82 research outputs found
Police Action and the State-Created Danger Doctrine: a Proposed Uniform Test
The state-created danger doctrine provides the basis for a potential claim when a state actor creates a danger that results in an injury to the plaintiff. The doctrine may be interpreted as an exception to the general rule that a state has no duty to protect one private citizen from another. Because the U.S. Supreme Court has not addressed the issue, many variations of the state-created danger doctrine exist across the federal circuits. The resulting lack of uniformity has led to inconsistent results, promoting unfairness for litigants throughout the country.
This Comment explores the history, objectives, and current approaches to the state-created danger doctrine. This Comment also examines the public policy considerations with which the federal circuits seem to struggle. A recent case involving police action demonstrates the perils of inconsistency and the need for balance to further the interests of the public. Finally, this Comment recommends a simplified uniform test to restore uniformity to the federal circuits
Coordinated mm/sub-mm observations of Sagittarius A* in May 2007
At the center of the Milky Way, with a distance of ~8 kpc, the compact source
Sagittarius A* (SgrA*) can be associated with a super massive black hole of
~4x10^6 solar masses. SgrA* shows strong variability from the radio to the
X-ray wavelength domains. Here we report on simultaneous
NIR/sub-millimeter/X-ray observations from May 2007 that involved the NACO
adaptive optics (AO) instrument at the European Southern Observatory's Very
Large Telescope, the Australian Telescope Compact Array (ATCA), the US mm-array
CARMA, the IRAM 30m mm-telescope, and other telescopes. We concentrate on the
time series of mm/sub-mm data from CARMA, ATCA, and the MAMBO bolometer at the
IRAM 30m telescope.Comment: 7 pages, 3 figures, contribution for the conference "The Universe
under the Microscope" (AHAR 2008), to be published in Journal of Physics:
Conference Series by Institute of Physics Publishin
Coordinated NIR/mm observations of flare emission from Sagittarius A*
We report on a successful, simultaneous observation and modelling of the
millimeter (mm) to near-infrared (NIR) flare emission of the Sgr A* counterpart
associated with the supermassive black hole at the Galactic centre (GC). We
present a mm/sub-mm light curve of Sgr A* with one of the highest quality
continuous time coverages and study and model the physical processes giving
rise to the variable emission of Sgr A*.Comment: 14 pages, 16 figure
Defining the role of real-world data in cancer clinical research: The position of the European Organisation for Research and Treatment of Cancer
The emergence of the precision medicine paradigm in oncology has led to increasing interest in the integration of real-world data (RWD) into cancer clinical research. As sources of real-world evidence (RWE), such data could potentially help address the uncertainties that surround the adoption of novel anticancer therapies into the clinic following their investigation in clinical trials. At present, RWE-generating studies which investigate antitumour interventions seem to primarily focus on collecting and analysing observational RWD, typically forgoing the use of randomisation despite its methodological benefits. This is appropriate in situations where randomised controlled trials (RCTs) are not feasible and non-randomised RWD analyses can offer valuable insights. Nevertheless, depending on how they are designed, RCTs have the potential to produce strong and actionable RWE themselves. The choice of which methodology to employ for RWD studies should be guided by the nature of the research question they are intended to answer. Here, we attempt to define some of the questions that do not necessarily require the conduct of RCTs. Moreover, we outline the strategy of the European Organisation for Research and Treatment of Cancer (EORTC) to contribute to the generation of robust and high-quality RWE by prioritising the execution of pragmatic trials and studies set up according to the trials-within-cohorts approach. If treatment allocation cannot be left up to random chance due to practical or ethical concerns, the EORTC will consider undertaking observational RWD research based on the target trial principle. New EORTC-sponsored RCTs may also feature concurrent prospective cohorts composed of off-trial patients
Defining the role of real-world data in cancer clinical research:The position of the European Organisation for Research and Treatment of Cancer
