Opioidergic and dopaminergic modulation of cost/benefit decision-making in Long Evans Rats

Eating disorders are associated with impaired decision-making and dysfunctional reward-related neurochemistry. The present study examined the potential contributions of dopamine and opioid signaling to these processes using two different decision-making tasks. In one task, Long Evans Rats chose between working for a preferred food (high-carbohydrate banana-flavored sucrose pellets) by lever pressing on a progressive-ratio schedule of reinforcement vs. obtaining less preferred laboratory chow that was concurrently available. In a second (effort-free) task, rats chose between the same two reinforcers when they were both available freely. Rats were trained in these tasks before receiving haloperidol (0.00, 0.05, 0.10 mg/kg, intraperitoneally (i.p.)) or naloxone (0.0, 1.5, 3.0 mg/kg, i.p.). In the first task, haloperidol decreased breakpoint, lever presses, number of reinforcers earned, and increased chow intake, whereas naloxone decreased breakpoint and number of reinforcers earned but had no effect on chow consumption. In the effort-free task, haloperidol reduced intakes of both foods without affecting preference, whereas naloxone selectively reduced the consumption of banana-pellets. The present findings support converging evidence suggesting that DA signaling affects processes more closely related to appetitive motivation, leaving other components of motivation unchanged. By contrast, opioid signaling appears to mediate aspects of hedonic feeding by selectively altering intakes of highly palatable foods. For preferred foods, both appetitive and consummatory aspects of food intake were altered by opioid receptor antagonism. Our findings argue against a general suppression of appetite by either compound, as appetite manipulations have been shown to unselectively alter intakes of both types of food regardless of the task employed

Optimization of cw sodium laser guide star efficiency

Context: Sodium laser guide stars (LGS) are about to enter a new range of laser powers. Previous theoretical and numerical methods are inadequate for accurate computations of the return flux and hence for the design of the next-generation LGS systems. Aims: We numerically optimize the cw (continuous wave) laser format, in particular the light polarization and spectrum. Methods: Using Bloch equations, we simulate the mesospheric sodium atoms, including Doppler broadening, saturation, collisional relaxation, Larmor precession, and recoil, taking into account all 24 sodium hyperfine states and on the order of 100 velocity groups. Results: LGS return flux is limited by "three evils": Larmor precession due to the geomagnetic field, atomic recoil due to radiation pressure, and transition saturation. We study their impacts and show that the return flux can be boosted by repumping (simultaneous excitation of the sodium D2a and D2b lines with 10-20% of the laser power in the latter). Conclusions: We strongly recommend the use of circularly polarized lasers and repumping. As a rule of thumb, the bandwidth of laser radiation in MHz (at each line) should approximately equal the launched laser power in Watts divided by six, assuming a diffraction-limited spot size.Comment: 15 pages, 12 figures, to be published in Astronomy & Astrophysics, AA/2009/1310

SOBRE POMBOS E GENTE: ALGUMAS OBSERVAÇÕES SOBRE DIFERENÇAS ENTRE ESPÉCIES EM ESCOLHA E AUTOCONTROLE

Cross-species continuity in behavior is widely assumed in behavior analysis, and yet some recent research appears to challenge a strong version of the continuity assumption. This paper reviews potential sources of human-nonhuman discontinuity in the area of choice and self-control. Special emphasis is given to differences in the procedures used to study humans and other animals, which hinder cross-species comparisons. Modifying the procedures used with nonhumans (through the use of token-type reinforcement systems) and with humans (through the use of consumable-type reinforcement systems) brings the choice patterns of humans and other animals into better accord. This suggests that at least some of the reported differences in self-control choices in humans and other animals reflect procedural differences rather than more fundamental differences in behavioral process. By narrowing the methodological chasm separating human and nonhuman procedures, this research points to more effective strategies for assessing cross-species continuity in behavior. Key words: choice, self-control, token reinforcement, consumable reinforcement, species continuity.A continuidade no comportamento entre espécies tem sido amplamente assumida na análise do comportamento, embora pesquisas recentes pareçam desafiar uma versão forte do pressuposto da continuidade. Este artigo apresenta uma revisão de fontes potenciais para a descontinuidade humano-não humano em escolha e auto-controle. Ênfase especial é colocada nas diferenças nos procedimentos empregados para estudar humanos e outros animais, que dificultam comparações entre espécies. Modificações nos procedimentos empregados com não-humanos (por meio do uso de sistemas de reforço do tipo fichas) e com humanos (por meio do emprego de sistemas de reforço do tipo consumatório) mostram maior acordo nos padrões de escolha de humanos e outros animais. Isto sugere que pelo menos algumas das diferenças relatadas sobre escolhas em procedimentos de autocontrole em humanos e outros animais refletem diferenças de procedimento, mais do que diferenças mais fundamentais em processos comportamentais. Ao estreitar as lacunas metodológicas que separam procedimentos empregados com humanos e não humanos, esta pesquisa aponta estratégias mais efetivas para avaliar a continuidade no comportamento entre espécies.Palavras-chave: escolha, autocontrole, reforçamento por fichas, reforço consumatório, continuidade entre espécies

