Results of Universal Prenatal Screening for Hepatitis C Infection in a Remote American Indian Primary Care Population

BACKGROUND: Although chronic liver disease remains a major area of health disparity for American Indian (AI) people, the epidemiology of hepatitis C virus (HCV) infection among AI people is poorly documented. Because of suspected high local prevalence, two remote AI clinics in the Northern Plains implemented universal prenatal HCV screening in 2005. When this screening program reported an unexpectedly high prenatal anti-HCV (anti-HCV antibody) positivity rate, we conducted a case-control study to determine risks for infection and opportunities for community intervention. MAIN FINDINGS: The clinics screened a total of 205 pregnant women (median age, 22 years). Of these 205 women, a total of 13 (6.3%; 95% confidence interval, 3.4–10.6) had anti-HCV confirmed. Of the anti-HCV-positive women, 10 (76.9%) were aged 15–24 years. We included 10 cases and 40 anti-HCV-negative prenatal controls in a case-control study. On multivariate analysis, only injection-drug use (IDU) remained associated with HCV seropositivity. CONCLUSIONS: Universal prenatal screening revealed a high prevalence of anti-HCV at these remote AI clinics. This population has not been previously described at being at elevated risk for HCV infection. In order to reduce health disparities, young, rural AI populations seeking prenatal care need to be included in interventions to reduce HCV transmission

Isospin-violating dark matter at liquid noble detectors: new constraints, future projections, and an exploration of target complementarity

There is no known reason that dark matter interactions with the Standard Model should couple to neutrons and protons in the same way. This isospin violation can have large consequences, modifying the sensitivity of existing and future direct detection experimental constraints by orders of magnitude. Previous works in the literature have focused on the zero-momentum limit which has its limitations when extending the analysis to the Non-Relativistic Effective Field Theory basis (NREFT). In this paper, we study isospin violation in a detailed manner, paying specific attention to the experimental setups of liquid noble detectors. We analyse two effective Standard Model gauge invariant models as interesting case studies as well as the more model-independent NREFT operators. This work demonstrates the high degree of complementarity between the target nuclei xenon and argon. Most notably, we show that the Standard Model gauge-invariant formulation of the standard spin-dependent interaction often generates a sizeable response from argon, a target nuclei with zero spin. This work is meant as an update and a useful reference to model builders and experimentalists.Comment: 22 pages in total, 13 figures, 1 table, 3 appendices. Data from the main results of this paper is available at https://doi.org/10.1140/epjc/s10052-023-11826-

The Relationship Between the Number of Shots and the Quality of Gamma Knife Radiosurgeries

Radiosurgery is a non-invasive alternative to brain surgery that uses a single focused application of high radiation to destroy intracerebral target tissues. A Gamma Knife delivers such treatments by using 201 cylindrically collimated cobalt-60 sources that are arranged in a hemispherical pattern and aimed to a common focal point. The accumulation of radiation at the focal point, called a \shot due to the spherical nature of the dose distribution, is used to ablate (or destroy) target tissue in the brain. If the target is small and spherical, it is easily treated by choosing one of four available collimators (4, 8, 14, or 18 mm). For large, irregular targets, multiple shots are typically required to treat the entire lesion, and the process of determining the optimal arrangement and number of shots is complex. In this research, fast simulated annealing and a novel objective function are used to investigate the relationship between the number of shots and the quality of the resulting treatment. Sets of 5, 10, 25, 50, and an unrestricted number of shots are studied for an arteriovenous malformation (AVM). As the shot limit increases the following improvements in plan quality are observed: the conformity of the prescription isodose line increases, the lesion dose becomes more homogeneous, and an increase use of smaller collimators to deposit dose. Large improvements in plan quality are realized by increasing the number of shots from 5 to 50, and to achieve a similar magnitude of improvement past 50 requires an increase over 1500 shots for the complex lesion investigated. This observation suggests that it is clinically valuable to improve the Gamma Knife\u27s delivery capabilities so that 50 shot treatments are possible

