Comparison of MSIS and Jacchia atmospheric density models for orbit determination and propagation

Two atmospheric density model families that are commonly chosen for orbit determination and propagation, Jacchia and MSIS, are compared for accuracy. The Jacchia 70 model, the MSISE-90 model, and the NRLMSISE-00 model may each be used to determine orbits over fitspans of several days and then to propagate forward. With observations kept over the propagation period, residuals may be computed and the accuracy of each model evaluated. We have performed this analysis for over 4000 cataloged satellites with perigee below 1000km for September-­October 1999, and the 60 HASDM calibration satellites with a large observation set for February 2001. The purpose of this study is to form a picture of the relative merits of the drag models in a comprehensive view, using all satellites in a manner consistent with the operational practice of US space surveillance centers. A further goal is to refine this knowledge to understand the orbital parameter regions where one of the models may be consistently superior

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques

Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive immunization can protect nonhuman primates and their fetuses during pregnancy has not been determined. Z004 and Z021 are neutralizing monoclonal antibodies to domain III of the envelope (EDIII) of ZIKV. Together the two antibodies protect nonpregnant macaques against infection even after Fc modifications to prevent antibody-dependent enhancement in vitro (ADE) and extend their half-lives. Here we report on prophylactic co-administration of the Fc-modified antibodies to pregnant rhesus macaques challenged 3 times with ZIKV during first and second trimester. The two antibodies did not entirely eliminate maternal viremia but limited vertical transmission protecting the fetus from neurologic damage. Thus, maternal passive immunization with two antibodies to EDIII can shield primate fetuses from the harmful effects of ZIKV

Diagnosis and management of functional tic-like phenomena

Over the past 3 years, a global phenomenon has emerged characterized by the sudden onset and frequently rapid escalation of tics and tic-like movements and phonations. These symptoms have occurred not only in youth known to have tics or Tourette syndrome (TS), but also, and more notably, in youth with no prior history of tics. The Tourette Association of America (TAA) convened an international, multidisciplinary working group to better understand this apparent presentation of functional neurological disorder (FND) and its relationship to TS. Here, we review and summarize the literature relevant to distinguish the two, with recommendations to clinicians for diagnosis and management. Finally, we highlight areas for future emphasis and research

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques

Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive immunization can protect nonhuman primates and their fetuses during pregnancy has not been determined. Z004 and Z021 are neutralizing monoclonal antibodies to domain III of the envelope (EDIII) of ZIKV. Together the two antibodies protect nonpregnant macaques against infection even after Fc modifications to prevent antibody-dependent enhancement in vitro (ADE) and extend their half-lives. Here we report on prophylactic co-administration of the Fc-modified antibodies to pregnant rhesus macaques challenged 3 times with ZIKV during first and second trimester. The two antibodies did not entirely eliminate maternal viremia but limited vertical transmission protecting the fetus from neurologic damage. Thus, maternal passive immunization with two antibodies to EDIII can shield primate fetuses from the harmful effects of ZIKV

CDIM: Cosmic Dawn Intensity Mapper Final Report

The Cosmic Dawn Intensity Mapper (CDIM) will transform our understanding of the era of reionization when the Universe formed the first stars and galaxies, and UV photons ionized the neutral medium. CDIM goes beyond the capabilities of upcoming facilities by carrying out wide area spectro-imaging surveys, providing redshifts of galaxies and quasars during reionization as well as spectral lines that carry crucial information on their physical properties. CDIM will make use of unprecedented sensitivity to surface brightness to measure the intensity fluctuations of reionization on large-scales to provide a valuable and complementary dataset to 21-cm experiments. The baseline mission concept is an 83-cm infrared telescope equipped with a focal plane of 24 x 2048^2 detectors capable of R = 300 spectro-imaging observations over the wavelength range of 0.75 to 7.5 µm using Linear Variable Filters (LVFs). CDIM provides a large field of view of 7.8 deg^2 allowing efficient wide area surveys, and instead of moving instrumental components, spectroscopic mapping is obtained through a shift-and-stare strategy through spacecraft operations. CDIM design and capabilities focus on the needs of detecting faint galaxies and quasars during reionization and intensity fluctuation measurements of key spectral lines, including Lyman-α and Hα radiation from the first stars and galaxies. The design is low risk, carries significant science and engineering margins, and makes use of technologies with high technical readiness level for space observations

On the mechanisms governing gas penetration into a tokamak plasma during a massive gas injection

A new 1D radial fluid code, IMAGINE, is used to simulate the penetration of gas into a tokamak plasma during a massive gas injection (MGI). The main result is that the gas is in general strongly braked as it reaches the plasma, due to mechanisms related to charge exchange and (to a smaller extent) recombination. As a result, only a fraction of the gas penetrates into the plasma. Also, a shock wave is created in the gas which propagates away from the plasma, braking and compressing the incoming gas. Simulation results are quantitatively consistent, at least in terms of orders of magnitude, with experimental data for a D 2 MGI into a JET Ohmic plasma. Simulations of MGI into the background plasma surrounding a runaway electron beam show that if the background electron density is too high, the gas may not penetrate, suggesting a possible explanation for the recent results of Reux et al in JET (2015 Nucl. Fusion 55 093013)