Modelling typhoid risk in Dhaka Metropolitan Area of Bangladesh: the role of socio-economic and environmental factors

BackgroundDeveloping countries in South Asia, such as Bangladesh, bear a disproportionate burden of diarrhoeal diseases such as Cholera, Typhoid and Paratyphoid. These seem to be aggravated by a number of social and environmental factors such as lack of access to safe drinking water, overcrowdedness and poor hygiene brought about by poverty. Some socioeconomic data can be obtained from census data whilst others are more difficult to elucidate. This study considers a range of both census data and spatial data from other sources, including remote sensing, as potential predictors of typhoid risk. Typhoid data are aggregated from hospital admission records for the period from 2005 to 2009. The spatial and statistical structures of the data are analysed and Principal Axis Factoring is used to reduce the degree of co-linearity in the data. The resulting factors are combined into a Quality of Life index, which in turn is used in a regression model of typhoid occurrence and risk.ResultsThe three Principal Factors used together explain 87% of the variance in the initial candidate predictors, which eminently qualifies them for use as a set of uncorrelated explanatory variables in a linear regression model. Initial regression result using Ordinary Least Squares (OLS) were disappointing, this was explainable by analysis of the spatial autocorrelation inherent in the Principal factors. The use of Geographically Weighted Regression caused a considerable increase in the predictive power of regressions based on these factors. The best prediction, determined by analysis of the Akaike Information Criterion (AIC) was found when the three factors were combined into a quality of life index, using a method previously published by others, and had a coefficient of determination of 73%.ConclusionsThe typhoid occurrence/risk prediction equation was used to develop the first risk map showing areas of Dhaka Metropolitan Area whose inhabitants are at greater or lesser risk of typhoid infection. This, coupled with seasonal information on typhoid incidence also reported in this paper, has the potential to advise public health professionals on developing prevention strategies such as targeted vaccination

OH detection by absorption of frequency-doubled diode laser radiation at 308nm

Radiation at 308 nm has been obtained by frequency doubling the output of a commercial diode laser cooled to 165 K. A single pass through a crystal of LiIO3 converted 1 mW of 616 nm radiation to 50 pW of UV, and this was used to detect the OH radical in absorption in a flow tube. Possible extensions of the method for detection of OH in the atmosphere are discussed

Field Guide to the Geology of the Harlan County Lake Area, Harlan County, Nebraska — with a History of Events Leading to Construction of Harlan County Dam

The year 2002 will mark the fiftieth anniversary of completion of the Harlan County Dam and Multi-Purpose Reservoir. This seems a good time to write about the history of and reasons for building the dam, the effects of the dam and reservoir on the Republican River valley, and the geologic features seen along the shores of the lake and areas nearby. As many junior authors helped produced this educational circular, they are listed in the table of contents. All other sections were written by the senior author. Includes July 2016 update: Addendum of photographs showing fault traces on drought-exposed lake bottom. Cretaceous Niobrara Chalk Formation and the younger Pierre Shale are also shown. Table of Contents Introduction 1 Location 1 Republican River Floods 1 The Republican River Flood of 1935 - D R Mohlman 1 Cautionary Notes (sidebar) 1 Events After the Flood Leading to Creation of Harlan County Lake 9 Stormer Ford Dog Town (sidebar) 10 Water 10 Surface Water Hydrology - S Summerside 10 Shoreline Springs and Seeps - F: E Harvey and K J Warren 12 Introduction 12 Using Water Chemistry to Identify Spring and Seep Origin 1 2 Geology 15 General Conditions Leading to Good Exposures 15 Stratigraphy of Unconsolidated Sediments and Rock Strata 15 Cretaceous System - Upper Cretaceous Series 15 Niobrara Formation - Smoky Hill Chalk Member 15 Pierre Shale 15 Tertiary System - Miocene Series 16 Ogallala Group -Ash Hollow Formation 16 Quaternary System - Pleistocene Series 16 Crete (?) Formation (Sands and Gravels) 1 6 Loveland Loess 16 Gliman Canyon Formation 16 Peoria and Bignell Loesses 16 Quaternary System - Holocene (Recent) Series 1 6 Unnamed Fluvial, Eolian, and Colluvial Deposits 16 Paleontology of the Various Formations 16 Plants 16 Invertebrates - R K Pabian 17 Cretaceous Marine Fossils 17 Niobrara Formation 17 Foraminifers 17 Post-Devonian Stromatoporoids 1 9 Mollusks 19 Bivalves 19 Ammonites 19 Pierre Shale Formation 19 Bivalves 19 Ammonites 19 Quaternary - Pleistocene (Ice Age) Invertebrate Fossils 19 Vertebrate Fossils - R G Corner 24 Late Cretaceous Fossils 24 Niobrara Formation 24 Niobrara Fishes 24 Niobrara Mosasaurs 29 Pierre Shale Formation 30 Protosphyvaena gladius: Giant Mystery Fish 30 Pierre Mosasaurs 32 Late Miocene Ogallala Group 32 Bone Cove I Fauna 32 Bone Cove II Fauna 32 Quaternary - Pleistocene (Ice Age) 33 Crete (?) Sands and Gravels 33 Gilman Canyon Formation 33 Peoria Loess 35 Late Pleistocene Fauna 35 Late Pleistocene Environments 37 Geologic Processes Affecting the Strata 37 Modem and Ancient Landslides 37 Modern Landslides D A Eversoll 37 Ancient Landslides - D A Eversoll and R F Diffendal, Jr 39 Geologic Structures 41 Introduction and Previous Work 41 Angular Unconformities 45 Joints 45 Faults and Folds 45 Ancient Landscapes (Paleotopography) 50 Quaternary River Terraces 50 Concluding Remarks 50 References Cited 51 Glossary Keywords: flooding 1930s, vertebrate fossils, earthquake faults, landslides, groundwater qualit

