Transitioning to Retirement: Useful topics for a Wellness Program with Retired Older Adults

Retirement has evolved from traditional stereotypes to an individualized plan. Transitioning into retirement can be a stressful time and it is generally accepted that pre-retirement attitudes impact post-retirement success (Marshall, Clarke & Ballantyne, 2001). A wellness program can make the transition into retirement less difficult by incorporating different dimensions of wellness: social, intellectual, occupational, physical, emotional, and spiritual (Strout & Howard, 2012). Currently there is very little research indicating the effectiveness of a wellness program that addresses these dimensions. The purpose of this phenomenological study was to gain insight into useful topics for a wellness program based on perspectives of currently retired adults to assist those who will retire in the future. A phenomenological research design was used to develop semi-structured interviews with four male retirees from the Midwest regions of Grand Forks, ND and Minneapolis, MN. Interviews were conducted to gather rich detail about the participants’ retirement experiences. Data analysis was based on methods developed by Giorgi and Giorgi (2008) to draw out common experiences among the participants. Themes that were important during the transition to retirement included retirement planning, supportive relationships, and maintenance of a healthy lifestyle. Finances and possible decline in health were the major concerns for retirees. A primary limitation of this study was due to the small, Midwest-based, male sample size

Role of Physicians in Addressing Food Insecurity in Vermont Seniors

Introduction: This study investigated Vermont physicians’ awareness of - and engagement in – addressing food insecurity experienced by their elderly patients. This information is needed to better understand the role physicians play in solving this problem and to know how education and access to services could ensure that the needs of elders are met in a culturally sensitive manner. Many elders must choose between paying bills, buying medication or buying food. Some elders are unaware that they qualify for food assistance, or would feel stigmatized using it. Nationally, 56% of physicians reported that they were not knowledgeable about food insecurity. Food insecurity can be screened for by using Hunger Free Vermont’s Two Question Screen. Screening, followed by a multidisciplinary team approach with contributions from dietitians, geriatricians, social workers and psychologists may be the most effective way of assessing at-risk patients.https://scholarworks.uvm.edu/comphp_gallery/1214/thumbnail.jp

Salinity has little effect on photosynthetic and respiratory responses to seasonal temperature changes in black mangrove (Avicennia germinans) seedlings

Temperature and salinity are important regulators of mangrove range limits and productivity, but the physiological responses of mangroves to the interactive effects of temperature and salinity remain uncertain. We tested the hypothesis that salinity alters photosynthetic responses to seasonal changes in temperature and vapor pressure deficit (D), as well as thermal acclimation_of leaf respiration in black mangrove (Avicennia germinans). To test this hypothesis, we grew seedlings of A. germinans in an outdoor experiment for ~ 12 months under four treatments spanning 0 to 55 ppt porewater salinity. We repeatedly measured seedling growth and in situ rates of leaf net photosynthesis (Asat) and stomatal conductance to water vapor (gs) at prevailing leaf temperatures, along with estimated rates of Rubisco carboxylation (Vcmax) and electron transport for RuBP regeneration (Jmax), and measured rates of leaf respiration at 25 °C (Rarea25). We developed empirical models describing the seasonal response of leaf gas exchange and photosynthetic capacity to leaf temperature and D, and the response of Rarea25 to changes in mean daily air temperature. We tested the effect of salinity on model parameters. Over time, salinity had weak or inconsistent effects on Asat, gs and Rarea25. Salinity also had little effect on the biochemical parameters of photosynthesis (Vcmax, Jmax) and individual measurements of Asat, gs, Vcmax and Jmax showed a similar response to seasonal changes in temperature and D across all salinity treatments. Individual measurements of Rarea25 showed a similar inverse relationship with mean daily air temperature across all salinity treatments. We conclude that photosynthetic responses to seasonal changes in temperature and D, as well as seasonal temperature acclimation of leaf R, are largely consistent across a range of salinities in A. germinans. These results might simplify predictions of photosynthetic and respiratory responses to temperature in young mangroves

Phototocatalytic Lithography of Poly(propylene sulfide) Block Copolymers: Toward High-Throughput Nanolithography for Biomolecular Arraying Applications

Photocatalytic lithography (PCL) is an inexpensive, fast, and robust method of oxidizing surface chemical moieties to produce patterned substrates. This technique has utility in basic biological research as well as various biochip applications. We report on porphyrin-based PCL for patterning poly(propylene sulfide) block copolymer films on gold substrates on the micrometer and submicrometer scales. We confirm chemical patterning with imaging ToF-SIMS and low-voltage SEM. Biomolecular patterning on micrometer and submicrometer scales is demonstrated with proteins, protein-linked beads. and fluorescently labeled proteins

BCAR3 Regulates Src/p130Cas Association, Src Kinase Activity, and Breast Cancer Adhesion Signaling*

The nonreceptor protein-tyrosine kinase c-Src is frequently overexpressed and/or activated in a variety of cancers, including those of the breast. Several heterologous binding partners of c-Src have been shown to regulate its catalytic activity by relieving intramolecular autoinhibitory interactions. One such protein, p130Cas (Cas), is expressed at high levels in both breast cancer cell lines and breast tumors, providing a potential mechanism for c-Src activation in breast cancers. The Cas-binding protein BCAR3 (breast cancer antiestrogen resistance-3) is expressed at high levels in invasive breast cancer cell lines, and this molecule has previously been shown to coordinate with Cas to increase c-Src activity in COS-1 cells. In this study, we show for the first time using gain- and loss-of-function approaches that BCAR3 regulates c-Src activity in the endogenous setting of breast cancer cells. We further show that BCAR3 regulates the interaction between Cas and c-Src, both qualitatively as well as quantitatively. Finally, we present evidence that the coordinated activity of these proteins contributes to breast cancer cell adhesion signaling and spreading. Based on these data, we propose that the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes