Comparison of time and frequency domain interpolation implementations for MB-OFDM UWB transmitters

This paper investigates the effect of time-domain (TD) and frequency-domain (FD) interpolation on the performance of a Multi-Band (MB) Orthogonal Frequency Division Multiplexing (OFDM) Ultra-Wideband (UWB) system. We introduce a FD interpolator implemented by a radix-8 512-point IFFT architecture for applications on MB-OFDM UWB transmitters. For the specific application where the interpolation factor is fixed to four, the FD interpolator outperforms the TD interpolator implemented with digital low-pass FIR filters in terms of computational complexity. On the other hand simulation results show that FD implementation degrades the overall system performance for certain UWB channels

Comparison of time and frequency domain interpolation implementations for MB-OFDM UWB transmitters

This paper investigates the effect of time-domain (TD) and frequency-domain (FD) interpolation on the performance of a Multi-Band (MB) Orthogonal Frequency Division Multiplexing (OFDM) Ultra-Wideband (UWB) system. We introduce a FD interpolator implemented by a radix-8 512-point IFFT architecture for applications on MB-OFDM UWB transmitters. For the specific application where the interpolation factor is fixed to four, the FD interpolator outperforms the TD interpolator implemented with digital low-pass FIR filters in terms of computational complexity. On the other hand simulation results show that FD implementation degrades the overall system performance for certain UWB channels

Data Aggregation, Fusion and Recommendations for Strengthening Citizens Energy-aware Behavioural Profiles

In this paper, ENTROPY platform, an IT ecosystem for supporting energy efficiency in buildings through behavioural change of the occupants is provided. The ENTROPY platform targets at providing a set of mechanisms for accelerating the adoption of energy efficient practices through the increase of the energy awareness and energy saving potential of the occupants. The platform takes advantage of novel sensor networking technologies for supporting efficient sensor data aggregation mechanisms, semantic web technologies for unified data representation, machine learning mechanisms for getting insights from the available data and recommendation mechanisms for providing personalised content to end users. These technologies are combined and provided through an integrated platform, targeting at leading to occupants' behavioural change with regards to their energy consumption profiles.Comment: To appear in the proceedings of Global IoT Summit 201

AI-powered Infrastructures for intelligence and automation in beyond-5G systems

In this paper, a vision for beyond-5G systems is proposed where automation, intelligence and data privacy in cloudnative infrastructures are in focus. Exploiting the convergence of cloud technologies at the edge and mobile communication networks, a set of architectural and technological solutions is discussed that will play a fundamental role on the path from 5G towards future sixth-generation systems. Currently, a strong need is felt in the telecommunication world for greater automation to meet the extreme requirements expected for future 6G applications. In this regard, Artificial Intelligence (AI) is gaining high momentum as one of the central enabling technologies for beyond-5G networks. Reinforcement Learning (RL) and Federated Learning (FL) are here proposed as technologies to enhance network automation and enable privacy-aware applications. Blockchain is proposed as a solution for non-repudiation and trustworthiness in the AI pipelines. These technologies are brought together in a comprehensive cloud-native architectural vision to fill the gap between current 5G systems and AI-powered secure systems of the future

Separation of concerns among application and network services orchestration in a 5G ecosystem

5G networks evolution is tightly bounded with the need to support vertical industries network performance and operating requirements. Such an objective is associated with a set of challenges related mainly to the provision of frameworks that can tackle aspects related to the various 5G stakeholders (e.g. software developers, application/service providers, telecom/infrastructure providers), without imposing strict requirements on their collaboration terms. Towards this direction, in the current manuscript, we detail a novel holistic framework tackling the overall lifecycle of 5G-ready applications design, development, deployment and orchestration over application-aware network slices. Separation of concerns among the related stakeholders per layer of the proposed architecture regards one of the basic considered principles

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.

Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.Wellcome Trust Investigator Award, 102942/Z/13/A Elizabeth P Murchison Leverhulme Trust Philip Leverhulme Prize Elizabeth P Murchison Royal Society Research Grant, RG130615 Elizabeth P Murchiso

Somatic evolution and global expansion of an ancient transmissible cancer lineage

Made available in DSpace on 2019-10-06T15:53:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-02GPD Charitable TrustLeverhulme TrustThe canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by “metastasizing” between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution.Transmissible Cancer Group Department of Veterinary Medicine University of CambridgeAnimal Management in Rural and Remote Indigenous Communities (AMRRIC)World VetsAnimal Shelter Stichting Dierenbescherming SurinameSikkim Anti-Rabies and Animal Health Programme Department of Animal Husbandry Livestock Fisheries and Veterinary Services Government of SikkimRoyal (Dick) School of Veterinary Studies Roslin Institute University of Edinburgh Easter Bush CampusConserLab Animal Preventive Medicine Department Faculty of Animal and Veterinary Sciences University of ChileCorozal Veterinary Hospital University of PanamáSt. George's UniversityNakuru District Veterinary Scheme LtdAnimal Medical CentreInternational Animal Welfare Training Institute UC Davis School of Veterinary MedicineCentro Universitário de Rio Preto (UNIRP)Department of Clinical and Veterinary Surgery São Paulo State University (UNESP)Ladybrand Animal ClinicVeterinary Clinic Sr. Dog'sWorld Vets Latin America Veterinary Training CenterNational Veterinary Research InstituteAnimal ClinicIntermunicipal Stray Animals Care Centre (DIKEPAZ)Animal Protection Society of SamoaFaculty of Veterinary Science University of ZuliaVeterinary Clinic BIOCONTROLFaculty of Veterinary Medicine School of Health Sciences University of ThessalyVeterinary Clinic El Roble Animal Healthcare Network Faculty of Animal and Veterinary Sciences University of ChileOnevetGroup Hospital Veterinário BernaUniversidade Vila VelhaVeterinary Clinic ZoovetservisÉcole Inter-états des Sciences et Médecine Vétérinaires de DakarDepartment of Small Animal Medicine Faculty of Veterinary Medicine Utrecht UniversityVetexpert Veterinary GroupVeterinary Clinic Lopez QuintanaClinique Veterinaire de Grand Fond Saint Gilles les BainsDepartment of Veterinary Sciences University of MessinaFacultad de Medicina Veterinaria y Zootecnia Universidad Autónoma del Estado de MéxicoSchool of Veterinary Medicine Universidad de las AméricasCancer Development and Innate Immune Evasion Lab Champalimaud Center for the UnknownTouray and Meyer Vet ClinicHillside Animal HospitalKampala Veterinary SurgeryAsavet Veterinary CharitiesVets Beyond BordersFaculty of Veterinary Medicine Autonomous University of YucatanLaboratorio de Patología Veterinaria Universidad de CaldasInterdisciplinary Centre of Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of LisbonFour Paws InternationalHelp in SufferingVeterinary Clinic Dr José RojasDepartment of Biotechnology Balochistan University of Information Technology Engineering and Management SciencesCorozal Veterinary ClinicVeterinary Clinic VetmasterState Hospital of Veterinary MedicineJomo Kenyatta University of Agriculture and TechnologyLaboratory of Biomedicine and Regenerative Medicine Department of Clinical Sciences Faculty of Animal and Veterinary Sciences University of ChileFaculty of Veterinary and Agricultural Sciences University of MelbourneAnimal Anti Cruelty LeagueClinical Sciences Department Faculty of Veterinary Medicine BucharestDepartment of Pathology Faculty of Veterinary Medicine Ankara UniversityFaculty of Veterinary Sciences National University of AsuncionLilongwe Society for Protection and Care of Animals (LSPCA)Wellcome Sanger InstituteDepartment of Cellular and Molecular Medicine University of California San DiegoDepartment of Clinical and Veterinary Surgery São Paulo State University (UNESP)Leverhulme Trust: 102942/Z/13/

Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

Abstract: Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells