A HOLISTIC APPROACH TO DEVELOP ENGINEERING PROGRAMME OUTCOMES: A CASE STUDY OF TAYLOR'S UNIVERSITY

Part fulfilment of providing an engineering programme which implements outcome based education includes various outcomes that are tied to what the graduate should achieve after, during and before graduation. The programme outcomes are specifically crafted to encapsulate attributes that must be attained by a student upon graduation. The following paper details the principles used to craft the programme outcomes of an engineering undergraduate degree programme. The principles used were chosen based its importance and innovative content as well as being aligned to the purpose of the university which is running the degree programme. Upon crafting the prescribed outcomes, the paper will also detail how stakeholders were engaged and how their opinion was accounted for in the final crafting of the new set of programme outcomes. The paper also highlights how a gap analysis was performed to capture areas which were not covered by the previous programme outcomes

Kinetics of mass transfer, colour, total polyphenol and texture change of Manilkara zapota during convective air drying

The effects of air temperature and product size on drying kinetics, retained total polyphenol content (TPC), hardness kinetics and total colour change (ΔE) kinetics of ciku (Manilkara zapota) were investigated. In addition, five terms of the theoretical model were used to estimate the effective diffusivity values during drying at temperatures from 40°C to 70°C. The drying rates of dried ciku were increased with increasing temperature and decreasing product size. It was found that hardness of ciku dried at temperature higher than 60°C increased significantly, when the moisture content was reduced to less than 0.5 g H2O/g DM (dry basis). In terms of nutritional value, the retained total polyphenol content (TPC) of dried ciku in hot air drying also increasing with temperature. The highest retained TPC was 141 mg GAE/ 100g of samples, which can be obtained from drying at 70°C

Drying kinetics, texture, color, and determination of effective diffusivities during sun drying of chempedak

Sun drying of chempedak (Artocarpus integer) was carried out on different sample sizes to investigate the effects on product quality. Fick's second law model was used to determine the effective diffusivities of sun–dried chempedak slabs based on the drying rate versus moisture content plots. In addition, texture degradation and total color changes were investigated. The texture and color changes of dried chempedak were relatively significant (p < 0.05) compared to fresh chempedak. There was an increase in dried fruit hardness and chewiness but a decrease in springiness and cohesiveness during drying

Drying models and quality analysis of sun-dried ciku

Sun drying of ciku (Manilkara zapota) was carried out on different sample sizes to investigate the effects on drying kinetics. It was found that the maximum drying rates of sun-dried ciku decreased with larger product size. Three sunny days are needed to dry the ciku slabs to an average final moisture content of 0.2 g H2O/g dry mass. The results showed that hardness and chewiness of the dried samples were significantly different (p 0.05) compared to fresh ciku slabs. In addition, sun-dried ciku retained a total polyphenol content (TPC) that was relatively low (p < 0.05) compared to fresh ciku

Drying kinetics and product quality of dried chempedak.

The objective of this study was to investigate the drying kinetics of chempedak (Artocarpus integer) at different drying temperatures (50 °C, 60 °C, 70 °C) and slab dimensions. The drying data were fitted to the different semi-theoretical models based on moisture ratio (MR) to predict the drying kinetics. A logarithmic model was found to be the best fit in this study for all the drying temperatures tested. Effective diffusivities were estimated from Fick’s 2nd law and the Arrhenius equation was used to determine the diffusivity constant (Do) and activation energy (Ea). The texture and color of dried product were altered significantly during drying. The total color change (ΔE), hardness and chewiness were found to be increased with elevated temperature; meanwhile, springiness and cohesiveness of dried chempedak were relatively constant

The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10−7 or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide association study of lung adenocarcinoma in never-smoking females (584 cases, 585 controls) among Han Chinese in Taiwan and found that the most significant association was for rs2736100 on chromosome 5p15.33 (p = 1.30×10−11). This finding was independently replicated in seven studies from East Asia totaling 1,164 lung adenocarcinomas and 1,736 controls (p = 5.38×10−11). A pooled analysis achieved genome-wide significance for rs2736100. This SNP marker localizes to the CLPTM1L-TERT locus on chromosome 5p15.33 (p = 2.60×10−20, allelic risk = 1.54, 95% Confidence Interval (CI) 1.41–1.68). Risks for heterozygote and homozygote carriers of the minor allele were 1.62 (95% CI; 1.40–1.87), and 2.35 (95% CI: 1.95–2.83), respectively. In summary, our results show that genetic variation in the CLPTM1L-TERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma

Вихретоковый анизотропный термоэлектрический первичный преобразователь лучистого потока

Представлена оригинальная конструкция первичного преобразователя лучистого потока, который может служить основой для создания приемника неселективного излучения с повышенной чувствительностью

Genome-Wide Association Study of Lung Adenocarcinoma in East Asia and Comparison With a European Population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction  = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications