1,289 research outputs found
A guide for performing system safety analysis
A general guide is presented for performing system safety analyses of hardware, software, operations and human elements of an aerospace program. The guide describes a progression of activities that can be effectively applied to identify hazards to personnel and equipment during all periods of system development. The general process of performing safety analyses is described; setting forth in a logical order the information and data requirements, the analytical steps, and the results. These analyses are the technical basis of a system safety program. Although the guidance established by this document cannot replace human experience and judgement, it does provide a methodical approach to the identification of hazards and evaluation of risks to the system
Cosmic ray modulation in a random anisotropic magnetic field
Inhomogeneities of the interplanetary magnetic field can be divided into small scale and large scale ones as may be required by the character of the problem of cosmic ray (CR) propagation. CR propagation in stochastic magnetic fields is of diffusion character. The main contribution into the scattering of CR particles is made by their interaction with inhomogeneities of the magnetic field H which have characteristic dimensions 1 of the order of Larmor radius R=cp/eH of particle (p is the absolute value of particle momentum, e is particle charge, c is velocity of light). Scattering of particles on such inhomogeneities leads to their diffusion mostly along a magnetic field with characteristic dimensions of variation in space exceeding the mean free path
Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice
<p>Abstract</p> <p>Background</p> <p>The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors.</p> <p>Methods</p> <p>C57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine.</p> <p>Results</p> <p>Place preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice.</p> <p>Conclusions</p> <p>Genetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indicating that separate mechanisms underlie the psychomotor and rewarding effects of cocaine.</p
Stellar evolution through the ages: period variations in galactic RRab stars as derived from the GEOS database and TAROT telescopes
The theory of stellar evolution can be more closely tested if we have the
opportunity to measure new quantities. Nowadays, observations of galactic RR
Lyr stars are available on a time baseline exceeding 100 years. Therefore, we
can exploit the possibility of investigating period changes, continuing the
pioneering work started by V. P. Tsesevich in 1969. We collected the available
times of maximum brightness of the galactic RR Lyr stars in the GEOS RR Lyr
database. Moreover, we also started new observational projects, including
surveys with automated telescopes, to characterise the O-C diagrams better. The
database we built has proved to be a very powerful tool for tracing the period
variations through the ages. We analyzed 123 stars showing a clear O-C pattern
(constant, parabolic or erratic) by means of different least-squares methods.
Clear evidence of period increases or decreases at constant rates has been
found, suggesting evolutionary effects. The median values are beta=+0.14
day/Myr for the 27 stars showing a period increase and beta=-0.20 day/Myr for
the 21 stars showing a period decrease. The large number of RR Lyr stars
showing a period decrease (i.e., blueward evolution) is a new and intriguing
result. There is an excess of RR Lyr stars showing large, positive
values. Moreover, the observed beta values are slightly larger than those
predicted by theoretical models.Comment: 15 pages, 9 figures; to be published in Astronomy and Astrophysics;
full resolution version available at
http://dbrr.ast.obs-mip.fr/tarot/publis/publis.htm
The effects of discreteness of galactic cosmic rays sources
Most studies of GeV Galactic Cosmic Rays (GCR) nuclei assume a steady
state/continuous distribution for the sources of cosmic rays, but this
distribution is actually discrete in time and in space. The current progress in
our understanding of cosmic ray physics (acceleration, propagation), the
required consistency in explaining several GCRs manifestation (nuclei,
,...) as well as the precision of present and future space missions
(e.g. INTEGRAL, AMS, AGILE, GLAST) point towards the necessity to go beyond
this approximation. A steady state semi-analytical model that describes well
many nuclei data has been developed in the past years based on this
approximation, as well as others. We wish to extend it to a time dependent
version, including discrete sources. As a first step, the validity of several
approximations of the model we use are checked to validate the approach: i) the
effect of the radial variation of the interstellar gas density is inspected and
ii) the effect of a specific modeling for the galactic wind (linear vs
constant) is discussed. In a second step, the approximation of using continuous
sources in space is considered. This is completed by a study of time
discreteness through the time-dependent version of the propagation equation. A
new analytical solution of this equation for instantaneous point-like sources,
including the effect of escape, galactic wind and spallation, is presented.
Application of time and space discretness to definite propagation conditions
and realistic distributions of sources will be presented in a future paper.Comment: final version, 8 figures, accepted in ApJ. A misprint in fig 8 labels
has been correcte
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