Disease activity and biologic use in patients with psoriatic arthritis or rheumatoid arthritis.

To compare disease burden and biologic use among psoriatic arthritis (PsA) or rheumatoid arthritis (RA) patients recruited to the Corrona registry. Retrospective study of patients with PsA or RA enrolled in Corrona between January 2002 and March 2013 and grouped in 2-year intervals. Clinical outcomes and biologic use were assessed. Biologic use increased over time in both cohorts, with 62 and 52% of patients with PsA and RA, respectively, receiving biologics by 2012-2013. However, 25 and 35% of patients with PsA and RA, respectively, continued to experience moderate/high disease activity. Overall, the progressive increase in biologic use accompanied progressive decreases in Clinical Disease Activity Index (from 14.2 to 10.4 for RA, and 12.4 to 8.1 for PsA) and mean Health Assessment Questionnaire score (from 0.36 to 0.34, and 0.3 to 0.24). Mean patient pain, the proportion of patients reporting morning stiffness, and the mean duration of morning stiffness remained similar for both cohorts. PsA and RA treated in the rheumatology setting had a comparable impact on patient quality of life and functional ability. Disease burden improved with increased biologic utilization in both groups; however, moderate/severe disease remains in a significant proportion of PsA and RA patients

Solutions for 10,000 Eclipsing Binaries in the Bulge Fields of OGLE II Using DEBiL

We have developed a fully-automated pipeline for systematically identifying and analyzing eclipsing binaries within large datasets of light curves. The pipeline is made up of multiple tiers which subject the light curves to increasing levels of scrutiny. After each tier, light curves that did not conform to a given criteria were filtered out of the pipeline, reducing the load on the following, more computationally intensive tiers. As a central component of the pipeline, we created the fully automated Detached Eclipsing Binary Light curve fitter (DEBiL), which rapidly fits large numbers of light curves to a simple model. Using the results of DEBiL, light curves of interest can be flagged for follow-up analysis. As a test case, we analyzed the 218699 light curves within the bulge fields of the OGLE II survey and produced 10862 model fits. We point out a small number of extreme examples as well as unexpected structure found in several of the population distributions. We expect this approach to become increasingly important as light curve datasets continue growing in both size and number.Comment: Accepted for publication in ApJ, 36 pages, 15 figures, 5 tables. See http://cfa-www.harvard.edu/~jdevor/DEBiL.html for high-resolution figures and further informatio

Absolute properties of BG Ind - a bright F3 system just leaving the Main Sequence

We present photometric and spectroscopic analysis of the bright detached eclipsing binary BG Ind. The masses of the components are found to be 1.428 +- 0.008 and 1.293 +- 0.008 Msun and the radii to be 2.290+-0.017 and 1.680+-0.038 Rsun for primary and secondary stars, respectively. Spectra- and isochrone-fitting coupled with color indices calibration yield [Fe/H]=-0.2+-0.1. At an age of 2.65+-0.20 Gyr BG Ind is well advanced in the main-sequence evolutionary phase - in fact, its primary is at TAMS or just beyond it. Together with three similar systems (BK Peg, BW Aqr and GX Gem) it offers an interesting opportunity to test the theoretical description of overshooting in the critical mass range 1.2-1.5 Msun.Comment: 8 pages, 5 figures, corrected bugs in author lis

Orbital and physical parameters of eclipsing binaries from the ASAS catalogue - IV. A 0.61 + 0.45 M_sun binary in a multiple system

We present the orbital and physical parameters of a newly discovered low-mass detached eclipsing binary from the All-Sky Automated Survey (ASAS) database: ASAS J011328-3821.1 A - a member of a visual binary system with the secondary component separated by about 1.4 seconds of arc. The radial velocities were calculated from the high-resolution spectra obtained with the 1.9-m Radcliffe/GIRAFFE, 3.9-m AAT/UCLES and 3.0-m Shane/HamSpec telescopes/spectrographs on the basis of the TODCOR technique and positions of H_alpha emission lines. For the analysis we used V and I band photometry obtained with the 1.0-m Elizabeth and robotic 0.41-m PROMPT telescopes, supplemented with the publicly available ASAS light curve of the system. We found that ASAS J011328-3821.1 A is composed of two late-type dwarfs having masses of M_1 = 0.612 +/- 0.030 M_sun, M_2 = 0.445 +/- 0.019 M_sun and radii of R_1 = 0.596 +/- 0.020 R_sun, R_2 = 0.445 +/- 0.024 R_sun, both show a substantial level of activity, which manifests in strong H_alpha and H_beta emission and the presence of cool spots. The influence of the third light on the eclipsing pair properties was also evaluated and the photometric properties of the component B were derived. Comparison with several popular stellar evolution models shows that the system is on its main sequence evolution stage and probably is more metal rich than the Sun. We also found several clues which suggest that the component B itself is a binary composed of two nearly identical ~0.5 M_sun stars.Comment: 12 pages, 7 figures, 7 tables, to appear in MNRA

Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary.

Fetuses, infants, and juveniles (preadults) should not be considered simply "small adults" when it comes to toxicological risk. We present specific examples of developmental toxicants that are more toxic to children than to adults, focusing on effects on the immune and respiratory systems. We describe differences in both the pharmacokinetics of the developing immune and respiratory systems as well as changes in target organ sensitivities to toxicants. Differential windows of vulnerability during development are identified in the context of available animal models. We provide specific approaches to directly investigate differential windows of vulnerability. These approaches are based on fundamental developmental biology and the existence of discrete developmental processes within the immune and respiratory systems. The processes are likely to influence differential developmental susceptibility to toxicants, resulting in lifelong toxicological changes. We also provide a template for comparative research. Finally, we discuss the application of these data to risk assessment

Understanding the association between skin involvement and joint activity in patients with psoriatic arthritis: experience from the Corrona Registry.

Objective: To compare the characteristics of patients with psoriatic arthritis among patient groups stratified by degree of skin and joint involvement, and to evaluate the relationship between skin severity and joint activity. Methods: Body surface area (BSA) and Clinical Disease Activity Index (CDAI) at enrolment were analysed. Patient characteristics were stratified by skin severity and joint activity. Baseline patient characteristics, clinical and disease characteristics and patient-reported outcomes were compared. The strength of the relationship of skin severity and joint activity was evaluated using methods for categorical variables (χ Results: 1542 adult patients in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry enrolled between 21 May 2013 and 20 September 2016 were analysed. Most patients in the BSA \u3e3%/CDAI moderate/high subgroup had worse clinical and patient-reported outcomes. A significant (p Conclusion: Skin severity is modestly correlated with joint activity, and patients with higher skin severity are two times more likely to have increased joint involvement. Clinicians need to address both skin severity and joint activity in treatment decisions

High-precision photometry by telescope defocussing. III. The transiting planetary system WASP-2

We present high-precision photometry of three transits of the extrasolar planetary system WASP-2, obtained by defocussing the telescope, and achieving point-to-point scatters of between 0.42 and 0.73 mmag. These data are modelled using the JKTEBOP code, and taking into account the light from the recently-discovered faint star close to the system. The physical properties of the WASP-2 system are derived using tabulated predictions from five different sets of stellar evolutionary models, allowing both statistical and systematic errorbars to be specified. We find the mass and radius of the planet to be M_b = 0.847 +/- 0.038 +/- 0.024 Mjup and R_b = 1.044 +/- 0.029 +/- 0.015 Rjup. It has a low equilibrium temperature of 1280 +/- 21 K, in agreement with a recent finding that it does not have an atmospheric temperature inversion. The first of our transit datasets has a scatter of only 0.42 mmag with respect to the best-fitting light curve model, which to our knowledge is a record for ground-based observations of a transiting extrasolar planet.Comment: Accepted for publication in MNRAS. 9 pages, 3 figures, 10 table

Upper Limits on a Stochastic Background of Gravitational Waves

The Laser Interferometer Gravitational-Wave Observatory has performed a third science run with much improved sensitivities of all three interferometers. We present an analysis of approximately 200 hours of data acquired during this run, used to search for a stochastic background of gravitational radiation. We place upper bounds on the energy density stored as gravitational radiation for three different spectral power laws. For the flat spectrum, our limit of Ω_0<8.4×10^(-4) in the 69–156 Hz band is ~10^5 times lower than the previous result in this frequency range

Limits on Gravitational-Wave Emission from Selected Pulsars Using LIGO Data

We place direct upper limits on the amplitude of gravitational waves from 28 isolated radio pulsars by a coherent multidetector analysis of the data collected during the second science run of the LIGO interferometric detectors. These are the first direct upper limits for 26 of the 28 pulsars. We use coordinated radio observations for the first time to build radio-guided phase templates for the expected gravitational-wave signals. The unprecedented sensitivity of the detectors allows us to set strain upper limits as low as a few times 10^(-24). These strain limits translate into limits on the equatorial ellipticities of the pulsars, which are smaller than 10^(-5) for the four closest pulsars