928 research outputs found
Design of a nanostructured mucoadhesive system containing curcumin for buccal application : from physicochemical to biological aspects
Mucoadhesive nanostructured systems comprising poloxamer 407 and Carbopol 974PŸ have already demonstrated good mucoadhesion, as well as improved mechanical and rheological properties. Curcumin displays excellent biological activity, mainly in oral squamous cancer; however, its physicochemical characteristics hinder its application. Therefore, the aim of this study was to develop nanostructured formulations containing curcumin for oral cancer therapy. The photophysical interactions between curcumin and the formulations were elucidated by incorporation kinetics and location studies. They revealed that the drug was quickly incorporated and located in the hydrophobic portion of nanometer-sized polymeric micelles. Moreover, the systems displayed plastic behavior with rheopexy characteristics at 37 °C, viscoelastic properties and a gelation temperature of 36 °C, which ensures increased retention after application in the oral cavity. The mucoadhesion results confirmed the previous findings with the nanostructured systems showing a residence time of 20 min in porcine oral mucosa under flow system conditions. Curcumin was released after 8 h and could permeate through the porcine oral mucosa. Cytotoxicity testing revealed that the formulations were selective to cancer cells over healthy cells. Therefore, these systems could improve the physicochemical characteristics of curcumin by providing improved release and permeation, while selectivity targeting cancer cells
Educação em ciĂȘncia e em audiovisual: olhares para a formação de leitores de ciĂȘncias
Oral health as a predictive factor for oral mucositis
OBJECTIVES: Oral mucositis is a complication frequently associated with hematopoietic stem cell transplantation, decreasing a patient's quality of life and increasing the occurrence of opportunistic infections. The purpose of this study was to determine the incidence and severity of oral mucositis and to assess the correlation of this disease with the oral health of an individual at the time of hematopoietic stem cell transplantation. METHODS: Before transplantation, patients' oral health and inflammatory conditions were determined using the gingival index and the plaque index, which are based on gingival bleeding and the presence of dental plaque, respectively. Additionally, the dental health status was determined using the decayed, missing, and filled teeth index. The monitoring of oral mucositis was based on the World Health Organization grading system and was performed for five periods: from Day 0 to D+5, from D+6 to D+10, from D+11 to D+15, from D+16 to D+20, and from D+21 to D+30. RESULTS: A total of 97 patients (56% male and 44% female) who underwent hematopoietic stem cell transplantation at the Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo between January 2008 and July 2009 were prospectively examined. The incidence of ulcerative mucositis was highest from days +6 to +10 and from days +11 to +15 in the patients who underwent autologous and allogeneic hematopoietic stem cell transplantation, respectively. CONCLUSION: The data, including the dental plaque and periodontal status data, showed that these oral health factors were predictive of the incidence and severity of oral mucositis in a cohort of patients with similar conditioning regimens before hematopoietic stem cell transplantation
The impact of cow nutrient status during the second and third trimesters on age at puberty, antral follicle count, and fertility of daughters
SĂntese e caracterização de nanopartĂculas de NiFe2O4 utilizando o mĂ©todo de sol-gel/combustĂŁo e combustĂŁo homogĂȘnea
As mĂșltiplas funçÔes da agricultura familiar: um estudo no assentamento Monte Alegre, regiĂŁo de Araraquara (SP).
A partir da emergĂȘncia da ideia de sustentabilidade, a agricultura adquiriu novas conotaçÔes, associadas nĂŁo apenas ao aspecto produtivo, mas tambĂ©m Ă conservação dos recursos naturais e dos territĂłrios rurais, em um reconhecimento de sua multifuncionalidade. Com base nesta noção, que valoriza as funçÔes socioambientais desempenhadas pelas famĂlias rurais e pelas agriculturas praticadas, o presente artigo analisa um assentamento rural no estado de SĂŁo Paulo, buscando identificar quais sĂŁo e de que forma se expressam as funçÔes para alĂ©m da produção neste territĂłrio particular. Por meio de uma metodologia de cunho quali-quantitativo, observou-se que, no assentamento em foco, a agricultura encerra em si questĂ”es de coesĂŁo territorial, manutenção da segurança alimentar, conservação da agrobiodiversidade e de fomento a outras atividades produtivas, sendo o elemento central da reconstrução de um modo de vida rural neste ambiente
Approximate Performance Analysis of Production Lines with Continuous Material Flows and Finite Buffers
Abordagem multivariada envolvendo caracterĂsticas fĂsicas e morfolĂłgicas do sĂȘmen bovino, idade dos touros e Ă©poca de colheita de sĂȘmen
Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy
We review HB stars in a broad astrophysical context, including both variable
and non-variable stars. A reassessment of the Oosterhoff dichotomy is
presented, which provides unprecedented detail regarding its origin and
systematics. We show that the Oosterhoff dichotomy and the distribution of
globular clusters (GCs) in the HB morphology-metallicity plane both exclude,
with high statistical significance, the possibility that the Galactic halo may
have formed from the accretion of dwarf galaxies resembling present-day Milky
Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the
second-parameter problem is presented. A technique is proposed to estimate the
HB types of extragalactic GCs on the basis of integrated far-UV photometry. The
relationship between the absolute V magnitude of the HB at the RR Lyrae level
and metallicity, as obtained on the basis of trigonometric parallax
measurements for the star RR Lyrae, is also revisited, giving a distance
modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are
studied. Finally, the conductive opacities used in evolutionary calculations of
low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and
Space Scienc
Efeito da densidade de população nos teores de ĂĄcido ascĂłrbico e carboidratos solĂșveis de couve-flor (Brassica oleracea var. botrytis)
Total soluble carbohydrates, glucose, fructose, sucrose and ascorbic acid contents were determined in cauliflower (Brassica oleracea CV. botrytis) samples. The effect of plants densities was studied in this paper. Statistically differences were not observed amoung treatments, although the samples from 20633 plants/ha showed higher level of ascorbic acid. Dry weight varied from 8.24 to 10.13% and ascorbic acid contents varied from 93.1 to 113.5 mg/100 g fresh weight basis. Soluble carbohydrates, in g/100 g fresh weight basis, were: total (3.17-4.54), sucrose (0.26-0.66), glucose (0.92-1.50) and fructose (0.91-1.45).Os teores de carboidratos solĂșveis, glucose, frutose, sacarose e ĂĄcido ascĂłrbico foram determinados em amostras de couve-flor (Brassica oleracea var. botrytis), obtidas de tratamentos apresentando diversas densidades de plantais. O efeito do espaçamento nĂŁo foi significativo para os dviersos constituintes analisados, embora o tratamento com 20.833 plantas/ha apresentasse maior teor de ĂĄcido ascĂłrbico. O peso seco das amostras variou de 8,24 a 10,13% e ĂĄcido ascĂłrbico de 93,1 a 113,5 mg/100 g de peso fresco. Os teores de carboidratos solĂșveis, expressos em g/100 g de peso fresco foram: totais (3,17-4,54) sacarose (0,26-0,66), glucose (0,92-1,50) e frutose (0,91-145)
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