Neuropsychological evidence for three distinct motion mechanisms

Published in final edited form as: Neurosci Lett. 2011 May 16; 495(2): 102–106. doi:10.1016/j.neulet.2011.03.048.We describe psychophysical performance of two stroke patients with lesions in distinct cortical regions in the left hemisphere. Both patients were selectively impaired on direction discrimination in several local and global second-order but not first-order motion tasks. However, only patient FD was impaired on a specific bi-stable motion task where the direction of motion is biased by object similarity. We suggest that this bi-stable motion task may be mediated by a high-level attention or position based mechanism indicating a separate neurological substrate for a high-level attention or position-based mechanism. Therefore, these results provide evidence for the existence of at least three motion mechanisms in the human visual system: a low-level first- and second-order motion mechanism and a high-level attention or position-based mechanism.Accepted manuscrip

Роман Ігоря Муратова “У сорочці народжений”: спроба аналізу

Ця стаття присвячена проблемі дослідження генезисних витоків та діалектиці становлення центрального героя роману Ігоря Муратова “У сорочці народжений” Федора Коляди та тих персонажів, які вплинули на розвиток його непересічного характеру. Відзначається високий рівень майстерності письменника, що виражається у яскравих, індивідуальних образах. Також розглядається короткий огляд тогочасного українського літературного процесу. Ґрунтовно проаналізовано не тільки персонажів, але й назву роману та назви усіх п’яти розділів. Ключові слова: час, місто, портрет, площина тексту, екстремальна ситуація, війна, натура.Эта статья посвящается проблеме исследования генезисных истоков и диалектике становления центрального героя романа Игоря Муратова “В сорочке рожденный” Федора Коляды и тех персонажей, которые повлияли на развитие его незаурядного характера. Отмечается высокий уровень мастерства писателя, что выражается в ярких, индивидуальных образах. Также подается короткий обзор украинского литературного процесса того времени. Тщательно проанализировано не только персонажи, а и название романа и названия всех пяти частей. Ключевые слова: время, город, портрет, пространство текста, экстремальная ситуация, война, натура.The article deals with the research of the genesis sources and development dialectics of Fedir Kolyada – the main hero of the novel “Born with a silver spoon in his mouth” (“U sorotchtzi narodzheny”) by Ihor Muratov – and other heroes, who influenced the progress of his outstanding character. The high level writer’s skill, embodied in bright, individual images, is marked off. The paper presents a brief review of the literary process of that period. It gives a deep analysis of not only the characters, but also the titles of the novel and its five chapters. Keywords: time, city, portrait, text level, extreme situation, war, nature

Gaze-contingent flicker pupil perimetry detects scotomas in patients with cerebral visual impairments or glaucoma

The pupillary light reflex is weaker for stimuli presented inside as compared to outside absolute scotomas. Pupillograph perimetry could thus be an objective measure of impaired visual processing. However, the diagnostic accuracy in detecting scotomas has remained unclear. We quantitatively investigated the accuracy of a novel form of pupil perimetry. The new perimetry method, termed gaze-contingent flicker pupil perimetry, consists of the repetitive on, and off flickering of a bright disk (2 hz; 320 cd/m; 4° diameter) on a gray background (160 cd/m) for 4 seconds per stimulus location. The disk evokes continuous pupil oscillations at the same rate as its flicker frequency, and the oscillatory power of the pupil reflects visual sensitivity. We monocularly presented the disk at a total of 80 locations in the central visual field (max. 15°). The location of the flickering disk moved along with gaze to reduce confounds of eye movements (gaze-contingent paradigm). The test lasted ~5 min per eye and was performed on 7 patients with cerebral visual impairment (CVI), 8 patients with primary open angle glaucoma (age >45), and 14 healthy, age/gender-matched controls. For all patients, pupil oscillation power (FFT based response amplitude to flicker) was significantly weaker when the flickering disk was presented in the impaired as compared to the intact visual field (CVI: 12%, AUC = 0.73; glaucoma: 9%, AUC = 0.63). Differences in power values between impaired and intact visual fields of patients were larger than differences in power values at corresponding locations in the visual fields of the healthy control group (CVI: AUC = 0.95; glaucoma: AUC = 0.87). Pupil sensitivity maps highlighted large field scotomas and indicated the type of visual field defect (VFD) as initially diagnosed with standard automated perimetry (SAP) fairly accurately in CVI patients but less accurately in glaucoma patients. We provide the first quantitative and objective evidence of flicker pupil perimetry's potential in detecting CVI-and glaucoma-induced VFDs. Gaze-contingent flicker pupil perimetry is a useful form of objective perimetry and results suggest it can be used to assess large VFDs with young CVI patients whom are unable to perform SAP

