Livestock and Local Development: Going to a New Humananimal Relationship

Along the past ten years, the French National Agency for Research (ANR) has financed projects regarding livestock. Results of five projects were gathered to understand the long-term livestock trends. At the end of the 19th century, animal breeding was oriented towards the production of goods to meet the local, regional, national and global demand, according to the zone. The market gradually became the key-factor to norm both production and consumption. It is now integrating environmental norms and is starting to invest in the social domain. However, this economical vision of animal production does not take into account the other functions of livestock, from “farm fork” to “table fork”. So, in parallel to the multi-functionality of livestock at the farm level, which is mentioned by several authors, livestock has a significant role at the local scale. Furthermore, in the past four decades, animal production sector has known several serious scandals with severe consequences in human health. At the same time, the FAO scoop in 2006 about the significant environmental impact of animal breeding has chocked a large part of the human society. Hence, in parallel to the discredit of animal production towards the consumers, these successive crises have led a part of the local and global society to question the human-animal relationship. In this way, a large part of the urban population with no contact with the rural world, would easily believe in animal welfare, and break the supply chain leading to the slaughterhouse. And to confirm this trend, research institutes are already seeking alternatives to meat and animal proteins. Consequently, maybe it is time now to think imagine other farming systems based on other human-animal relationships and other environment-society interactions; and perhaps to establish an adequate set of policies to strengthen this perspective

Livestock and Local Development: Going to a New Human-Animal Relationship

Along the last ten years, the French National Agency for Research (ANR) has financed several projects regarding livestock at local and global scale. Five of these projects decided to gather their results in order to better understand the long-term livestock dynamics and the scenarios for the future. Research actions have been developed in fifteen sites in diverse biomes located in seven countries of Europe, Africa, America and Asia. Review of literature and preliminary data collected in the sites showed the high complexity of the livestock dynamics. For example, in some cases, intensification of the livestock farming systems regards land. In other cases, intensification regards labor. In other cases, breeders are adopting more extensive practices. Similar process had been noticed for the farm size which increases or decreases according to the site and the type of farms. Diverse strategies have been mentioned regarding marketing, collective actions and environment impacts. To face this complexity, the analysis has been developed site by site and project by project, before a comparative approach

From local to global: mental models of local people about livestock sector

MOUVE project and the LIFLOD network are developing a research focused on the better understanding of the mental models about livestock at local scale, with the goal to report the results at global scale. The authors present the results based on a set of 13 sites selected according to: (1) the interest of the local team; (2) significance of the local context, and its representation of the diversity at global scale

Facilitation of Employability for Maternity and Parental Leavers in Europe: A Scoping Review

This report presents the findings of an European project concerning facilitation of employability for parental leavers in European countries. The conclusions and recommendations in this report build on comparisons of relevant European policy documents, country nates from five European countries (France, Hungary, the Netherlands, Norway and Slovakia) and a search in relevant databases. Taken together, these data form an approximate scoping review - to map a wide range of literature. Both the concepts of maternal and parental leave are used in the present report. Research related to leave in connection with young children use the term maternity leave until the last decades where more frequent parental leave is used. We are aware that a distinction between parental and maternity leave does not apply in same countries. A main finding is that parental leave and employability is a complex and context sensitive area. This relates to the fact that parental leave must be seen in connection with both individual, organisational, cultural, historical and political (legislative) issues on both national and European level. In this study, the focus has been mainly descriptive on the political (legislative) level, while a more interpretative analysis is made on how to develop tools and educational programs concerning development of employability skills relevant for parental leavers and employers. Analysis of the situation regarding parental leavers' employment in the partner countries shows that maternal employment in France, Slovakia and Hungary is rather low. Although, in Hungary there are networks which provide special counselling for women and support them when it comes to their (re)integration into the labour market. In Western Europe, such as the Netherlands and Norway, the situation is more favourable, employers are more flexible and part-time job is a frequent option offered. However, the up-to-date level of skills of parental leavers coming back to work may be a challenge in these countries too. The duration and generosity of paid parental leave seems to affect when (after what time) parents return to work. The period of leave cannot be too short, nor too long. The optimal length of the leave varies greatly depending on national conditions and cultural frameworks. In any case, it should not be so long that the parental leavers become uninteresting for the labour market and lose working competence (Kalb, 2018; Whitehouse, Romaniuk, Lucas & Nicholson, 2013).This project has been funded with support from the Erasmus+ Programme of the European Commission

LRP-1 Promotes Cancer Cell Invasion by Supporting ERK and Inhibiting JNK Signaling Pathways

