AJ Clark

AM Guerts

CJ Palgrave

D Yang

DF Carlson

FD Urnov

ID Carbery

J Hauschild

JC Miller

JJ Whyte

SC Fahrenkrug

T Flisokowska

VM Bedell

WS Tan

Scientific Reports

English

Transcription activator-like effector nuclease (TALEN) and zinc finger nuclease (ZFN) genome editing technology enables site directed engineering of the genome. Here we demonstrate for the first time that both TALEN and ZFN injected directly into pig zygotes can produce live genome edited pigs. Monoallelic as well as heterozygous and homozygous biallelic events were identified, significantly broadening the use of genome editor technology in livestock by enabling gene knockout in zygotes from any chosen mating

Lillico, Simon

Proudfoot, Christopher

Carlson, D. F.

Stverakova, Dana

Neil, Claire

Blain, Carol

King, Tim

Ritchie, WA

Tan, Spring

Mileham, A

Mclaren, D

Fahrenkrug, Scott C

Whitelaw, Bruce

Edinburgh Research Explorer

Live pigs produced from genome edited zygotes

Simon G. Lillico

Chris Proudfoot

Daniel F. Carlson

Dana Stverakova

Claire Neil

Carol Blain

Tim J. King

William A. Ritchie

Wenfang Tan

Alan J. Mileham

David G. McLaren

Scott C. Fahrenkrug

C. Bruce A. Whitelaw

Crossref

Live pigs produced from genome edited zygotes

Abstract

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