La conservación de los documentos electrónicos en la normativa parlamentaria: las “Normas de política de gestión de documentos electrónicos de la Junta General del Principado de Asturias”

Parliamentary regulations for the preservation of electronic record

La conservación de los documentos electrónicos en la normativa parlamentaria: las “Normas de política de gestión de documentos electrónicos de la Junta General del Principado de Asturias”

Parliamentary regulations for the preservation of electronic record

La Plataforma de Tortosa (Cuenca catalana) durante el Jurásico Medio: unidades litoestratigráficas, paleogeografía y ciclos ambientales

El presente trabajo constituye una guía de campo de un transecto de la Plataforma de Tortosa, en dirección SW-NE, desde el Estrecho de Beceite hacia las proximidades del Alto de Tarragona. Los afloramientos situados en las proximidades de Alfara, Tivenys, Llaberia y Cap Salou permiten reconocer las sucesivas unidades litoestratigráficas, así como las variaciones de espesor y facies en los distintos sectores, facilitando la reconstrucción paleogeográfica y secuencial de la Cuenca Catalana para este intervalo temporal, entre el Toarciense y el Oxfordiense. Los materiales del Jurásico Medio en la Cuenca Catalana forman una potente sucesión carbonática que sobrepasa los 350 m de potencia, y muestran una fuerte reducción de espesor hacia el norte (área de Llaberia) y el nordeste (el llamado Alto de Tarragona). Estos materiales han sido estudiados a partir de los datos de superficie (más de 30 perfiles estratigráficos) y de subsuelo (más de 30 sondeos petrolíferos). Se han reconocido tres formaciones que habían sido previamente definidas: la Fm. Sant Blai, preferentemente carbonatada (Toarciense inferior a Bajociense inferior), la Fm. Cardó, preferentemente margosa (Bajociense inferior a Bajociense superior), y la Fm. La Tossa, formada por calizas y dolomías (Bajociense superior a Calloviense medio). En la Fm. Sant Blai se distingue a su vez cinco miembros estratigráficamente sucesivos. Por encima de la Fm. La Tossa se desarrolla la Fm. Serra de la Creu, formada por calizas bioclásticas y peloidales (Oxfordiense medio a superior). Las variaciones de facies y de espesor son indicativas de que la sedimentación estuvo controlada por fracturas de basamento, que condicionaron el desarrollo de diversas plataformas carbonáticas así como sucesivos cambios relativos del nivel del mar. No obstante, las discontinuidades de mayor amplitud, localizadas en el Aaleniense (Biozona Murchisonae), en el límite Batboniense - Calloviense (Biozona Discus) y en el límite Calloviense - Oxfordiense, se encuentran también en la Cuenca Ibérica y fueron debidas a factores alocíclicos. Las profundidades relativas de estas áreas de plataforma epicontinental alcanzaron valores mínimos durante el desarrollo de estas tres discontinuidades mencionadas, que localmente pudieron corresponder a episodios prolongados de exposición subaérea. Los máximos valores batimétricos se alcanzaron durante el Bajociense superior (Biocrón Niortense) y durante el Oxfordiense medio (biocronos Schilli y Rotoides). Durante estos intervalos de máxima profundización relativa se registraron las únicas evidencias de colonización generalizada de la Cuenca Catalana por poblaciones de ammonites

Optimal attainment, high performance standards and flow in health professionals, professors and university students. An introductory approximation

Optimizar el rendimiento personal, académico o profesional y ser competitivos en un marco de excelencia, tanto en la vida personal como laboral, puede ser un reto gratificante o por el contrario, convertirse en una experiencia que afecte a la salud o se viva con estrés y afectividad negativa. En el entorno laboral y académico, con el desarrollo de la inteligencia social y emocional, entender que puede aspirarse a rendimientos óptimos o altos desempeños no solo sin perjudicar la salud, sino incluso incrementando los niveles de satisfacción personal y bienestar psicológico, es una interesante aportación. En este trabajo se presenta una aproximación inicial teórica, centrada en los constructos psicológicos de rendimiento cumbre, patrones de alto desempeño y flow. Igualmente se expone una investigación experimental con diseño ex post facto cuyo objetivo es estudiar la calidad de la experiencia en distintos colectivos profesionales y universitarios y explorar las relaciones entre el constructo flow y otras variables psicológicas afines: afecto positivo, bienestar psicológico, autoeficacia, autoconcordancia, absorción, placer e interés intrínseco. La muestra está compuesta por 294 sujetos, profesionales sanitarios y estudiantes universitarios. Los resultados obtenidos muestran altas correlaciones con las variables afines al flow y que algunas de estas, son capaces de predecir parte de la varianza del mismo, del placer y de la absorción. Estos resultados se pueden considerar interesantes para delimitar la naturaleza del flow y sus relaciones con otros constructos afines.To optimize personal, academic or professional performance and remain competitive amid standards of excellence, both in personal life and at work, can be a gratifying challenge or lead to stress and a negative impact on a person's health and overall productivity. It is interesting, however, with the development of social and emotional intelligence, to consider that in professional and academic spheres it is possible to aspire to optimal performance not only without generating negative health outcomes but actually increasing personal satisfaction and psychological wellbeing. This revision presents an initial research and theoretical approximation to the hypothesis concentrating on psychological constructs of optimal attainment, high performance standards and flow. It also presents an experimental research with ex post facto design whose goal is to study the quality of the experience in different professional and university groups and explore the relations between the flow construct and other related psychological variables: positive fondness, psychological wellness, self-efficacy, self-concordance, absorption, pleasure and intrinsic interest. The sample consists of 294 subjects, health professionals and university students. The results obtained show high correlations with the variables related to flow, and some of these are able to predict part of its variance, in pleasure and in absorption. These results can be considered interesting in order to determine the nature of flow in different professionals and its relationship with other related constructs