A revision of the African genus Mesanthemum (Eriocaulaceae)

Mesanthemum is a genus comprising 16 species in the family Eriocaulaceae and is native to Africa and Madagascar. Eriocaulaceae are characterised by a basal tuft or rosette of narrow leaves and small flowers in heads. Mesanthemum can be recognised by diplostemonous flowers and fused glandular pistillate petals. While most Mesanthemum species are large perennial herbs, two small ephemeral species from West Africa, M. albidum and M. auratum differ from the rest of the genus by their shorter life cycle, smaller size, simpler floral structures and different seed surface patterning. A molecular phylogenetic study, morphological comparisons and scanning electron microscope (SEM) examination of seed coat sculpture were carried out to determine whether they should be separated as a new genus. The molecular results indicate that the two ephemeral species are nested in the Mesanthemum clade. However, they are not closely related to each other. All species of Mesanthemum are here revised, including the description of a new species M. alenicola from Equatorial Guinea. An identification key is provided, together with taxonomic descriptions, synonymy and notes. Images of the seeds as seen under SEM are provided where available. Lectotypifications are provided for Mesanthemum albidum, M. bennae, M. pilosum, M. prescottianum, M. pubescens and M. variabile. A neotype is selected for M. rutenbergianum, which is synonymised with M. pubescens

Constructing the First Year Experience: Improving Retention and Graduation Rates at a Hispanic-Serving Institution

In 2012, UNM teamed up with the Gardner Institute for Excellence in Undergraduate Education, to conduct a Foundations of Excellence® (FoE) First College Year Self Study addressing student success. As members of the First Year Steering Committee, we invented, coordinated, measured, and documented programs for linking students to the academic experiences and support that were best attuned to their needs

Social Problem Solving in Adolescents Engaging in Non-Suicidal Self-Injury Compared with Adolescent Suicide Attempters

The aim of the present study was to examine social problem solving skills among adolescents engaging in various self-injurious behaviors. Previous research has supported the claim that deficits in social problem solving skills are associated with engagement in non-suicidal self-injury (NSSI) and suicide attempts, but no research has been done comparing the two self-injury groups together. Data was collected from 176 adolescent females with history of mental health problems measuring their self-injurious behaviors and social problems solving skills. After answering various questions regarding their social problem solving skills over four social scenarios, participants experienced a stressful task and were then given the remaining four social scenarios. This manipulation was intended to simulate a state of high arousal – more like their physical state would be in the event a social problem had just occurred. Results suggested that adolescents who had reported attempting suicide experienced greater increases in avoidant problem solving strategies after the stressful task than adolescents who had only engaged in NSSI or those who had never injured themselves for any purpose. Implications of these findings, limitations of the current study, and directions for future research are discussed.Bachelor of Art

Probabilistic Clustering of Sequences: Inferring new bacterial regulons by comparative genomics

Genome wide comparisons between enteric bacteria yield large sets of conserved putative regulatory sites on a gene by gene basis that need to be clustered into regulons. Using the assumption that regulatory sites can be represented as samples from weight matrices we derive a unique probability distribution for assignments of sites into clusters. Our algorithm, 'PROCSE' (probabilistic clustering of sequences), uses Monte-Carlo sampling of this distribution to partition and align thousands of short DNA sequences into clusters. The algorithm internally determines the number of clusters from the data, and assigns significance to the resulting clusters. We place theoretical limits on the ability of any algorithm to correctly cluster sequences drawn from weight matrices (WMs) when these WMs are unknown. Our analysis suggests that the set of all putative sites for a single genome (e.g. E. coli) is largely inadequate for clustering. When sites from different genomes are combined and all the homologous sites from the various species are used as a block, clustering becomes feasible. We predict 50-100 new regulons as well as many new members of existing regulons, potentially doubling the number of known regulatory sites in E. coli.Comment: 27 pages including 9 figures and 3 table