21 research outputs found
Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults.
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND: As the population ages, maintaining mental health and well-being of older adults is a public health priority. Beyond objective measures of health, self-perceived quality of life (QoL) is a good indicator of successful aging. In older adults, it has been shown that QoL is related to structural brain changes. However, QoL is a multi-faceted concept and little is known about the specific relationship of each QoL domain to brain structure, nor about the links with other aspects of brain integrity, including white matter microstructure, brain perfusion and amyloid deposition, which are particularly relevant in aging. Therefore, we aimed to better characterize the brain biomarkers associated with each QoL domain using a comprehensive multimodal neuroimaging approach in older adults. METHODS: One hundred and thirty-five cognitively unimpaired older adults (mean age ± SD: 69.4 ± 3.8 y) underwent structural and diffusion magnetic resonance imaging, together with early and late florbetapir positron emission tomography scans. QoL was assessed using the brief version of the World Health Organization's QoL instrument, which allows measuring four distinct domains of QoL: self-perceived physical health, psychological health, social relationships and environment. Multiple regression analyses were carried out to identify the independent global neuroimaging predictor(s) of each QoL domain, and voxel-wise analyses were then conducted with the significant predictor(s) to highlight the brain regions involved. Age, sex, education and the other QoL domains were entered as covariates in these analyses. Finally, forward stepwise multiple regressions were conducted to determine the specific items of the relevant QoL domain(s) that contributed the most to these brain associations. RESULTS: Only physical health QoL was associated with global neuroimaging values, specifically gray matter volume and white matter mean kurtosis, with higher physical health QoL being associated with greater brain integrity. These relationships were still significant after correction for objective physical health and physical activity measures. No association was found with global brain perfusion or global amyloid deposition. Voxel-wise analyses revealed that the relationships with physical health QoL concerned the anterior insula and ventrolateral prefrontal cortex, and the corpus callosum, corona radiata, inferior frontal white matter and cingulum. Self-perceived daily living activities and self-perceived pain and discomfort were the items that contributed the most to these associations with gray matter volume and white matter mean kurtosis, respectively. CONCLUSIONS: Better self-perceived physical health, encompassing daily living activities and pain and discomfort, was the only QoL domain related to brain structural integrity including higher global gray matter volume and global white matter microstructural integrity in cognitively unimpaired older adults. The relationships involved brain structures belonging to the salience network, the pain pathway and the empathy network. While previous studies showed a link between objective measures of physical health, our findings specifically highlight the relevance of monitoring and promoting self-perceived physical health in the older population. Longitudinal studies are needed to assess the direction and causality of the relationships between QoL and brain integrity
The value of open-source clinical science in pandemic response: lessons from ISARIC
- Author
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- Wicky P. H.
- Wiedemann A.
- Wijaya S. O.
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- Williams V.
- Wils E. -J.
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- Yamazaki M.
- Yazdanpanah Y.
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- Yeoh C. H.
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- Yonis H.
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- Zambon M.
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- Zucman D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
- Abdukahil S. A.
- Abdulkadir N. N.
- Abe R.
- Abel L.
- Abrous A.
- Absil L.
- Acker A.
- Adam E.
- Adriao D.
- Ahmed S.
- Ainscough K.
- Aisa T.
- Akimoto T.
- Akmal E.
- Akwani C.
- Al Ageel S.
- Al Qasim E.
- Al-dabbous T.
- Al-Fares A.
- Alalqam R.
- Alberti A.
- Alegesan S.
- Alessi M.
- Alex B.
- Alexander P. M. A.
- Alexandre K.
- Alfoudri H.
- Ali I.
- Alidjnou K. E.
- Aliudin J.
- Alkhafajee Q.
- Allavena C.
- Allou N.
- Alves J.
- Alves J. M.
- Alves R.
- Amaral M.
- Amira N.
- Ampaw P.
- Andini R.
- Andrejak C.
- Angheben A.
- Angoulvant F.
- Ansart S.
- Anthonidass S.
- Antonelli M.
- Apriyana A.
- Arabi Y.
- Aragao I.
- Arancibia F.
- Araujo C.
- Arcadipane A.
- Archambault P.
- Arenz L.
- Arlet J. -B.
- Arnold-Day C.
- Arora L.
- Arora R.
- Artaud-Macari E.
- Aryal D.
- Asensio A.
- Ashraf M.
- Assie J. B.
- Asyraf A.
- Atif M.
- Atikah Ahmad Ridzuan S. N.
- Atique A.
- Auchabie J.
- Aumaitre H.
- Auvet A.
- Ayadi Kamaluddin M. A.
- Azemar L.
- Azoulay C.
- Bach B.
- Bachelet D.
- Badr C.
- Baig N.
- Baillie J. K.
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- Bakakos A.
- Bakar N. A.
- Bal A.
- Balakrishnan M.
- Balan V.
- Balazote P. S.
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- Barbalho R.
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings
The value of open-source clinical science in pandemic response: lessons from ISARIC
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- Zucman D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
- Author
- Abbas A.
- Abdukahil S. A.
- Abdulkadir N. N.
- Abe R.
- Abel L.
- Absil L.
- Acharya S.
- Acker A.
- Adam E.
- Adriao D.
- Ahmed S.
- Ainscough K.
- Airlangga E.
- Aisa T.
- Akimoto T.
- Akmal E.
- Al Ageel S.
- Al Qasim E.
- Al-Dabbous T.
- Al-Fares A.
- Alalqam R.
- Alberti A.
- Alegesan S.
- Alegre C.
- Alessi M.
- Alex B.
- Alexandre K.
- Alfoudri H.
- Ali A.
- Ali I.
- Alidjnou K. E.
- Aliudin J.
- Alkhafajee Q.
- Allavena C.
- Allou N.
- Altaf A.
- Alves J.
- Alves J. M.
- Alves R.
- Amaral M.
- Amira N.
- Ampaw P.
- Andini R.
- Andrejak C.
- Angheben A.
- Angoulvant F.
- Ansart S.
- Anthonidass S.
- Antonelli M.
- Antunes De Brito C. A.
- Apriyana A.
- Arabi Y.
- Aragao I.
- Arancibia F.
- Araujo C.
- Arcadipane A.
- Archambault P.
- Arenz L.
- Argin G.
- Arlet J. -B.
- Arnold-Day C.
- Arora L.
- Arora R.
- Artaud-Macari E.
- Aryal D.
- Asensio A.
- Ashraf M.
- Asif N.
- Asim M.
- Assie J. B.
- Asyraf A.
- Atique A.
- Attanyake A. M. U. L.
- Auchabie J.
- Aumaitre H.
- Auvet A.
- Azemar L.
- Azoulay C.
- Bach B.
- Bachelet D.
- Badr C.
- Baig N.
- Baillie J. K.
- Baird J. K.
- Bak E.
- Bakakos A.
- Bakar N. A.
- Bal A.
- Balakrishnan M.
- Balan V.
- Bani-Sadr F.
- Barbalho R.
- Barbosa N. Y.
- Barclay W. S.
- Barnett S. U.
- Barnikel M.
- Barrasa H.
- Barrelet A.
- Barrigoto C.
- Barrio N. G.
- Bartoli M.
- Baruch J.
- Bashir M.
- Basmaci R.
- Basri M. F. H.
- Battaglini D.
- Bauer J.
- Bautista Rincon D. F.
- Bazan Dow D.
- Beane A.
- Bedossa A.
- Bee K. H.
- Begum H.
- Behilill S.
- Beishuizen A.
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- Beljantsev A.
- Bellemare D.
- Beltrame A.
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- Bennett S.
- Bento L.
- Berdal J. -E.
- Bergeaud D.
- Bergin H.
- Bernal Sobrino J. L.
- Bertoli G.
- Bertolino L.
- Bessis S.
- Bevilcaqua S.
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- Bhatt A.
- Bhavsar K.
