2,645 research outputs found
automRm: An R Package for Fully Automatic LC-QQQ-MS Data Preprocessing Powered by Machine Learning
Preprocessing of liquid chromatography-mass spectrometry (LC-MS) raw data facilitates downstream statistical and biological data analyses. In the case of targeted LC-MS data, consistent recognition of chromatographic peaks is a main challenge, in particular, for low abundant signals. Fully automatic preprocessing is faster than manual peak review and does not depend on the individual operator. Here, we present the R package automRm for fully automatic preprocessing of LC-MS data recorded in MRM mode. Using machine learning (ML) for detection of chromatographic peaks and quality control of reported results enables the automatic recognition of complex patterns in raw data. In addition, this approach renders automRm generally applicable to a wide range of analytical methods including hydrophilic interaction liquid chromatography (HILIC), which is known for sample-to-sample variations in peak shape and retention time. We demonstrate the impact of the choice of training data set, of the applied ML algorithm, and of individual peak characteristics on automRm’s ability to correctly report chromatographic peaks. Next, we show that automRm can replicate results obtained by manual peak review on published data. Moreover, automRm outperforms alternative software solutions regarding the variation in peak integration among replicate measurements and the number of correctly reported peaks when applied to a HILIC-MS data set. The R package is freely available from gitlab (https://gitlab.gwdg.de/joerg.buescher/automrm)
Polarized Proton Beams from Laser-induced Plasmas
We report on the concept of an innovative source to produce polarized
proton/deuteron beams of a kinetic energy up to several GeV from a laser-driven
plasma accelerator. Spin effects have been implemented into the PIC simulation
code VLPL to make theoretical predictions about the behavior of proton spins in
laser-induced plasmas. Simulations of spin-polarized targets show that the
polarization is conserved during the acceleration process. For the experimental
realization, a polarized HCl gas-jet target is under construction using the
fundamental wavelength of a Nd:YAG laser system to align the HCl bonds and
simultaneously circular polarized light of the fifth harmonic to
photo-dissociate, yielding nuclear polarized H atoms. Subsequently, their
degree of polarization is measured with a Lamb-shift polarimeter. The final
experiments, aiming at the first observation of a polarized particle beam from
laser-generated plasmas, will be carried out at the 10 PW laser system SULF at
SIOM/Shanghai.Comment: 7 pages, 7 figure
Phenomenological analysis of K+ meson production in proton-nucleus collisions
Total and differential cross sections from literature, on the production of
K+ mesons in pA interactions at projectile energies between T=0.8 and 2.9 GeV,
covering the transition across the free nucleon-nucleon threshold at 1.58 GeV,
have been investigated. From the target-mass dependence of the production cross
sections no evidence for the expected change of the dominant reaction mechanism
from two-step to direct kaon production was found. At T=1.0 GeV the A
dependences of the total cross sections and of the most recent data from
COSY-Juelich, differential cross sections measured under forward angles, are
strongly different. The invariant K+ production cross sections show an overall
exponential scaling behavior with the squared four-momentum transfer between
the beam proton and the produced K+ meson for t< -0.05 GeV^2 independent of the
beam energy and emission angle. The data from COSY-Juelich reveal a strongly
different t dependence in the region of t>0 GeV^2. Further data at forward
angles and different beam energies should be taken in order to explore this
region of kinematically extreme conditions.Comment: 9 Pages, 11 Figure
Shape Isomerism at N = 40: Discovery of a Proton Intruder in 67Co
The nuclear structure of 67Co has been investigated through 67Fe beta-decay.
