Strong Lensing Model of SPT-CLJ0356-5337, a Major Merger Candidate at Redshift 1.0359

We present an analysis of the mass distribution inferred from strong lensing by SPT-CL J0356-5337, a cluster of galaxies at redshift z = 1.0359 revealed in the follow-up of the SPT-SZ clusters. The cluster has an Einstein radius of Erad=14 for a source at z = 3 and a mass within 500 kpc of M_500kpc = 4.0+-0.8x10^14Msol. Our spectroscopic identification of three multiply-imaged systems (z = 2.363, z = 2.364, and z = 3.048), combined with HST F606W-band imaging allows us to build a strong lensing model for this cluster with an rms of <0.3'' between the predicted and measured positions of the multiple images. Our modeling reveals a two-component mass distribution in the cluster. One mass component is dominated by the brightest cluster galaxy and the other component, separated by ~170 kpc, contains a group of eight red elliptical galaxies confined in a ~9'' (~70 kpc) diameter circle. We estimate the mass ratio between the two components to be between 1:1.25 and 1:1.58. In addition, spectroscopic data reveal that these two near-equal mass cores have only a small velocity difference of 300 km/s between the two components. This small radial velocity difference suggests that most of the relative velocity takes place in the plane of the sky, and implies that SPT-CL J0356-5337 is a major merger with a small impact parameter seen face-on. We also assess the relative contributions of galaxy-scale halos to the overall mass of the core of the cluster and find that within 800 kpc from the brightest cluster galaxy about 27% of the total mass can be attributed to visible and dark matter associated with galaxies, whereas only 73% of the total mass in the core comes from cluster-scale dark matter halos.Comment: 19 pages, 11 figures. Submitted to Ap

Inferring More from Less: Prospector as a Photometric Redshift Engine in the Era of JWST

The advent of the James Webb Space Telescope (JWST) signals a new era in exploring galaxies in the high-$z$ universe. Current and upcoming JWST imaging will potentially detect galaxies out to $z \sim 20$, creating a new urgency in the quest to infer accurate photometric redshifts (photo-$z$) for individual galaxies from their spectral energy distributions, as well as masses, ages and star formation rates. Here we illustrate the utility of informed priors encoding previous observations of galaxies across cosmic time in achieving these goals. We construct three joint priors encoding empirical constraints of redshifts, masses, and star formation histories in the galaxy population within the \prospector\ Bayesian inference framework. In contrast with uniform priors, our model breaks an age-mass-redshift degeneracy, and thus reduces the mean bias error in masses from 0.3 to 0.1 dex, and in ages from 0.6 to 0.2 dex in tests done on mock JWST observations. Notably, our model recovers redshifts at least as accurately as the state-of-the-art photo-$z$ code \eazy\ in deep JWST fields, but with two advantages: tailoring a model based on a particular survey renders mostly unnecessary given well-motivated priors; obtaining joint posteriors describing stellar, active galactic nuclei, gas, and dust contributions becomes possible. We can now confidently use the joint distribution to propagate full non-Gaussian redshift uncertainties into inferred properties of the galaxy population. This model, ``\prospector-$\beta$'', is intended for fitting galaxy photometry where the redshift is unknown, and will be instrumental in ensuring the maximum science return from forthcoming photometric surveys with JWST. The code is made publicly available online as a part of \prospector.Comment: Accepted for publication in ApJL. 13 pages, 6 figures, 2 tables. The code is made publicly available online as a part of Prospector; the version used in this work corresponds to the state of the Git repository at commit 820ad7

Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS)) : Part B

In 2014 the International Endohernia Society (IEHS) published the first international "Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias". Guidelines reflect the currently best available evidence in diagnostics and therapy and give recommendations to help surgeons to standardize their techniques and to improve their results. However, science is a dynamic field which is continuously developing. Therefore, guidelines require regular updates to keep pace with the evolving literature. Methods For the development of the original guidelines all relevant literature published up to year 2012 was analyzed using the ranking of the Oxford Centre for Evidence-Based-Medicine. For the present update all of the previous authors were asked to evaluate the literature published during the recent years from 2012 to 2017 and revise their statements and recommendations given in the initial guidelines accordingly. In two Consensus Conferences (October 2017 Beijing, March 2018 Cologne) the updates were presented, discussed, and confirmed. To avoid redundancy, only new statements or recommendations are included in this paper. Therefore, for full understanding both of the guidelines, the original and the current, must be read. In addition, the new developments in repair of abdominal wall hernias like surgical techniques within the abdominal wall, release operations (transversus muscle release, component separation), Botox application, and robot-assisted repair methods were included. Results Due to an increase of the number of patients and further development of surgical techniques, repair of primary and secondary abdominal wall hernias attracts increasing interests of many surgeons. Whereas up to three decades ago hernia-related publications did not exceed 20 per year, currently this number is about 10-fold higher. Recent years are characterized by the advent of new techniques-minimal invasive techniques using robotics and laparoscopy, totally extraperitoneal repairs, novel myofascial release techniques for optimal closure of large defects, and Botox for relaxing the abdominal wall. Furthermore, a concomitant rectus diastasis was recognized as a significant risk factor for recurrence. Despite still insufficient evidence with respect to these new techniques it seemed to us necessary to include them in the update to stimulate surgeons to do research in these fields. Conclusion Guidelines are recommendations based on best available evidence intended to help the surgeon to improve the quality of his daily work. However, science is a continuously evolving process, and as such guidelines should be updated about every 3 years. For a comprehensive reference, however, it is suggested to read both the initially guidelines published in 2014 together with the update. Moreover, the presented update includes also techniques which were not known 3 years before

The Expression of Inflammatory Mediators in Bladder Pain Syndrome.

Background: Bladder pain syndrome (BPS) pathology is poorly understood. Treatment strategies are empirical, with limited efficacy, and affected patients have diminished quality of life. Objective: We examined the hypothesis that inflammatory mediators within the bladder contribute to BPS pathology. Design, setting, and participants: Fifteen women with BPS and 15 women with stress urinary incontinence without bladder pain were recruited from Cork University Maternity Hospital from October 2011 to October 2012. During cystoscopy, 5-mm bladder biopsies were taken and processed for gene expression analysis. The effect of the identified genes was tested in laboratory animals. Outcome measures and statistical analysis: We studied the expression of 96 inflammation-related genes in diseased and healthy bladders. We measured the correlation between genes and patient clinical profiles using the Pearson correlation coefficient. Results and limitations: Analysis revealed 15 differentially expressed genes, confirmed in a replication study. FGF7 and CCL21 correlated significantly with clinical outcomes. Intravesical CCL21 instillation in rats caused increased bladder excitability and increased c-fos activity in spinal cord neurons. CCL21 atypical receptor knockout mice showed significantly more c-fos upon bladder stimulation with CCL21 than wild-type littermates. There was no change in FGF7-treated animals. The variability in patient samples presented as the main limitation. We used principal component analysis to identify similarities within the patient group. Conclusions: Our study identified two biologically relevant inflammatory mediators in BPS and demonstrated an increase in nociceptive signalling with CCL21. Manipulation of this ligand is a potential new therapeutic strategy for BPS. Patient summary: We compared gene expression in bladder biopsies of patients with bladder pain syndrome (BPS) and controls without pain and identified two genes that were increased in BPS patients and correlated with clinical profiles. We tested the effect of these genes in laboratory animals, confirming their role in bladder pain. Manipulating these genes in BPS is a potential treatment strategy

Manual versus automatic bladder wall thickness measurements: a method comparison study

Purpose To compare repeatability and agreement of conventional ultrasound bladder wall thickness (BWT) measurements with automatically obtained BWT measurements by the BVM 6500 device. Methods Adult patients with lower urinary tract symptoms, urinary incontinence, or postvoid residual urine were urodynamically assessed. During two subsequent cystometry sessions the infusion pump was temporarily stopped at 150 and 250 ml bladder filling to measure BWT with conventional ultrasound and the BVM 6500 device. For each method and each bladder filling, repeatability and variation was assessed by the method of Bland and Altman. Results Fifty unselected patients (30 men, 20 women) aged 21–86 years (median 62.5 years) were prospectively evaluated. Invalid BWT measurements were encountered in 2.1–14% of patients when using the BVM 6500 versus 0% with conventional ultrasound (significant only during the second measurement at 150 ml bladder filling). Mean difference in BWT values between the measurements of one technique was -0.1 to +0.01 mm. Measurement variation between replicate measurements was smaller for conventional ultrasound and the smallest for 250 ml bladder filling. Mean difference between the two techniques was 0.11–0.23 mm and did not differ significantly. The BVM 6500 device was not able to correctly measure BWTs above 4 mm. Conclusions Both BWT measurements are repeatable and agree with each other. However, conventional ultrasound measurements have a smaller measurement variance, can measure BWT in all patients, and BWTs above 4 mm

Altered motivation states for physical activity and ‘appetite’ for movement as compensatory mechanisms limiting the efficacy of exercise training for weight loss

