Mechanical On-Chip Microwave Circulator

Nonreciprocal circuit elements form an integral part of modern measurement and communication systems. Mathematically they require breaking of time-reversal symmetry, typically achieved using magnetic materials and more recently using the quantum Hall effect, parametric permittivity modulation or Josephson nonlinearities. Here, we demonstrate an on-chip magnetic-free circulator based on reservoir engineered optomechanical interactions. Directional circulation is achieved with controlled phase-sensitive interference of six distinct electro-mechanical signal conversion paths. The presented circulator is compact, its silicon-on-insulator platform is compatible with both superconducting qubits and silicon photonics, and its noise performance is close to the quantum limit. With a high dynamic range, a tunable bandwidth of up to 30 MHz and an in-situ reconfigurability as beam splitter or wavelength converter, it could pave the way for superconducting qubit processors with integrated and multiplexed on-chip signal processing and readout.Comment: References have been update

Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer

Background: Tripe palms is a descriptive term for a cutaneous paraneoplastic keratoderma. Tripe palms are frequently associated with gastric and pulmonary carcinoma. The pathogenetic mechanism remains unknown. Objective: To determine the influence of receptor tyrosine kinases, which are both expressed in pulmonary carcinomas and in human skin, we performed expression studies on epidermal growth factor receptor (EGFR), HER2, HERS in a skin sample of tripe palms obtained from a patient with non-small-cell lung cancer with lymph node involvement. Two months after diagnosis, the patient had developed palmoplantar `tripe palms'. Additionally, the expression of SRC, c-myc and p16/CDKN2 were studied. Method: Conventional reverse-transcription polymerase chain reaction was performed on a tissue sample of tripe palms. Results: Weak expression of HER2 and of p16/CDKN2 was found. EGFR, HERS, c-myc and SRC were not expressed. Conclusion: Receptor tyrosine kinases of subclass I, the tyrosine kinase SRC and the oncogene c-myc play no major role in the pathogenesis of this case of tripe palms. Copyright (C) 2000 S. Karger AG. Basel

On the Extraction of Cross Sections for pi0 and eta Photoproduction off Neutrons from Deuteron Data

We discuss the procedure of extracting the photoproduction cross section for neutral pseudoscalar mesons off neutrons from deuteron data. The main statement is that the final-state interaction (FSI) corrections for the proton and neutron target are in general not equal, but for pi0 production there are special cases were they have to be identical and there are large regions in the parameter space of incident photon energy and pion polar angle, \theta^*, where they happen to be quite similar. The corrections for both target nucleons are practically identical for $\pi_0$ production in the energy range of the Delta(1232)3/2+ resonance due to the specific isospin structure of this excitation. Also above the $\Delta$-isobar range large differences between proton and neutron correction factors are only predicted for extreme forward angles ($\theta^*$ < 20 deg), but the results are similar for larger angles. Numerical results for the gp-->pi0p and gn-->pi0n correction factors are discussed. Also the model description for the available data on the differential gd-->pi0pn cross sections are given.Comment: 16 pages, 5 figures; v2 fixed several minor typo

Superconducting cavity-electromechanics on silicon-on-insulator

Fabrication processes involving anhydrous hydrofluoric vapor etching are developed to create high-Q aluminum superconducting microwave resonators on free-standing silicon membranes formed from a silicon-on-insulator wafer. Using this fabrication process, a high-impedance 8.9-GHz coil resonator is coupled capacitively with a large participation ratio to a 9.7-MHz micromechanical resonator. Two-tone microwave spectroscopy and radiation pressure backaction are used to characterize the coupled system in a dilution refrigerator down to temperatures of T_f=11  mK, yielding a measured electromechanical vacuum coupling rate of g_0/2π = 24.6  Hz and a mechanical resonator Q factor of Q_m = 1.7 × 10^7. Microwave backaction cooling of the mechanical resonator is also studied, with a minimum phonon occupancy of n_m ≈ 16 phonons being realized at an elevated fridge temperature of T_f = 211  mK

Life Coaching: Possibilities for Occupational Therapy Practice

No abstract availabl

Probing the Subcellular Localization of Hopanoid Lipids in Bacteria Using NanoSIMS

The organization of lipids within biological membranes is poorly understood. Some studies have suggested lipids group into microdomains within cells, but the evidence remains controversial due to non-native imaging techniques. A recently developed NanoSIMS technique indicated that sphingolipids group into microdomains within membranes of human fibroblast cells. We extended this NanoSIMS approach to study the localization of hopanoid lipids in bacterial cells by developing a stable isotope labeling method to directly detect subcellular localization of specific lipids in bacteria with ca. 60 nm resolution. Because of the relatively small size of bacterial cells and the relative abundance of hopanoid lipids in membranes, we employed a primary ^2H-label to maximize our limit of detection. This approach permitted the analysis of multiple stable isotope labels within the same sample, enabling visualization of subcellular lipid microdomains within different cell types using a secondary label to mark the growing end of the cell. Using this technique, we demonstrate subcellular localization of hopanoid lipids within alpha-proteobacterial and cyanobacterial cells. Further, we provide evidence of hopanoid lipid domains in between cells of the filamentous cyanobacterium Nostoc punctiforme. More broadly, our method provides a means to image lipid microdomains in a wide range of cell types and test hypotheses for their functions in membranes

Suppression of the ferromagnetic state in LaCoO3 films by rhombohedral distortion

Epitaxially strained LaCoO3 (LCO) thin films were grown with different film thickness, t, on (001) oriented (LaAlO3)0.3(SrAl0.5Ta0.5O3)0.7 (LSAT) substrates. After initial pseudomorphic growth the films start to relieve their strain partly by the formation of periodic nano-twins with twin planes predominantly along the direction. Nano-twinning occurs already at the initial stage of growth, albeit in a more moderate way. Pseudomorphic grains, on the other hand, still grow up to a thickness of at least several tenths of nanometers. The twinning is attributed to the symmetry lowering of the epitaxially strained pseudo-tetragonal structure towards the relaxed rhombohedral structure of bulk LCO. However, the unit-cell volume of the pseudo-tetragonal structure is found to be nearly constant over a very large range of t. Only films with t > 130 nm show a significant relaxation of the lattice parameters towards values comparable to those of bulk LCO.Comment: 31 pages, 10 figure

Quantum electromechanics of a hypersonic crystal

Radiation pressure within engineered structures has recently been used to couple the motion of nanomechanical objects with high sensitivity to optical and microwave electromagnetic fields. Here, we demonstrate a form of electromechanical crystal for coupling microwave photons and hypersonic phonons by embedding the vacuum-gap capacitor of a superconducting resonator within a phononic crystal acoustic cavity. Utilizing a two-photon resonance condition for efficient microwave pumping and a phononic bandgap shield to eliminate acoustic radiation, we demonstrate large cooperative coupling ($C \approx 30$) between a pair of electrical resonances at $10$GHz and an acoustic resonance at $0.425$GHz. Electrical read-out of the phonon occupancy shows that the hypersonic acoustic mode has an intrinsic energy decay time of $2.3$ms and thermalizes close to its quantum ground-state of motion (occupancy $1.5$) at a fridge temperature of $10$mK. Such an electromechanical transducer is envisioned as part of a hybrid quantum circuit architecture, capable of interfacing to both superconducting qubits and optical photons.Comment: 16 pages, 12 figures, 8 appendice