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ~30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death
Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study
- Author
- Ada Ebo
- Adam Ali
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Agnès Meybeck
- Agnès Sommet
- Aidan Burrell
- Alamin Mustafa
- Albert Sotto
- Aldric Manuel
- Alexa Debard
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Aline-Marie Florence
- Alison M Meynert
- Alistair D Nichol
- Aliya Mohammed Alameen
- Alpha Diallo
- Alphonsine Diouf
- Amal Abrous
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amiel A Dror
- Ana da SilvaFilipe
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Tveita
- Andrea Angheben
- Andrea Cortegiani
- Andrea Rossanese
- Andreas Lind
- Andrew Dagens
- André Cabie
- Andy Law
- Anissa Chair
- Ankana Satya
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne-Hélène Boivin
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annemarie B Docherty
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonia Ricchiuto
- Antonio Lalueza
- Ariel Bolanga
- Arnaud Scherpereel
- Arne Søraas
- Arsène Kpangon
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Barbara Wanjiru Citarella
- Bato Hammarström
- Battaglini Denise
- Beatrice Alex
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Berline Fotso
- Bernard Cholley
- Bertrand Dussol
- Birgitte Stiksrud
- Blandine Rammaert
- Bouchra Loufti
- Brigitte Elharrar
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Cameron J Fairfield
- Camile Bouisse
- Camille Couffignal
- Cammandji Damien
- Carine Roy
- Caroline Mudara
- Carrol Gamble
- Catherine A Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Cecile Azoulay
- Cedric Djadda
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Charpentier
- Charlotte Summers
- Chiara Piubelli
- Cho Sung-Min
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A Green
- Claire Andrejak
- Claire Levy-Marchal
- Clare Jackson
- Clark D Russell
- Claudine Badr
- Clotilde Allavena
- Clément Bihan
- Colin McArthur
- Coralie Tardivon
- Cristina De Rose
- Cyril Bris
- Cyril Cadoz
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cécile Yelnik
- Cédric Joseph
- Cédric Laouénan
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- Damien Bouhour
- Daniel Glikman
- Daniel Perez
- Danielle Jaafar
- Danilo Buonsenso
- Dario Sinatti
- David L Robertson
- David Stuart
- David Zucma
- Debby Bogaert
- Deepjyoti Kalita
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Denis Garot
- Denis Malvy
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Diana Hernandez
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Dominique Deplanque
- Dominique Luton
- Donald Buri
- Drashti Patel
- Duc Nguyen
- Eder Caceres
- Edouard Soum
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elisabetta Spinuzza
- Elise Artaud-Macari
- Elodie Curlier
- Elsa Nyamankolly
- Else Quist-Paulsen
- Emma C Thomson
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric Delaveuve
- Eric D’Ortenzio
- Eric Oziol
- Eric Senneville
- Erwan Fourn
- Erwan L’Her
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eve Defous
- Ewen M Harrison
- Eyrun Floerecke Kjetland Kjetland
- Eyvind W Axelsen
- Fabrice Laine
- Fanny Vuotto
- Fara Diop
- Fernanda Dias Da Silva
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- Fouda Atangana
- France Mentré
- François Angoulvant
- François Dubos
- François Goehringer
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Fredrik Müller
- Félix Djossou
- Gabriel Macheda
- Gail Carson
- Galyna Kutsyna
- Gary Leeming
- Gayatri Vishwanathan
- Geoffrey Liegeon
- Georges Falher
- Georgios Pollakis
- Gervais Eneli
- Gilles Peytavin
- Girish Sindhwani
- Giulia Bertoli
- Grace Assi
- Graham S Cooke
- Grégory Corvaisier
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guylaine Castor-Alexandre
- Gwenaël Moal
- Gwenhaël Colin
- Haider Hirkani
- Hayley Hardwick
- Hervé Nagard
- Hiba Zayyad &
- Hikombo Hitoto
- Hodane Yonis
- Hugo Mouquet
- Hugues Aumaitre
- Hugues Cordel
- Husna Begum
- Hélène Esperou
- Hélène Salvator
- Ikram Houas
- Ilka Engelmann
- Ingrid G Bustos
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Michelet
- ISARIC Clinical Characterization Group Laurent Abel
- Jade Ghosn
- Jaime Cruz Rojo
- Jake Dunning
- James Lee
- James Scott-Brown
- Janet Harrison
- Janet T Scott
- Jean Baptiste Assie
- Jean-Benoît Arlet
- Jean-Charles Gagnard
- Jean-Daniel Lelievre
- Jean-François Payen
- Jean-François Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-Sébastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jennifer Lee
- Jia Wei
- Jimmy Mullaert
- Jo Dalton
- Joaquín Baruch
- Johann Auchabie
- John Arne Dahl
- John Kenneth Baillie
- John Marshall
- Jose Andres Calvache
- José Luis Bernal Sobrino
- Juan Luis Cruz Bermúdez
- Jules Bauer
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Justine Pages
- Jérémie Guedj
- Jérémie Pasquier
- Jérôme Dimet
- Kalynn Kennon
- Kamal Abu Jabal
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Kazali Enagnon Alidjnou
- Kenneth A McLean
- Krish Kherajani
- Krishna Bhavsar
- Kristian Tonby
- Kyle Gomez
- Kévin Alexandre
- Kévin Bouiller
- Kévin Didier
- Laetitia Bodenes
- Lance C. W. Turtle
- Lars Heggelund
- Laura Marsh
- Laura Merson
- Laure Goubert
- Lauren Eloundou
- Laurence Bouillet
- Laurence Maulin
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- Laurène Azemar
- Leonard Numfor
- Liem Luong
- Lila Bouadma
- Linda Gail Skeie
- Linn Margrete Eggesbø
- Lionel Piroth
- Liv Hesstvedt
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lucia Moro
- Lucie Fevre
- Lucille Blumberg
- Lysa Tagherset
- Léo Chenard
- Mahdad Noursadeghi
- Mahendra Singh
- Maire-Laure Casanova
- Malcolm G Semple
- Manuel Etienne
- Manuel Rosa-Calatrava
- Manuella Ademnou
- Marc Fabre
- Marc Lambert
- Marc Leone
- Margaux Isnard
- Maria Zambon
- Mariachiara Ippolito
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marina Esposito-Farese
- Marine Beluze
- Marine Livrozet
- Marion Maréchal
- Marion Schneider
- Marion Zabbe
- Mark G Pritchard
- Marlène Murris
- Marta Alessi
- Martin Guego
- Martin Martinot
- Martine Remy
- Massimo Palmarini
- Mathew Thorpe
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvallées
- Matthew Hall
- Matthieu Revest
- Maude Bouscambert
- Maxime Hentzien
- Mayka Mergeay-Fabre
- Maïder Pagadoy
- Meera Chand
- Mehdi Mezidi
- Mercé Jourdain
- Merete Ellingjord-Dale
- Merson Laura
- Michael Edelstein
- Michelle Girvan
- Miles Lunn
- Minerva Cervantes-Gonzalez
- Minh Le
- Mirjam Evers
- Mohammed ElSanharawi
- Moise Massoma
- Moïse Machado
- Murray Dryden
- Murray Wham
- Mylène Maillet
- Mélanie Roriz
- Nadhem Lafhej
- Nadia Ouamara
- Nadia Saidani
- Nadir Hadri
- Nadège Neant
- Nastia Medombou
- Natalie Wright
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Nerissa Niba
- Nicholas Sedillot
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Noelia García Barrio
- Noémie Mercier
- Noémie Tissot
- Noémie Vanel
- Oana Săndulescu
- Odile Launay
- Oksana Kruglova
- Olga Martynenko
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Ouifiya Kafif
- Palmer Masumbe
- Paola Rodari
- Pascal Granier
- Pasquale Anania
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Loubet
- Paul Otiku
- Pauline Caraux-Paz
- Peter Horby
- Peter Openshaw
- Philippine Eloy
- Piero L Olliaro
- Piero Valentini
- Pierre Delobel
- Pierre Ondobo
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marie Roger
- Premraj Lavienraj
- Pulak Kedia
- Quentin Hingrat
- Quentin Lepiller
- Rachael Parke
- Rachel Essaka
- Rachida Ouissa
- Rafael Mahieu
- Raphaël Borie
- Raphaël Favory
- Rebecca Hamidfar
- Renaud Tamisier
- Richa Su
- Riinu Pius
- Roar Bævre-Jensen
- Robba Chiara
- Robert A Fowler
- Roberta Meta
- Rohan Shetty
- Romain Basmaci
- Romain Decours
- Romain Guery
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rupert Higgins
- Ryadh Pokeerbux
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sadie Kelly
- Sakshi Lath
- Salma Jaafoura
- Samira Laribi
- Samreen Ijaz
- Samuel Markowicz
- Sandra Bichoka
- Sandrine Couffin-Cadiergues
- Sara Clohisey
- Sarah E McDonald
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Tubiana
- Saye Khoo
- Segolène Greffe
- Seán Keating
- Shiranee Sriskandan
- Shona C Moore
- Simon Bessis
- Simon-Djamel Thiberville
- Soizic Mestre
- Sonja Hjellegjerde Brunvoll
- Sophie Halpin
- Sophie Letrou
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stephanie Kouba
- Stephanie Roberts
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphanie Cousse
- Stéphanie Fry
- Sue Smith
- Susanne Dudman
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie Kwedi
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Sébastien Preau
- Sérgio Gaião
- Séverine Ansart
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Drake
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomson David
- Thushan de Silva
- Tiffany Trouillon
- Timothy M Uyeki
- Tiphaine Goulenok
- Tom Fletcher
- Tom Solomon
- Tristan Gigante
- Trude Steinsvik
- Vadim Tieroshyn
- Valentine Campana
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Victoria Manda
- Victoria Shaw
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Véronique Lemee
- Waasila Jassat
- Walter Picard
- Wanjiru Citarella Barbara
- Wendy S Barclay
- White Nicole M
- William A Paxton
- William Finlayson
- William Greenhalf
- Wilna Oosthuyzen
- Xavier Duval
- Yanay Gorelik
- Yash Doshi
- Yazdan Yazdanpanah
- Yoan Lavie-Badie
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yves Levy
- Zeno Bisoffi
- Publication venue
- Publication date
- 06/12/2023
- Field of study
in this study we aimed to characterize the type and prevalence of neurological symptoms related to neurological long-COVID-19 from a large international multicenter cohort of adults after discharge from hospital for acute COVID-19
Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study
- Author
- Adam Ali
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Agnès Meybeck
- Agnès Sommet
- Aidan Burrell
- Albert Sotto
- Aldric Manuel
- Aleksander Rygh Holten
- Alexa Debard
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Aline-Marie Florence
- Alison M Meynert
- Alistair D Nichol
- Aliya Mohammed Alameen
- Alpha Diallo
- Alphonsine Diouf
- Amal Abrous
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amiel A Dror
- Ana da Silva Filipe
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Benteson Nygaard
- Anders Tveita
- Andrea Angheben
- Andrea Cortegiani
- Andrea Rossanese
- Andreas Lind
- Andrew Dagens
- André Cabie
- Andy Law
- Anissa Chair
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne-Hélène Boivin
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annemarie B Docherty
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonia Ricchiuto
- Antonio Lalueza
- Arnaud Scherpereel
- Arne Søraas
- Arora Rakesh C
- Arsène Kpangon
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Aurore Bousquet
- Axelle Braconnier
- Baillie Kenneth
- Barbara Wanjiru Citarella
- Bassi Gianluigi Li
- Bato Hammarström
- Battaglini Denise
- Beathe Kiland Granerud
- Beatrice Alex
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Bernard Cholley
- Bertrand Dussol
- Bénédicte Lefebvre
- Birgitte Stiksrud
- Blandine Rammaert
- Bouchra Loufti
- Brigitte Elharrar
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Cameron J Fairfield
- Camile Bouisse
- Camille Couffignal
- Carine Roy
- Carlos Lumbreras Bermejo
- Carrol Gamble
- Catherine A Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Cecile Azoulay
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cécile Yelnik
- Cédric Joseph
- Cédric Laouénan
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Charpentier
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chiara Piubelli
- Cho Sung-Min
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A Green
- Citarella Barbara Wanjiru
- Claire Andréjak
- Claire Levy-Marchal
- Clara Mouton Perrot
