6,562 research outputs found

    Secondary Flow Control in Low Aspect Ratio Vanes Using Splitters

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    Low aspect ratio vanes, often the result of overall engine architecture constraints, create strong secondary flows and high end-wall loss. In this paper, a splitter concept is demonstrated that reduces secondary flow strength and improves stage performance. An analytic conceptual study, corroborated by inviscid computations, shows that the total secondary kinetic energy (SKE) of the secondary flow vortices is reduced when the number of passages is increased and, for a given number of vanes, when the inlet end-wall boundary layer is evenly distributed between the passages. Viscous computations show that, for this to be achieved in a splitter configuration, the pressure-side leg of the low aspect ratio vane horseshoe vortex, must enter the adjacent passage (and not “jump” in front of the splitter leading edge). For a target turbine application, four vane designs were produced using a multi-objective optimization approach. These designs represent current practice for a low aspect ratio vane, a design exempt from thickness constraints, and two designs incorporating splitter vanes. Each geometry is tested experimentally, as a sector, within a low-speed turbine stage. The vane designs with splitter geometries were found to reduce the measured secondary kinetic energy, by up to 85%, to a value similar to the design exempt from thickness constraints. The resulting flow field was also more uniform in both the circumferential and radial directions. One splitter design was selected for a full annulus test where a mixed-out loss reduction, compared to the current practice design, of 15.3% was measured and the stage efficiency increased by 0.88%.The work was funded by Rolls-Royce plc under the SILOET 2 work package

    Two cases of food aversion with semantic dementia

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    Accounts of altered eating behavior in semantic dementia generally emphasize gluttony and abnormal food preferences. Here we describe two female patients with no past history of eating disorders who developed early prominent aversion to food in the context of an otherwise typical semantic dementia syndrome. One patient (aged 57) presented features in line with anorexia nervosa while the second patient (aged 58) presented with a syndrome more suggestive of bulimia nervosa. These cases add to the growing spectrum of apparently dichotomous behavior patterns in the frontotemporal dementias and illustrate a potentially under-recognized cause of eating disorders presenting in later life

    An Unsteady Pressure Probe for the Measurement of Flow Unsteadiness in Tidal Channels

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    IEEE An unsteady five-hole probe has been developed for the measurement of turbulent flow in tidal channels. Such measurements are vital for accurate prediction of unsteady loads on tidal turbines. Existing field-based velocimeters are either unable to capture the required range of frequencies or are too expensive to profile the variation of turbulence across a typical tidal power site, and thus the available data is inadequate for turbine design. This work adapts the traditional five-hole wind tunnel probe to achieve a low-cost device with sufficient frequency range for tidal turbine applications. The main issue in the marine environment is that the ambient hydrostatic pressure is much higher than the dynamic pressure. This has been overcome by using novel calibration coefficients and differential transducers. In flume tank tests against laser Doppler velocimeter measurements, the frequency response of the probe has been shown to be sufficient to capture all the frequencies necessary for tidal turbine design

    Cerebellar Integrity in the Amyotrophic Lateral Sclerosis - Frontotemporal Dementia Continuum

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    Amyotrophic lateral sclerosis (ALS) and behavioural variant frontotemporal dementia (bvFTD) are multisystem neurodegenerative disorders that manifest overlapping cognitive, neuropsychiatric and motor features. The cerebellum has long been known to be crucial for intact motor function although emerging evidence over the past decade has attributed cognitive and neuropsychiatric processes to this structure. The current study set out i) to establish the integrity of cerebellar subregions in the amyotrophic lateral sclerosis-behavioural variant frontotemporal dementia spectrum (ALS-bvFTD) and ii) determine whether specific cerebellar atrophy regions are associated with cognitive, neuropsychiatric and motor symptoms in the patients. Seventy-eight patients diagnosed with ALS, ALS-bvFTD, behavioural variant frontotemporal dementia (bvFTD), most without C9ORF72 gene abnormalities, and healthy controls were investigated. Participants underwent cognitive, neuropsychiatric and functional evaluation as well as structural imaging using voxel-based morphometry (VBM) to examine the grey matter subregions of the cerebellar lobules, vermis and crus. VBM analyses revealed: i) significant grey matter atrophy in the cerebellum across the whole ALS-bvFTD continuum; ii) atrophy predominantly of the superior cerebellum and crus in bvFTD patients, atrophy of the inferior cerebellum and vermis in ALS patients, while ALS-bvFTD patients had both patterns of atrophy. Post-hoc covariance analyses revealed that cognitive and neuropsychiatric symptoms were particularly associated with atrophy of the crus and superior lobule, while motor symptoms were more associated with atrophy of the inferior lobules. Taken together, these findings indicate an important role of the cerebellum in the ALS-bvFTD disease spectrum, with all three clinical phenotypes demonstrating specific patterns of subregional atrophy that associated with different symptomology

    Physiological phenotyping of dementias using emotional sounds.

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    INTRODUCTION: Emotional behavioral disturbances are hallmarks of many dementias but their pathophysiology is poorly understood. Here we addressed this issue using the paradigm of emotionally salient sounds. METHODS: Pupil responses and affective valence ratings for nonverbal sounds of varying emotional salience were assessed in patients with behavioral variant frontotemporal dementia (bvFTD) (n = 14), semantic dementia (SD) (n = 10), progressive nonfluent aphasia (PNFA) (n = 12), and AD (n = 10) versus healthy age-matched individuals (n = 26). RESULTS: Referenced to healthy individuals, overall autonomic reactivity to sound was normal in Alzheimer's disease (AD) but reduced in other syndromes. Patients with bvFTD, SD, and AD showed altered coupling between pupillary and affective behavioral responses to emotionally salient sounds. DISCUSSION: Emotional sounds are a useful model system for analyzing how dementias affect the processing of salient environmental signals, with implications for defining pathophysiological mechanisms and novel biomarker development

    Behavioral implications of shortlisting procedures

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    We consider two-stage “shortlisting procedures” in which the menu of alternatives is first pruned by some process or criterion and then a binary relation is maximized. Given a particular first-stage process, our main result supplies a necessary and sufficient condition for choice data to be consistent with a procedure in the designated class. This result applies to any class of procedures with a certain lattice structure, including the cases of “consideration filters,” “satisficing with salience effects,” and “rational shortlist methods.” The theory avoids background assumptions made for mathematical convenience; in this and other respects following Richter’s classical analysis of preference-maximizing choice in the absence of shortlisting
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