Integrated product relationships management : a model to enable concurrent product design and assembly sequence planning

The paper describes a novel approach to product relationships management in the context of concurrent engineering and product lifecycle management (PLM). Current industrial practices in product data management and manufacturing process management systems require better efficiency, flexibility, and sensitivity in managing product information at various levels of abstraction throughout its lifecycle. The aim of the proposed work is to manage vital yet complex and inherent product relationship information to enable concurrent product design and assembly sequence planning. Indeed, the definition of the product with its assembly sequence requires the management and the understanding of the numerous product relationships, ensuring consistency between the product and its components. This main objective stresses the relational design paradigm by focusing on product relationships along its lifecycle. This paper gives the detailed description of the background and models which highlight the need for a more efficient PLM approach. The proposed theoretical approach is then described in detail. A separate paper will focus on the implementation of the proposed approach in a PLM-based application, and an in-depth case study to evaluate the implementation of the novel approach will also be given

Multiple viewpoint modelling framework enabling integrated product-process design

Nowadays, companies have to cope with numerous constraints at organisational and technical levels in order to improve their competitiveness edges such as productivity, efficiency, and flexibility. Integrated product-process design becomes more and more complex to manage because of increasingly customized products related to various stakeholders and concerns geographically distributed. It is still represents a huge challenge, especially in the early phases of product development process. In such a context, the management of information within integrated product-process design highlights needs in a consistent engineering model that enables product lifecycle management (PLM) integration. The paper presents a novel multiple viewpoint framework called multiple viewpoint assembly oriented, considering product design and assembly process domains in the broader context of concurrent engineering and PLM. The proposed framework describes the consistency, the propagation of information change, and mechanisms of views generation among the product lifecycle stages in order to support assembly oriented design philosophy. A new modelling language called System Modeling Language is used to describe the proposed model from a systems engineering point of view. The implementation of the model in a Web-service called PEGASUS as an application for PLM systems is describe

Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose

Sublingual immunotherapy (SLIT) is an effective and well-tolerated method of treating allergic respiratory diseases associated with seasonal and perennial allergens. In contrast to the subcutaneous route, SLIT requires a much greater amount of antigen to achieve a clinical effect. Many studies have shown that SLIT involves a dose-response relationship, and therefore it is important to use a proven clinically effective dose from the onset of treatment, because low doses are ineffective and very high doses may increase the risk of side effects. A well-defined standardization of allergen content is also crucial to ensure consistent quality, potency and appropriate immunomodulatory action of the SLIT product. Several methods of measuring antigenicity are used by manufacturers of SLIT products, including the index of reactivity (IR), standardized quality tablet unit, and bioequivalent allergy unit. A large body of evidence has established the 300 IR dose of SLIT as offering optimal efficacy and tolerability for allergic rhinitis due to grass and birch pollen and HDM, and HDM-induced moderate, persistent allergic asthma. The 300 IR dose also offers consistency of dosing across a variety of different allergens, and is associated with higher rates of adherence and patient satisfaction. Studies in patients with grass pollen allergies showed that the 300 IR dose has a rapid onset of action, is effective in both adults and children in the short term and, when administered pre-coseasonally in the long term, and maintains the clinical benefit, even after cessation of treatment. In patients with HDM-associated AR and/or asthma, the 300 IR dose also demonstrated significant improvements in symptoms and quality of life, and significantly decreased use of symptomatic medication. The 300 IR dose is well tolerated, with adverse events generally being of mild or moderate severity, declining in frequency and severity over time and in the subsequent courses. We discuss herein the most important factors that affect the selection of the optimal dose of SLIT with natural allergens, and review the rationale and evidence supporting the use of the 300 IR dose

Management of the polyallergic patient with allergy immunotherapy: A practice-based approach

Background: The great majority (60-80 %) of patients consulting specialist physicians for allergic respiratory disease are polysensitized and thus may be potentially clinically polyallergic. However, management approaches to allergen immunotherapy (AIT) in polysensitized and polyallergic patients are not standardized. Methods: An international group of clinicians with in-depth expertise in AIT product development, clinical trials and clinical practice met to generate up-to-date, unambiguous, pragmatic guidance on AIT in polysensitized and polyallergic patients. The guidance was developed after reviewing (1) the current stance of regulatory bodies and learned societies, (2) the literature data on single- and multi-AIT and (3) the members' confirmed clinical experience with polysensitized patients. Results: AIT is safe and effective in polysensitized and polyallergic patients, and should always be based on the identification of one or more clinically relevant allergens (based on the type and severity of symptoms, the duration of induced symptoms, the impact on quality of life and how difficult an allergen is to avoid). Single-AIT is recommended in polyallergic patients in whom one of the relevant allergens is nevertheless clearly responsible for the most intense and/or bothersome symptoms. Parallel 2-allergen immunotherapy or mixed 2-allergen immunotherapy is indicated in polyallergic patients in whom two causal relevant allergens have a marked clinical and QoL impact. In parallel 2-allergen immunotherapy (whether subcutaneous or sublingual), high-quality, standardized, single-allergen formulations must be administered with an interval of 30 min. Mixing of allergen extracts may be considered, as long as (1) the mixture is technically feasible, (2) the mixture is allowed from a regulatory standpoint, (3) the allergen doses are reduced in proportion to the number of components but are still at concentrations with demonstrated efficacy. Conclusions: Physicians can prescribe AIT (preferably with high-quality, standardized, single-allergen formulations) with confidence in polysensitized and polyallergic patients by focusing on clinical/QoL relevance and safety

Conflitos de uso do espaço público na vida noturna do bairro Cidade Baixa : as percepções sobre moradores e frequentadores acerca do conflito

A Cidade Baixa é um bairro de Porto Alegre que se desenvolveu ao longo das décadas tendo como principais características a sua boêmia e o fato desta estar atrelada à classes sociais marginalizadas na sociedade e com menor poder econômico, como os negros e imigrantes. Na atualidade, a população do bairro é mais diversa, mas a característica boemia permaneceu, sendo esse bairro um dos grandes polos da vida noturna em Porto Alegr e, com grande ocupação de seus espaços públicos e privados, como os bares. Essa s ituação causa desconforto nos residentes do bairro, além do bairro ser frequentemente alvo de intervenções da administração pública. Dessa forma, o presente trabalho busca investigar esse conflito entre frequentadores e moradores do bairro Cidade Baixa dur ante o período noturno , fazendo uma leitura um mais aprofundada sobre esse fenômeno , por meio de questionários com os grupos presentes no conflito. O que obtivemos como resultado geral foi uma melhor compreensão sobre o conflito e os principais pontos de tensão. A resposta geral foi positiva, com ambos os lados cientes do problema e dispostos a solucioná-lo, compreendo a relevância histórica e presente que o bairro tem para ambos

Patient engagement and patient support programs in allergy immunotherapy: A call to action for improving long-term adherence

Allergy immunotherapy (AIT) is acknowledged to produce beneficial mid- and long-term clinical and immunologic effects and increased quality of life in patients with allergic respiratory diseases (such as allergic rhinoconjunctivitis and allergic asthma). However, poor adherence to AIT (due to intentional and/or non-intentional factors) is still a barrier to achieving these benefits. There is an urgent need for patient support programs (PSPs) that encompass communication, educational and motivational components. In the field of AIT, a PSP should be capable of (1) improving adherence, (2) boosting patient engagement, (3) explaining how AIT differs from pharmacological allergy treatments; (4) increasing health literacy about chronic, progressive, immunoglobulin-E-mediated immune diseases, (5) helping the patient to understand and manage local or systemic adverse events, and (6) providing and/or predicting local data on aeroallergen levels. We reviewed the literature in this field and have identified a number of practical issues to be addressed when implementing a PSP for AIT: the measurement of adherence, the choice of technologies, reminders, communication channels and content, the use of "push" messaging and social networks, interactivity, and the involvement of caregivers and patient leaders. A key issue is "hi-tech" (i.e. approaches based mainly on information technology) vs. "hi-touch" (based mainly on interaction with humans, i.e. family members, patient mentors and healthcare professionals). We conclude that multistakeholder PSPs (combining patient-, provider and society-based actions) must now be developed and tested with a view to increasing adherence, efficacy and safety in the field of AIT

A common language to assess allergic rhinitis control : results from a survey conducted during EAACI 2013 Congress

Peer reviewedPublisher PD

An IgE immediate reaction to thiocolchicoside.

Hypersensitivity reactions due to muscle relaxant drugs may be related either to a nonspecific release of allergic mediators or to allergic reactions induced by the molecules themselves. Rare cases of hypersensitivity reactions have been associated to thiocolchicoside, and no case of IgE-mediated immediate reaction has actually been reported to date. We report the first documented case of immediate anaphylaxis to thiocolchicoside

Multi-scale and multi-representation CAD models reconciliation for knowledge synthesis

Over the last decades, concurrent engineering and design for X approaches have introduced knowledgebased decision supports, analysis methods and feature-based modelling techniques to deliver designed solutions ready for specific lifecycle purposes. However, to cover the emerging knowledge synthesis issue in engineering design, the underlying 3D representations need to be better understood and chained. This paper aims at developing original multi-representation and multi-scale CAD models to integrate properly knowledge in their most suitable form. Reconciliation mechanisms can be set up to validate semantic continuity of the geometric models and to justify the knowledge structuring the design solutions space