The emergence of the precision medicine paradigm in oncology has led to increasing interest in the integration of real-world data (RWD) into cancer clinical research. As sources of real-world evidence (RWE), such data could potentially help address the uncertainties that surround the adoption of novel anticancer therapies into the clinic following their investigation in clinical trials. At present, RWE-generating studies which investigate antitumour interventions seem to primarily focus on collecting and analysing observational RWD, typically forgoing the use of randomisation despite its methodological benefits. This is appropriate in situations where randomised controlled trials (RCTs) are not feasible and non-randomised RWD analyses can offer valuable insights. Nevertheless, depending on how they are designed, RCTs have the potential to produce strong and actionable RWE themselves. The choice of which methodology to employ for RWD studies should be guided by the nature of the research question they are intended to answer. Here, we attempt to define some of the questions that do not necessarily require the conduct of RCTs. Moreover, we outline the strategy of the European Organisation for Research and Treatment of Cancer (EORTC) to contribute to the generation of robust and high-quality RWE by prioritising the execution of pragmatic trials and studies set up according to the trials-within-cohorts approach. If treatment allocation cannot be left up to random chance due to practical or ethical concerns, the EORTC will consider undertaking observational RWD research based on the target trial principle. New EORTC-sponsored RCTs may also feature concurrent prospective cohorts composed of off-trial patients
Traces of past activity in the Galactic Centre
The Milky Way centre hosts a supermassive Black Hole (BH) with a mass of
~4*10^6 M_Sun. Sgr A*, its electromagnetic counterpart, currently appears as an
extremely weak source with a luminosity L~10^-9 L_Edd. The lowest known
Eddington ratio BH. However, it was not always so; traces of "glorious" active
periods can be found in the surrounding medium. We review here our current view
of the X-ray emission from the Galactic Center (GC) and its environment, and
the expected signatures (e.g. X-ray reflection) of a past flare. We discuss the
history of Sgr A*'s past activity and its impact on the surrounding medium. The
structure of the Central Molecular Zone (CMZ) has not changed significantly
since the last active phase of Sgr A*. This relic torus provides us with the
opportunity to image the structure of an AGN torus in exquisite detail.Comment: Invited refereed review. Chapter of the book: "Cosmic ray induced
phenomenology in star forming environments" (eds. Olaf Reimer and Diego F.
Torres
In situ formation of SgrA* stars via disk fragmentation: parent cloud properties and thermodynamics
The formation of the massive young stars surrounding SgrA* is still an open
question. In this paper, we simulate the infall of a turbulent molecular cloud
towards the Galactic Center (GC). We adopt two different cloud masses (4.3x10^4
and 1.3x10^5 solar masses). We run five simulations: the gas is assumed to be
isothermal in four runs, whereas radiative cooling is included in the fifth
run. In all the simulations, the molecular cloud is tidally disrupted, spirals
towards the GC, and forms a small, dense and eccentric disk around SgrA*. With
high resolution simulations, we follow the fragmentation of the gaseous disk.
Star candidates form in a ring at ~0.1-0.4 pc from the super-massive black hole
(SMBH) and have moderately eccentric orbits (~0.2-0.4), in good agreement with
the observations. The mass function of star candidates is top-heavy only if the
local gas temperature is high (>~100 K) during the star formation and if the
parent cloud is sufficiently massive (>~10^5 solar masses). Thus, this study
indicates that the infall of a massive molecular cloud is a viable scenario for
the formation of massive stars around SgrA*, provided that the gas temperature
is kept sufficiently high (>~100 K).Comment: 16 pages, 16 figures, accepted for publication in Ap
Star Formation and Dynamics in the Galactic Centre
The centre of our Galaxy is one of the most studied and yet enigmatic places
in the Universe. At a distance of about 8 kpc from our Sun, the Galactic centre
(GC) is the ideal environment to study the extreme processes that take place in
the vicinity of a supermassive black hole (SMBH). Despite the hostile
environment, several tens of early-type stars populate the central parsec of
our Galaxy. A fraction of them lie in a thin ring with mild eccentricity and
inner radius ~0.04 pc, while the S-stars, i.e. the ~30 stars closest to the
SMBH (<0.04 pc), have randomly oriented and highly eccentric orbits. The
formation of such early-type stars has been a puzzle for a long time: molecular
clouds should be tidally disrupted by the SMBH before they can fragment into
stars. We review the main scenarios proposed to explain the formation and the
dynamical evolution of the early-type stars in the GC. In particular, we
discuss the most popular in situ scenarios (accretion disc fragmentation and
molecular cloud disruption) and migration scenarios (star cluster inspiral and
Hills mechanism). We focus on the most pressing challenges that must be faced
to shed light on the process of star formation in the vicinity of a SMBH.Comment: 68 pages, 35 figures; invited review chapter, to be published in
expanded form in Haardt, F., Gorini, V., Moschella, U. and Treves, A.,
'Astrophysical Black Holes'. Lecture Notes in Physics. Springer 201
Linking changes in species composition and biomass in a globally distributed grassland experiment
Global change drivers, such as anthropogenic nutrient inputs, are increasing globally. Nutrient deposition simultaneously alters plant biodiversity, species composition and ecosystem processes like aboveground biomass production. These changes are underpinned by species extinction, colonisation and shifting relative abundance. Here, we use the Price equation to quantify and link the contributions of species that are lost, gained or that persist to change in aboveground biomass in 59 experimental grassland sites. Under ambient (control) conditions, compositional and biomass turnover was high, and losses (i.e. local extinctions) were balanced by gains (i.e. colonisation). Under fertilisation, the decline in species richness resulted from increased species loss and decreases in species gained. Biomass increase under fertilisation resulted mostly from species that persist and to a lesser extent from species gained. Drivers of ecological change can interact relatively independently with diversity, composition and ecosystem processes and functions such as aboveground biomass due to the individual contributions of species lost, gained or persisting.Fil: Ladouceur, Emma. Martin Luther University Halle-Wittenberg; Alemania. Universitat Leipzig; Alemania. German Centre for Integrative Biodiversity Research (iDiv) Leipzig-Halle-Jena; AlemaniaFil: Blowes, Shane A.. Martin Luther University Halle-Wittenberg; Alemania. German Centre for Integrative Biodiversity Research (iDiv) Leipzig-Halle-Jena; AlemaniaFil: Chase, Jonathan M.. German Centre for Integrative Biodiversity Research (iDiv) Leipzig-Halle-Jena; Alemania. Martin Luther University Halle-Wittenberg; AlemaniaFil: Clark, Adam T.. Martin Luther University Halle-Wittenberg; Alemania. German Centre for Integrative Biodiversity Research (iDiv) Leipzig-Halle-Jena; Alemania. University of Graz; AustriaFil: Garbowski, Magda. German Centre for Integrative Biodiversity Research (iDiv) Leipzig-Halle-Jena; Alemania. Universitat Leipzig; AlemaniaFil: Alberti, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Arnillas, Carlos Alberto. University of Toronto; CanadáFil: Bakker, Jonathan. University of Washington; Estados UnidosFil: Barrio, Isabel C.. Agricultural University of Iceland; IslandiaFil: Bharath, Siddharth. Atria University; IndiaFil: Borer, Elizabeth. University of Minnesota; Estados UnidosFil: Brudvig, Lars A.. Michigan State University; Estados UnidosFil: Cadotte, Marc W.. University of Toronto; CanadáFil: Chen, Qingqing. Peking University; ChinaFil: Collins, Scott L.. University of New Mexico; Estados UnidosFil: Dickman, Christopher R.. The University Of Sydney; AustraliaFil: Donohue, Ian. Trinity College Dublin; IrlandaFil: Du, Guozhen. Lanzhou University; ChinaFil: Ebeling, Anne. Universitat Jena; AlemaniaFil: Eisenhauer, Nico. Martin Luther University Halle—Wittenberg; Alemania. German Centre For Integrative Biodiversity Research (idiv) Halle-jena-leipzig; AlemaniaFil: Fay, Philip A.. USDA-ARS Grassland Soil and Water Research Lab; Estados UnidosFil: Hagenah, Nicole. University Of Pretoria; SudáfricaFil: Hautier, Yann. University of Utrecht; Países BajosFil: Jentsch, Anke. University of Bayreuth; AlemaniaFil: Jónsdóttir, Ingibjörg S.. University of Iceland; IslandiaFil: Komatsu, Kimberly J.. Smithsonian Environmental Research Center; Estados UnidosFil: MacDougall, Andrew. University of Guelph; CanadáFil: Martina, Jason P.. Texas State University; Estados UnidosFil: Moore, Joslin L.. Arthur Rylah Institute For Environmental Research; Australia. Monash University; AustraliaFil: Morgan, John W.. La Trobe University; AustraliaFil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Defining the role of real-world data in cancer clinical research: The position of the European Organisation for Research and Treatment of Cancer
The emergence of the precision medicine paradigm in oncology has led to increasing interest in the integration of real-world data (RWD) into cancer clinical research. As sources of real-world evidence (RWE), such data could potentially help address the uncertainties that surround the adoption of novel anticancer therapies into the clinic following their investigation in clinical trials. At present, RWE-generating studies which investigate antitumour interventions seem to primarily focus on collecting and analysing observational RWD, typically forgoing the use of randomisation despite its methodological benefits. This is appropriate in situations where randomised controlled trials (RCTs) are not feasible and non-randomised RWD analyses can offer valuable insights. Nevertheless, depending on how they are designed, RCTs have the potential to produce strong and actionable RWE themselves. The choice of which methodology to employ for RWD studies should be guided by the nature of the research question they are intended to answer. Here, we attempt to define some of the questions that do not necessarily require the conduct of RCTs. Moreover, we outline the strategy of the European Organisation for Research and Treatment of Cancer (EORTC) to contribute to the generation of robust and high-quality RWE by prioritising the execution of pragmatic trials and studies set up according to the trials-within-cohorts approach. If treatment allocation cannot be left up to random chance due to practical or ethical concerns, the EORTC will consider undertaking observational RWD research based on the target trial principle. New EORTC-sponsored RCTs may also feature concurrent prospective cohorts composed of off-trial patients
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