Языковая картина мира американской молодежи 50-60 гг. ХХ века на материале литературы бит – поколения

The article considers specific characteristics of the language world view of the linguosociety under research and the concepts implemented in the literature of the Beat Generation. Cognitive approach to the study of concepts as constituent parts of the national conceptual sphere allows to single out universal concept (freedom), relatively specific concepts (home, road) and absolutely specific concepts (madness, addiction) organized in a system.В статье рассматриваются характерные особенности языковой картины мира указанного лингвосоциума, а также исследуются ключевые концепты на материале литературы бит-поколения. Лингвокогнитивный подход к исследованию концептов как части национальной концептосферы позволяет выделить универсальный концепт (freedom), относительно специфические концепты (home, road) и абсолютно специфические концепты (madness, addiction), которые представляют собой части единой концептуальной системы

Low temperature resistive elements integrated into superconductive NbN nanowires produced under ion beam irradiation

The work was supported by the NRC “Kurchatov Institute” (№1639)

Exploratory metabolomics study of the experimental opisthorchiasis in a laboratory animal model (golden hamster, Mesocricetus auratus).

Opisthorchiasis is a parasitic infection caused by the liver flukes of the Opisthorchiidae family. Both experimental and epidemiological data strongly support a role of these parasites in the etiology of the hepatobiliary pathologies and an increased risk of intrahepatic cholangiocarcinoma. Understanding a functional link between the infection and hepatobiliary pathologies requires a detailed description a host-parasite interaction on different levels of biological regulation including the metabolic response on the infection. The last one, however, remains practically undocumented. Here we are describing a host response on Opisthorchiidae infection using a metabolomics approach and present the first exploratory metabolomics study of an experimental model of O. felineus infection.We conducted a Nuclear Magnetic Resonance (NMR) based longitudinal metabolomics study involving a cohort of 30 animals with two degrees of infection and a control group. An exploratory analysis shows that the most noticeable trend (30% of total variance) in the data was related to the gender differences. Therefore further analysis was done of each gender group separately applying a multivariate extension of the ANOVA-ASCA (ANOVA simultaneous component analysis). We show that in the males the infection specific time trends are present in the main component (43.5% variance), while in the females it is presented only in the second component and covers 24% of the variance. We have selected and annotated 24 metabolites associated with the observed effects and provided a physiological interpretation of the findings.The first exploratory metabolomics study an experimental model of O. felineus infection is presented. Our data show that at early stage of infection a response of an organism unfolds in a gender specific manner. Also main physiological mechanisms affected appear rather nonspecific (a status of the metabolic stress) the data provides a set of the hypothesis for a search of the more specific metabolic markers of the Opisthorchiidae infection

A graphical outline of the experimental design.

<p>A graphical outline of the experimental design.</p

ANOVA simultaneous component analysis loadingplot on metabolites satisfying the F test with p value < 0.005 on the interaction coefficients: Time × infection.

<p>A, B—males, C,D—females.</p

The score plots of the first two principal components of a PCA model built on the entire dataset; Every block of the figure represents the same model colored according to different factors; A—infection group, B—season, C—gender, D—time in weeks.

<p>The score plots of the first two principal components of a PCA model built on the entire dataset; Every block of the figure represents the same model colored according to different factors; A—infection group, B—season, C—gender, D—time in weeks.</p