- Clare Jackson
- Clark D Russell
- Claudia Milena Orozco-Chamorro
- Claudine Badr
- Clément Le Bihan
- Clotilde Allavena
- Colin McArthur
- Coralie Tardivon
- Cristina De Rose
- Cyril Cadoz
- Cyril Le Bris
- Dag Henrik Reikvam
- Damien Bouhour
- Daniel Glikman
- Daniel Perez
- Danielle Jaafar
- Danilo Buonsenso
- Dario Sinatti
- David L Robertson
- David Stuart
- David Zucman
- Debby Bogaert
- Deepjyoti Kalita
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Denis Garot
- Denis Malvy
- Diana Hernandez
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Dominique Deplanque
- Dominique Luton
- Duc Nguyen
- Eder Caceres
- Edouard Soum
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elisabetta Spinuzza
- Elise Artaud-Macari
- Elodie Curlier
- Elsa Nyamankolly
- Else Quist-Paulsen
- Emma C Thomson
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric D'Ortenzio
- Eric Delaveuve
- Eric Oziol
- Eric Senneville
- Erwan Fourn
- Erwan L'Her
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eve Defous
- Ewen M Harrison
- Eyrun Floerecke Kjetland Kjetland
- Eyvind W Axelsen
- Fabrice Laine
- Fanning Jonathon Paul
- Fanny Vuotto
- Fara Diop
- Fernanda Dias Da Silva
- Félix Djossou
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- France Mentré
- François Angoulvant
- François Bompart
- François Dubos
- François Goehringer
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Frank Olav Pettersen
- Fraser John
- Fredrik Müller
- Gabriel Macheda
- Gail Carson
- Galyna Kutsyna
- Gary Leeming
- Geoffrey Liegeon
- Georges Le Falher
- Georgios Pollakis
- Gilles Peytavin
- Girish Sindhwani
- Giulia Bertoli
- Graham S Cooke
- Grégory Corvaisier
- Griffee Matthew
- Gry Kloumann Bekken
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guillermo Maestro de la Calle
- Guylaine Castor-Alexandre
- Gwenaël Le Moal
- Gwenhaël Colin
- Hayley Hardwick
- Hervé Le Nagard
- Hélène Esperou
- Hélène Salvator
- Hiba Abu Zayyad
- Hikombo Hitoto
- Hodane Yonis
- Hugo Mouquet
- Hugues Aumaitre
- Hugues Cordel
- Husna Begum
- Ikram Houas
- Ilka Engelmann
- Ingrid G Bustos
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Michelet
- ISARIC Clinical Characterization Group: Laurent Abel
- Jade Ghosn
- Jaime Cruz Rojo
- Jake Dunning
- James Scott-Brown
- Jan Cato Holter
- Janet Harrison
- Janet T Scott
- Jean Baptiste Assie
- Jean Christophe Lucet
- Jean-Benoît Arlet
- Jean-Charles Gagnard
- Jean-Daniel Lelievre
- Jean-François Payen
- Jean-François Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-Sébastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jennifer Lee
- Jérémie Guedj
- Jérémie Pasquier
- Jérôme Dimet
- Jia Wei
- Jimmy Mullaert
- Jo Dalton
- Joaquín Baruch
- Johann Auchabie
- John Arne Dahl
- John Kenneth Baillie
- John Marshall
- Jose Andres Calvache
- José Luis Bernal Sobrino
- Juan Luis Cruz Bermúdez
- Jules Bauer
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Justine Pages
- Kalynn Kennon
- Kamal Abu Jabal
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Karl Erik Müller
- Karl Trygve Kalleberg
- Kazali Enagnon Alidjnou
- Kenneth A McLean
- Kévin Alexandre
- Kévin Bouiller
- Kévin Didier
- Krishna Bhavsar
- Kristian Tonby
- Kyle Gomez
- Laetitia Bodenes
- Lance C W Turtle
- Lars Heggelund
- Laura Merson
- Laure Goubert
- Laurence Bouillet
- Laurence Maulin
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- Laurène Azemar
- Lene Bergendal Solberg
- Léo Chenard
- Liem Luong
- Lila Bouadma
- Lina Morales Cely
- Linda Gail Skeie
- Linn Margrete Eggesbø
- Lionel Piroth
- Liv Hesstvedt
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lucia Moro
- Lucie Le Fevre
- Luis Felipe Reyes
- Lysa Tagherset
- Mahdad Noursadeghi
- Maire-Laure Casanova
- Maïder Pagadoy
- Malcolm G Semple
- Manuel Etienne
- Manuel Rosa-Calatrava
- Marc Fabre
- Marc Lambert
- Marc Leone
- Margaux Isnard
- Maria Zambon
- Mariachiara Ippolito
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marina Esposito-Farese
- Marine Beluze
- Marine Livrozet
- Marion Le Maréchal
- Marion Schneider
- Marion Zabbe
- Mark G Pritchard
- Marlène Murris
- Marta Alessi
- Martin Guego
- Martin Martinot
- Martine Remy
- Massimo Palmarini
- Mathew Thorpe
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvallées
- Matthew Hall
- Matthieu Revest
- Maude Bouscambert
- Maxime Hentzien
- Mayka Mergeay-Fabre
- Meera Chand
- Mehdi Mezidi
- Mercé Jourdain
- Merete Ellingjord-Dale
- Merson Laura
- Mette Stausland Istre
- Mélanie Roriz
- Michael Edelstein
- Michelle Girvan
- Miguel Pedrera Jiménez
- Miles Lunn
- Minerva Cervantes-Gonzalez
- Minh Le
- Mirjam Evers
- Mohammed El Sanharawi
- Moïse Machado
- Murray Wham
- Mylène Maillet
- Nadège Neant
- Nadhem Lafhej
- Nadia Ouamara
- Nadir Hadri
- Nassima Si Mohammed
- Natalie Wright
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Nicholas Sedillot
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Noelia García Barrio
- Noémie Mercier
- Noémie Tissot
- Noémie Vanel
- Oana Sandulescu
- Odile Launay
- Oksana Kruglova
- Olga Martynenko
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Ouifiya Kafif
- Pablo Serrano Balazote
- Paola Rodari
- Paolo Cattaneo
- Pascal Granier
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Loubet
- Paul Otiku
- Pauline Caraux-Paz
- Peter Horby
- Peter Openshaw
- Philippine Eloy
- Piero L Olliaro
- Piero Valentini
- Pierre Delobel
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marie Roger
- Prasan Kumar Panda
- Premraj Lavienraj
- Quentin Le Hingrat
- Quentin Lepiller
- Rachael Parke
- Rachida Ouissa
- Rafael Mahieu
- Raphaël Borie
- Raphaël Favory
- Rebecca Hamidfar
- Renaud Tamisier
- Richa Su
- Riinu Pius
- Roar Bævre-Jensen
- Robba Chiara
- Robert A Fowler
- Roberta Meta
- Roberto Roncon-Albuquerque
- Romain Basmaci
- Romain Decours
- Romain Guery
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rupert Higgins
- Ryadh Pokeerbux
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sadie Kelly
- Salma Jaafoura
- Samira Laribi
- Samreen Ijaz
- Samuel Markowicz
- Sandrine Couffin-Cadiergues
- Sara Clohisey
- Sarah E McDonald
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Tubiana
- Saye Khoo
- Scott Janet T
- Seán Keating
- Segolène Greffe
- Semple Malcolm G
- Sébastien Preau
- Sérgio Gaião
- Séverine Ansart
- Shiranee Sriskandan
- Shona C Moore
- Sigfrid Louise
- Silje Bakken Jørgensen
- Simon Bessis
- Simon-Djamel Thiberville
- Soizic Le Mestre
- Solomon Tom
- Sonja Hjellegjerde Brunvoll
- Sophie Halpin
- Sophie Letrou
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stephanie Roberts
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphanie Cousse
- Stéphanie Fry
- Sue Smith
- Suen Jacky
- Susanne Dudman
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Drake
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomson David
- Thushan de Silva
- Tiffany Trouillon
- Timothy M Uyeki
- Tiphaine Goulenok
- Tom Fletcher
- Tom Solomon
- Tristan Gigante
- Trude Steinsvik
- Vadim Tieroshyn
- Valentine Campana
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Véronique Lemee
- Victoria Manda
- Victoria Shaw
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Víctor Quirós González
- Walter Picard
- Wei Shen Lim
- Wendy S Barclay
- White Nicole
- Whitman Glenn
- William A Paxton
- William Finlayson
- William Greenhalf
- Wilna Oosthuyzen
- Xavier Duval
- Yanay Gorelik
- Yazdan Yazdanpanah
- Yoan Lavie-Badie
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yves Levy
- Zeno Bisoffi
- Publication venue
- Publication date
- 09/02/2024
- Field of study
: Although it is known that coronavirus disease 2019 can present with a range of neurological manifestations and in-hospital complications, sparse data exist on whether these initial neurological symptoms of coronavirus disease 2019 are closely associated with post-acute neurological sequelae of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; PANSC) and whether female versus male sex impacts symptom resolution. In this international, multi-centre, prospective, observational study across 407 sites from 15 countries (30 January 2020 to 30 April 2022), we report the prevalence and risk factors of PANSC among hospitalized adults and investigate the differences between males and females on neurological symptom resolution over time. PANSC symptoms included altered consciousness/confusion, fatigue/malaise, anosmia, dysgeusia and muscle ache/joint pain, on which information was collected at index hospitalization and during follow-up assessments. The analysis considered a time to the resolution of individual and all neurological symptoms. The resulting times were modelled by Weibull regression, assuming mixed-case interval censoring, with sex and age included as covariates. The model results were summarized as cumulative probability functions and age-adjusted and sex-adjusted median times to resolution. We included 6862 hospitalized adults with coronavirus disease 2019, who had follow-up assessments. The median age of the participants was 57 years (39.2% females). Males and females had similar baseline characteristics, except that more males (versus females) were admitted to the intensive care unit (30.5 versus 20.3%) and received mechanical ventilation (17.2 versus 11.8%). Approximately 70% of patients had multiple neurological symptoms at the first follow-up (median = 102 days). Fatigue (49.9%) and myalgia/arthralgia (45.2%) were the most prevalent symptoms of PANSC at the initial follow-up. The reported prevalence in females was generally higher (versus males) for all symptoms. At 12 months, anosmia and dysgeusia were resolved in most patients, although fatigue, altered consciousness and myalgia remained unresolved in >10% of the cohort. Females had a longer time to the resolution (5.2 versus 3.4 months) of neurological symptoms at follow-up for those with more than one neurological symptom. In the multivariable analysis, males were associated with a shorter time to the resolution of symptoms (hazard ratio = 1.53; 95% confidence interval = 1.39-1.69). Intensive care unit admission was associated with a longer time to the resolution of symptoms (hazard ratio = 0.68; 95% confidence interval = 0.60-0.77). Post-discharge stroke was uncommon (0.3% in females and 0.5% in males). Despite the methodological challenges involved in the collection of survey data, this international multi-centre prospective cohort study demonstrated that PANSC following index hospitalization was high. Symptom prevalence was higher and took longer to resolve in females than in males. This supported the fact that while males were sicker during acute illness, females were disproportionately affected by PANSC
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
- Author
- Aasiyah Rashan
- Abid Khatak
- Abigail Beane
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnes Meybeck
- Agnes Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Rahman
- Ahmed Farooq
- Aidan Burrell
- Albert Groenendijk
- Albert Sotto
- Albertus Beishuizen
- Aldric Manuel
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexandra Bedossa
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- Alexandre Ducancelle
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- Ali Hachemi
- Alif Adlan Thabit
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- Andrea Angheben
- Andrea Rossanese
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- Ashraf Sheharyar
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- Bronner P. Gonçalves
- Bruno Levy
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- Christelle Paul
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- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Claire Andrejak
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- Clara Flateau
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- Clare Jackson
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- Claudia Figueiredo-Mello
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- Didier Laureillard
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- Diogo Borges
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- Eva Geraud
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- Ewa Talarek
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
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- Filipa Cardoso
- Filipe Cardoso
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- Florence Jego
- Florent Peelman
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- France Mentré
- François Angoulvant
- François Bissuel
- François Bompart
- François Dubos
- François Goehringer
- François Lellouche
- François Martin Carrier
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Félix Djossou
- Gabriel Macheda
- Gail Carson
- Gamage Dona Priyadarshani
- Gan Ee Xian
- Ganesh Kumar
- Gary Leeming
- Geoffrey Liegeon
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- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Gilles Peytavin
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- Giulia Bertoli
- Graham S. Cooke
- Grazielle Viana Ramos
- Gry Kloumann Bekken
- Grégory Corvaisier
- Gugapriyaa Muyandy
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guillermo Maestro de la Calle
- Guylaine Castor-Alexandre
- Gwenaël Le Moal
- Gwenhaël Colin
- Ha Sha Lene
- Hajnal-Gabriela Illes
- Hanan Fateena
- Hanna Renk
- Hannah Habraken
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- Harald Vonkeman
- Hashmi Madiha
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- Heidi Gruner
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- Himed Musaab
- Hiu Jian Chua
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- Huda Alfoudri
- Hugo Inácio
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- Husna Begum
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- Ilka Engelmann
- Ilonka van Veen
- Ingrid G Bustos
- Irfan Khan
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
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- Ithan D. Peltan
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- J. Kenneth Baillie
- Jacky Y. Suen
- Jade Ghosn
- Jaganathan Selvanayagam
- Jaime Cruz Rojo
- Jake Dunning
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- James Lee
- James Scott-Brown
- James Vickers
- Jananee Thirumanickam
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- Janet T. Scott
- Jaques Sztajnbok
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- Jean-Charles Preiser
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- Jean-Daniel Lelievre
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- Jennifer Lee
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- Jia Wei
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- Jimmy Mullaert
- Jin Yi Goh
- Jo Dalton
- Joana Alves Cabrita
- Joana Ferrão
- Joaquín Baruch
- Job van der Palen
- Johann Auchabie
- John F Fraser
- John Marshall
- Jolanta Popielska
- Jonathan Bitton
- Jonathan Chua
- Jonathan Remppis
- Jordan Zhien Toh
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Jose Andres Calvache
- Jose M. Mandei
- Joshua Solomon
- José Casimiro
- José Ernesto Vidal
- José Luis Sobrino
- José Ramalho
- João Estevão
- João Teixeira
- Juan Luis Bermúdez
- Jules Bauer
- Julian Chica
- Juliana Damas
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Juliette Patrier
- Juliette Romaru
- Justine Pages Maïder Pagadoy
- Jérémie Pasquier
- Jérôme Dimet
- Kah Chuan Lim
- Kalaiarasu Peariasamy
- Kalynn Kennon
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Karisha Sivam
- Karl Erik Müller
- Karolina Nowicka
- Katharina Weil
- Kathy Brickell
- Katie O'Hearn
- Kazali Enagnon Alidjnou
- Kenneth A McLean
- Ker Hong Bee
- Kevin Katz
- Khor How Kiat
- Kim Keat Tan
- Kok Wei Hao
- Kong Yeow Kang
- Konrad Zawadka
- Krishna Bhavsar
- Kuan Pei Xuan
- Kusum Menon
- Kévin Alexandre
- Kévin Bouiller
- Kévin Didier
- Laetitia Bodenes
- Lai Hui Pang
- Lance C.W. Turtle
- Lara Absil
- Lars Heggelund
- Laura Marsh
- Laura Merson
- Laure Goubert
- Lauren Deconninck
- Laurence Bouillet
- Laurence Maulin
- Laurent Abel
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- Laurène Azemar
- Lee Lee Low
- Leong Chee Loon
- Leong Chin Tho
- Liem Luong
- Lila Bouadma
- Lim Lina
- Lim Saio Xian
- Lim Yuen Han
- Lina Morales Cely
- Linda O'Shea
- Lionel Eric Benjiman
- Lionel Piroth
- Lisa Norman
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lucia Moro
- Lucie Le Fevre
- Lucille Blumberg
- Luis Felipe Reyes
- Luís Val-Flores
- Lysa Tagherset
- M Azhari Taufik
- Mageswari Selvarajoo
- Mahdad Noursadeghi
- Maire-Laure Casanova
- Malcolm G. Semple
- Malte Kohns Vasconcelos
- Malte Kohns Vasconcelos
- Manuel Etienne
- Manuel Rosa-Calatrava
- Maram Zahran
- Marc Fabre
- Marc Lambert
- Marc Leone
- Marcel van den Berge
- Marcela Vieira Freire
- Margarida Torres
- Margaux Isnard
- Maria Amaral
- Maria Donnelly
- Maria Pokorska-Spiewak
- Maria Zambon
- Mariana Cascão
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marieke Haalboom
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marije Lowik
- Marina Esposito-Farèse
- Marina Lanza
- Marine Beluze
- Marine Livrozet
- Marion Le Maréchal
- Marion Noret
- Marion Schneider
- Marion Zabbe
- Marjolein Brusse-Keizer
- Mark G. Pritchard
- Mark Joseph
- Marlene Murris
- Marsilla Marzukie
- Marta Leal Santos
- Marta Torre
- Martin Guego
- Martin Martinot
- Martina Escher
- Martine Remy
- Mary Copland
- Marília Andreia Fernandes
- Masliza Zahid
- Massimo Palmarini
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvallées
- Matthew Hall
- Matthew Pellan Cheng
- Matthieu Revest
- Maude Bouscambert
- Maureen Masha
- Maxime Hentzien
- Maximilien Saint-Gilles
- Mayka Mergeay-Fabre
- Meera Chand
- Megan Coles
- Mehdi Mezidi
- Melissa Parker
- Menaldi Rasmin
- Merce Jourdain
- Mical Paul
- Michael Rose
- Michele Petrovic
- Michelle Girvan
- Miguel Pedrera Jiménez
- Minerva Cervantes-Gonzalez
- Minh Le
- Mirjam Evers
- Mohammad Shamsah
- Mohammed El Sanharawi
- Mohammed Quraishi
- Mohan Dass Pathmanathan
- Mohanaprasanth Balakrishnan
- Mohd Nazlin Kamarudin
- Mohiuddin Shiekh
- Morgane Gilg
- Morgane Snacken
- Moshe Matan
- Moïse Machado
- Muhammad Aisar Kamaluddin
- Muhammad Ashraf
- Muhammad Fadhli Basri
- Muhammad Rayhan
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mylène Maillet
- Mário Ferraz
- Mélanie Roriz
- Nadia Ettalhaoui
- Nadia Malik
- Nadia Ouamara
- Nadiah Ismail
- Nadiah Kamarudin
- Nadir Hadri
- Nadirah Abdul Wahid
- Nadège Neant
- Nagarajan Ramakrishnan
- Nassima Si Mohammed
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Gault
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Navy Lolong
- Nazreen Abu Bakar
- Neerusha Kaisbain
- Neurinda Permata Kusumastuti
- Ng Yong Muh
- Ng Yong Siang
- Nicholas Sedillot
- Nicholas Yee Hing
- Nick Daneman
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Nicole White
- Nidyanara Castanheira
- Nik Nur Mohamed
- Nikita Nekliudov
- Nina Jamieson
- Noelia García Barrio
- Noor Hidayu Wahab
- Nor Arisah Misnan
- Nor Zaila Zaidan
- Nowneet Kumar Bhat
- NoéMie Mercier
- Noémie Tissot
- Noémie Vanel
- Nuno Germano
- Nur Amira
- Nurnaningsih Nurnaningsih
- Nurul Amani Noordin
- Nurul Faten Norharizam
- Nurul Najmee Abdulkadir
- Nurul Zaynah
- Oana Sândulescu
- Obada Yousif
- Odile Launay
- Ogechukwu Menkiti
- Oleksa Rewa
- Olivia V Swann
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Ong Yiaw Joe
- Oriane Puechal
- Oryane Mabiala
- Ouifiya Kafif
- Pablo Serrano Balazote
- Pamela Combs
- Paola Rodari
- Paolo Cattaneo
- Parthena Savvidou
- Pascal Granier
- Pathik Dhanger
- Patricia Fontela
- Patricia Gordon
- Patricia Lizotte
- Patrick Archambault
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Campbell
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul Tierney
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pavan Kumar Vecham
- Pedro Faria
- Peter de Vries
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- PG Ishara Udayanga
- Philippe Jouvet
- Philippine Eloy
- Phoebe Ampaw
- Piero L Olliaro
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marie Roger
- Pieter Depuydt
- Polina Bugaeva
- Prasan Kumar Panda
- Pratap Karpayah
- Quentin Le Hingrat
- Quentin Lepiller
- Quratul Ain Khan
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas França
- Rafael Mahieu
- Raphael Favory
- Raphaël Borie
- Raquel Pinto
- Rashan Haniffa
- Rasidah Bt Senian
- Raul Neto
- Rebecca Hamidfar
- Renata Barbalho
- Richard S. Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rob Klont
- Robert A Fowler
- Robert A. Fowler
- Roberta Cavalin
- Robin Kobbe
- Rodrigo Díaz
- Romain Basmaci
- Romain Decours
- Romain Guery
- Romans Matulevics
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Caetano Garcês
- Rui Pereira
- Rupert Higgins
- Ruth Lyons
- Ryadh Pokeerbux
- Ryan Khoo
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saijad Orakzai
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samira Laribi
- Samreen Ijaz
- Samuel Hinton
- Samuel Markowicz
- Sandrine Couffin-Cadiergues
- Sanka Sri Darshana
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Machado
- Sarah E McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Sebastien Preau
- Segolène Greffe
- Seán Keating
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shaminee Veeran
- Sharma Keshav
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C Moore
- Sia Loong Tonnii
- Sim Choon Ean
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Siri Goepel
- Siti Nurul Ridzuan
- Siti Rohani Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Sobia Masood
- Sofia Cardoso
- Soizic Le Mestre
- Sophie Halpin
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stella Rousset
- Stephanie Roberts
- Stephanie Yerkovich
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Subhash Acharya
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thurai
- Suresh Kumar Chidambaram
- Sushil Khanal
- Suvintheran Thangavelu
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Sze Kye Teoh
- Séverine Ansart
- Tae Song
- Tahira Jamal Mohamed
- Tala Al-Dabbous
- Tan Pei Wen
- Tatiana Fonseca
- Teck Fung Wong
- Teresa Lawrence
- Thalha Rashan
- Tharmini Ravi
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tony Trapani
- Tristan Gigante
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubée
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinod Kumar
- Vinothini Krishnan
- Véronique Lemee
- Víctor Quirós González
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Ymkje Stienstra
- Yoan Lavie-Badie
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- 'BMJ'
- Publication date
- 01/10/2022
- Field of study
Background The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries.Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria.Results A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)).Conclusion Mortality and morbidities were higher in LMICs than HICs, and it may be attributable to differences in patient demographics, complications and access to supportive and treatment modalities
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- Author
- Abad Jorge
- Abad Sebastien
- Abassi Radhiya
- Abdelhadi Nour Mekki
- Abdellaoui Abdelrafie
- Abdelmalek Abdelkrim
- Abdoul Hendy
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abergel Helene
- Abeud Fariza
- Abgrall Sophie
- Abisror Noemie
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Accordino Giulia
- Achille Cristian
- Adechian Marylise
- Aderdour Nordine
- Admane Hakeem Farid
- Adnet Frederic
- Afritt Sara
- Agostini Helene
- Agra Juan José Cáceres
- Aguilar Claire
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Agut Sophie
- Aiello Tommaso Francesco
- Aiuti Alessandro
- Ajeenthiravasan Gokula
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Muhsen Saleh Zaid
- Al-Mulla Fahd
- Alauzy Virginie
- Alavi Darazam Ilad
- Alavoine Loubna
- Alba Camille
- Albisures Jonathan Antonio Roblero
- Alby-Laurent Fanny
- Aldave Juan C.
