A service evaluation: EllenorLions Hospices Children and Young Peoples Service: Executive Summary

Between January and June 2011, the EllenorLions Hospices commissioned a team from Canterbury Christ Church University to independently review the Children and Young Peoples Service to evaluate the integrated service model which delivers both palliative care and community oncology to children and young people with life threatening and life limiting illnesses. The project brief was conducted in two phases. In Phase 1 an information review was undertaken and in Phase 2 the effectiveness and usability of the service for service users and staff was analysed by qualitative methods (individual and focus group interviews). 10 families, 4 young people, and 12 Professional/ Support Staff were involved. The evaluation team presented the draft report to the EllenorLions Management Team in June 2011 and the final report was presented in August 2011

An integrated discrete event simulation and particle swarm optimisation model for optimising efficiency of cancer diagnosis pathways

The National Health Service (NHS) constitution sets out minimum standards for rights of access of patients to NHS services. The ‘Faster Diagnosis Standard’ (FDS) states that 75% of patients should be told whether they have a diagnosis of cancer or not within 28 days of an urgent GP referral. Timely diagnosis and treatment lead to improved outcomes for cancer patients, however, compliance with these standards has recently been challenged, particularly in the context of operational pressures and resource constraints relating to the COVID-19 pandemic. In order to minimise diagnostic delays, the National Physical Laboratory in collaboration with the Royal Free London (RFL) NHS Foundation Trust address this problem by treating it as a formal resource optimisation, aiming to minimise the number of patients who breach the FDS. We use discrete event simulation and particle swarm optimisation to identify areas for improving the efficiency of cancer diagnosis at the RFL. We highlight capacity-demand mismatches in the current cancer diagnosis pathways at the RFL, including imaging and endoscopy investigations. This is due to the volume of patients requiring these investigations to meet the 28-day FDS target. We find that increasing resources in one area alone does not fully solve the problem. By looking at the system as a whole we identify areas for improvement which will have system-wide impact even though individually they do not necessarily seem significant. The outcomes and impact of this project have the potential to make a valuable impact on shaping future hospital activity

The role of vitamers and dietary-based metabolites of vitamin D in prevention of vitamin D deficiency

There is little doubt that vitamin D deficiency across all age groups in Europe is a problem. Low vitamin D status arises due to limited, if any, dermal synthesis during the winter months at latitudes above 40°N, putting increased importance on dietary supply of the vitamin. However, dietary intakes by most populations are low due to the limited supply of vitamin D-rich foods in the food chain. Thus strategies that effectively address this public health issue are urgently required. It has been emphasized and re-emphasized that there are only a limited number of public health strategies available to correct low dietary vitamin D intake: (1) improving intake of naturally occurring vitamin D-rich foods, (2) vitamin D fortification (mandatory or voluntarily) of food, and (3) vitamin D supplementation. Recent evidence suggests that the levels of vitamin D added to food would need to be high so as to ensure dietary requirements are met and health outcomes optimized. In addition, knowledge of the most effective forms of vitamin D to use in some of these preventative approaches is important. There is still uncertainty in relation to the relative efficacy of vitamin D2 versus D3, the two main food derived forms and those used in vitamin D supplements. The major metabolite of vitamin D with biological activity is 1,25(OH)2D; however, this is usually used for pharmacological purposes and is not typically used in normal, healthy people. The other major metabolite, 25(OH)D, which has also been used for pharmacological purposes is present in certain foods such as meat and meat products (particularly offal) as well as eggs. This metabolite may have the potential to boost vitamin D status up to five times more effectively that native vitamin D3 in foods. However, the exact bioactivity of this compound needs to be established

Multipliers for p-Bessel sequences in Banach spaces

Multipliers have been recently introduced as operators for Bessel sequences and frames in Hilbert spaces. These operators are defined by a fixed multiplication pattern (the symbol) which is inserted between the analysis and synthesis operators. In this paper, we will generalize the concept of Bessel multipliers for p-Bessel and p-Riesz sequences in Banach spaces. It will be shown that bounded symbols lead to bounded operators. Symbols converging to zero induce compact operators. Furthermore, we will give sufficient conditions for multipliers to be nuclear operators. Finally, we will show the continuous dependency of the multipliers on their parameters.Comment: 17 page

Conceptualizing the impact of dust-contaminated infrared radiances on data assimilation for numerical weather prediction

Numerical weather prediction systems depend on Hyperspectral Infrared Sounder (HIS) data, yet the impacts of dust-contaminated HIS radiances on weather forecasts has not been quantified. To determine the impact of dust aerosol on HIS radiance assimilation, we use a modified radiance assimilation system employing a one-dimensional variational assimilation system (1DVAR) developed under the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) Numerical Weather Prediction–Satellite Application Facility (NWP-SAF) project, which uses the Radiative Transfer for TOVS (RTTOV). Dust aerosol impacts on analyzed temperature and moisture fields are quantified using synthetic HIS observations from rawinsonde, Micropulse Lidar Network (MPLNET), and Aerosol Robotic Network (AERONET). Specifically, a unit dust aerosol optical depth (AOD) contamination at 550 nm can introduce larger than 2.4 and 8.6 K peak biases in analyzed temperature and dewpoint, respectively, over our test domain. We hypothesize that aerosol observations, or even possibly forecasts from aerosol predication models, may be used operationally to mitigate dust induced temperature and moisture analysis biases through forward radiative transfer modeling.This study is supported by the NASA ROSES Science of Terra and Aqua program (T. Lee; 80HQTR18T0085). The MPLNET project is funded by the NASA Radiation Sciences Program and Earth Observing System. MPLNET observations at the Santa Cruz de Tenerife site are supported by the INTA Grant IGE03004