The 67Fe isotopes were produced at the LISOL facility in proton-induced fission
of 238U and selected using resonant laser ionization combined with mass
separation. The application of a new correlation technique unambiguously
revealed a 496(33) ms isomeric state in 67Co at an unexpected low energy of 492
keV. A 67Co level scheme has been deduced. Proposed spin and parities suggest a
spherical (7/2-) 67Co ground state and a deformed first excited (1/2-) state at
492 keV, interpreted as a proton 1p-2h prolate intruder state.Comment: 4 pages, 5 figures, preprint submitted to Physical Review Letter
Conserving Conflict? Transfrontier Conservation, Development Discourses and Local Conflict Between South Africa and Lesotho
This paper describes and analyses how discourses of conservation and development as well as migrant labour practices can be understood as transnational dynamics that both cement and complicate transnational relations. It also looks into how these dynamics articulate with, shape and are being shaped by ‘the local’. Focusing on the north-eastern boundary of Lesotho in the area of the ‘Maloti-Drakensberg transfrontier conservation and development project’, we show how conflictual situations put the ethnographic spotlight on the ways in which ‘local people’ in Lesotho deal with dual forces of localisation and transnationalisation. We argue that they accommodate, even appropriate, these dual pressures by adopting an increasingly flexible stance in terms of identity, alliances, livelihood options and discourses
Maximum Significance at the LHC and Higgs Decays to Muons
We present a new way to define and compute the maximum significance
achievable for signal and background processes at the LHC, using all available
phase space information. As an example, we show that a light Higgs boson
produced in weak--boson fusion with a subsequent decay into muons can be
extracted from the backgrounds. The method, aimed at phenomenological studies,
can be incorporated in parton--level event generators and accommodate
parametric descriptions of detector effects for selected observables.Comment: 7 pages, 2 figures, changes to wording and new references, published
versio
The energy dependence of the pp->K+ n Sigma+ reaction close to threshold
The production of the Sigma+ hyperon through the pp->K+nSigma+ reaction has
been investigated at four energies close to threshold, 1.826, 1.920, 1.958, and
2.020 GeV. At low energies, correlated K+pi+ pairs can only originate from
Sigma+ production so that their measurement allows the total cross section for
the reaction to be determined. The results obtained are completely consistent
with the values extracted from the study of the K+-proton correlation spectra
obtained in the same experiment. These spectra, as well as the inclusive K+
momentum distributions, also provide conservative upper limits on the Sigma+
production rates. The measurements show a Sigma+ production cross section that
varies roughly like phase space and, in particular, none of the three
experimental approaches used supports the anomalously high near-threshold
pp->K+ nSigma+ total cross section previously reported [T. Rozek et al., Phys.
Lett. B 643, 251 (2006)].Comment: Submitted to PR
Subthreshold antiproton production in proton-carbon reactions
Data from KEK on subthreshold antiproton as well as on pi(+-) and K(+-)
production in proton-nucleus reactions are described at projectile energies
between 3.5 and 12.0 GeV. We use a model which considers a hadron-nucleus
reaction as an incoherent sum over collisions of the projectile with a varying
number of target nucleons. It samples complete events and allows thus for the
simultaneous consideration of all particle species measured. The overall
reproduction of the data is quite satisfactory. It is shown that the
contributions from the interaction of the projectile with groups of several
target nucleons are decisive for the description of subthreshold production.
Since the collective features of subthreshold production become especially
significant far below the threshold, the results are extrapolated down to COSY
energies. It is concluded that an antiproton measurement at ANKE-COSY should be
feasible, if the high background of other particles can be efficiently
suppressed.Comment: 15 pages, 5 figures, gzipped tar file, submitted to J. Phys. G v2:
Modification of text due to demands of referee
Early onset of ground-state deformation in the neutron-deficient polonium isotopes
In-source resonant ionization laser spectroscopy of the even- polonium
isotopes Po has been performed using the
to ( nm) transition in the polonium atom
(Po-I) at the CERN ISOLDE facility. The comparison of the measured isotope
shifts in Po with a previous data set allows to test for the first
time recent large-scale atomic calculations that are essential to extract the
changes in the mean-square charge radius of the atomic nucleus. When going to
lighter masses, a surprisingly large and early departure from sphericity is
observed, which is only partly reproduced by Beyond Mean Field calculations.Comment: As submitted to PR
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