in the framework of probing the so-called Red Giant Branch phase transition (RGB Ph-T). By using the Elson & Fall s-parameter as an age indicator, the observed RGB population shows a sharp enhancement (both in number and luminosity) at s=36. Obviously, the corresponding absolute age strictly depends on the details of theoretical models adopted to calibrate the s-parameter. Curiously, the currently available calibrations of the s-parameter in term of age based on canonical (by Elson & Fall 1988) and overshooting (Girardi et al. 1995) models provide ages that well agree within 10%, suggesting that the full development of the Red Giant Branch occurs at t=700 Myr and be a relatively fast event (delta t=300 Myr). However, the RGB Ph-T epoch derived from the overshooting calibration of the s-parameter turns out to be significantly earlier than the epoch provided by the recent evolutionary tracks by Girardi et al. (2000). A new calibration of the s-parameter based on high quality Color Magnitude Diagrams and updated models is urged to address the origin of this discrepancy and finally establish the epoch of the RGB Ph-T.Comment: ApJ, in pres

Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses

Alongside vaccines, antiviral drugs are becoming an integral part of our response to the SARS-CoV-2 pandemic. Nirmatrelvir-an orally available inhibitor of the 3-chymotrypsin-like cysteine protease-has been shown to reduce the risk of progression to severe COVID-19. However, the impact of nirmatrelvir treatment on the development of SARS-CoV-2-specific adaptive immune responses is unknown. Here, by using mouse models of SARS-CoV-2 infection, we show that nirmatrelvir administration blunts the development of SARS-CoV-2-specific antibody and T cell responses. Accordingly, upon secondary challenge, nirmatrelvir-treated mice recruited significantly fewer memory T and B cells to the infected lungs and mediastinal lymph nodes, respectively. Together, the data highlight a potential negative impact of nirmatrelvir treatment with important implications for clinical management and might help explain the virological and/or symptomatic relapse after treatment completion reported in some individuals