Reclaiming youth work: from evidence-based practice to practice-based evidence.

A thesis submitted to the University of Bedfordshire, in partial fulfilment of the reqiurements for the degree of Doctor of Philosophy.An abiding criticism of youth work is the inability of its practitioners either to articulate the theoretical basis of their practice or evidence its practical impact (House of Commons, Services for Young People: Third Report of Session 2010-12). This study explores whether, and to what extent, youth workers can articulate their practice wisdom in a form that can generate a body of ‘practice-based evidence’; sufficiently robust to persuade both those responsible for formulating youth work policy and those commissioning services of its efficacy. It develops a model which aims to assist youth workers in this endeavour, designed to support them in contributing to critical debates about the nature of their practice. This thesis is based upon a case study undertaken with a large voluntary sector youth organisation in the north of England. A number of research methods were used in the study including the design of an Economic and Social Research Council (ESRC) funded knowledge exchange event, the administration of questionnaires to student youth workers at the University of Bedfordshire and semi-structured interviews with practitioners. The study uses Interpretative Phenomenological Analysis (IPA) as the lens through which the findings are derived from the data. The findings suggest that youth workers are able to conceptualise and articulate their practice wisdom and that the opportunity to engage in knowledge transfer activities is methodologically extremely helpful. It appears that practice-based evidence can be generated via such a process which helps to make explicit the nature of the work and its impact upon young people. On the basis of these findings, the author presents a model describing the key prerequisites for the generation of practice-based evidence in youth work. However, the current social, political and economic climate in England has meant that the applicability of such a model is entirely dependent upon the political and administrative context in which youth work is practiced. The imposition of tightly demarcated targets and narrowly defined outcomes, together with the individualisation of much service provision for young people requiring case work interventions, has meant that youth work’s phronetic intentions have become obscured, and for some organisations, lost. This is against the backcloth of the needs of the young people being targeted by youth services becoming more complex, requiring a more specialist, therapeutic intervention. The author suggests that the time has come for bolder initiatives utilising critical social pedagogy as a threshold concept which, she asserts may allow the profession to embark upon a process of ‘reclaiming’ its professional roots

Research into gang-associated sexual exploitation and sexual violence : interim report

The research has been commissioned by the Office of the Children’s Commissioner for England (OCC) as part of their Inquiry into Child Sexual Exploitation in Gangs and Groups (CSEGG).This report presents the interim findings of a two year study into gang-associated sexual exploitation and violenc

"It's wrong - but you get used to it" : a qualitative study of gang-associated sexual violence towards, and exploitation of, young people in England

A report commissioned by the Office of the Children’s Commissioner’s Inquiry into Child Sexual Exploitation in Gangs and GroupsThe research was commissioned by the Office of the Children’s Commissioner for England as part of its Inquiry into Child Sexual Exploitation in Gangs and Groups. The research aimed to consider: the scale and nature of gang-associated sexual violence and exploitation in six areas of England; the main pathways into gang-related sexual violence and exploitation for young people living in these neighbourhoods; and potential models for an effective multi-agency response to the issue

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: A large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Introduction: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the

Refined histopathological predictors of BRCA1 and BRCA2 mutation status : a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Abstract Introduction The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach. Results ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)). Conclusions These results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management

Gang-involved young people: custody and beyond: a practitioner's guide

This practitioner’s guide examines how knowledge about the specific needs of gang-involved young people and the factors relating to desistance from gang-related crime can inform effective practice with current and former gang-involved young people during their time in custody and beyond.A significant amount of research into the onset of, and involvement in, gangs, gang crime, and serious youth violence has already been carried out. However, there is a limited amount of material available on desistance from gang crime, the resettlement of gang-involved young people and, in particular, how their period of incarceration and return to the community might best be managed. This practitioner’s guide examines how knowledge about the specific needs of gang-involved young people and the factors relating to desistance from gang-related crime can inform effective practice with current and former gang-involved young people during their time in custody and beyond. This guide uses the current literature, interviews with policy makers and practitioners and focus groups with professionals and young people who were either serving, or had recently served a custodial sentence for a gang-related offence. The full research report by Fiona Factor and Professor John Pitts with Dr Tim Bateman upon which this briefing is based, along with full details of the references used, is available at www.beyondyouthcustody.net

Gang-involved young people: custody and beyond

Report based upon a review of the English language literature on the rehabilitation of gang-involved young peopleThis report is based upon a review of the English language literature on the rehabilitation of gang-involved young people aged between 10 and 25. The information in the literature review is augmented by interviews with policy makers and practitioners. The fieldwork was undertaken between October and December 2014. 27 professionals attended focus groups in the south-east and north-west of England at which findings from the literature review and the challenges faced by practitioners were explored. Additionally, interviews with resettlement professionals and young people were conducted at six sites. The young people were either in custody or had recently served custodial sentences for gang-related offences. 19 young people aged between 16 and 25 were interviewed, three of whom were female. In addition, eight interviews were conducted with professionals responsible for resettlement programmes both in custody and the community

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia.

IntroductionThe distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling.MethodsSelection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach.ResultsER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)).ConclusionsThese results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management