Proceedings of the Rank Forum on Vitamin D

The Rank Forum on Vitamin D was held on 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. The workshop consisted of a series of scene-setting presentations to address the current issues and challenges concerning vitamin D and health, and included an open discussion focusing on the identification of the concentrations of serum 25-hydroxyvitamin D (25(OH)D) (a marker of vitamin D status) that may be regarded as optimal, and the implications this process may have in the setting of future dietary reference values for vitamin D in the UK. The Forum was in agreement with the fact that it is desirable for all of the population to have a serum 25(OH)D concentration above 25 nmol/l, but it discussed some uncertainty about the strength of evidence for the need to aim for substantially higher concentrations (25(OH)D concentrations . 75 nmol/l). Any discussion of ‘optimal’ concentration of serum 25(OH)D needs to define ‘optimal’ with care since it is important to consider the normal distribution of requirements and the vitamin D needs for a wide range of outcomes. Current UK reference values concentrate on the requirements of particular subgroups of the population; this differs from the approaches used in other European countries where a wider range of age groups tend to be covered. With the re-emergence of rickets and the public health burden of low vitamin D status being already apparent, there is a need for urgent action from policy makers and risk managers. The Forum highlighted concerns regarding the failure of implementation of existing strategies in the UK for achieving current vitamin D recommendations

Measures on Banach Manifolds and Supersymmetric Quantum Field Theory

We show how to construct measures on Banach manifolds associated to supersymmetric quantum field theories. These measures are mathematically well-defined objects inspired by the formal path integrals appearing in the physics literature on quantum field theory. We give three concrete examples of our construction. The first example is a family $\mu_P^{s,t}$ of measures on a space of functions on the two-torus, parametrized by a polynomial $P$ (the Wess-Zumino-Landau-Ginzburg model). The second is a family \mu_\cG^{s,t} of measures on a space \cG of maps from $\P^1$ to a Lie group (the Wess-Zumino-Novikov-Witten model). Finally we study a family $\mu_{M,G}^{s,t}$ of measures on the product of a space of connection s on the trivial principal bundle with structure group $G$ on a three-dimensional manifold $M$ with a space of \fg-valued three-forms on $M.$ We show that these measures are positive, and that the measures \mu_\cG^{s,t} are Borel probability measures. As an application we show that formulas arising from expectations in the measures \mu_\cG^{s,1} reproduce formulas discovered by Frenkel and Zhu in the theory of vertex operator algebras. We conjecture that a similar computation for the measures $\mu_{M,SU(2)}^{s,t},$ where $M$ is a homology three-sphere, will yield the Casson invariant of $M.$Comment: Minor correction

Comparison of mesospheric winds from a high-altitude meteorological analysis system and meteor radar observations during the boreal winters of 2009–2010 and 2012–2013

We present a study of horizontal winds in the mesosphere and lower thermosphere (MLT) during the boreal winters of 2009–2010 and 2012–2013 produced with a new high-altitude numerical weather prediction (NWP) system. This system is based on a modified version of the Navy Global Environmental Model (NAVGEM) with an extended vertical domain up to ∼116 km altitude coupled with a hybrid four-dimensional variational (4DVAR) data assimilation system that assimilates both standard operational meteorological observations in the troposphere and satellite-based observations of temperature, ozone and water vapor in the stratosphere and mesosphere. NAVGEM-based MLT analyzed winds are validated using independent meteor radar wind observations from nine different sites ranging from 69°N–67°S latitude. Time-averaged NAVGEM zonal and meridional wind profiles between 75 and 95 km altitude show good qualitative and quantitative agreement with corresponding meteor radar wind profiles. Wavelet analysis finds that the 3-hourly NAVGEM and 1-hourly radar winds both exhibit semi-diurnal, diurnal, and quasi-diurnal variations whose vertical profiles of amplitude and phase are also in good agreement. Wavelet analysis also reveals common time-frequency behavior in both NAVGEM and radar winds throughout the Northern extratropics around the times of major stratospheric sudden warmings (SSWs) in January 2010 and January 2013, with a reduction in semi-diurnal amplitudes beginning around the time of a mesospheric wind reversal at 60°N that precedes the SSW, followed by an amplification of semi-diurnal amplitudes that peaks 10–14 days following the onset of the mesospheric wind reversal. The initial results presented in this study demonstrate that the wind analyses produced by the high-altitude NAVGEM system accurately capture key features in the observed MLT winds during these two boreal winter periods

Chemistry and the Science of Transformation in Mary Shelley’s Frankenstein

This essay reads the novel in a new way, examining the way that Victor Frankenstein's chemical education (he does not train to be a doctor!) enables his creation of the monster. It reveals that chemists of the period had a different worldview to others where they saw the world in constant transformation and flux. I have written this essay co-written the introduction to the special issue, and co-edited the whole