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- AlKhater Suzan A.
- Allard Lucie
- Allardet-Servent Jerome
- Allende Luis M.
- Alonso-Arias Rebeca
- Alosaimi Mohammed Faraj
- Alshahrani Mohammed S.
- Alsina Laia
- Alsohime Fahad M.
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Alyanakian Marie-Alexandra
- Amam Sabrina
- Amara Yasmina Ould
- Amat Karine
- Amoura Zahir
- Amrouche Lucile
- Amsterdam UMC Covid-19 Biobank [missing]
- Anderson Mark S.
- Andreakos Evangelos
- Andrejak Claire
- Andronikof Marc
- Anglicheau Dany
- Angoulvant François
- Anguel Nadia
- Annane Djillali
- Antolí Arnau
- Aounzou Mohammed
- Aparicio Caroline
- Appelman Brent
- Aratus Gladys
- Arias Andrés A.
- Arias Andrés Augusto
- Arlet Jean-Benoit
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arzoine Jeremy
- Asano Takaki
- Aslangul Elisabeth
- Assefi Mona
- Aubart Mélodie
- Aubry Adeline
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- Avramenko Iryna
- Awotar Celine
- Aytekin Gokhan
- Aytekin Gökhan
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- Badsi Aïda
- Baghdadi Jamila El
- Bahram Seiamak
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- Baris-Feldman Hagit
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- Barthelemy Romain
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
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- Baudel Jean-Luc
- Baudry Camille
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- Bauters Fre
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- Behillil Sylvie
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- Catherinot Emilie
- Cauchy Marion
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- Chalumeau Nathalie Costedoat
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- Chas Julie
- Chauveau Simon
- Chauvin Anthony
- Chauvin Clement
- Chavarot Nathalie
- Chaïbi Khalil
- Chebbout Kamélia
- Cheng Matthew P.
- Cherai Mustapha
- Cherubini Ilaria
- Chevalier Amelie
- Chiarabini Thibault
- Chinet Thierry
- Chirouze Catherine
- Chirouze Catherine
- Chocron Richard
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- Christodoulou John
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- Citerio Giuseppe
- Clarke Ada
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- Comarmond Chloé
- Comarmond Cloé
- Combacon Emeline
- Combe Caroline Lascoux
- Combes Alain
- Combes Alain
- Comoli Patrizia
- Comparon Celine
- Condino-Neto Antonio
- Constantin Jean-Michel
- Constantinescu Stefan N.
- Contro Ernesto
- Cooper Megan A.
- Cordel Hugues
- Cordier Anne-Gael
- Corsico Angelo G.
- Costantini Adrien
- Couffignal Camille
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coupeau Doriane
- CoV-Contact Cohort [missing]
- COVID Clinicians [missing]
- COVID Human Genetic Effort [missing]
- COVID-STORM Clinicians [missing]
- COVIDeF Study Group [missing]
- Covill Laura E.
- Coşkuner Taner
- Creange Alain
- Cuadros Esmeralda Nuñez
- Cvetkovski Aleksandar
- Cyrus Cyril
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- Dalgard Clifton L.
- Dalmau David
- Danielson Jeffrey J.
- Danion François
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- Dauby Nicolas
- Dauger Stéphane
- De Bouille Jeanne Goupil
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- De Castro Nathalie
- De Chambrun Marc Pineton
- de Chambrun Marc Pineton
- de Diego Rebeca Pérez
- De Farcy Pauline Mary
- de Jong Menno D.
- De Munter Paul
- de Pontual Loic
- de Rotte Maurits C. F. J.
- De Rycke Yann
- de Vera Martín Castillo
- de Vries Heder
- Debray Marie-Pierre
- Dechanet Aline
- Declercq Jozefien
- Deconinck Lauren
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- del Prado Maria Yolanda Ruiz
- Delannoy Quentin
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- Deleris Robin
- Deleuze Jean-François
- Delforge Juliette
- Delmonte Ottavia M.
- Delphine Laëtitia
- Delplancq Geoffroy
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- Demerville Lauren
- Demirkol Yasemin Kendir
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- Deplanque Dominique
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- Di Sabatino Antonio
- Diallo Alpha
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- Djillali Hadjer
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- Dobbs Kerry
- Domínguez-Garrido Elena
- Dongelmans Dave A.
- Donneger Severine
- Dorival Céline
- Dos Santos Catarina
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- Dres Martin
- Droctove Laura
- Drogrey Marie
- Drolet Beth A.
- Dropy Margot
- Drouet Elodie
- Dubos François
- Dubosq Valérie
- Dubost Clément
- Dubreucq Evelyne
- Dubus Estelle
- Duchemann Boris
- Duchenoy Thibault
- Dudoignon Emmanuel
- Dufau Romain
- Dujardin Romein W. G.
- Dumas Florence
- Duran Clara
- Durand Anne Bourgarit
- Duron Emmanuelle
- Durrbach Antoine
- Duval Xavier
- Duval Xavier
- Duvivier Claudine
- D’Angio’ Mariella
- d’Ortenzio Eric
- Ebstein Nathan
- Ecobichon Jean-Luc
- Ekwall Olov
- El Zein Loubna
- Elabbadi Alexandre
- Elbers Paul
- Elharrar Brigitte
- Elie Caroline
- Elnagdy Marwa H.
- Eloy Philippine
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- Enouf Vincent
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- Espinosa-Padilla Sara
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- Etienne Manuel
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- Eyer Xavier
- Fabio Giovanna
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- Fartoukh Muriel sarah
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- Ferreres Jose
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- Fouchard Julie
- Fournier Benjamin
- Fournier Marie-Céline
- Franco Jose Luis
- Franco José Luis
- Francois Bruno
- Francois Hélène
- French COVID Cohort Study Group [missing]
- Freynet Olivia
- Frezouls Wahiba
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- Froidure Antoine
- Fromont Isaure
- Fuentes Axelle
- Fumadó Victoria
- Fung Kitty S. C.
- Furet Thomas
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Galand Joris
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- Garçon Pierre
- Gatineau Audrey Giraud
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- Gault Nathalie
- Gaussem Pascale
- Gauthier Damien
- Gautier Maxime
- Gaymard Alexandre
- Gayretli Zeynep
- Geijtenbeek Suzanne Geerlings Theo
- Georgin-Lavialle Sophie
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- Goas Carole L. E.
- Godínez Karen Alejandra Cifuentes
- Goffard Jean-Christophe
- Gomes Doryan
- Gomes-Pires Elisabete
- Gonzales Nacho
- Gonzalez-Granado Luis I.
- González-Montelongo Rafaela
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- Gregersen Peter K.
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- Guidet Bertrand
- Guillo Matthias
- Gulczynski Mariechristelle
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- Hammarström Lennart
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- Hausfater Pierre
- Hautem Coraline
- Heath James R.
- Heijmans Catherine
- Hekimian Guillaume
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- Henrickson Sarah E.
- Heppekcan Deniz
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- Hung Ivan F. N.
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- Iglesias Alejandro D.
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- Imarazene Meriem
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- Lucet Jean Christophe
- Lucet Jean-Christophe
- Lung Kwok-Cheung
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- Matos Larissa R. B.
- Matthews Gail V.
- Mattiaccio Alessandro
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- Mayaux Julien
- McLaughlin-Garcia Raquel
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- Mizoguchi Yoko
- Modi Bhavi P.
- Mogensen Trine H.
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- Morandeira Francisco
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- Morbieu Caroline
- Mordacq Cléemence
- Morelle Guillaume
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- Mortelette Helene
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- Mouly Stéphane J.
- Mouquet Hugo
- Mullaert Jimmy
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- Mège Jean-Louis
- Nacerddine Cherifa Iness
- Nadal Marine
- Nadif Hajer
- Nadji Seyed Alireza
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- Narvaez Rafael Usubillaga
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- Neant Nadège
- Nellen Jeaninne
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- Neves João Farela
- Ng Lisa F. P.
- Ng Lisa F. P.
- Ng Yuk-Yung
- Nguyen Caroline
- Nguyen Duc
- Nguyen Duc
- NIAID-USUHS COVID Study Group [missing]
- Nicolas Leturque
- Nielly hubert
- Nlomenyengue Luc
- Noel Nicolas
- Noret Marion
- Nossent Esther J.
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nseir Saad
- Nunes Hilario
- Nussbaum Robert
- N’Guyen Bao
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okamoto Keisuke
- Oler Andrew J.
- Omar Edris
- Orchestra Working Group [missing]
- Oualha Mehdi
- Ouazene Zineb
- Ouedrani Amani
- Ouedraogo Elise
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- Paris Christophe
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- Paul Stéphane
- Paulus Frederique
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- Philippot Quentin
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- Pina-Fuentes Dan A. I.
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- Pippucci Tommaso
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- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
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- Pistone Thierry
- Planas Anna M.
- Planas-Serra Laura
- Planquette Benjamin
- Pleguezuelo Daniel E.
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- Poissy Julien
- Pomel Anne-Laure
- Poncelet Géraldine
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- Ponscarme Diane
- Poulakou Garyphallia
- Pouletty Marie S.
- Pourcelot Annegaelle
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- Pourshahnazari Persia
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- Preckel Bennedikt
- Prever Florian
- Previlon Miresta
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- Prins Jan M.
- Provoost Marie-Julie
- Puel Anne
- Pueyo David Martínez
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- Puéchal Oriane
- Pérez-Fernández Xosé Luis
- Qiu-Chen Jia Li
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- Quintin Caroline
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- Raasveld Jorinde
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- Ramaswamy Sathishkumar
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- Ramos Miquel Alfonso
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- Raphalen Jean Herle
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- Reby Michael
- Redin Claire
- Regent Alexis
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- Ricart Pilar
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- Richard Lucie
- Richard Mariecaroline
- Rigo-Bonnin Raúl
- rivet Nadia
- Rivière Jacques G.
- Robert Maxence
- Rocamora-Blanch Gemma
- Rodero Mathieu P.
- Rodrigo Carlos
- Rodriguez Luis Antonio
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- Rodriguez-Palmero Agustí
- Rodríguez-Gallego Carlos
- Rohaut Benjamin
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- Rolland-Debord Camille
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- Rosa-Calatrava Manuel
- Rosenberger John
- Rossi Camillo
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- Rossignol Patrick
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- Schrauwen Femke A. P.
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- Schultz Marcus J.
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- Schweitzer Cyril E.
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- Sene Damien
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- Seppänen Mikko R. J.
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- Slim Marleen A.
- Slimani Miassa
- Smadja David M.
- Smeele Patrick
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- Smith Nikaia
- Snauwaert Aurélie
- Snow Andrew L.
- Snow Andrew L.
- Sobh Ali
- Sokol Harry
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- Stijnis Cornelis S.
- Stilma Willemke
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- Su Helen C.
- Su Helen C.
- Su Richa
- Suarez Lydia
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- Tacconelli Evelina
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- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
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- Tantet Claire
- Tardivon Coralie
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- Troya Jesus
- Troya Jesús
- Truchot Jennifer
- Tsang Owen T. Y.
- Tserel Liina
- Tso Eugene Y. K.
- Tsonas Anissa M.
- Tual Christelle
- Tubach Florence
- Tubiana Sarah
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- Tuinman Pieter R.
- Tunesi Simone
- Turpin Agathe
- Turpin Matthieu
- Turvey Stuart E.
- Téoulé François
- Uddin Furkan
- Uddin Mohammed J.
- Urbina Tomas
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- Utsumi Takanori
- Uzunhan Yurdagul
- Uzunhan Yurdagul
- Vabres Pierre
- Vacher Yannick
- Vaittinadaayar Prabakar
- Valencia-Ramos Juan
- Valent Arnaud
- Valentian Maelle
- Valin Nadia
- Vallet Hélène
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- Van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- Van Den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- Van Der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- Van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vaz Marina
- Vazquezibarra Miguel-Alejandro
- Vedie Benoit
- Veelo Denise
- Vega Clara Campos
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Velly Laetitia
- Verstuyft Celine
- Viallette Cedric
- Vicaut Eric
- Vidaud Michel
- Vidigal Mateus C.
- Viel Sébastien
- Vignali Valérie
- Vignes Dorothee
- Vilaire-Meunier Marie E.
- Villain Cédric
- Villar-García Judit
- Vimpere Damien
- Vincent Audrey
- Vinh Donald C.
- Virlouvet Myriam
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander P. J.
- Voiriot Guillaume
- Voiriot Guillaume
- Voisot Lena
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- Vught Lonneke A.
- Vuotto Fanny
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Weiss Emmanuel
- Weiss Nicolas
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wilkerson Matthew D.
- Winchenne Anaïs
- Wouters Dorien
- Wu Alan K. L.
- Wu Tak-Chiu
- Yahşi Aysun
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yesilbas Osman
- Yildiz Mehmet
- Yordanov Youri
- Youkou Christy Gaëlla Kotokpo
- Young Barnaby E.
- Yüksek Saliha Kanık
- Yükselmiş Ufuk
- Zafrani Lara
- Zaidan Mohamad
- Zaidi Wissem
- Zak Cathia
- Zarhrate-Ghoul Aida
- Zatout Ouassila
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zecca Marco
- Zeino Suzanne
- Zeitouni Michel
- Zemirli Naïma
- Zerah Lorene
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Xijun
- Zhang Yu
- Zia Ounsa
- Ziol Marianne
- Zolario Oceane
- Zuber Julien
- Zuccaro Valentina
- Zwinderman A. H.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/01/2023
- Field of study
BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old
Liver injury in hospitalized patients with COVID-19: An International observational cohort study
- Author
- Abby Hurd
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abigail Beane
- Adam Hall
- Adam Nowinski
- Adhikari Neill K. J.
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnès Meybeck
- Agnès Sommet
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Aidan Burrell
- Ailbhe Hayes
- Aine McCarthy
- Aisling Gavin
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Al-Fares Abdulrahman
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Albert Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J. Mentzer
- Alexander King
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Ait Hssain
- Ali Hachemi
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Aline-Marie Florence
- Alison M. Meynert
- Alistair Nichol
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Amal Abrous
- Amanda Corley
- Amanda Palacios
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Amélie Valran
- Ami Stuart
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anant Kataria
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell’Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Law
- Andrew Udy
- Andrey Svistunov
- André Cabie
- André Roberto
- Andriy Bal
- Angela Alberti
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O Callaghan
- Annmarie O’Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ho
- Antonio Arcadipane
- Antonio Pesenti
- António Mesquita
- Aquiles Henriquez
- Ardiyan Apriyana
- Arfan Ikram
- Argin G
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arnaud Scherpereel
- Arsène Kpangon
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Asim Rana
- Asma Moin
- Audrey Barrelet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Aurore Bousquet
- Axelle Braconnier
- Azlan Mat Soom
- Bailey Cassandra
- Bairbre McNicholas
- Bambang Pujo Semedi
- Barbara Wanjiru Citarella
- Baruch Joaquin
- Basri Mat Nor
- Beathe Kiland Granerud
- Beatrice Alex
- Beatriz Amorim Beltrão
- Ben Morton
- Benedict Sim Lim Heng
- Benigno Ferreira
- Benjamin Bach
- Benjamin Lefèvre
- Benjamin Smood
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Bernard Cholley
- Bernardo Ferreira
- Bernhard Roessler
- Bertrand Dussol
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Bharath Kumar Tirupakuzhi Vijayaraghavan
- Bianca Boxma
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- Blake Mergler
- Blandine Rammaert
- Bouchra Loufti
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- Brenda Reeve
- Brigitte Elharrar
- Bruno Levy
- Bruno Lina
- Bruno Pastene
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- Bryan Whelan
- Budha Charan Singh
- Calvache Jose A.
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Caren Friedrich
- Carine Roy
- Carla Eira
- Carlo Giaquinto
- Carlos Alexandre Antunes de Brito
- Carlos M. Luna
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
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- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
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- Catarina Espírito Santo
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- Catherine A. Shaw
- Catherine Blier
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- Catherine Chirouze
- Catherine L. Hough
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- Cecilia Canepa
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- Cédric Laouénan
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- Céline Ficko
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- Chih-Hsien Wang
- Chloe Donohue
- Chris Kandel
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
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- Christian Rabaud
- Christiana Kartsonaki
- Christl A. Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Christy Kay
- Citarella Barbara Wanjiru
- Claire Andrejak
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- Claire Levy-Marchal
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- Clark D. Russell
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- Cleide Barrigoto
- Clément Le Bihan
- Clotilde Allavena
- Colin McArthur
- Colin McCloskey
- Coline Jaud-Fischer
- Colleen Curran
- Conar O’Neil
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Craig French
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Dafsah Juzar
- Dag Henrik Reikvam
- Daisuke Kasugai
- Damien Bouhour
- Dan Meyer
- Daniel Glikman
- Daniel Haber
- Daniel Ivulich
- Daniel Mathieu
- Daniel Munblit
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- Daniela Guerreiro
- Danielle Jaafar
- Darren Dahly
- David Bellemare
- David Dean
- David L. Robertson
- David Maslove
- David Richardson
- David S. Y. Ong
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- David Thomson
- David Zucman.
