Groundwork for the Development of Testing Plans for Concurrent Software

While multi-threading has become commonplace in many application domains (e.g., embedded systems, digital signal processing (DSP), networks, IP services, and graphics), multi-threaded code often requires complex co-ordination of threads. As a result, multi-threaded implementations are prone to subtle bugs that are difficult and time-consuming to locate. Moreover, current testing techniques that address multi-threading are generally costly while their effectiveness is unknown. The development of cost-effective testing plans requires an in-depth study of the nature, frequency, and cost of concurrency errors in the context of real-world applications. The full paper will lay the groundwork for such a study, with the purpose of informing the creation of a parametric cost model for testing multi-threaded software. The current version of the paper provides motivation for the study, an outline of the full paper, and a bibliography of related papers

Seamless Mobile Communications for mHealth

There is a growing trend in the health domain to incorporate Smartphones and other wireless technologies to provide more efficient, cost effective, and higher quality healthcare. With newer more sophisticated mobile devices for example, Smartphones this is an escalating practice. To date the use of mobile phone technology in the healthcare domain (mHealth) has been limited to uses such as disseminating information. However, mHealth is beginning to include software and data applications based on mobile devices and technologies. This movement is largely due to the advent of newer technologies associated with Smartphones. Some Smartphones can now be considered to be intelligent sensors with sensing capabilities such as GPS location, proximity and accelerometers. This paper examines the use of such technology in providing seamless mobile communications for mHealth

Should there be a future for Tablet PCs in schools?

Tablet PCs are a relatively new format of computer, which seem to offer features which may be beneficial to schools. The uptake of Tablet PCs by schools has been somewhat limited, not least due to their greater cost than laptops of a 'similar' specification. This paper explores the key question of the extent to which schools should be investing in Tablet PCs, if at all, in preference to other formats of fully functional PCs, drawing on evidence from a Becta funded evaluation of the use of Tablet PCs in schools in England conducted in 2004-2005. The Computer Practice Framework was used to develop a set of questions which helped structure a meta-analysis of the data from 12 case studies that formed part of this evaluation. The methodology used and some limitations of the evaluation are outlined, and the key findings are described. The paper concludes that Tablet PCs do appear to offer significant potential to schools, though this potential was not being fully realised in most of the case study schools. A number of specific circumstances in which Tablet PCs do appear to be the most cost effective option are also identified

Agile Principles Applied to a Complex Long Term Research Activity - The PERIMETER Approach

Agile software development is a group of software development methodologies that are based on similar principles, as defined in the Agile Manifesto. Agile software projects are characterized by iterative and incremental development, accommodation of changes and active customer participation. The popularity of agile principles is steadily increasing. Their adopters report that this development process leads to higher software quality and customer satisfaction ratings when compared to using traditional methods, with more productive and motivated developers. Whilst smaller developer teams have cited higher success rates than larger teams, agile principles can and have been applied successfully to large scale projects and distributed teams. Despite these advantages, there are very few research activities that apply agile principles in their development. Perhaps this is due to the nature of research projects, which usually span years rather than months, frequently involve experimental work, and consist of team members with varying levels of experience, often coming from different organizations, research groups and countries. This paper examines how agile principles can be adapted to suit one such long term research activity; PERIMETER

QoE Testbed Infrastructure and Services: Enriching the End User’s Experience

Quality of Experience (QoE) is the subjective judgment of the satisfaction an end user perceives from an application running over a given network topology and configuration. The information provided by end users regarding their QoE preferences, experience and feedback is invaluable in providing a service that meets with their mobile activity needs within various access networks. The PERIMETER project progresses the QoE thematic research area by taking end user-related QoE factors for end user-centric mobility experimentation, thus empowering them to always have a service in which their QoE is high. This paper will detail the components of the PERIMETER framework and the user centric scenario based process adopted to implement and develop such a framework. This paper provides an insight into the federated testbed infrastructure, testing methodology and tools, operating system and applications used in the project, thus demonstrating PERIMETER’s innovative advances within the QoE end user domain

National Self-Harm Registry Ireland annual report 2017.

This is the sixteenth annual report from the National Self-Harm Registry Ireland. It is based on data collected on persons presenting to hospital emergency departments following self-harm in 2017 in the Republic of Ireland. The Registry had near complete coverage of the country’s hospitals for the period 2002-2005 and, since 2006, all general hospital and paediatric hospital emergency departments in the Republic of Ireland have contributed data to the Registry. Role of alcohol in self-harm: Alcohol was involved in 31% of all cases. Alcohol was significantly more often involved in male episodes of self-harm than female episodes (33% and 29%, respectively). In line with previous years, misuse or abuse of alcohol is one of the factors associated with the higher rate of self-harm presentations on Sundays, Mondays and public holidays, around the hours of midnight. Recent publications from the Registry data have highlighted the role of alcohol in selfharm. Such complex presentations indicate the need for active consultation and collaboration between the mental health services and addiction treatment services for patients who present with dual diagnoses. In addition, alcohol involvement has been shown to be strongly associated with self-harm presentations out-of-hours, at weekends and on public holidays. The Registry findings related to alcohol provide further support for the full implementation of the Public Health (Alcohol) Bill, which would introduce evidence-based policies to reduce the burden of alcohol harm on our society by improving health, safety and wellbeing. Restricting access to means: …In line with previous years, drug overdose was the most common method of self-harm recorded. Over the years, the Registry has identified the drug types most frequently involved in intentional overdoses. New research has classified the range of drugs recorded by the Registry according to the World Health Organisation’s (WHO) Anatomical Therapeutic Chemical (ATC) classification system. This work has systematically classified the wide range of drugs involved in intentional overdoses, and will be instrumental in facilitating comparative work in this area. This system has allowed for examination of trends in specific drug types, with a recent publication highlighting the increasing involvement of gabapentinoids (prescription-only neuropathic pain medication). Despite a decrease in their involvement in intentional overdose in 2017, minor tranquillisers have been the most frequently used type of drug involved in intentional overdoses. Reducing access to frequently used drugs should be an ongoing priority

