Setúbal e a Primeira Guerra Mundial (1914-1918)

A presente dissertação é circunscrita no espaço e no tempo, tendo como objecto de estudo fundamental o concelho de Setúbal durante a I Guerra Mundial (1914-1918). Enquadrando historicamente os impactos do conflito no contexto nacional, Setúbal é revisitada entre os finais de oitocentos e os primórdios do século XX a fim de retratar política, económica, social e culturalmente um dos maiores centros urbanos portugueses dos finais da Monarquia Constitucional e do início da I República. Numa lógica de impactos políticos e económico-sociais, esta investigação promove o redescobrir das vivências quotidianas de Setúbal durante um dos períodos mais negros da História da Humanidade. Através do estudo dos mecanismos de acção e intervenção municipais, bem como dos resultados eleitorais e dinâmicas políticopartidárias locais, transmite-se como foram vividos acontecimentos marcantes da vida pública de Portugal, nomeadamente o 14 de Maio de 1915 e o coup d’état sidonista, realçando como dimensões operárias anárquicas e sindicalistas conviviam com grupos conservadores, católicos e monárquicos. Num plano de economia de guerra, o mundo agrícola é abordado em diferentes sectores, nomeadamente na laranja, na cortiça e nos vinhos, dando maior atenção às questões relacionadas com a decadência da fruta e à abertura de novos mercados exportadores, como o Brasil, pela Casa José Maria da Fonseca. A indústria de conservas de peixe, que viveu um boom neste período como resultado da intensa procura externa dos países aliados que tinham nas latas de conserva o alimento das tropas nas trincheiras, representa outro foco de análise deste trabalho. Consequentemente aborda-se o papel da estrutura portuária local na resposta às necessidades de consumo britânicas, francesas e italianas. Por fim, os impactos sociais do conflito em Setúbal constituem um dos enunciados desta investigação, compreendendo como o estudo de uma imprensa dividida na questão intervencionismo versus anti-intervencionismo reflectiu um concelho que viveu como poucos a crise de abastecimentos e a carestia de vida. A proliferação de greves, manifestações contra a guerra, as deserções militares e os assaltos colectivos representam o culminar de um vulcão que entrou em erupção e que ainda sofreu as agruras da epidemia da gripe pneumónica até ao final do ano de 1918.This work is limited in space and time with the object of study the county of Setúbal during World War I (1914-1918). Historically overviewing the impacts of the conflict in Portugal, Setúbal is revisited between the end of nineteenth century and the beginnings of the twentieth century to portray politically, economically, socially and culturally one of the biggest portuguese cities between the end of the constitutional monarchy and the beginning of the First Republic. By studying the political, economic and social impacts of the Great War, this research promotes the rediscovery of the everyday experiences of Setúbal during one of the darkest periods in human history. By analyzing the mechanisms of action and municipal intervention, and also the election results and local political parties, it is transmitted how were experienced significant events of the public life in Portugal, namely 14 May 1915 and the sidonista revolution, stressing as anarchic and union worker’s dimensions lived with conservative, catholic and monarchists groups. By understanding how the economics of war worked, agrarian world is addressed in sectors including orange, cork and wine, focusing its attention on issues related to fruit decay and the creation of new export markets in the House José Maria da Fonseca. One of the epicenters of this dissertation is the canned fish industry, which experienced a boom during this period because of the intense foreign necessities of the allied countries, which saw the canned tins as food for the troops in the trenches. Consequently, addresses the role of the local port structure in response to the british, french and italian consumer needs. Finally, the social impacts of the conflict in Setubal ends the themes studied in this research, understanding how a divided press on the issue interventionism versus antiinterventionism was the reflection of a county that lived like few others the crisis of supply and the high costs of living. The proliferation of strikes and protests against the war, military defections and collective assaults represent the culmination of a volcano that erupted and still suffered the hardships of the pneumonic flu epidemic until the end of the year 1918

Locke's legacy

A organização de um colóquio em torno da “herança de Locke” foi uma ideia que nasceu no Centro de Estudos Anglísticos da Universidade de Lisboa, no âmbito do núcleo de investigação dedicado aos estudos de cultura inglesa. Vários textos de Locke são regularmente incluídos nos programas de graduação e de pósgraduação em Estudos Anglísticos, além de objecto de estudo especializado no Centro de Estudos Anglísticos. Assim, fazia todo o sentido comemorar, no ano de 2004, a passagem de mais um centenário sobre a morte de Locke, e celebrar a vitalidade da sua obra ao longo de três séculos reunindo especialistas que, publicamente, apresentassem e discutissem aspectos dessa obra que continuam activos no presente. O volume que agora se publica reúne as comunicações apresentadas em Janeiro de 2004. A variedade dos temas abordados e a manifesta relevância de que se revestem para o estudo da modernidade demonstram que a herança de Locke continua a produzir riqueza, e que constitui património cultural a ser herdado por novas gerações.Fundação para a Ciência e a Tecnologi

Weaki Desktop App: a tool for agile software documentation

Uma aplicação multi-plataforma para documentação de software em ambiente agile desenvolvida em Node, Electron e React. Weaki foca-se em maximizar a reutilização ao, por exemplo, oferecer um sistema de páginas tipificadas reduzindo assim o esforço necessário aquando se pretende produzir diversas páginas semelhantes. Para além deste aspecto a aplicação também facilita o seu uso ao ter uma interface muito semelhante a outras aplicações usadas pelos developers tais como o editor de texto Atom e ao integrar com ferramentas como o Git.Software documentation is an important aspect of software development but unfortunately nottreated as such most of the time. There are many known ways to document software and theseshould be adopted by the developers taking their work environment into account. The target audi-ence is the most important factor since it dictates the contents and structure of the documentationand assumes the pre-acquired knowledge of the reader. Documentation for the product's end-usershould be completely different to the one viewed by the development team for example.Agile development describes a mindset which focuses on doing only what is required when itis required. This can also be applied to documentation and there is a set of guidelines to followamong which reusability and simplicity stand out. These two guidelines can be interpreted as themost basic requirements for agile software documentation tools.Weaki is a cross-platform desktop application, based on the Electron framework, for agilesoftware documentation meant to extend its web version based on DokuWiki. Its principles arebased on weakly-typed wikis which means that the pages are structured but it is not enforced onthe user who has the freedom to gradually adopt stricter rules but with benefits. Running nativelyon the desktop brings many benefits such as direct access to the file system, integration with Gitand the ability to customize the application to the user.The application is developed with the use of agile methods in which at the end of each iteration,one week-long, there's palpable progress and reports on the situation. Starting by implementingthe core features of the web version of Weaki, at the end of 3 months it is expected to start workingfor the next month on refinements and extra-features such as integrating with Slack, GitHub andGoogle Drive. The results are then compared to the initial goals and the conclusions are taken

Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-04-23T17:44:38Z No. of bitstreams: 1 Moreira DRM Conformational restriction....pdf: 1062616 bytes, checksum: 2f9250256b9569bd49a2a776fd0360cb (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-04-23T18:13:22Z (GMT) No. of bitstreams: 1 Moreira DRM Conformational restriction....pdf: 1062616 bytes, checksum: 2f9250256b9569bd49a2a776fd0360cb (MD5)Made available in DSpace on 2018-04-23T18:13:22Z (GMT). No. of bitstreams: 1 Moreira DRM Conformational restriction....pdf: 1062616 bytes, checksum: 2f9250256b9569bd49a2a776fd0360cb (MD5) Previous issue date: 2014CNPq (grant 471461/2011-3 to A.C.L.L. and 477435/2012-2 to R.S.F.) and FACEPEFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, BrasilUniversidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, BrasilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, BrasilChagas disease, caused by Trypanosoma cruzi, is a life-threatening infection leading to approximately 12,000 deaths per year. T. cruzi is susceptible to thiosemicarbazones, making this class of compounds appealing for drug development. Previously, the homologation of aryl thiosemicarbazones resulted in an increase in anti-T. cruzi activity in comparison to aryl thiosemicarbazones without a spacer group. Here, we report the structural planning, synthesis and anti-T. cruzi evaluation of new aryl thiosemicarbazones (9a-x), designed as more conformationally restricted compounds. By varying substituents attached to the phenyl ring, substituents were observed to retain, enhance or greatly increase the anti-T. cruzi activity, in comparison to the nonsubstituted derivative. In most cases, hydrophobic and bulky substituents, such as bromo, biphenyl and phenoxyl groups, greatly increased antiparasitic activity. Specifically, thiosemicarbazones were identified that inhibit the epimastigote proliferation and were toxic for trypomastigotes without affecting mouse splenocytes viability. The most potent anti-T. cruzi thiosemicarbazones were evaluated against cruzain. However, inhibition of this enzyme was not observed, suggesting that the compounds work through another mechanism. In addition, examination of T. cruzi cell death showed that these thiosemicarbazones induce apoptosis. In conclusion, the structural design executed within the series of aryl thiosemicarbazones (9a-x) led to the identification of new potent anti-T. cruzi agents, such as compounds (9h) and (9r), which greatly inhibited epimastigote proliferation, and demonstrated a toxicity for trypomastigotes, but not for splenocytes. Mechanistically, these compounds do not inhibit the cruzain, but induce T. cruzi cell death by an apoptotic process

Termos de Compromisso de Estágios de 2011 (G)

Neste arquivo contém os TCEs de 25 estagiários no perído de 20/04/2011 à 29/09/2011UFS

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data