Diagnosing Borderline Personality Disorder During Adolescence: A Review of the Published Literature

Borderline personality disorder (BPD) is a debilitating disorder that occurs in approximately 1% to 3% of the general population. BPD is not only relatively prevalent; it is also associated with significant public health and security concerns. The clinical and social burden of adult BPD diagnosis has resulted in the desire for early diagnosis and the implementation of early intervention programs. A qualitative review of the scientific literature suggested that adolescence is a critical point for the early identification and therapeutic treatment of BPD. Although findings are far from conclusive, the inter-rater reliability and internal consistency of the Diagnostic and Statistical Manual of Mental Disorders symptom criteria for BPD during adolescence seem adequate. Recent studies based on a rigorous methodology of BPD assessment and large community samples reported prevalence rates for BPD diagnosis during adolescence that were less suspect than previous findings. A number of research studies addressed the construct validity of BPD in adolescents (i.e., whether a BPD diagnosis during adolescence actually measures what is intending to measure) and reported consistent relationships between BPD and associated areas of dysfunction and distress as evidence of the validity of the BPD diagnosis. Research evidence indicates that there is no single symptom that is predictive of later BPD diagnosis during adolescence; rather, a pattern of two to three selected BPD symptoms that are evident during adolescence seemed to be highly predictive of later BPD diagnosis, particularly when measures that were specifically designed to assess for BPD during adolescence were used as part of the assessment process

Diagnosing Borderline Personality Disorder in Adolescence: A Review of the Published Literature

Borderline personality disorder (BPD) is a debilitating disorder that occurs in approximately 1% to 3% of the general population. BPD is not only relatively prevalent; it is also associated with significant public health and security concerns. The clinical and social burden of adult BPD diagnosis has resulted in the desire for early diagnosis and the implementation of early intervention programs. A qualitative review of the scientific literature suggested that adolescence is a critical point for the early identification and therapeutic treatment of BPD. Although findings are far from conclusive, the inter-rater reliability and internal consistency of the Diagnostic and Statistical Manual of Mental Disorders symptom criteria for BPD during adolescence seem adequate. Recent studies based on a rigorous methodology of BPD assessment and large community samples reported prevalence rates for BPD diagnosis during adolescence that were less suspect than previous findings. A number of research studies addressed the construct validity of BPD in adolescents (i.e., whether a BPD diagnosis during adolescence actually measures what is intending to measure) and reported consistent relationships between BPD and associated areas of dysfunction and distress as evidence of the validity of the BPD diagnosis. Research evidence indicates that there is no single symptom that is predictive of later BPD diagnosis during adolescence; rather, a pattern of two to three selected BPD symptoms that are evident during adolescence seemed to be highly predictive of later BPD diagnosis, particularly when measures that were specifically designed to assess for BPD during adolescence were used as part of the assessment process

Real-time vehicle tracking for driving assistance

Detecting car taillights at night is a task which can nowadays be accomplished very fast on cheap hardware. We rely on such detections to build a vision-based system that, coupling them in a rule-based fashion, is able to detect and track vehicles. This allows the generation of an interface that informs a driver of the relative distance and velocity of other vehicles in real time and triggers a warning when a potentially dangerous situation arises. We demonstrate the system using sequences shot using a camera mounted behind a car's windshiel

Bridging the Gap between Detection and Tracking for 3D Human Motion Recovery

The aim of this thesis is to build a system able to automatically and robustly track human motion in 3–D starting from monocular input. To this end two approaches are introduced, which tackle two different types of motion: The first is useful to analyze activities for which a characteristic pose, or key-pose, can be detected, as for example in the walking case. On the other hand the second can be used for cases in which such pose is not defined but there is a clear relation between some easily measurable image quantities and the body configuration, as for example in the skating case where the trajectory followed by a subject is highly correlated to how the subject articulates. In the first proposed technique we combine detection and tracking techniques to achieve robust 3D motion recovery of people seen from arbitrary viewpoints by a single and potentially moving camera. We rely on detecting key postures, which can be done reliably, using a motion model to infer 3D poses between consecutive detections, and finally refining them over the whole sequence using a generative model. We demonstrate our approach in the cases of golf motions filmed using a static camera and walking motions acquired using a potentially moving one. We will show that this approach, although monocular, is both metrically accurate because it integrates information over many frames and robust because it can recover from a few misdetections. The second approach is based on the fact that the articulated body models used to represent human motion typically have many degrees of freedom, usually expressed as joint angles that are highly correlated. The true range of motion can therefore be represented by latent variables that span a low-dimensional space. This has often been used to make motion tracking easier. However, learning the latent space in a problem independent way makes it non trivial to initialize the tracking process by picking appropriate initial values for the latent variables, and thus for the pose. In this thesis, it will be shown that by directly using observable quantities as latent variables, this issue can be eliminated