Weight loss is a major motive for engaging in exercise, despite substantial evidence that exercise training results in compensatory responses that inhibit significant weight loss. According to the Laws of Thermodynamics and the CICO (Calories in, Calories out) model, increased exercise-induced energy expenditure (EE), in the absence of any compensatory increase in energy intake, should result in an energy deficit leading to reductions of body mass. However, the expected negative energy balance is met with both volitional and non-volitional (metabolic and behavioral) compensatory responses. A commonly reported compensatory response to exercise is increased food intake (i.e., Calories in) due to increased hunger, increased desire for certain foods, and/or changes in health beliefs. On the other side of the CICO model, exercise training can instigate compensatory reductions in EE that resist the maintenance of an energy deficit. This may be due to decreases in non-exercise activity thermogenesis (NEAT), increases in sedentary behavior, or alterations in sleep. Related to this EE compensation, the motivational states associated with the desire to be active tend to be overlooked when considering compensatory changes in non-exercise activity. For example, exercise-induced alterations in the wanting of physical activity could be a mechanism promoting compensatory reductions in EE. Thus, one’s desires, urges or cravings for movement–also known as “motivation states” or “appetence for activity”-are thought to be proximal instigators of movement. Motivation states for activity may be influenced by genetic, metabolic, and psychological drives for activity (and inactivity), and such states are susceptible to fatigue-or reward-induced responses, which may account for reductions in NEAT in response to exercise training. Further, although the current data are limited, recent investigations have demonstrated that motivation states for physical activity are dampened by exercise and increase after periods of sedentarism. Collectively, this evidence points to additional compensatory mechanisms, associated with motivational states, by which impositions in exercise-induced changes in energy balance may be met with resistance, thus resulting in attenuated weight loss

The Cosmic Telescope that Lenses the Sunburst Arc, PSZ1 G311.65-18.48: Strong Gravitational Lensing model and Source Plane Analysis

We present a strong lensing analysis of the cluster PSZ1 G311.65-18.48, based on Hubble Space Telescope imaging, archival VLT/MUSE spectroscopy, and Chandra X-ray data. This cool-core cluster (z=0.443) lenses the brightest lensed galaxy known, dubbed the "Sunburst Arc" (z=2.3703), a Lyman continuum (LyC) emitting galaxy multiply-imaged 12 times. We identify in this field 14 additional strongly-lensed galaxies to constrain a strong lens model, and report secure spectroscopic redshifts of four. We measure a projected cluster core mass of M(<250 kpc)=2.93+0.01/-0.02x10^14M_sun. The two least-magnified but complete images of the Sunburst Arc's source galaxy are magnified by ~13x, while the LyC clump is magnified by ~4-80x. We present time delay predictions and conclusive evidence that a discrepant clump in the Sunburst Arc, previously claimed to be a transient, is not variable, thus strengthening the hypothesis that it results from an exceptionally high magnification. A source plane reconstruction and analysis of the Sunburst Arc finds its physical size to be 1x2 kpc, and that it is resolved in three distinct directions in the source plane, 0, 40, and 75 degrees (east of North). We place an upper limit of r <~ 50 pc on the source plane size of unresolved clumps, and r<~ 32 pc for the LyC clump. Finally, we report that the Sunburst Arc is likely in a system of two or more galaxies separated by <~6 kpc in projection. Their interaction may drive star formation and could play a role in the mechanism responsible for the leaking LyC radiation.Comment: 31 pages, 14 figures, 4 tables. Submitted to Ap

Synthesizing Stellar Populations in South Pole Telescope Galaxy Clusters. I. Ages of Quiescent Member Galaxies at 0.3 < z < 1.4

Using stellar population synthesis models to infer star formation histories (SFHs), we analyze photometry and spectroscopy of a large sample of quiescent galaxies that are members of Sunyaev-Zel’dovich (SZ)-selected galaxy clusters across a wide range of redshifts. We calculate stellar masses and mass-weighted ages for 837 quiescent cluster members at 0.3 < z < 1.4 using rest-frame optical spectra and the Python-based Prospector framework, from 61 clusters in the SPT-GMOS Spectroscopic Survey (0.3 < z < 0.9) and three clusters in the SPT Hi-z cluster sample (1.25 < z < 1.4). We analyze spectra of subpopulations divided into bins of redshift, stellar mass, cluster mass, and velocity-radius phase-space location, as well as by creating composite spectra of quiescent member galaxies. We find that quiescent galaxies in our data set sample a diversity of SFHs, with a median formation redshift (corresponding to the lookback time from the redshift of observation to when a galaxy forms 50% of its mass, t 50) of z = 2.8 ± 0.5, which is similar to or marginally higher than that of massive quiescent field and cluster galaxy studies. We also report median age-stellar mass relations for the full sample (age of the universe at t 50 (Gyr) = 2.52 (±0.04)-1.66 (±0.12) log10(M/1011 M ⊙)) and recover downsizing trends across stellar mass; we find that massive galaxies in our cluster sample form on aggregate ∼0.75 Gyr earlier than lower-mass galaxies. We also find marginally steeper age-mass relations at high redshifts, and report a bigger difference in formation redshifts across stellar mass for fixed environment, relative to formation redshifts across environment for fixed stellar mass