Gaze-Contingent Flicker Pupil Perimetry Detects Scotomas in Patients With Cerebral Visual Impairments or Glaucoma

Background: The pupillary light reflex is weaker for stimuli presented inside as compared to outside absolute scotomas. Pupillograph perimetry could thus be an objective measure of impaired visual processing. However, the diagnostic accuracy in detecting scotomas has remained unclear. We quantitatively investigated the accuracy of a novel form of pupil perimetry.Methods: The new perimetry method, termed gaze-contingent flicker pupil perimetry, consists of the repetitive on, and off flickering of a bright disk (2 hz; 320 cd/m2; 4° diameter) on a gray background (160 cd/m2) for 4 seconds per stimulus location. The disk evokes continuous pupil oscillations at the same rate as its flicker frequency, and the oscillatory power of the pupil reflects visual sensitivity. We monocularly presented the disk at a total of 80 locations in the central visual field (max. 15°). The location of the flickering disk moved along with gaze to reduce confounds of eye movements (gaze-contingent paradigm). The test lasted ~5 min per eye and was performed on 7 patients with cerebral visual impairment (CVI), 8 patients with primary open angle glaucoma (age >45), and 14 healthy, age/gender-matched controls.Results: For all patients, pupil oscillation power (FFT based response amplitude to flicker) was significantly weaker when the flickering disk was presented in the impaired as compared to the intact visual field (CVI: 12%, AUC = 0.73; glaucoma: 9%, AUC = 0.63). Differences in power values between impaired and intact visual fields of patients were larger than differences in power values at corresponding locations in the visual fields of the healthy control group (CVI: AUC = 0.95; glaucoma: AUC = 0.87). Pupil sensitivity maps highlighted large field scotomas and indicated the type of visual field defect (VFD) as initially diagnosed with standard automated perimetry (SAP) fairly accurately in CVI patients but less accurately in glaucoma patients.Conclusions: We provide the first quantitative and objective evidence of flicker pupil perimetry's potential in detecting CVI-and glaucoma-induced VFDs. Gaze-contingent flicker pupil perimetry is a useful form of objective perimetry and results suggest it can be used to assess large VFDs with young CVI patients whom are unable to perform SAP

Linear systems analysis for laminar fMRI: evaluating BOLD amplitude scaling for luminance contrast manipulations

A fundamental assumption of nearly all functional magnetic resonance imaging (fMRI) analyses is that the relationship between local neuronal activity and the blood oxygenation level dependent (BOLD) signal can be described as following linear systems theory. With the advent of ultra-high field (7T and higher) MRI scanners, it has become possible to perform sub-millimeter resolution fMRI in humans. A novel and promising application of sub-millimeter fMRI is measuring responses across cortical depth, i.e. laminar imaging. However, the cortical vasculature and associated directional blood pooling towards the pial surface strongly influence the cortical depth-dependent BOLD signal, particularly for gradient-echo BOLD. This directional pooling may potentially affect BOLD linearity across cortical depth. Here we assess whether the amplitude scaling assumption for linear systems theory holds across cortical depth. For this, we use stimuli with different luminance contrasts to elicit different BOLD response amplitudes. We find that BOLD amplitude across cortical depth scales with luminance contrast, and that this scaling is identical across cortical depth. Although nonlinearities may be present for different stimulus configurations and acquisition protocols, our results suggest that the amplitude scaling assumption for linear systems theory across cortical depth holds for luminance contrast manipulations in sub-millimeter laminar BOLD fMRI

Cortical depth dependent population receptive field attraction by spatial attention in human V1

Visual spatial attention concentrates neural resources at the attended location. Recently, we demonstrated that voluntary spatial attention attracts population receptive fields (pRFs) toward its location throughout the visual hierarchy. Theoretically, both a feed forward or feedback mechanism could underlie pRF attraction in a given cortical area. Here, we use sub-millimeter ultra-high field functional MRI to measure pRF attraction across cortical depth and assess the contribution of feed forward and feedback signals to pRF attraction. In line with previous findings, we find consistent attraction of pRFs with voluntary spatial attention in V1. When assessed as a function of cortical depth, we find pRF attraction in every cortical portion (deep, center and superficial), although the attraction is strongest in deep cortical portions (near the gray-white matter boundary). Following the organization of feed forward and feedback processing across V1, we speculate that a mixture of feed forward and feedback processing underlies pRF attraction in V1. Specifically, we propose that feedback processing contributes to the pRF attraction in deep cortical portions

Size constancy affects the perception and parietal neural representation of object size

Humans and animals rely on accurate object size perception to guide behavior. Object size is judged from visual input, but the relationship between an object's retinal size and its real-world size varies with distance. Humans perceive object sizes to be relatively constant when retinal size changes. Such size constancy compensates for the variable relationship between retinal size and real-world size, using the context of recent retinal sizes of the same object to bias perception towards its likely real-world size. We therefore hypothesized that object size perception may be affected by the range of recently viewed object sizes, attracting perceived object sizes towards recently viewed sizes. We demonstrate two systematic biases: a central tendency attracting perceived size towards the average size across all trials, and a serial dependence attracting perceived size towards the size presented on the previous trial. We recently described topographic object size maps in the human parietal cortex. We therefore hypothesized that neural representations of object size here would be attracted towards recently viewed sizes. We used ultra-high-field (7T) functional MRI and population receptive field modeling to compare object size representations measured with small (0.05-1.4°diameter) and large objects sizes (0.1-2.8°). We found that parietal object size preferences and tuning widths follow this presented range, but change less than presented object sizes. Therefore, perception and neural representation of object size are attracted towards recently viewed sizes. This context-dependent object size representation reveals effects on neural response preferences that may underlie context dependence of object size perception

Стилі керівництва як моделі вербальної поведінки у корпоративному дискурсі

Статья посвящена анализу лингвистических особенностей директивного и демократического стилей руководства как распространенных моделей вербального поведения в корпоративном дискурсе. Внимание уделяется также гендерному фактору, который учитывается при авторитарном коммуникативном поведении.Стаття присвячена аналізові лінгвістичних особливостей директивного та демократичного стилів керівництва як поширених моделей вербальної поведінки у корпоративному дискурсі. Увага приділяється також гендерному фактору, який враховується в авторитарній комунікативній поведінці.The article is dedicated to the analysis of linguistic peculiarities of the directive and democratic management styles as models of the verbal behaviour in the corporate discourse. Attention is also paid to the gender factor, which is considered in the authoritarian communicative behaviour

Triple visual hemifield maps in a case of optic chiasm hypoplasia

In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare individual with chiasma hypoplasia, where visual cortex plasticity is challenged to accommodate three hemifield maps. Using high-resolution fMRI at 7T and diffusion-weighted MRI at 3T, we found three hemiretinal inputs, instead of the normal two, to converge onto the left hemisphere. fMRI-based population receptive field mapping of the left V1-V3 at 3T revealed three superimposed hemifield representations in the left visual cortex, i.e. two representations of opposing visual hemifields from the left eye and one right hemifield representation from the right eye. We conclude that developmental plasticity including the re-wiring of local intra- and cortico-cortical connections is pivotal to support the coexistence and functioning of three hemifield maps within one hemisphere