Cardiac Memory-induced T-wave Inversions

Introduction: Cardiac memory refers to T-wave inversions that result when normal ventricular activation resumes following a period of abnormal ventricular activation.Case Report: We present a case of a 29-year-old man with a pacemaker who presented with new, deep symmetric T-wave inversions caused by cardiac memory.Discussion: Abnormal ventricular activation is most commonly induced by ventricular pacing but can also occur in the setting of transient left bundle branch blocks, ventricular tachycardia, and intermittent ventricular pre-excitation.Conclusion: Recognition of this phenomenon may help to reduce unnecessary admissions, cardiac testing, and cardiac catheterizations

Modeling the Formation of Clouds in Brown Dwarf Atmospheres

Because the opacity of clouds in substellar mass object (SMO) atmospheres depends on the composition and distribution of particle sizes within the cloud, a credible cloud model is essential for accurately modeling SMO spectra and colors. We present a one--dimensional model of cloud particle formation and subsequent growth based on a consideration of basic cloud microphysics. We apply this microphysical cloud model to a set of synthetic brown dwarf atmospheres spanning a broad range of surface gravities and effective temperatures (g_surf = 1.78 * 10^3 -- 3 * 10^5 cm/s^2 and T_eff = 600 -- 1600 K) to obtain plausible particle sizes for several abundant species (Fe, Mg2SiO4, and Ca2Al2SiO7). At the base of the clouds, where the particles are largest, the particle sizes thus computed range from ~5 microns to over 300 microns in radius over the full range of atmospheric conditions considered. We show that average particle sizes decrease significantly with increasing brown dwarf surface gravity. We also find that brown dwarfs with higher effective temperatures have characteristically larger cloud particles than those with lower effective temperatures. We therefore conclude that it is unrealistic when modeling SMO spectra to apply a single particle size distribution to the entire class of objects.Comment: 25 pages; 8 figures. We have added considerable detail describing the physics of the cloud model. We have also added discussions of the issues of rainout and the self-consistent coupling of clouds with brown dwarf atmospheric models. We have updated figures 1, 3, and 4 with new vertical axis labels and new particle sizes for forsterite and gehlenite. Accepted to the Astrophysical Journal, Dec. 2, 200

Hybrid guiding-centre/full-orbit simulations in non-axisymmetric magnetic geometry exploiting general criterion for guiding-centre accuracy

To identify under what conditions guiding-centre or full-orbit tracing should be used, an estimation of the spatial variation of the magnetic field is proposed, not only taking into account gradient and curvature terms but also parallel currents and the local shearing of field-lines. The criterion is derived for general three-dimensional magnetic equilibria including stellarator plasmas. Details are provided on how to implement it in cylindrical coordinates, and in flux coordinates that rely on the geometric toroidal angle. A means of switching between guiding-centre and full-orbit equations at first order in Larmor radius with minimal discrepancy is shown. Techniques are applied to a MAST (Mega Amp Spherical Tokamak) helical core equilibrium in which the inner kinked flux-surfaces are tightly compressed against the outer axisymmetric mantle and where the parallel current peaks at the nearly rational surface. This is put in relation with the simpler situation $\vec{B}(x,y,z) = B_0 [\sin(kx) \vec{e_y} + \cos(kx)\vec{e_z}]$, for which full orbits and lowest order drifts are obtained analytically. In the kinked equilibrium, the full orbits of NBI fast ions are solved numerically and shown to follow helical drift surfaces. This result partially explains the off-axis redistribution of NBI fast particles in the presence of MAST Long-Lived Modes (LLM).Comment: 12 pages, 12 figure

Cell regulation by phosphotyrosine-targeted ubiquitin ligases

Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. Because ubiquitination frequently routes proteins for degradation by the lysosome or proteasome, these E3 ligases are able to potently inhibit tyrosine kinase signaling. Their loss or mutational inactivation can contribute to cancer, autoimmunity, or endocrine disorders, such as diabetes. However, these ligases also have biological functions that are independent of their ubiquitination activity. Here we review relevant literature and then focus on more-recent developments in understanding the structures, substrates, and pathways through which the phosphotyrosine-specific ubiquitin ligases regulate diverse aspects of cell biology

Decapods as food, companions and research animals: Legal impact of ascribing sentience

This commentary provides an overview of the practical implications of attributing sentience to protect decapods as food, companion and research animals in the UK context. Recognising their capacity to suffer has implications for humane slaughter in farming and fishing sectors. It should also place a greater duty of care on owners of captive decapods, considering their needs and avoiding unnecessary suffering. The recognition of decapod sentience should also have an impact on their protection as research animals, although research with a potential to cause suffering may be needed to better understand decapods’ capacity to suffer

Identification of backbone curves of nonlinear systems from resonance decay responses

AbstractBackbone curves can offer valuable insight into the behaviour of nonlinear systems along with significant information about any coupling between the underlying linear modes in their response. This paper presents a technique for the extraction of backbone curves of lightly damped nonlinear systems that is well suited for the experimental investigation of structures exhibiting nonlinear behaviour. The approach is based on estimations of the instantaneous frequency and the envelope amplitude of a decaying response following a tuned steady-state oscillation of the system. Results obtained from simulations and experiments demonstrate that the proposed procedure is capable of achieving an accurate estimation of the backbone curves and damping ratios of the system provided that the premise of damping having low impact on its oscillation frequency is met

Towards a new understanding of NCL pathogenesis

AbstractThe Neuronal Ceroid Lipofuscinoses (NCLs, Batten disease) are a group of inherited neurodegenerative disorders that have been traditionally grouped together on the basis of certain shared clinical and pathological features. However, as the number of genes that appear to cause new forms of NCL continues to grow, it is timely to reassess our understanding of the pathogenesis of these disorders and what groups them together. The various NCL subtypes do indeed share features of a build-up of autofluorescent storage material, progressive neuron loss and activation of the innate immune system. The characterisation of animal models has highlighted the selective nature of neuron loss and its intimate relationship with glial activation, rather than the generalised build-up of storage material. More recent data provide evidence for the pathway-dependent nature of pathology, the contribution of glial dysfunction, and the involvement of new brain regions previously thought to be unaffected, and it is becoming apparent that pathology extends beyond the brain. These data have important implications, not just for therapy, but also for our understanding of these disorders. However, looking beneath these broadly similar pathological themes evidence emerges for marked differences in the nature and extent of these events in different forms of NCL. Indeed, given the widely different nature of the mutated gene products it is perhaps more surprising that these disorders resemble each other as much as they do. Such data raise the question whether we should rethink the collective grouping of these gene deficiencies together, or whether it would be better to consider them as separate entities. This article is part of a Special Issue entitled: Current Research on the Neuronal Ceroid Lipofuscinoses (Batten Disease)