Solar winds along curved magnetic field lines

Both remote-sensing measurements using the interplanetary scintillation (IPS) technique and in situ measurements by the Ulysses spacecraft show a bimodal structure for the solar wind at solar minimum conditions. At present what makes the fast wind fast and the slow wind slow still remains to be answered. While a robust empirical correlation exists between the coronal expansion rate $f_c$ of the flow tubes and the speeds $v$ measured in situ, further data analysis suggests that $v$ depends on more than just $f_c$. We examine whether the non-radial shape of field lines, which naturally accompanies any non-radial expansion, could be an additional geometrical factor. We solved the transport equations incorporating the heating due to turbulent Alfv\'en waves for an electron-proton solar wind along curved field lines given by an analytical magnetic field model, representative of a solar minimum corona. The field line shape is found to influence substantially the solar wind parameters, reducing the asymptotic speed by up to $\sim 130$ km s$^{-1}$, or by $\sim 28$ in relative terms, compared with the case neglecting the field line curvature. This effect was interpreted in the general framework of energy addition in the solar wind: Relative to the straight case, the field line curvature enhances the effective energy deposition to the subsonic flow, resulting in a higher proton flux and a lower terminal proton speed. Our computations suggest that the field line curvature could be a geometrical factor which, in addition to the tube expansion, substantially influences the solar wind speed. Furthermore, at solar minima although the field line curvature unlikely affects the polar fast solar wind, it does help make the wind at low latitudes slow, thereby helping better reproduce the Ulysses measurements.Comment: 7 pages, 3 figures, accepted by Astronomy and Astrophysic

The infrared supernova rate in starburst galaxies

We report the results of our ongoing search for extincted supernovae (SNe) at near-infrared wavelengths. We have monitored at 2.2 micron a sample of 46 Luminous Infrared Galaxies and detected 4 SNe. The number of detections is still small but sufficient to provide the first estimate of supernova rate at near-infrared wavelengths. We measure a SN rate ofv 7.6+/-3.8 SNu which is an order of magnitude larger than observed in quiescent galaxies. On the other hand, the observed near-infrared rate is still a factor 3-10 smaller than that estimated from the far-infrared luminosity of the galaxies. Among various possibilities, the most likely scenario is that dust extinction is so high (Av>30) to obscure most SNe even in the near-IR. The role of type Ia SNe is also discussed within this context. We derive the type Ia SN rate as a function of the stellar mass of the galaxy and find a sharp increase toward galaxies with higher activity of star formation. This suggests that a significant fraction of type Ia SNe are associated with young stellar populations. Finally, as a by-product, we give the average K-band light curve of core-collapse SNe based on all the existing data, and review the relation between SN rate and far-infrared luminosity.Comment: A&A, in press, 13 page

Cell-Free Synthesis of the Mitochondrial ADP/ATP Carrier Protein of Neurospora crassa

ADP/ATP carrier protein was synthesized in heterologous cell-free systems programmed with Neurospora poly(A)-containing RNA and homologous cell-free systems from Neurospora. The apparent molecular weight of the product obtained in vitro was the same as that of the authentic mitochondrial protein. The primary translation product obtained in reticulocyte lysates starts with formylmethionine when formylated initiator methionyl-tRNA (fMet-tRNAfMet) was present. The product synthesized in vitro was released from the ribosomes into the postribosomal supernatant. The evidence presented indicates that the ADP/ATP carrier is synthesized as a polypeptide with the same molecular weight as the mature monomeric protein and does not carry an additional sequence