- Davide Chiumello
- Dawn Higgins
- Debby Bogaert
- Deepak Vijayan
- Deepali Kumar
- Deepashankari Suppiah
- Dehbia Benkerrou
- Deirdre Flynn
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Denise Richardson
- Derbrenn OConnor
- Dewi Guellec
- Diana Adrião
- Diana Hernandez
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Bastos Porto
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Dominique Deplanque
- Dominique Luton
- Dori-Ann Martin
- Dorothea Rosenberger
- Dorothy Breen
- Dounia Bouhmani
- Douwe F. Postma
- Duc Nguyen
- Dzawani Muhamad
- Edel Meaney
- Eder Caceres
- Edmund Manning
- Edouard Soum
- Edward Wilson Grandin
- Efstathia Mihelis
- Eglantine Ferrand Devouge
- Egle Saviciute
- Eibhlin Higgins
- Eka Yudha Lantang
- Elaine McPartlan
- Elena Molinos
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Adam
- Elisabeth Botelho-Nevers
- Elisabetta Spinuzza
- Elise Artaud-Macari
- Ellen Shadowitz
- Elmi Theron
- Elodie Curlier
- Elsa Nyamankolly
- Else Quist-Paulsen
- Eman Al Qasim
- Emily Martin
- Emily Neumann
- Emily Somers
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric Delaveuve
- Eric D’Ortenzio
- Eric Gnall
- Eric Oziol
- Eric Senneville
- Erica Bak
- Erlina Burhan
- Ernita Akmal
- Erwan Fourn
- Erwan L’Her
- Esteban Garcia-Gallo
- Ethan Kurtzman
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eve Defous
- Evert-Jan Wils
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
- Fadi-Fadi Qutishat
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Felwa Bin Humaid
- Fernanda Dias Da Silva
- Fernando Augusto Bozza
- Fernando Rainieri
- Ferran Roche-Campo
- Félix Djossou
- Filipa Brás Monteiro
- Filipa Cardoso
- Filipa Sequeira
- Filipe Cardoso
- Fiona Griffiths
- Fiona Toal
- Fionnuala O Brien
- Firouzé Bani-Sadr
- Flávio Marino
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- France Mentré
- Francisco Arancibia
- François Angoulvant
- François Bissuel
- François Bompart
- François Dubos
- François Goehringer
- François Lellouche
- François Martin Carrier
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Frank Manetta
- Frank Olav Pettersen
- Fredrik Müller
- Gabriel Macheda
- Gabriel Suen
- Gabriele Sales
- Gail Carson
- Galyna Kutsyna
- Gan Ee Xian
- Ganesh Kumar
- Gary Leeming
- Gayle Carney
- Gennaro Martucci
- Geoffrey Liegeon
- Georges Le Falher
- Georgios Pollakis
- Giacomo Grasselli
- Gianluigi Li Bassi
- Gilles Peytavin
- Giorgia Montrucchio
- Giovanna Occhipinti
- Giovanna Panarello
- Giri Shan Rajahram
- Giulia Bertoli
- Giuseppe Foti
- Gloria Crowl
- Graham S. Cooke
- Grazielle Viana Ramos
- Gregory Purcell
- Gretchen Lemmink
- Grégory Corvaisier
- Gry Kloumann Bekken
- Gugapriyaa Muyandy
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guylaine Castor-Alexandre
- Gwenaël Le Moal
- Gwenhaël Colin
- Gyan Sandhu
- Ha Sha Lene
- Haixia Shi
- Hajnal-Gabriela Illes
- Hanan Fateena
- Hanna Renk
- Hannah Keane
- Harald Vonkeman
- Hashmi Madiha
- Hassan Tawfik
- Hayley Hardwick
- Hazel Bergin
- Heidi Dalton
- Heidi Gruner
- Helen Tuite
- Heng Gee Lee
- Henk Vanoverschelde
- Hernando Torres-Zevallos
- Hervé Le Nagard
- Hélène Esperou
- Hélène Salvator
- Hiba Zayyad
- Hikombo Hitoto
- Himed Musaab
- Hiroaki Hiraiwa
- Hiroaki Shimizu
- Hiu Jian Chua
- Hodane Yonis
- Holger Neb
- Hon Shen Png
- Hongru Ren
- Hubert Tessier-Grenier
- Huda Alfoudri
- Hugo Inácio
- Hugo Miranda-Maldonado
- Hugo Mouquet
- Hugues Aumaitre
- Hugues Cordel
- Husna Begum
- Iam Claire E. Sarmiento
- Ignacio Martin-Loeches
- Ikram Houas
- Ilka Engelmann
- Ilonka van Veen
- Imran Ali
- Imrana Khalid
- Indrek Rätsep
- Inês Carqueja
- Ingrid G. Bustos
- Ionna Deligiannis
- Iqbal Hussain
- Irene Aragao
- Irfan Khan
- Isabel Ferreira
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- Isabelle Pironneau
- Ithan D. Peltan
- Ivo Castro
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- Jack Song Chia
- Jacky Y. Suen
- Jacobien Ellerbroek
- Jade Ghosn
- Jae Burm Kim
- Jake Dunning
- Jamel Ortoleva
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jan Cato Holter
- Jan Heerman
- Jan-Erik Berdal
- Jananee Thirumanickam
- Janet Harrison
- Janet T. Scott
- Jaques Sztajnbok
- Jarne Van Hattem
- Jason Bouziotis
- Javier Osatnik
- Jean Baptiste Assie
- Jean Christophe Lucet
- Jean Foley
- Jean-Benoît Arlet
- Jean-Charles Gagnard
- Jean-Charles Preiser
- Jean-Christophe Goffard
- Jean-Daniel Lelievre
- Jean-François Payen
- Jean-François Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-Sébastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jee Yan Ong
- Jeff Powis
- Jeffrey Aliudin
- Jelmer Talsma
- Jennifer Connolly
- Jennifer Lee
- Jenny Lennon
- Jérémie Guedj
- Jérémie Pasquier
- Jérôme Dimet
- Jia Shyi Loy
- Jia Wei
- Jimmy Ming-Yang Hsu
- Jimmy Mullaert
- Jin Yi Goh
- Jo Dalton
- Joan Gómez-Junyent
- Joana Alves Cabrita
- Joana Ferrão
- Joanne Downey
- Joao Joao Mendes
- Joaquín Baruch
- João Camões
- João Estevão
- João Melo Alves
- João Oliveira
- João Teixeira
- Job van der Palen
- Johann Auchabie
- Johannes Gebauer
- John Bourke
- John F Fraser
- John G. Laffey
- John Marshall
- John Robert Sheenan
- Johnny McKeown
- Jonathan Chua
- Jonathan Crump
- Jonathan Golob
- Jonathan Remppis
- Jordan Zhien Yang Toh
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Jose Andres Calvache
- Jose I Nunez
- Jose Pedro Cidade
- José Casimiro
- José Ernesto Vidal
- José Ramalho
- Joshua Solomon
- Joy Ann Villanueva
- Juan Fiorda
- Juan Pablo Horcajada
- Judit Villar
- Jules Bauer
- Julian Chica
- Juliana Damas
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Juliette Duthoit
- Juliette Patrier
- Juliette Romaru
- Justine Pages
- Kah Chuan Lim
- Kai Zacharowski
- Kalaiarasu Peariasamy
- Kalynn Kennon
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Karisha Sivam
- Karl Erik Müller
- Karolina Krawczyk
- Kartsonaki Christiana
- Katarzyna Lewandowska
- Kate Ainscough
- Kathy Brickell
- Kazali Enagnon Alidjnou
- Keiki Shimizu
- Kenneth A. McLean
- Ker Hong Bee
- Kevin Katz
- Kévin Alexandre
- Kévin Bouiller
- Kévin Didier
- Khor How Kiat
- Kim Keat Tan
- Koji Hoshino
- Kok Wei Hao
- Kong Yeow Kang
- Konstanty Szuldrzynski
- Kota Hoshino
- Krishna Bhavsar
- Kristian Tonby
- Kuan Pei Xuan
- Laetitia Bodenes
- Lai Hui Pang
- Lamees Kayyali
- Lance C. W. Turtle
- Lara Absil
- Larissa Oliveira
- Lars Heggelund
- Lars S. Maier
- Laura Feeney
- Laura Marsh
- Laura Merson
- Laura van Gulik
- Laura Walsh
- Laure Goubert
- Lauren Deconninck
- Laurence Bouillet
- Laurence Maulin
- Laurent Abel
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- Laurène Azemar
- Leanne Hays
- Lee Lee Low
- Lefèvre Benjamin
- Leonardo Salazar
- Leong Chee Loon
- Leong Chin Tho
- Léo Chenard
- Liadain Reid
- Liem Luong
- Lila Bouadma
- Lim Lina
- Lim Saio Xian
- Lim Yuen Han
- Lina Morales Cely
- Linda Gail Skeie
- Linda O’Shea
- Lionel Eric Benjiman
- Lionel Piroth
- Lisa Mc Sweeney
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Lorna Murphy
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lovkesh Arora
- Luca Brazzi
- Lucia Moro
- Lucia Proença
- Lucian Durham III
- Lucie Le Fevre
- Lucille Blumberg
- Luis Felipe Reyes
- Luis Melo
- Luis Periel
- Luisa Quesada
- Luís Bento
- Luís Patrão
- Luís Val-Flores
- Lukas Arenz
- Lysa Tagherset
- Machteld Van der Feltz
- Maeve Kelsey
- Maeve Kernan
- Maeve Ryan
- Mageswari Selvarajoo
- Maggie Mechlin
- Mahdad Noursadeghi
- Maire-Laure Casanova
- Maisa Guimarães de Castro
- Maïder Pagadoy
- Makoto Uchiyama
- Malcolm G. Semple
- Mangala Narasimhan
- Manuel Etienne
- Manuel Rosa-Calatrava
- Maram Zahran
- Marc Csete
- Marc Fabre
- Marc Lambert
- Marc Leone
- Marcel van den Berge
- Marcela Vieira Freire
- Marco Echeverria-Villalobos
- Marco Giani
- Mare Pejkovska
- Margarite Grable
- Margaux Isnard
- Maria Amaral
- Maria Angelica Rivera Nuñez
- Maria Boylan
- Maria de Piero
- Maria Ines Ribeiro
- Maria Joao Silva
- Maria Lawrensia Tampubolon
- Maria Sousa Uva
- Maria Zambon
- Mariachiara Ippolito
- Mariana Cascão
- Marianne Fraher
- Mariano Esperatti
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marieke Haalboom
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marije Lowik
- Marina Esposito-Farese
- Marina Lanza
- Marina Wainstein
- Marine Beluze
- Marine Livrozet
- Marion Le Maréchal
- Marion Noret
- Marion Schneider
- Marion Zabbe
- Marília Andreia Fernandes
- Marjolein Brusse-Keizer
- Mark Downing
- Mark G. Pritchard
- Mark Joseph
- Marlene Santos
- Marlène Murris
- Marsilla Marzukie
- Marta Alessi
- Marta Sousa
- Marta Torre
- Martin Guego
- Martin Martinot
- Martina Escher
- Martina Hennessy
- Martine Remy
- Mary Copland
- Mary Mone
- Masahiro Fukuda
- Masaki Yamazaki
- Masliza Zahid
- Massimo Palmarini
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvallées
- Mathilde Duplaix
- Matteo Rossetti
- Matthew Cummings
- Matthew Griffee
- Matthew Hall
- Matthew Pellan Cheng
- Matthieu Revest
- Maude Bouscambert
- Mauro Panigada
- Max O’Donnell
- Maxime Hentzien
- Maximilian Malfertheiner
- Maximilien Saint-Gilles
- Mayka Mergeay-Fabre
- Mário Ferraz
- Meera Chand
- Meeyai Aronrag
- Megan Coles
- Mehdi Mezidi
- Mehul Desai
- Menaldi Rasmin
- Mercé Jourdain
- Merson Laura
- Mélanie Roriz
- Mical Paul
- Michael Collins
- Michael Maxwell
- Michael Piagnerelli
- Michael Rose
- Michael Schwameis
- Michael Sonntagbauer
- Michael Varrone
- Michaela Barnikel
- Michela Leone
- Michele Petrovic
- Michelle E Kho
- Michelle Girvan
- Michelle Smyth
- Miguel Zambrano
- Minahel Atif
- Minerva Cervantes-Gonzalez
- Minh Le
- Miriam O’Sullivan
- Mirjam Evers
- Mohamed Fayed
- Mohamed Zubair
- Mohammad Shamsah
- Mohammed El Sanharawi
- Mohammed Quraishi
- Mohan Dass Pathmanathan
- Mohanaprasanth Balakrishnan
- Mohd Nazlin Bin Kamarudin
- Moirangthem Bikram Singh
- Moïse Machado
- Morgane Gilg
- Morgane Snacken
- Moshe Matan
- Muhammad Aisar Ayadi Kamaluddin
- Muhammad Ashraf
- Muhammad Fadhli Hassin Basri
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mylène Maillet
- Myung Jin Song
- Nadège Neant
- Nadhem Lafhej
- Nadia Baig
- Nadia Ettalhaoui
- Nadia Malik
- Nadia Ouamara
- Nadiah Ismail
- Nadiah Kamarudin
- Nadir Hadri
- Nadirah Abdul Wahid
- Nagarajan Ramakrishnan
- Namra Asif
- Nassima Si Mohammed
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Gault
- Nathalie M. Delfos
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Naveed Latif
- Navy Lolong
- Nazreen Abu Bakar
- Neerusha Kaisbain
- Nelson Cardoso
- Nestor Luque
- Ng Yong Muh
- Ng Yong Siang
- Niamh Kelly
- Niamh Ni Leathlobhair
- Nicholas Rizer
- Nicholas Sedillot
- Nicholas Yee Liang Hing
- Nicholas Yuri Barbosa
- Nick Daneman
- Nicky Van Der Vekens
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Nicole White
- Nidyanara Castanheira
- Nik Nur Eliza Mohamed
- Nikita Nekliudov
- Nilar Lwin
- Nina Buchtele
- Nina Jamieson
- Nobuya Kitamura
- Noémie Mercier
- Noémie Tissot
- Noémie Vanel
- Noor Hidayu Wahab
- Nor Arisah Misnan
- Nor Zaila Binti Zaidan
- Nora Fuentes
- Nuno Germano
- Nuno Martins
- Nur Amira
- Nurul Amani Mohd Noordin
- Nurul Faten Izzati Norharizam
- Nurul Najmee Abdulkadir
- Nurul Zaynah
- Oana Sandulescu
- Obada Yousif
- Odile Launay
- Ohshimo Shinichiro
- Oksana Kruglova
- Olavi Maasikas
- Oleksa Rewa
- Olga Martynenko
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Olliaro Piero
- Omar Mehkri
- Ong Yiaw Joe
- Oriane Puéchal
- Oryane Mabiala
- Osama Metwally
- Oscar Hoiting
- Ouifiya Kafif
- Paddy Mallon
- Pamela Combs
- Paola Rodari
- Paolo Cattaneo
- Parthena Savvidou
- Pascal Granier
- Pathik Dhanger
- Patricia Gordon
- Patricia Lizotte
- Patricia Patricio
- Patrick Archambault
- Patrick Biston
- Patrick Imbert
- Patrick Murray
- Patrick Rispal
- Patrick Rossignol
- Paul Campbell
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pavan Kumar Vecham
- Pedro Faria
- Pedro Povoa
- Peter de Vries
- Peter Doran
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- Petra Bryda
- Phil Gallagher
- Philippine Eloy
- Phoebe Ampaw
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marc Villeneuve
- Pierre-Marie Roger
- Pieter Depuydt
- Piret Sillaots
- Pleun Terpstra
- Polina Bugaeva
- Pompini Agustina Sitompul
- Pooja Varghese
- Pranya Sakiyalak
- Prasan Kumar Panda
- Prasanth Sukumar
- Pratap Karpayah
- Pratima Sharma
- Priscila Diaz
- Prompak Nitayavardhana
- Quentin Le Hingrat
- Quentin Lepiller
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas de Oliveira França
- Rafael Mahieu
- Rakesh Arora
- Rana Imran Sikander
- Raphaël Borie
- Raphaël Favory
- Rashan Haniffa
- Rasidah Bt Senian
- Raul Neto
- Rebecca Hamidfar
- Rebekha Garcia
- Renata Barbalho
- Renato Reis
- Ricardo Fritz
- Richa Su
- Richard S. Tedder
- Riinu Pius
- Rita Alves
- Ritika Ranjan
- Rob Klont
- Robert A. Fowler
- Roberta Cavalin
- Roberto Roncon-Albuquerque Jr
- Robin Kobbe
- Rodrigo Diaz
- Rogério Silva
- Rolando Claure-Del Granado
- Romain Basmaci
- Romain Decours
- Romain Guery
- Roman Ullrich
- Romans Matulevics
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Caetano Garcês
- Rui Pereira
- Rumaisah Satyawati
- Rupert Higgins
- Ruth Jimbo-Sotomayor
- Ruth Lyons
- Ruth N. Jorge García
- Ryadh Pokeerbux
- Ryan Khoo
- Ryan S. Thwaites
- Ryuzo Abe
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saleh Al Ageel
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samira Laribi
- Samreen Ijaz
- Samuel Hinton
- Samuel Markowicz
- Sandrine Couffin-Cadiergues
- Sanne Wesselius
- Santi Dewayanti
- Sara Clohisey
- Sara Machado
- Sara Taleb
- Sara Ventura
- Sarah E. McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Seamus Daly
- Sean Donohue
- Seán Keating
- Sebastian Vencken
- Sebastiano Maria Colombo
- Segolène Greffe
- Senthilkumar Alegesan
- Sergio Poli
- Sébastien Preau
- Sérgio Gaião
- Séverine Ansart
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shaminee Veeran
- Sharma Keshav
- Shaun Thompson
- Shaunagh Browne
- Sherry McDermott
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C. Moore
- Sia Loong Tonnii
- Silvia Castañeda
- Silvia Lourenco
- Sim Choon Ean
- Simão Rodeia
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Sinead Monahan
- Siobhan Casey
- Siri Goepel
- Siti Nurul Atikah Ahmad Ridzuan
- Siti Rohani Binti Mohd Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Sílvia Ferreira
- Sofia Cardoso
- Soizic Le Mestre
- Sophie Halpin
- Sophie Letrou
- Sophie Mahy
- Sree Satyapriya
- Srinivas Murthy
- Stanislas Rebaudet
- Steffi Ryckaert
- Stella Huo
- Stella Rousset
- Stephanie Nonas
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Stijn Van de Velde
- Stuart Houltham
- Su Hwan Lee
- Subbarao Elapavaluru
- Sudhir Krishnan
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thanga Thurai
- Suresh Kumar Chidambaram
- Surya Otto Wijaya
- Susana Fernandes
- Susanne Dudman
- Sushil Khanal
- Suvintheran Thangavelu
- Suzanne Bennett
- Suzette Willems
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Sze Kye Teoh
- Taccone Fabio Silvio
- Tae Song
- Tahira Jamal Mohamed
- Takako Akimoto
- Taku Tanaka
- Tala Al-dabbous
- Tan Pei Wen
- Tarek Elshazly
- Tatiana Fonseca
- Tawnya Ogston
- Tânia Sequeira
- Teck Fung Wong
- Teresa Lawrence
- Terese Hammond
- Tharmini Ravi
- Thavamany Kaleesvran
- Théo Trioux
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Tiago Isidoro
- Tiago Reyes
- Tiffany Trouillon
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Tirupakuzhi Vijayaraghavan Bharath Kumar
- Tjard Schermer
- Todd C. Lee
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- Vadim Tieroshyn
- Valentine Campana
- Valentine Piquard
- Valeria Balan
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Vera Irawany
- Véronique Lemee
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yves Levy
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- PUBLIC LIBRARY SCIENCE
- Publication date
- 01/10/2023
- Field of study
Background: Using a large dataset, we evaluated prevalence and severity of alterations in liver enzymes in COVID-19 and association with patient-centred outcomes.MethodsWe included hospitalized patients with confirmed or suspected SARS-CoV-2 infection from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) database. Key exposure was baseline liver enzymes (AST, ALT, bilirubin). Patients were assigned Liver Injury Classification score based on 3 components of enzymes at admission: Normal; Stage I) Liver injury: any component between 1-3x upper limit of normal (ULN); Stage II) Severe liver injury: any component & GE;3x ULN. Outcomes were hospital mortality, utilization of selected resources, complications, and durations of hospital and ICU stay. Analyses used logistic regression with associations expressed as adjusted odds ratios (OR) with 95% confidence intervals (CI).ResultsOf 17,531 included patients, 46.2% (8099) and 8.2% (1430) of patients had stage 1 and 2 liver injury respectively. Compared to normal, stages 1 and 2 were associated with higher odds of mortality (OR 1.53 [1.37-1.71]; OR 2.50 [2.10-2.96]), ICU admission (OR 1.63 [1.48-1.79]; OR 1.90 [1.62-2.23]), and invasive mechanical ventilation (OR 1.43 [1.27-1.70]; OR 1.95 (1.55-2.45). Stages 1 and 2 were also associated with higher odds of developing sepsis (OR 1.38 [1.27-1.50]; OR 1.46 [1.25-1.70]), acute kidney injury (OR 1.13 [1.00-1.27]; OR 1.59 [1.32-1.91]), and acute respiratory distress syndrome (OR 1.38 [1.22-1.55]; OR 1.80 [1.49-2.17]).ConclusionsLiver enzyme abnormalities are common among COVID-19 patients and associated with worse outcomes