Melatonin decreases glucose metabolism in prostate cancer cells: A 13C stable isotope-resolved metabolomic study

The pineal neuroindole melatonin exerts an exceptional variety of systemic functions. Some of them are exerted through its specific membrane receptors type 1 and type 2 (MT1 and MT2) while others are mediated by receptor-independent mechanisms. A potential transport of melatonin through facilitative glucose transporters (GLUT/SLC2A) was proposed in prostate cancer cells. The prostate cells have a particular metabolism that changes during tumor progression. During the first steps of carcinogenesis, oxidative phosphorylation is reactivated while the switch to the “Warburg effect” only occurs in advanced tumors and in the metastatic stage. Here, we investigated whether melatonin might change prostate cancer cell metabolism. To do so, 13C stable isotope-resolved metabolomics in androgen sensitive LNCaP and insensitive PC-3 prostate cancer cells were employed. In addition to metabolite 13C-labeling, ATP/AMP levels, and lactate dehydrogenase or pentose phosphate pathway activity were measured. Melatonin reduces lactate labeling in androgen-sensitive cells and it also lowers 13C-labeling of tricarboxylic acid cycle metabolites and ATP production. In addition, melatonin reduces lactate 13C-labeling in androgen insensitive prostate cancer cells. Results demonstrated that melatonin limits glycolysis as well as the tricarboxylic acid cycle and pentose phosphate pathway in prostate cancer cells, suggesting that the reduction of glucose uptake is a major target of the indole in this tumor type

Slavery and the african cultural legacy in the Caribbean

Con autorización de la editorial para este libro.[EN] The purpose of this book is to raise awareness among a wide audience of one of the most significant and shameful phenomena for humanity, as was the enslavement of over twelve and a half million Africans who were brought to America and forced to work and live as slaves. Many countries participated in the slave trade at different times and withvaried intensity (Great Britain, Portugal, France, Spain, Denmark, Netherlands, Germany, United States...).[ES] El propósito de esta obra es dar a conocer a un público amplio uno de los fenómenos de mayor trascendencia y vergüenza para la humanidad como fue la esclavización de más de doce millones y medio de africanos que fueron trasladados a América, obligados a trabajar y vivir como esclavos. Muchos países participaron en la trata de esclavos en distintos momentos y con diferente intensidad (Gran Bretaña, Portugal, Francia, España, Dinamarca, Países Bajos, Alemania, Estados Unidos…).Connected Worlds: The Caribbean, Origin of Modern World. This project has received funding from the European Union´s Horizon 2020 research and innovation programme under the Marie Sklodowska Curie grant agreement Nº 823846. This project is directed by professor Consuelo Naranjo Orovio, Institute of History-CSIC.Peer reviewe

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Association of candidate gene polymorphisms with chronic kidney disease : Results of a case-control analysis in the NEFRONA cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2,445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionization-time of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

El archivo tallado: documentos de piedra y barro en la iglesia de San Antolín de Bedón

Archives are defined as a organic whole of records; structured groups of recorded data with an «archival bond», proof of administrative and legal actions. Although new means of codifying information have changed recently the traditional state of affairs, giving rise to «hybrid fonds» in which new types of records are kept alongside conventional ones, this is not entirely novel: this is not the first time that a single process has been used for issuing and receiving both ordinary documents and others information-bearing objects that, without using the written word, relied on social conventions to provide proof of rights and to bear witness to activities with legal relevance: records «avant la lettre», so to speak. Is the case of the medieval stone mason’s marks, sometimes used as signatures or seals to constitute proof of economic rights: reliable legal instruments which bear witness to the rights and obligations that hold between two parties, making them records/archives in the true sense of the word, accumulated and deposited “stratigraphically,”inside the fonds as a structure and outside the archive as a physical place

Un microespacio en la montaña asturiana: Presorias1

This work is an micro-spatial analysis of a medieval uninhabited place located in Asturias highlands. The use of various kind of sources -documents, study of place-names, fieldwork- made possible to define the old village’s limits and to know its internal structure -habitat, fields, and notes about agricultural uses-. This analysis is completed with a vision of previous establishments to that medieval villa; also, with a study of the village and surrounds evolution after the depopulation, when it was transformed in pastures for the nears villages profit.El presente trabajo es el análisis microespacial de un despoblado medieval situado en la montaña asturiana. La utilización del mayor número posible de fuentes, de carácter diverso -documentales, toponímicas, trabajo de campo-, ha permitido delimitar el término de la antigua aldea, así como conocer su estructuración interna -hábitat, espacios de cultivo, características del aprovechamiento agrícola y ganadero, etc.-. El análisis se completa con una visión de los antecedentes inmediatos de la villa medieval, así como de la evolucion posterior del espacio tras su abandono como núcleo habitado y su conversión en espacio de pasto para el ganado de las aldeas vecinas