Aquagenic urticaria in twins

We describe the case of 18 year old twin brothers who presented to our unit with a 3 year history of aquagenic urticaria. This rare form of urticaria usually presents within an hour of contact with water. The aetiology is unknown. Most cases are sporadic but there are a small number of familial cases in the medical literature. A specific genetic mutation has not yet been found. To our knowledge, this is the first report of aquagenic urticaria in monozygotic twins, further supporting a genetic component to this disease

A survey of the treatment and management of patients with severe chronic spontaneous urticaria.

Chronic spontaneous urticaria (CSU) is characterized by the recurrent appearance of weals, angio‐oedema or both, occurring at least twice weekly for longer than 6 weeks.1 It is often managed with antihistamines, but occasionally requires other systemic agents in recalcitrant cases. A cross‐sectional survey was conducted by means of an internet‐based survey tool (Typeform; https://www.typeform.com). Participating consultants with a specialist interest in urticaria were identified through the specialist registers of the British Society of Allergy and Clinical Immunology (BSACI), the Improving Quality in Allergy Services (IQAS) Group and the British Association of Dermatologists (BAD), and invited to take part. The survey content was based on current CSU treatment guidelines from EAACI/GA2LEN/EDF/WAO1 and the British Society for Allergy and Clinical Immunology (BSACI).2 The EAACI/GA2LEN/EDF/WAO guidelines are a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA2LEN) (a European Union‐funded network of excellence), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO). To standardize responses, all participants were presented with a case of recalcitrant CSU (failed on maximum dose of nonsedating antihistamines and montelukast), requiring alternative systemic treatment. Questions covered usage of systemic treatments, routine disease severity assessments, adherence to treatment guidelines and perceived barriers to prescribing. Responses (Table 1) were received from 19 UK consultants (26 surveys sent; completion rate 73%), 15 of whom had > 10 years’ experience in the treatment of CSU. The majority were allergy (58%) and dermatology consultants (37%). Of the 19 consultants, 56% provide a dedicated urticaria service, 37% treat both adult and paediatric patients, and the majority (79%) use systemic medications other than antihistamines and montelukast. Omalizumab and ciclosporin were the most commonly used first‐line agents (47% and 27% respectively) (Fig. 1). The majority (84%) of consultants use validated measures to assess disease severity, including the weekly Urticaria Activity Score (UAS‐7, 63%), the Physician Global Assessment (63%), the Patient Global Assessment (44%) and the Dermatology Quality of Life Index (DLQI) (38%). Guidelines are used by 89% to direct their management of CSU, with 50% using the EAACI/GA2LEN/EDF/WAO guideline,1 compared with 31% primarily using the BSACI guideline.2 The main perceived barriers to prescribing systemic medications were potential adverse effects (AEs) (32% strongly agreed), potential long‐term toxicity (26% strongly agreed), cost of treatment (42% strongly agreed), and views expressed by the patient and their family (37% agreed)

Applying Brain Research to Classroom Strategies

Research in the field of neuroscience has exploded in the past decade. The word brain appears in the title of nearly 40,000 books and CDs indicating intense interest in this area of study. What can music educators learn from recent investigations—often termed brain research—to guide music teaching and learning? The following ideas are intended to have broad applications and may inspire you to investigate this fascinating area of literature more thoroughly. While some findings are new, other studies affirm what music educators have previously found to be effective

Applying Brain Research to Classroom Strategies

Research in the field of neuroscience has exploded in the past decade. The word brain appears in the title of nearly 40,000 books and CDs indicating intense interest in this area of study. What can music educators learn from recent investigations—often termed brain research—to guide music teaching and learning? The following ideas are intended to have broad applications and may inspire you to investigate this fascinating area of literature more thoroughly. While some findings are new, other studies affirm what music educators have previously found to be effective

The influence of the strength of bone on the deformation of acetabular shells : a laboratory experiment in cadavers

Date of Acceptance: 24/08/2014 ©2015 The British Editorial Society of Bone & Joint Surgery. The authors would like to thank N. Taylor (3D Measurement Company) for his work with regard to data acquisition and processing of experimental data. We would also like to thank Dr A. Blain of Newcastle University for performing the statistical analysis The research was supported by the NIHR Newcastle Biomedical Research Centre. The authors P. Dold, M. Flohr and R. Preuss are employed by Ceramtec GmbH. Martin Bone received a salary from the joint fund. The author or one or more of the authors have received or will receive benefits for personal or professional use from a commercial party related directly or indirectly to the subject of this article. This article was primary edited by G. Scott and first proof edited by J. Scott.Peer reviewedPostprin

The Haldane-Rezayi Quantum Hall State and Conformal Field Theory

We propose field theories for the bulk and edge of a quantum Hall state in the universality class of the Haldane-Rezayi wavefunction. The bulk theory is associated with the $c=-2$ conformal field theory. The topological properties of the state, such as the quasiparticle braiding statistics and ground state degeneracy on a torus, may be deduced from this conformal field theory. The 10-fold degeneracy on a torus is explained by the existence of a logarithmic operator in the $c=-2$ theory; this operator corresponds to a novel bulk excitation in the quantum Hall state. We argue that the edge theory is the $c=1$ chiral Dirac fermion, which is related in a simple way to the $c=-2$ theory of the bulk. This theory is reformulated as a truncated version of a doublet of Dirac fermions in which the $SU(2)$ symmetry -- which corresponds to the spin-rotational symmetry of the quantum Hall system -- is manifest and non-local. We make predictions for the current-voltage characteristics for transport through point contacts.Comment: 37 pages, LaTeX. Some references added, minor changes at the end of section

How to write a Critically Appraised Topic: evidence to underpin routine clinical practice

Critically appraised topics (CATs) are essential tools for busy clinicians who wish to ensure that their daily clinical practice is underpinned by evidence-based medicine. CATs are short summaries of the most up-to-date, high-quality available evidence that is found using thorough structured methods. They can be used to answer specific, patient-orientated questions that arise recurrently in real-life practice. This article provides readers with a detailed guide to performing their own CATs. It is split into four main sections reflecting the four main steps involved in performing a CAT: formulation of a focused question, a search for the most relevant and highest-quality evidence, critical appraisal of the evidence and application of the results back to the patient scenario. As well as helping to improve patient care on an individual basis by answering specific clinical questions that arise, CATs can help spread and share knowledge with colleagues on an international level through publication in the evidence-based dermatology section of the British Journal of Dermatolog

The N=1 triplet vertex operator superalgebras

We introduce a new family of C_2-cofinite N=1 vertex operator superalgebras SW(m), $m \geq 1$, which are natural super analogs of the triplet vertex algebra family W(p), $p \geq 2$, important in logarithmic conformal field theory. We classify irreducible SW(m)-modules and discuss logarithmic modules. We also compute bosonic and fermionic formulas of irreducible SW(m) characters. Finally, we contemplate possible connections between the category of SW(m)-modules and the category of modules for the quantum group U^{small}_q(sl_2), q=e^{\frac{2 \pi i}{2m+1}}, by focusing primarily on properties of characters and the Zhu's algebra A(SW(m)). This paper is a continuation of arXiv:0707.1857.Comment: 53 pages; v2: references added; v3: a few changes; v4: final version, to appear in CM