656 research outputs found
Situating organizational action: the relational sociology of organizations
This paper advances a relational sociology of organization that seeks to address concerns over how organizational action is understood and situated. The approach outlined here is one which takes ontology seriously and requires transparency and consistency of position. It aims at causal explanation over description and/or prediction and seeks to avoid pure voluntarism or structural determinism in such explanation. We advocate relational analysis that recognizes and engages with connections within and across organization and with wider contexts. We develop this argument by briefly reviewing three promising approaches: relational pragmatism, the social theorizing of Bourdieu and critical realism, highlighting their ontological foundations, some similarities and differences and surfacing some methodological issues. Our purpose is to encourage analysis that explores the connections within and between perspectives and theoretical positions. We conclude that the development of the field of organization theory will benefit from self conscious and reflexive engagement and debate both within and across our various research positions and traditions only if such debates are conducted on the basis of holistic evaluations and interpretations that recognize (and value) difference
âJapanese Management 20 Years On: The Contemporary Relevance of Japanese Management Practicesâ
"I can't be arsed": A small-scale exploration of students' self-reported motivation on entering a course of study and eventual "success"
Purpose: The purpose of this paper is to explore the university course trajectories of students from entry to a 3-year full-time undergraduate programme, to graduation with an honours degree, in the light of their self-reported motivations to study. This small-scale investigation took place at a UK Higher Education Institution (HEI). Design/methodology/approach: A small-scale survey using the Academic Motivation (to study) Scale was administered to 102 students on entry to a full-time undergraduate degree course in an interdisciplinary information-based department in a UK HEI. The students' motivation profiles were assessed in relation to their trajectory through the degree course and selected students were interviewed just prior to graduation. Findings: The report focuses on the pattern of student motivations - in general students who achieved "good" degrees were likely to have lower motivation and students achieving "not so good" degrees were likely to self-report higher levels of both autonomous and controlled motivations. Whilst the small sample size and individual variation may partly explain these results, interviews with a small number of participants allowed some further explication of these patterns. Research limitations/implications: Because of the complexity of variables potentially involved in studies relating to motivation, the focus of this study was practitioner reflection. Thus, it examines self-reported motivations measured on a established scale and 'success' in terms of progression and attainment. The research findings were from a small cohort study in a convenience sample of 102 students in a particular context, so there are necessarily limits on the generalisability of the study. Practical implications: Elements around student achievement and progression related to their motivation are identified, and may contribute to effective design of learning experiences that students "can be arsed" to engage in. Originality/value: New empirical data are reported which provide an insight into student attitudes to study and the applicability of teacher responses, which are briefly discussed in relation to socio-cognitive and socio-cultural perspectives. © Emerald Group Publishing Limited
CaMKII-dependent responses to ischemia and reperfusion challenges in the heart
Ischemic heart disease is a leading cause of death, and there is considerable imperative to identify effective therapeutic interventions. Cardiomyocyte Ca2+ overload is a major cause of ischemia and reperfusion injury, initiating a cascade of events culminating in cardiomyocyte death, myocardial dysfunction, and occurrence of lethal arrhythmias. Responsive to fluctuations in intracellular Ca2+, Ca2+/calmodulin-dependent protein kinase II (CaMKII) has emerged as an enticing therapeutic target in the management of ischemic heart injury. CaMKII is activated early in ischemia and to a greater extent in the first few minutes of reperfusion, at a time when reperfusion arrhythmias are particularly prominent. CaMKII phosphorylates and upregulates many of the key proteins involved in intracellular Na+ and Ca2+ loading in ischemia and reperfusion. Experimentally, selective inhibition of CaMKII activity reduces cardiomyocyte death and arrhythmic incidence post-ischemia. New evidence is emerging that CaMKII actions in ischemia and reperfusion involve specific splice variant targeted actions, selective and localized post-translational modifications, and organelle-directed substrate interactions. A more complete mechanistic understanding of CaMKII mode of action in ischemia and reperfusion is required to optimize intervention opportunities. This review summarizes the current experimentally derived understanding of CaMKII participation in mediating the pathophysiology of the heart in ischemia and in reperfusion, and highlights priority future research directions.Centro de Investigaciones Cardiovasculare
Amplifying staff development through film: the case of a university staff visit to a sixth form college
Purpose: The literature on student transition to university commonly investigates student expectations, perceptions and experiences and rarely focuses on university academic staff viewpoints. This paper explores the staff development potential of a filmed visit of university academic staff to a sixth form college. Design/methodology/approach: The project created a space for eight university colleagues from a wide range of discipline areas in a large metropolitan university and ten college students from one local sixth form feeder college to observe and reflect on their experiences of learning and teaching in the two environments. Findings: Staff development episodes were subsequently designed to allow staff who had not attended the visit to comprehend the experiences of learning and teaching in colleges and promote a consideration of pedagogies for student transition. Observations and reflections from this âsecond audienceâ are presented. Research limitations/implications:This was a case study of a visit of a small group of university academic staff to one Roman Catholic 6th form college who selected students to speak on film. The visit occurred just prior to final exams at the end of the academic year. Practical implications: Packaging the visit via film and workshop activity enabled university staff to hear their own colleaguesâ reflections on how students learn in college and the step up to university study. This combination of vicarious/peer learning could be used in a range of staff development and training settings. Originality/value: This study explored a practical way of extending a small-scale episode of experiential staff development to a much larger staff audience via the use of filmed reflections of participants, combined with workshop activity and online comment and discussion
Foundation and empire : a critique of Hardt and Negri
In this article, Thompson complements recent critiques of Hardt and Negri's Empire (see Finn Bowring in Capital and Class, no. 83) using the tools of labour process theory to critique the political economy of Empire, and to note its unfortunate similarities to conventional theories of the knowledge economy
Weak Interaction Studies with 6He
The 6He nucleus is an ideal candidate to study the weak interaction. To this
end we have built a high-intensity source of 6He delivering ~10^10 atoms/s to
experiments. Taking full advantage of that available intensity we have
performed a high-precision measurement of the 6He half-life that directly
probes the axial part of the nuclear Hamiltonian. Currently, we are preparing a
measurement of the beta-neutrino angular correlation in 6He beta decay that
will allow to search for new physics beyond the Standard Model in the form of
tensor currents.Comment: 5 pages, 4 figures, proceedings for the Eleventh Conference on the
Intersections of Particle and Nuclear Physics (CIPANP 2012
Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism
The calcium-sensing receptor (CaR) modulates renal calcium reabsorption and parathyroid hormone (PTH) secretion and is involved in the etiology of secondary hyperparathyroidism in CKD. Supraphysiologic changes in extracellular pH (pH(o)) modulate CaR responsiveness in HEK-293 (CaR-HEK) cells. Therefore, because acidosis and alkalosis are associated with altered PTH secretion in vivo, we examined whether pathophysiologic changes in pH(o) can significantly alter CaR responsiveness in both heterologous and endogenous expression systems and whether this affects PTH secretion. In both CaR-HEK and isolated bovine parathyroid cells, decreasing pH(o) from 7.4 to 7.2 rapidly inhibited CaR-induced intracellular calcium (Ca(2+)(i)) mobilization, whereas raising pH(o) to 7.6 potentiated responsiveness to extracellular calcium (Ca(2+)(o)). Similar pH(o) effects were observed for Ca(2+)(o)-induced extracellular signal-regulated kinase phosphorylation and actin polymerization and for L-Phe-induced Ca(2+)(i) mobilization. Intracellular pH was unaffected by acute 0.4-unit pH(o) changes, and the presence of physiologic albumin concentrations failed to attenuate the pH(o)-mediated effects. None of the individual point mutations created at histidine or cysteine residues in the extracellular domain of CaR attenuated pH(o) sensitivity. Finally, pathophysiologic pH(o) elevation reversibly suppressed PTH secretion from perifused human parathyroid cells, and acidosis transiently increased PTH secretion. Therefore, pathophysiologic pH(o) changes can modulate CaR responsiveness in HEK-293 and parathyroid cells independently of extracellular histidine residues. Specifically, pathophysiologic acidification inhibits CaR activity, thus permitting PTH secretion, whereas alkalinization potentiates CaR activity to suppress PTH secretion. These findings suggest that acid-base disturbances may affect the CaR-mediated control of parathyroid function and calcium metabolism in vivo
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