Proinflammatory response of canine trophoblasts to Brucella canis infection

Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis–induced abortion are unknown, but heavily infected trophoblasts are consistently observed. As trophoblasts responses to other pathogens contribute to placental inflammation leading to abortion, the aim of the present study was to characterize the cytokine response of canine trophoblasts to B. canis infection. To achieve this, trophoblasts isolated from term placenta of healthy female dogs were infected with B. canis, culture supernatants were harvested for cytokine determinations, and the load of intracellular viable B. canis was determined at different times post-infection. Additionally, cytokine responses were assessed in non-infected trophoblasts stimulated with conditioned media (CM) from B. canis-infected canine monocytes and neutrophils. Finally, cytokine response and bacteria replication were assessed in canine placental explants infected ex vivo. B. canis successfully infected and replicated in primary canine trophoblasts, eliciting an increase in IL-8 and RANTES (CCL5) secretion. Moreover, the stimulation of trophoblasts with CM from B. canis-infected monocytes and neutrophils induced a significant increase in IL-8, IL-6 and RANTES secretion. B. canis replication was confirmed in infected placental explants and the infection elicited an increased secretion of TNF-α, IL-8, IL-6 and RANTES. This study shows that canine trophoblasts produce proinflammatory cytokines in response to B. canis infection and/or to stimulation with factors produced by infected monocytes and neutrophils. These cytokines may contribute to placental inflammation leading to abortion in B. canis-infected pregnant bitches.Fil: Fernandez, Andrea Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Hielpos, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Ferrero, Mariana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Fossati, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Baldi, Pablo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentin

Numerical simulations of normal and oblique impact on single and double-layered aluminium Al6061-T6 plates

Studies of ballistic penetration into metal plates and their numerical simulation currently present an important topic in ballistics, however, no congruent results have been presented so far, especially when it comes to impacts on multi-layered plates. Presently, as far as ballistic limits are concerned, the choice between layered and monolithic structures is not completely straightforward and unproblematic. The effect of introducing air gaps between metallic layers is not fully understood and explained either. Furthermore, these issues are more investigated for normal impacts than for oblique impacts for which only limited results are available. Therefore, the aim of this paper is to conduct a numerical analysis in order to evaluate the effect on the ballistic limit on layered targets for both normal and oblique impacts. A validated numerical methodology will be used, though validated with a limited number of experiments. The target material is an Al6061-T6 aluminium alloy the mechanical behaviour of which (hardening, strain rate, failure, etc.) is already known and described. Several configurations will be numerically tested and the results critically evaluated

CONFRONTO NUMERICO E SPERIMENTALE TRA LA VERSIONE RIVETTATA E INCOLLATA DI UNA GIUNZIONE MECCANICA

Le giunzioni metalliche incollate offrono diversi vantaggi nei confronti dei tradizionali collegamenti meccanici (rivettatura, bullonatura, ecc.), tuttavia richiedono un’estensiva caratterizzazione meccanica al fine di garantire un’adeguata affidabilità delle strutture in cui vengono inserite. In questo lavoro si presentano i risultati delle prove sperimentali e delle simulazioni numeriche condotte nell’ambito della riprogettazione di una giunzione rivettata di un componente reale, sfruttando la tecnologia dell’incollaggio. L’adesivo usato è una resina epossidica bicomponente, caratterizzata attraverso una campagna di prove sperimentali e simulazioni numeriche, su provini di tipo single-lap e T-peel. Si presenta quindi un confronto, sia numerico che sperimentale, delle prestazioni meccaniche della giunzione rivettata con l’analoga giunzione incollata. I risultati hanno evidenziato un sostanziale miglioramento in termini di rigidezza e resistenza con l’uso della tecnica dell’incollaggio

Numerical simulations of an explosion confined inside a cylindrical pipe made of aluminium alloy Al6061-T6

Simulation of the behaviour of structural components subjected to high explosive detonation is one of the current challenges in the field of numerical simulation. Along with experimental tests, numerical analysis is necessary to give an in-depth insight of this event, as well to reduce costs for some further experimental tests. High values of strain rate, temperature and pressure, together with failure phenomenon, govern the complex interaction between the explosion and the structure involved. In a scenario of this type, capabilities and performance of the numerical software used are crucial to the quality and the outcome of the simulation. Besides the simulation itself, this paper provides a comparison between different finite element programs such as ABAQUS, AUTODYN and LS-DYNA in an explosion event. In the event descibed in the paper, the behaviour of tube made of aluminium alloy Al6061-T6 and filled with explosive material is under investigation. A fully coupled Eulerian and Lagrangian formulation is used together with a complete mechanical behaviour and constitutive equations of all the materials involved in the simulation (aluminium alloy Al6061-T6, explosive C4, air). Finally, results and comparison between the mentioned numerical solvers will be reported and critically discussed