Ingeniería tisular: aplicación de células madre en reparación de defectos epidérmicos

Premio Extraordinario de Doctorado 2007Premio de la Sociedad de Condueños 200

Ingeniería tisular: aplicación de células madre en reparación de defectos epidérmicos

Premio Extraordinario de Doctorado 2007Premio de la Sociedad de Condueños 200

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross-Sectional Study

Objective: To evaluate the impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Methods: This was a cross-sectional analysis of the baseline visit from the Cardiovascular in Rheumatology study. Multivariate models with physical function as the dependent variable (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire for AS and PsA, respectively) were performed. Independent variables were a proxy for the Charlson Comorbidity Index (CCIp; range 0-27), sociodemographic data, disease activity (erythrocyte sedimentation rate [ESR] and Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] in AS; Disease Activity Score in 28 joints [DAS28] using the ESR in PsA), disease duration, radiographic damage, and treatments. Results were reported as beta coefficients, 95% confidence intervals (95% CIs), and P values. Results: We included 738 patients with AS and 721 with PsA; 21% of patients had >1 comorbidity. Comorbidity burden (CCIp) was independently associated with worse adjusted physical function in patients with PsA (? = 0.11). Also, female sex (? = 0.14), disease duration (? = 0.01), disease activity (DAS28-ESR; ? = 0.19), and the use of nonsteroidal antiinflammatory drugs (? = 0.09), glucocorticoids (? = 0.11), and biologics (? = 0.15) were associated with worse function in patients with PsA. A higher education level was associated with less disability (? = -0.14). In patients with AS, age (? = 0.03), disease activity (BASDAI; ? = 0.81), radiographic damage (? = 0.61), and the use of biologics (? = 0.51) were independently associated with worse function on multivariate analyses, but CCIp was not. Conclusion: The presence of comorbidities in patients with PsA is independently associated with worse physical function. The detection and control of the comorbidities may yield an integral management of the disease.The CARMA project has been supported by an unrestricted Grant from Abbvie, Spain. The sponsor had no role in the study design, the collection, analysis or interpretation of the data; in the writing of the report; or in the decision to submit the article for publication. Dr. González-Gay’s studies have been supported by Grants from “Fondo de Investigaciones Sanitarias,” Spain PI06/0024, PI09/00748, PI12/00060, PI15/00525, PI18/00043 and RD12/0009/0013(RIER) and RD16/0012 (RIER) from “Instituto de Salud Carlos III” (ISCIII), Spain