A Beam-Space Active Sensing Scheme for Integrated Communication and Sensing Applications

In this paper, we develop an active sensing strategy for a millimeter wave (mmWave) band Integrated Sensing and Communication (ISAC) system adopting a realistic hybrid digital-analog (HDA) architecture. To maintain a desired SNR level, initial beam acquisition (BA) must be established prior to data transmission. In the considered setup, a Base Station (BS) Tx transmits data via a digitally modulated waveform and a co-located radar receiver simultaneously performs radar estimation from the backscattered signal. In this BA scheme, a single common data stream is broadcast over a wide angular sector such that the radar receiver can detect the presence of not yet acquired users and perform coarse parameter estimation (angle of arrival, time of flight, and Doppler). As a result of the HDA architecture, we consider the design of multi-block adaptive RF-domain 'reduction matrices' (from antennas to RF chains) at the radar receiver, to achieve a compromise between the exploration capability in the angular domain and the directivity of the beamforming patterns. Our numerical results demonstrate that the proposed approach is able to reliably detect multiple targets while significantly reducing the initial acquisition time.Comment: 17 page

Beam-Space MIMO Radar for Joint Communication and Sensing with OTFS Modulation

Motivated by automotive applications, we consider joint radar sensing and data communication for a system operating at millimeter wave (mmWave) frequency bands, where a Base Station (BS) is equipped with a co-located radar receiver and sends data using the Orthogonal Time Frequency Space (OTFS) modulation format. We consider two distinct modes of operation. In Discovery mode, a single common data stream is broadcast over a wide angular sector. The radar receiver must detect the presence of not yet acquired targets and perform coarse estimation of their parameters (angle of arrival, range, and velocity). In Tracking mode, the BS transmits multiple individual data streams to already acquired users via beamforming, while the radar receiver performs accurate estimation of the aforementioned parameters. Due to hardware complexity and power consumption constraints, we consider a hybrid digital-analog architecture where the number of RF chains and A/D converters is significantly smaller than the number of antenna array elements. In this case, a direct application of the conventional MIMO radar approach is not possible. Consequently, we advocate a beam-space approach where the vector observation at the radar receiver is obtained through a RF-domain beamforming matrix operating the dimensionality reduction from antennas to RF chains. Under this setup, we propose a likelihood function-based scheme to perform joint target detection and parameter estimation in Discovery, and high-resolution parameter estimation in Tracking mode, respectively. Our numerical results demonstrate that the proposed approach is able to reliably detect multiple targets while closely approaching the Cramer-Rao Lower Bound (CRLB) of the corresponding parameter estimation problem.Comment: 33 Page

Integrated Sensing and Communication with MOCZ Waveform

In this work, we propose a waveform based on Modulation on Conjugate-reciprocal Zeros (MOCZ) originally proposed for short-packet communications in [1], as a new Integrated Sensing and Communication (ISAC) waveform. Having previously established the key advantages of MOCZ for noncoherent and sporadic communication, here we leverage the optimal auto-correlation property of Binary MOCZ (BMOCZ) for sensing applications. Due to this property, which eliminates the need for separate communication and radar-centric waveforms, we propose a new frame structure for ISAC, where pilot sequences and preambles become obsolete and are completely removed from the frame. As a result, the data rate can be significantly improved. Aimed at (hardware-) cost-effective radar-sensing applications, we consider a Hybrid Digital-Analog (HDA) beamforming architecture for data transmission and radar sensing. We demonstrate via extensive simulations, that a communication data rate, significantly higher than existing standards can be achieved, while simultaneously achieving sensing performance comparable to state-of-the-art sensing systems

Multi-static Parameter Estimation in the Near/Far Field Beam Space for Integrated Sensing and Communication Applications