PERIMETER: A Quality of Experience Framework

Although Quality of Experience (QoE) is perceived as a subjective measure of a user’s experience, it is the only measure that actually counts to a user of a service. For the success of the Future Internet, it is essential to identify, quantify and ultimately improve the perception of QoE for a user, in a given situation. PERIMETER pushes the boundaries to improve a user’s experience by identifying a more user-centric network selection based on QoE preferences, high level rules and policies. With the fundamental focus on the user’s preferences, PERIMETER will support generic QoE definition, QoE signalling, and QoE based content adaptation. This paper provides an insight into PERIMETER’s QoE model and management system which are responsible for the definition, gathering, description and management of QoE-related parameters, indicators and enablers. This paper will demonstrate how PERIMETER will proceed beyond the state of the art in the QoE thematic research area and contribute to research of the Future Internet

Venous access devices for the delivery of long-term chemotherapy: the CAVA three-arm RCT

Background: Venous access devices are used for patients receiving long-term chemotherapy. These include centrally inserted tunnelled catheters or Hickman-type devices (Hickman), peripherally inserted central catheters (PICCs) and centrally inserted totally implantable venous access devices (PORTs). Objectives: To evaluate the clinical effectiveness, safety, cost-effectiveness and acceptability of these devices for the central delivery of chemotherapy. Design: An open, multicentre, randomised controlled trial to inform three comparisons: (1) peripherally inserted central catheters versus Hickman, (2) PORTs versus Hickman and (3) PORTs versus peripherally inserted central catheters. Pre-trial and post-trial qualitative research and economic evaluation were also conducted. Setting: This took place in 18 UK oncology centres. Participants: Adult patients (aged ≥ 18 years) receiving chemotherapy (≥ 12 weeks) for either a solid or a haematological malignancy were randomised via minimisation. Interventions: Hickman, peripherally inserted central catheters and PORTs. Primary outcome: A composite of infection (laboratory confirmed, suspected catheter related and exit site infection), mechanical failure, venous thrombosis, pulmonary embolism, inability to aspirate blood and other complications in the intention-to-treat population. Results: Overall, 1061 participants were recruited to inform three comparisons. First, for the comparison of peripherally inserted central catheters (n = 212) with Hickman (n = 212), it could not be concluded that peripherally inserted central catheters were significantly non-inferior to Hickman in terms of complication rate (odds ratio 1.15, 95% confidence interval 0.78 to 1.71). The use of peripherally inserted central catheters compared with Hickman was associated with a substantially lower cost (–£1553) and a small decrement in quality-adjusted life-years gained (–0.009). Second, for the comparison of PORTs (n = 253) with Hickman (n = 303), PORTs were found to be statistically significantly superior to Hickman in terms of complication rate (odds ratio 0.54, 95% confidence interval 0.37 to 0.77). PORTs were found to dominate Hickman with lower costs (–£45) and greater quality-adjusted life-years gained (0.004). This was alongside a lower complications rate (difference of 14%); the incremental cost per complication averted was £1.36. Third, for the comparison of PORTs (n = 147) with peripherally inserted central catheters (n = 199), PORTs were found to be statistically significantly superior to peripherally inserted central catheters in terms of complication rate (odds ratio 0.52, 95% confidence interval 0.33 to 0.83). PORTs were associated with an incremental cost of £2706 when compared with peripherally inserted central catheters and a decrement in quality-adjusted life-years gained (–0.018) PORTs are dominated by peripherally inserted central catheters: alongside a lower complications rate (difference of 15%), the incremental cost per complication averted was £104. The qualitative work showed that attitudes towards all three devices were positive, with patients viewing their central venous access device as part of their treatment and recovery. PORTs were perceived to offer unique psychological benefits, including a greater sense of freedom and less intrusion in the context of personal relationships. The main limitation was the lack of adequate power (54%) in the non-inferiority comparison between peripherally inserted central catheters and Hickman. Conclusions: In the delivery of long-term chemotherapy, peripherally inserted central catheters should be considered a cost-effective option when compared with Hickman. There were significant clinical benefits when comparing PORTs with Hickman and with peripherally inserted central catheters. The health economic benefits were less clear from the perspective of incremental cost per quality-adjusted life-years gained. However, dependent on the willingness to pay, PORTs may be considered to be cost-effective from the perspective of complications averted. Future work: The deliverability of a PORTs service merits further study to understand the barriers to and methods of improving the service. Trial registration: This trial is registered as ISRCTN44504648. Funding: This project was funded by the National Institute for Health Research (NHIR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 25, No. 47. See the NIHR Journals Library website for further project information

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist