5,588 research outputs found
Structural templating as a route to improved photovoltaic performance in copper phthalocyanine/fullerene (C60) heterojunctions
We have developed a method to improve the short circuit current density in copper phthalocyanine (CuPc)/fullerene (C60) organic solar cells by ~60% by modifying the CuPc crystal orientation through use of a molecular interlayer to maximize charge transport in the direction between the two electrodes. Powder x-ray diffraction and electronic absorption spectroscopy show that a thin 3,4,9,10-perylenetetracarboxylic dianhydride interlayer before CuPc growth templates the CuPc film structure, forcing the molecules to lie flat with respect to the substrate surface, although the intrastack orientation is unaffected. This modified stacking configuration facilitates charge transport and improves charge collection
Testing Models of Intrinsic Brightness Variations in Type Ia Supernovae, and their Impact on Measuring Cosmological Parameters
For spectroscopically confirmed Type Ia supernovae we evaluate models of
intrinsic brightness variations with detailed data/Monte Carlo comparisons of
the dispersion in the following quantities: Hubble-diagram scatter, color
difference (B-V-c) between the true B-V color and the fitted color (c) from the
SALT-II light curve model, and photometric redshift residual. The data sample
includes 251 ugriz light curves from the 3-season Sloan Digital Sky Survey-II,
and 191 griz light curves from the Supernova Legacy Survey 3-year data release.
We find that the simplest model of a wavelength-independent (coherent) scatter
is not adequate, and that to describe the data the intrinsic scatter model must
have wavelength-dependent variations. We use Monte Carlo simulations to examine
the standard approach of adding a coherent scatter term in quadrature to the
distance-modulus uncertainty in order to bring the reduced chi2 to unity when
fitting a Hubble diagram. If the light curve fits include model uncertainties
with the correct wavelength dependence of the scatter, we find that the bias on
the dark energy equation of state parameter is negligible. However,
incorrect model uncertainties can lead to a significant bias on the distance
moduli, with up to ~0.05 mag redshift-dependent variation. For the recent SNLS3
cosmology results we estimate that this effect introduces an additional
systematic uncertainty on of ~0.02, well below the total uncertainty.
However, this uncertainty depends on the samples used, and thus this small
-uncertainty is not guaranteed in future cosmology results.Comment: accepted by Ap
Modified differentials and basic cohomology for Riemannian foliations
We define a new version of the exterior derivative on the basic forms of a
Riemannian foliation to obtain a new form of basic cohomology that satisfies
Poincar\'e duality in the transversally orientable case. We use this twisted
basic cohomology to show relationships between curvature, tautness, and
vanishing of the basic Euler characteristic and basic signature.Comment: 20 pages, references added, minor corrections mad
R-parity violating resonant stop production at the Large Hadron Collider
We have investigated the resonant production of a stop at the Large Hadron
Collider, driven by baryon number violating interactions in supersymmetry. We
work in the framework of minimal supergravity models with the lightest
neutralino being the lightest supersymmetric particle which decays within the
detector. We look at various dilepton and trilepton final states, with or
without b-tags. A detailed background simulation is performed, and all possible
decay modes of the lighter stop are taken into account. We find that higher
stop masses are sometimes easier to probe, through the decay of the stop into
the third or fourth neutralino and their subsequent cascades. We also comment
on the detectability of such signals during the 7 TeV run, where, as expected,
only relatively light stops can be probed. Our conclusion is that the resonant
process may be probed, at both 10 and 14 TeV, with the R-parity violating
coupling {\lambda}"_{312} as low as 0.05, for a stop mass of about 1 TeV. The
possibility of distinguishing between resonant stop production and
pair-production is also discussed.Comment: 20 pages, 4 figures, 6 tables; Version accepted by JHE
Adjuvanted recombinant zoster vaccine in adult autologous stem cell transplant recipients : polyfunctional immune responses and lessons for clinical practice
PLAIN LANGUAGE SUMMARY What is the context? After haematopoletic stem cell transplantation, patlents have impaired immunity from conditioning chemotherapy regimens, often exacerbated by underlying diseases, putting them at high risk of developing herpes zoster. In this population, antiviral prophylaxis is the current standard of care to reduce herpes zoster risk. Vaccination provides an additional means to prevent herpes zoster. Live-attenuated vaccines are generally contraindicated in immuonocompromised patients. A non-live, adjuvanted recombinant zoster vaccine (RZV, Shingrix, GSK), has been approved for use in adults 250 years of age in the European Union, United States, Canada, Australia, Japan, and China. This vaccine is highly efficacious at preventing herpes zoster in adults over 50 years of age, as demonstrated in large, placebo-controlled randomised trials. Importantly, Shingrix use is not contraindicated in immunocompromised conditions, and was found to be highly efficacious in adults who had recently undergone autologous haematopoleticstem cell transplant. What is new? In autologous haematopoietic stem cell transplant recipients in whom Shingrix has demonstrated efficacy, two doseselicited high and persistent immune responses. Date presented here further support our understanding of the impact of specific factors such as age or underlying diseases on the vaccine's effect in the population studies, as well as the characteristics of the elicited cell-mediated immune responses. What is the impact? These results indicate that Shingrix, given shortly after haematopoletic stem cell transplant, can induce robust immune responses and reduce the risk of herpes zoster, even in individuals with immunosuppression due to underlying disease and/or use of immunosuppressive therapies, regardless of age or underlying disease. Immunocompromised individuals, particularly autologous hematopoietic stem cell transplant (auHSCT) recipients, are at high risk for herpes zoster (HZ). We provide an in-depth description of humoral and cell-mediated immune (CMI) responses by age (protocol-defined) or underlying disease (post-hoc) as well as efficacy by underlying disease (post-hoc) of the adjuvanted recombinant zoster vaccine (RZV) in a randomized observer-blind phase III trial (ZOE-HSCT, NCT01610414). 1846 adult auHSCT recipients were randomized to receive a first dose of either RZV or placebo 50-70 days post-auHSCT, followed by the second dose at 1-2 months (M) later. In cohorts of 114-1721 participants, at 1 M post-second vaccine dose: Anti-gE antibody geometric mean concentrations (GMCs) and median gE-specific CD4[2+] T-cell frequencies (CD4 T cells expressing >= 2 of four assessed activation markers) were similar between 18-49 and >= 50-year-olds. Despite lower anti-gE antibody GMCs in non-Hodgkin B-cell lymphoma (NHBCL) patients, CD4[2+] T-cell frequencies were similar between NHBCL and other underlying diseases. The proportion of polyfunctional CD4 T cells increased over time, accounting for 79.6% of gE-specific CD4 T cells at 24 M post-dose two. Vaccine efficacy against HZ ranged between 42.5% and 82.5% across underlying diseases and was statistically significant in NHBCL and multiple myeloma patients. In conclusion, two RZV doses administered early post-auHSCT induced robust, persistent, and polyfunctional gE-specific immune responses. Efficacy against HZ was also high in NHBCL patients despite the lower humoral response.Peer reviewe
Catastrophizing and fear of tinnitus predict quality of life in patients with chronic tinnitus
Objectives: It is well established that catastrophic misinterpretations and fear are involved in the suffering and disability of patients with chronic pain. This study investigated whether similar processes explain suffering and disability in patients with chronic tinnitus. We hypothesized that patients who catastrophically (mis)interpret their tinnitus would be more fearful of tinnitus, more vigilant toward their tinnitus, and report less quality of life. Moreover, tinnitus-related fear was expected to act as a mediator in reduced quality of life. Design: Sixty-one tinnitus patients from an outpatient ENT department of the University Hospital of Antwerp (Belgium) completed a number of questionnaires about their tinnitus. Hierarchical regression analyses were performed to test hypothesized associations and to assess mediation by tinnitus-related fear. Results: Analyses revealed significant associations between catastrophizing and fear and between catastrophizing and increased attention toward the tinnitus. Furthermore, both tinnitus-related catastrophizing and fear were negatively associated with quality of life; moreover, tinnitus-related fear fully mediated the association between catastrophizing about the tinnitus and quality of life. Conclusions: The findings confirm earlier suggestions that tinnitus-related concerns and fears are associated with impaired quality of life, which is in line with a cognitive behavioral account of chronic tinnitus. Future research avenues and clinical applications are discussed
Numerical Simulation of Pulsed Pressure Waves in Attenuative and Dispersive Media
This paper proposes a method of simulating pulsed pressure waves in attenuative fluids as typically exist in biological medium. The numerical algorithm is based upon an explicit time domain formulation which is capable of determining the form of an acoustic wave as it evolves in both time and space
Machine detector interface for the future circular collider
The international Future Circular Collider (FCC) study aims at a design of
, , colliders to be built in a new 100 km tunnel in the Geneva
region. The collider (FCC-ee) has a centre of mass energy range
between 90 (Z-pole) and 375 GeV (tt_bar). To reach such unprecedented energies
and luminosities, the design of the interaction region is crucial. The
crab-waist collision scheme has been chosen for the design and it will be
compatible with all beam energies. In this paper we will describe the machine
detector interface layout including the solenoid compensation scheme. We will
describe how this layout fulfills all the requirements set by the parameters
table and by the physical constraints. We will summarize the studies of the
impact of the synchrotron radiation, the analysis of trapped modes and of the
backgrounds induced by single beam and luminosity effects giving an estimate of
the losses in the interaction region and in the detector.Comment: 6 pages, 7 figures, 62th ICFA ABDW on High Luminosity Circular
Colliders, eeFACT2018, Hong Kong, Chin
Growth patterns and shape development of the paediatric mandible – A 3D statistical model
BACKGROUND/AIM: To develop a 3D morphable model of the normal paediatric mandible to analyse shape development and growth patterns for males and females. METHODS: Computed tomography (CT) data was collected for 242 healthy children referred for CT scan between 2011 and 2018 aged between 0 and 47 months (mean, 20.6 ± 13.4 months, 59.9% male). Thresholding techniques were used to segment the mandible from the CT scans. All mandible meshes were annotated using a defined set of 52 landmarks and processed such that all meshes followed a consistent triangulation. Following this, the mandible meshes were rigidly aligned to remove translation and rotation effects, while size effects were retained. Principal component analysis (PCA) was applied to the processed meshes to construct a generative 3D morphable model. Partial least squares (PLS) regression was also applied to the processed data to extract the shape modes with which to evaluate shape differences for age and sex. Growth curves were constructed for anthropometric measurements. RESULTS: A 3D morphable model of the paediatric mandible was constructed and validated with good generalisation, compactness, and specificity. Growth curves of the assessed anthropometric measurements were plotted without significant differences between male and female subjects. The first principal component was dominated by size effects and is highly correlated with age at time of scan (Spearman's r = 0.94, p < 0.01). As with PCA, the first extracted PLS mode captures much of the size variation within the dataset and is highly correlated with age (Spearman's r = −0.94, p < 0.01). Little correlation was observed between extracted shape modes and sex with either PCA or PLS for this study population. CONCLUSION: The presented 3D morphable model of the paediatric mandible enables an understanding of mandibular shape development and variation by age and sex. It allowed for the construction of growth curves, which contains valuable information that can be used to enhance our understanding of various disorders that affect the mandibular development. Knowledge of shape changes in the growing mandible has potential to improve diagnostic accuracy for craniofacial conditions that impact the mandibular morphology, objective evaluation, surgical planning, and patient follow-up
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