Background: The low-density lipoprotein receptor-related protein-1 (LRP-1) is an endocytic receptor mediating the clearance of various extracellular molecules involved in the dissemination of cancer cells. LRP-1 thus appeared as an attractive receptor for targeting the invasive behavior of malignant cells. However, recent results suggest that LRP-1 may facilitate the development and growth of cancer metastases in vivo, but the precise contribution of the receptor during cancer progression remains to be elucidated. The lack of mechanistic insights into the intracellular signaling networks downstream of LRP-1 has prevented the understanding of its contribution towards cancer. Methodology/Principal Findings: Through a short-hairpin RNA-mediated silencing approach, we identified LRP-1 as a main regulator of ERK and JNK signaling in a tumor cell context. Co-immunoprecipitation experiments revealed that LRP-1 constitutes an intracellular docking site for MAPK containing complexes. By using pharmacological agents, constitutively active and dominant-negative kinases, we demonstrated that LRP-1 maintains malignant cells in an adhesive state that is favorable for invasion by activating ERK and inhibiting JNK. We further demonstrated that the LRP-1-dependent regulation of MAPK signaling organizes the cytoskeletal architecture and mediates adhesive complex turnover in cancer cells. Moreover, we found that LRP-1 is tethered to the actin network and to focal adhesion sites and controls ERK and JNK targeting to talin-rich structures. Conclusions: We identified ERK and JNK as the main molecular relays by which LRP-1 regulates focal adhesion disassembly of malignant cells to support invasion

Mycobacterium tuberculosis Lipolytic Enzymes as Potential Biomarkers for the Diagnosis of Active Tuberculosis

BACKGROUND: New diagnosis tests are urgently needed to address the global tuberculosis (TB) burden and to improve control programs especially in resource-limited settings. An effective in vitro diagnostic of TB based on serological methods would be regarded as an attractive progress because immunoassays are simple, rapid, inexpensive, and may offer the possibility to detect cases missed by standard sputum smear microscopy. However, currently available serology tests for TB are highly variable in sensitivity and specificity. Lipolytic enzymes have recently emerged as key factors in lipid metabolization during dormancy and/or exit of the non-replicating growth phase, a prerequisite step of TB reactivation. The focus of this study was to analyze and compare the potential of four Mycobacterium tuberculosis lipolytic enzymes (LipY, Rv0183, Rv1984c and Rv3452) as new markers in the serodiagnosis of active TB. METHODS: Recombinant proteins were produced and used in optimized ELISA aimed to detect IgG and IgM serum antibodies against the four lipolytic enzymes. The capacity of the assays to identify infection was evaluated in patients with either active TB or latent TB and compared with two distinct control groups consisting of BCG-vaccinated blood donors and hospitalized non-TB individuals. RESULTS: A robust humoral response was detected in patients with active TB whereas antibodies against lipolytic enzymes were infrequently detected in either uninfected groups or in subjects with latent infection. High specifity levels, ranging from 93.9% to 97.5%, were obtained for all four antigens with sensitivity values ranging from 73.4% to 90.5%, with Rv3452 displaying the highest performances. Patients with active TB usually exhibited strong IgG responses but poor IgM responses. CONCLUSION: These results clearly indicate that the lipolytic enzymes tested are strongly immunogenic allowing to distinguish active from latent TB infections. They appear as potent biomarkers providing high sensitivity and specificity levels for the immunodiagnosis of active TB

Generalized weight properties of resultants and discriminants, and applications to projective enumerative geometry

In a book dating back to 1862, Salmon stated a formula giving the first terms of the Taylor expansion of the discriminant of a plane algebraic curve, and from it derived various enumerative quantities for surfaces in the 3-dimensional projective space. In this text, we provide complete proofs of this formula and its enumerative applications, and extend Salmon's considerations to hypersurfaces in a projective space of arbitrary dimension. To this end, we extend reduced elimination theory by introducing the concept of reduced discriminant, and provide a thorough study of its weight properties; the latter are deeply linked to projective enumerative geometric properties. Then, following Salmon's approach, we compute the number of members of a pencil of hyperplanes that are bitangent to a fixed projective hypersurface. Some other results in the same spirit are also discussed

On the automorphisms of Mukai varieties

Mukai varieties are Fano varieties of Picard number one and coindex three. In genus seven to ten they are linear sections of some special homogeneous varieties. We describe the generic automorphism groups of these varieties. When they are expected to be trivial for dimensional reasons, we show they are indeed trivial, up to three interesting and unexpected exceptions in genera 7, 8, 9, and codimension 4, 3, 2 respectively. We conclude in particular that a generic prime Fano threefold of genus g has no automorphisms for 7 ≤ g ≤ 10. In the Appendix by Y. Prokhorov, the latter statement is extended to g = 12