Evaluation of the current knowledge limitations in breast cancer research: a gap analysis

BACKGROUND A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients. METHODS Fifty-six Breast Cancer Campaign grant holders and prominent UK breast cancer researchers participated in a gap analysis of current breast cancer research. Before, during and following the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion. Summary papers were prepared by each group and collated into this position paper highlighting the research gaps, with recommendations for action. RESULTS Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included: (1) genetics (knowledge of genetic changes, their effects and interactions); (2) initiation of breast cancer (how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation); (3) progression of breast cancer (deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis); (4) therapies and targets (understanding who develops advanced disease); (5) disease markers (incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers); (6) prevention (strategies to prevent oestrogen-receptor negative tumours and the long-term effects of chemoprevention for oestrogen-receptor positive tumours); (7) psychosocial aspects of cancer (the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds). CONCLUSION Through recommendations to address these gaps with future research, the long-term benefits to patients will include: better estimation of risk in families with breast cancer and strategies to reduce risk; better prediction of drug response and patient prognosis; improved tailoring of treatments to patient subgroups and development of new therapeutic approaches; earlier initiation of treatment; more effective use of resources for screening populations; and an enhanced experience for people with or at risk of breast cancer and their families. The challenge to funding bodies and researchers in all disciplines is to focus on these gaps and to drive advances in knowledge into improvements in patient care

Crop Updates 2000 Cereals - part 3

This session covers eighteen papers from different authors: BARLEY AND OAT AGRONOMY 1. Unicorn barley must meet malting specifications to be a viable option, Roslyn Jettnerand Blakely Paynter, Agriculture Western Australia 2. Optimum oat seed rates, Glenn McDonald, Agriculture Western Australia 3. Production and Quality of export Oaten Hay (1998 and 1989), Pierre Fievez, Pierre Fievez and Associates FROST 4. Climatology of Frost in Southern Western Australia, Ian Foster, Agriculture Western Australia 5. Flowering calculator, David Tennant, Agriculture Western Australia 6. Some options for managing the risk of frost damage, Wal Anderson, Agriculture Western Australia PASTURE 7. TIMERITE® Control of redlegged earth mite in south western Australia with a spring spray to pastures, James Ridsdill-Smith and Celia Pavri, CSIRO Entomology, University of Western Australia 8. The pattern of seed softening in subterranean clover in relation to presicted false break risk, Ross Chapman and Senthold Asseng, CSIRO Plant Industry, Centre for Mediterranean Agricultural Research 9. Charano serradella – a viable option for 1:1 cropping, Steve Carr and Brad Nutt IAMA Agri-Services Western Australia and Centre for Legumes in Mediterranean Agriculture, University of Western Australia 10. Alfalfa mosaic virus in alternative annual pasture and forage legumes, Lindrea Latham and Roger Jones, Crop Improvement Institute, Agriculture Western Australia and Centre for Legumes in Mediterranean Agriculture, University of Western Australia 11. Pasture mixture performs better than single-species-based pasture – 1999, Anyou Liu, Clinton Revell and David Ferris, Centre for Cropping Systems, Agriculture Western Australia 12. Better pasture management improves performance of following crops – 1999, Anyou Liu, Clinton Revell and David Ferris, Centre for Cropping Systems, Agriculture Western Australia 13. Lucerne Benefits Crop Production, Roy Latta1, Lisa-Jane Blacklow2, Chris Matthews1 1Agriculture Western Australia 2University of Western Australia 14. Does size count? Determining optimum release number of red apion for biocontrol of doublegee, Tim Woodburn and Paul Yeoh, CSIRO Entomology/CRC Weed Management Systems, Perth 15. Herbicide tolerance of some new cultivars of annual pasture legumes, Clinton Revell and Ian Rose, Centre for Cropping Systems, Agriculture Western Australia 16. Lucerne – crop rotations in the Esperance region, Anita Lyons, Roy Latta and Chris Matthews,Agriculture Western Australia PRECISION AGRICULTURE 17. Assessing the results of on-farm experiments using yield monitors, Simon Cook and Matthew Adams, CSIRO Land and Water 18. Achiever: A GIS based achievable yield and fertiliser recommendation system for precision agriculture, Robert J. Corner, Matthew L. Adams, Precision Agriculture Research Group CSIRO Land and Wate

Passive spectral bathymetry using satellite remote sensing in Cockburn Sound, W.A.

Conventional bathymetric surveying is a costly and time consuming business. Even today many areas of shallow inshore ocean, some which encompass potential oil and gas fields, are only minimally charted. There is a need for reconnaissance systems which can effectively direct more expensive detailed surveys to best effect. Remote spectral bathymetry is one such system.A review of candidate sensor systems and processing algorithms highlighted problems due to changing bottom cover types and water quality parameters. A method, proposed and theoretically validated by other workers, was chosen for further investigation. This method develops an approximate relationship between the spectral content of the satellite data and water depths and then, by an iterative phase in the spatial domain, seeks to minimise the effect of spatially dependant variations.A study site in Cockburn Sound, Western Australia was chosen for a demonstration of this method. Spectral data are from the Landsat Thematic Mapper instrument and depth data are taken from Admiralty Charts. A variation on the originally proposed algorithm introduces spatial preprocessing phase, in which the image is segmented into zones where spectral relationships are expected to be more uniform. Two different methods of spatial mapping are used.The results demonstrate the capability of spatial modelling to improve remotely sensed depth estimates in the depth range of 5 to 12 m. The need for further research to better understand the shallow water spectral relationships is identified