Derecho de acceso a la información en Brasil y México: entre cabestros, jefes y sociedad civil

The present article aims to present the characteristics of the process of creation of Access to Public Information Laws in Brazil and Mexico, whose cultures present traces of opacity due to phenomena such as caciquism and patrimonialism. Through bibliographical research and interviews, a comparison is made of the controversies that involve civil society in the insertion of the issue on the government’s agenda. First, the experience of the Oaxaca group in Mexico is shown, followed by the mobilization of organizations in the Forum on the Right of Access to Public Information in Brazil. It is possible to perceive the multidimensionality of the challenges that permeate the culture of both Latin American realities for the implementation of State transparency measures.El artículo tiene como objetivo presentar las características del proceso de creación de Leyes de Acceso a la Información Pública en Brasil y México, cuyas culturas muestran rastros de opacidad debido a fenómenos como el caciquismo y el patrimonialismo. A través de investigaciones bibliográficas y entrevistas, se comparan las controversias que involucran a la sociedad civil en la inserción del tema en la agenda del gobierno. Primero, se muestra la experiencia del grupo Oaxaca en México, seguida de la movilización de organizaciones en el Foro sobre el Derecho de Acceso a la Información Pública en Brasil. Es posible percibir la multidimensionalidad de los desafíos que permean la cultura de ambas realidades latinoamericanas para la implementación de las medidas de transparencia del Estado

Lenalidomide Maintenance and Measurable Residual Disease in a Real-World Multiple Myeloma Transplanted Population Receiving Different Treatment Strategies Guided by Access to Novel Drugs in Brazil

Despite recent advances in multiple myeloma (MM), the incorporation of novel agents and measurable residual disease (MRD) monitoring in low-income countries remains a challenge. Although lenalidomide maintenance (M-Len) after autologous stem cell transplantation (ASCT) has been associated with improved outcomes and MRD has refined the prognosis of complete response (CR) cases, until now, there have been no data on the benefits of these approaches in Latin America. Here, we evaluate the benefits of M-Len and MRD using next-generation flow cytometry (NGF-MRD) at Day + 100 post-ASCT (n = 53). After ASCT, responses were evaluated based on the International Myeloma Working Group criteria and NGF-MRD. MRD was positive in 60% of patients with a median progression-free survival (PFS) of 31 months vs. not reached (NR) for MRD-negative cases (p = 0.05). The patients who received M-Len continuously had a significantly better PFS and overall survival (OS) than those without M-Len (median PFS: NR vs. 29 months, p = 0.007), with progression in 11% vs. 54% of cases after a median follow-up of 34 months, respectively. In a multivariate analysis, MRD status and M-Len therapy emerged as independent predictors of PFS (median PFS of M-Len/MRD− vs. no M-Len/MRD+ of NR vs. 35 months, respectively; p = 0.01). In summary, M-Len was associated with improved survival outcomes in our real-world MM cohort in Brazil, with MRD emerging as a useful reproducible tool to identify patients at an earlier risk of relapse. The inequity in drug access remains a hurdle in countries with financial constraints, with a negative impact on MM survival.This work was supported by from Coordenação de Aperfeiçomento de Pessoal de Nível Superior—Brazil (CAPES) Finance code 001-8888.331795/2010-01; Programa de Oncobiologia 001/2017 and 004/2017; Centro Investigación Biomédica em Red—Cáncer (CIBERONC code CB//00400) of Instituto de Salud Carlos III, Ministry of Science and Innovation (Madrid, Spain), number CB16/12/00400; The International Myeloma Foundation-Black Swan Research Initiative (Los Angeles, CA) (Grant: LSHB-CT-2006-018708). A.B.S.S. was supported by a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES/PROEX, number: 88887.688096/2022-00. R.M.P. was supported by a grant from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/DGPU), number: 000281/2016-06 and CAPES/PROEX 641/2018, Brazil, and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro of Brazil (FAPERJ), number: E01/200/537/2018. E.S.B. was supported by a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES/PROEX, number: 88887.335769/2019-00 and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), number: E-26/200.192/2020, Brazil

Temperatura da pele: parâmetro clínico importante na prevenção de lesões por pressão

As lesões por pressão (LP) são danos localizados na pele e/ou tecidos moles subjacentes, geralmente sobre uma proeminência óssea ou relacionada ao uso de dispositivo médico ou a outro artefato. Estudos sobre a temperatura da superfície da pele como parâmetro clínico para a prevenção de LP são uma lacuna no conhecimento produzido. Logo, tem-se como objetivo apresentar dados obtidos pelas pesquisas realizadas pelo Grupo de Pesquisa Gestão e Atenção em Saúde e Enfermagem, acerca da temperatura da superfície da pele em calcanhares de adultos e idosos. Serão trazidos resultados de três estudos realizados por membros do grupo de pesquisa, o qual pertence ao Programa de Pós-graduação em Enfermagem da Universidade Federal de Santa Maria (PPGENF-UFSM)info:eu-repo/semantics/publishedVersio