This work proposes a maximum likelihood (ML)-based parameter estimation framework for a millimeter wave (mmWave) integrated sensing and communication (ISAC) system in a multi-static configuration using energy-efficient hybrid digital-analog arrays. Due to the typically large arrays deployed in the higher frequency bands to mitigate isotropic path loss, such arrays may operate in the near-field regime. The proposed parameter estimation in this work consists of a two-stage estimation process, where the first stage is based on far-field assumptions, and is used to obtain a first estimate of the target parameters. In cases where the target is determined to be in the near-field of the arrays, a second estimation based on near-field assumptions is carried out to obtain more accurate estimates. In particular, we select beamfocusing array weights designed to achieve a constant gain over an extended spatial region and re-estimate the target parameters at the receivers. We evaluate the effectiveness of the proposed framework in numerous scenarios through numerical simulations and demonstrate the impact of the custom-designed flat-gain beamfocusing codewords in increasing the communication performance of the system.Comment: 16 page

Extended Target Parameter Estimation and Tracking with an HDA Setup for ISAC Applications

We investigate radar parameter estimation and beam tracking with a hybrid digital-analog (HDA) architecture in a multi-block measurement framework using an extended target model. In the considered setup, the backscattered data signal is utilized to predict the user position in the next time slots. Specifically, a simplified maximum likelihood framework is adopted for parameter estimation, based on which a simple tracking scheme is also developed. Furthermore, the proposed framework supports adaptive transmitter beamwidth selection, whose effects on the communication performance are also studied. Finally, we verify the effectiveness of the proposed framework via numerical simulations over complex motion patterns that emulate a realistic integrated sensing and communication (ISAC) scenario.Comment: 6 page

From OTFS to DD-ISAC: Integrating Sensing and Communications in the Delay Doppler Domain

Next-generation vehicular networks are expected to provide the capability of robust environmental sensing in addition to reliable communications to meet intelligence requirements. A promising solution is the integrated sensing and communication (ISAC) technology, which performs both functionalities using the same spectrum and hardware resources. Most existing works on ISAC consider the Orthogonal Frequency Division Multiplexing (OFDM) waveform. Nevertheless, vehicle motion introduces Doppler shift, which breaks the subcarrier orthogonality and leads to performance degradation. The recently proposed Orthogonal Time Frequency Space (OTFS) modulation, which exploits various advantages of Delay Doppler (DD) channels, has been shown to support reliable communication in high-mobility scenarios. Moreover, the DD waveform can directly interact with radar sensing parameters, which are actually delay and Doppler shifts. This paper investigates the advantages of applying the DD communication waveform to ISAC. Specifically, we first provide a comprehensive overview of implementing DD communications, based on which several advantages of DD-ISAC over OFDM-based ISAC are revealed, including transceiver designs and the ambiguity function. Furthermore, a detailed performance comparison are presented, where the target detection probability and the mean squared error (MSE) performance are also studied. Finally, some challenges and opportunities of DD-ISAC are also provided.Comment: Magazine paper submitted to IEE

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Adenylyl Cyclase (AC) Mediates the Antidepressant-Like Effects of Tropisetron on a Mouse Model of Maternal Separation Stress

The adenylyl cyclase (AC) pathway is involved in the pathophysiology of depression. Finding new antidepressants with high medicinal properties and low side effects is warranted. Therefore, this study was designed to determine the antidepressant-like effect of tropisetron on a maternal separation (MS) model in mice, considering the possible role of AC. NMRI male mice were divided into eleven groups. The control group was treated with saline and MS groups were treated with saline, tropisetron (a 5-HT3 receptor antagonist) at doses of 1, 3, and 5 mg/kg; forskolin (an activator of AC) at doses of 5, 10, and 25 mg/kg; a subeffective dose of forskolin with a subeffective dose of tropisetron; and an effective dose of tropisetron plus an effective dose of NB001 (3 mg/kg) (an AC inhibitor). After treatment, animals were subjected to behavioral tests including the forced swimming test (FST), splash test, and open field test (OFT). We showed that MS caused depressive-like behaviors determined as an increase in the immobility time in the forced swimming test (FST) and decreased grooming time in the splash test. Our results showed that administration of tropisetron, as well as forskolin, mitigated the depressive-like behaviors in MS mice. We found that coadministration of a subeffective dose of tropisetron plus a subeffective dose of forskolin potentiated the antidepressant-like effect of tropisetron. However, coadministration of an effective dose of NB001 with an effective dose of tropisetron did not significantly affect the antidepressant-like effect of tropisetron. We concluded that the antidepressant-like effects of tropisetron on MS mice are partially mediated through the adenylyl cyclase pathway